Making Sweetness Blocker (and trying it)

[@THYZOID]

The triphosgene step was amazing. Nice to see!

[@HoneyHanya32]

Finally, the missing component to my Feline Life Simulator™️

[@drasiella]

Its the saddest fact I ever learned, and my kitty loves sweet wafer cookies with creamy filling!

[@Physhi]

You already have the RNA set up to make your tongue reverse spiked?

[@Fireclaws10]

@@drasiellait must be the dairy your cat likes i guess

[@FentForEnt]

​@@drasiella kitty likely only eats because of the fat

[@francisnaveen9041]

Loved the depth in which you covered synthesis. I had no idea that TEA would interfere with Tripiphosgene.

[@Cairlos001]

We have recently stumbled across that reaction where I work. Tri-substituted amines react with phosgene ('normal' COCl2 in our case), where one of the substituents (alkyl or aryl) is kicked off and displaced with the carbamoylchloride group. My colleague was preparing some N,N-diethylcarbamoylchloride from diethylamine and phosgene and we were all surprised how he could have gotten a 300 % yield of what all analyses confirmed was the product and was perfectly dry. Apparently, he used triethylamine as a base to reduce the urea formation, but it turned out to produce more of the desired product :D

[@Chemiolis]

I tried a second synth where it was 1.1 eq Triphosgene to the reactant in DCM. Without base yet, likely giving 100% carbamate first. And afterward they added triethylamine. That was horrible and exothermic. Other procedures kept it at -35C too so maybe that prevents something. It did yield some isocyanate but it was dirty and it gave a bunch of weird TEA-phosgene products that could be distilled off. But it also leaves behind TEA HCl which I dont want in the next reaction.

[@DerunerlaubteName]

I really despise the open flask in the isocyanate step. You had phosgene present, maybe pass the exhaust of the reaction through a neutralizing agent. Except the safety concern: Great video and very interesting reaction.

[@Chemiolis]

It's possible to set up some kind of trap but in this case the reaction is very fast and the DCM dissolves it immediately upon release (no bubbles seen rising from the DCM layer). I didn't notice any significant amount of release, pretty much all should be consumed in the reaction.

[@RhombicChthulhuSONIC]

From my observation it looked like it was being consumed quickly enough that it wouldn't really have a chance of escaping.

[@RhombicChthulhuSONIC]

It is good practice to put toxic gases through neutralization though just in case there was any that escaped.

[@DerunerlaubteName]

Yeah, I get it, but safety measures are better to be put in place beforehand. Especially if you haven't done the reaction before, because if a huge portion of the phosgene escapes, you wouldn't have time to react.

[@JennaHasm]

​@@Chemiolis Do you also have experience in silicone polymers?

[@williambouthillier8611]

Insanely cool chemistry as always! And your organic chemistry theory and mechanisms are getting on point!

[@gafrers]

Always fascinating, always interesting and well explained. 👍👍

[@kinexkid]

The negatively charged sulfate group with a positive sodium ion is eerily similar to Sodium Lauryl Sulfate (SLS) but with a lot more going on than a simple carbon chain. SLS is the compound in toothpaste that makes drinking orange juice afterwards taste disgusting by what I'd assume is a similar action of blocking sweetness. Maybe the sodium sulfate part of the molecule is what's responsible for it

[@Chemiolis]

They do mention it in the paper it could be from membrane disruption, but they didn't confirm how it works.

[@chemdelic]

I might need this for how sweet you are🤤

[@FuzzImp]

A cure for r/niceguys

[@Lukesab3r]

I've learned so much from your content. I think I'm hooked for life.

[@sserpant4826]

This is the first video i understood all the terms my chemistry is improving

[@MetalMaggot46]

just casually beginning the synthesis with carbon tet. nbd

[@Mister_Brown]

that's how you know it's in germany or the netherlands

[@Chromium-24.]

You are satisfying my synthesis cravings 💯

[@edoardoberardocco]

video to watch before going to sleep

[@captainchicky3744]

The triphosgene step holy shit

[@JipperdeR]

Nice video! And nice job with the mechanism!

[@aaronkingsley8459]

I wonder if that would reduce the sweetness tasted from eating miraculin and something sour

[@jopmens6960]

Interesting! I thought simply toothpaste also causes this phenomenon for about 10-15 minutes and this causes the somewhat well known issue of orange juice being gross because sweetness is blocked and bitterness enhanced or idk some kinda dysgeusia. Even if that is correct as from wide anecdotal evidence, no idea what ingredient causes it.

[@sirjaustin9140]

Hell yeah new video nice

[@Quinazolinking]

Allee da is keigoe jong, ik hebbe zeer genoten van dieser video

[@jirischimer9540]

I have a question - where do you get hold of 500 ml of CCl4? I actually really need it for brominations in lab and usually have to replace it with dce or trifluorotoluene - which are not worse. I disagree with the amines as bases strongly - it works fine in DCM at 0 degrees with triphosgene. We synthesized like 25 urea based inhibitors in one paper and all were done with DIPEA as a base with yields 80%+ after column. Triphosgene was used as 0.35 eq - so only timy excess. Dont know if TEA is so different though

[@patrickdowney2126]

You know it's going to be banger when we start with carbon tet

[@Edseltje]

Chemiolis, how do you arrange the chemicals, lab space and spectroscopy equipment for your experiments? I have some photochemistry ideas which I would love to verify experimentally. Unfortunately these ideas do not align with local research groups their time, resources, and research interests.

[@mheijne2]

So great stuff to improve the sweet taste of alcohol free beer. Could not taste worse anyway

[@andrews.4780]

The chem god dropped before work 🔥🫡

[@jamesmnguyen]

How many projects do you have working in parallel at any given time? (on average)

[@Chemiolis]

Ideally I only run one at a time but generally 2 and sometimes 3. Mostly because waiting times for one procedure means I can set the other up. Also sometimes just waiting for chems. But space is limited so it depends what it is.

[@user255]

4:14 shouldn't this work without CCl4?

[@ashe1.070]

DCM or Chloroform would work, but you’d need extra chlorine because they would also get chlorinated.

[@user21XXL]

can this be done in chloroform? with Ccl4 as a byproduct?

[@Chemiolis]

Probably yes if you make sure the chloroform has no ethanol stabilizer inside.

[@htomerif]

You might have also lost some yield from dimethyl carbonate loss as the hydrogen chloride carried it away. I know when I was making chloral, I lost about half of it from the ethanol being carried away on the HCl gas stream even under reflux. I had to use < 0C coolant for my reflux column to get the yield to not be terrible. I mean 87 percent is still good though.

[@abs0lute-zer061]

Hell yeah!

[@111455]

i wonder if that compound is present in onions, iv'e always found after eating raw onion i cannot taste sugar at all

[@punkdigerati]

Can you synthesize Miraculin for the opposite?

[@ChemCrafter]

At 8:37 the positive charge should be drawn on the oxygen of the water moiety

[@rezaalijanianzadeh4202]

Very nice

[@jimsvideos7201]

I’m surprised the UV step worked - or was that quartz glassware? My understanding is that silica glass is basically opaque to UV.

[@ashe1.070]

Borosilicate lets small amounts of UV through.

[@andersjjensen]

UV is a spectrum. When you only need UV A normal glassware is good enough. If you need UV B, DUV or EUV (don't ask what happened to C and why the letters are in front) you start getting increasingly screwed.

[@chr1ms1n55]

Blocking is great but is there a chemical or process that removes exclusively sugar, sucrose, glucose, fructose, sucralose, ace-k, (et al) from drinks entirely?

[@Chemiolis]

No there isn’t. Just drink water or make your own drinks.

[@user21XXL]

yeast - but you end up with alkohol

[@DownyViper]

Make hgh next

[@pushs_cool_stuff]

Make 6 6'-dibromoindigo aka tyrian purple, afaik no one on youtube has synthesized it

[@thompinhas]

i would buy those

[@multiarray2320]

anything new with the "that chemist" drama?

[@Thaumius]

idk, TC just kinda assumed no one cares anymore and continued doing videos like nothing happened.

[@Thaumius]

Complains about phosgene toxicity while he works with Carbon Tetrachloride

[@ashe1.070]

Carbon tetrachloride is nowhere near as toxic as phosgene.

[@leliondemer]

Sheesh, I'm using CDI to make ap pseudo isocyanate right now

[@twocvbloke]

Now if only there were solutions to neutralise the artificial sweeteners (aspartame, ace-K, sucralose, etc.) in soft drinks so they didn't taste so yucky, that'd be fun... :P

[@Chemiolis]

Unfortunately many of them have a bitter aftertaste, I don’t like them either so I generally avoid all artificial sweeteners. I’m good with sugar lol

[@boothbytcd6011]

I think they call what you are looking for 'water'.

[@JustinAlexanderBell]

Ever try Synsepalum dulcificum?

[@chandantiwari5626]

Wait, what's that at 0:32? Iodoacetamide? Seriously? That's Iodoacetic acid and the authors are dumb enough to write it as iodoacetamide, where is amide group there? And you, Chemiolis, are also saying it iodoacetamide, very disappointed man.

[@Chemiolis]

Read text I put above it 🤫

[@Rdx4568]

@@ChemiolisGood that you edited it later.

[@calebsynnes3439]

It’ll be ok

[@David-bh7hs]

Could you make a supplement that increase the pH of the body ?

[@Chemiolis]

It’s not possible, the body regulates its own pH to the appropriate level. We die if the pH is wrong, our proteins stop functioning.

[@David-bh7hs]

@@Chemiolis I know

[@exziy]

20 sec ago

[@_thisnameistaken]

this video is very sigma ohio rizz

[@highlander723]

First

[@_thisnameistaken]

L