Making Schizo Powder (PCMO)

[@Ru-mk8lp]

I think they should invent a kitchen knife that doesnt whisper

[@jeffreydallas6047]

Don't tell them about me...

[@jessepinkman1471]

that's funny as fuck Lmfao

[@Mailmanzkidd]

This is the comment and thread I came for but we’re the only ones that get it because we saw that video of the ex waiting affiliate that did the ween stage dive off his balcony but he still has a nice shaft even though they didn’t replace the rest right. That’s the joke right yinz aren’t actually talking to the cutlery again right? 😅

[@jessepinkman1471]

@@Mailmanzkidd masha allah brother

[@Prodluud1]

Always anoying when the couch tells you your penis is on fire

[@triple_gem_shining]

WE'RE MAKING IT INTO THE MENTAL HOSPITAL WITH THIS ONE

[@lm-rh3qo]

Gonna hit them with the hyper mania. You can fly!

[@kaboom4679]

Come on , voices , we're going home !

[@amogusenjoyer]

​@@kaboom4679what if they are already home 😳. They never left the walls

[@Sniperboy5551]

Dissociatives suck.

[@abreada]

My arm is numb 3 days 3 days 3 days

[@morningstar8187]

Three out of four wall voices agree that PCP is the best.

[@kaboom4679]

I wouldn't know. None of mine speak English , and the one that did , just up and quit without any explanation .

[@gonelucid]

The 4th prefers datura

[@blazing_pyro67]

The 4th is having a bad trip and wishes he had some MDMA.

[@mj.l]

@@gonelucid having done pcp and datura, i can confirm that datura creates horror delirium and voices. pcp is a perfectly good drug when used responsibly, but demonised due to prohibitionist racism of the 70s and 80s.

[@quantummechanicalengineeri7016]

Space!

The voiceover of you saying: "It wasn't an issue and the condenser kept everything inside" while we can see a column of liquid rising in the liebig condenser was extremely funny. We really like to play down near-misses on accidents.

[@deadlikedisco4726]

Yeah that's how things went in my silver fulminate synthesis. Just don't worry about spillover on a hot surface. It's fine. Everything is fine.

[@Thatonefuckinguy]

I mean if it ain't exploding or on fire, then your probally doing it right. (unless you want it to explode or set on fire.)

[@billynomates920]

i don't know what it is in other languages but that 'uhwowowooh' every english speaker half-says, half-chuckles on surviving a near-death incident. 😂

[@christopherleubner6633]

Anyone who has played around with O chem has had the fountain of reacting chemicals at least once. 😂

[@Chemiolis]

I’m too impatient for Grignards and always push it to near-disaster

[@rob1732]

Just seeing 3 rings arranged like that screams “I will fuck you up”

[@MajorenSnor]

Exactly what I was thinking

[@douchebagginsmctalibancock2510]

How so exactly? Just curious. Always interest in chemistry but failed miserably in math and couldn't really advance anywhere meaningful in it

[@deletdis6173]

Quite

[@zurkxees4992]

@@douchebagginsmctalibancock2510triangles are angry

[@tclfan0180]

Can you explain? Is it cus the bonds look looser than a more stable molecule?

[@tobias_cz8719]

I absolutely love how this guy casually makes HCN as a biproduct and doesnt bother putting any disclaimer. Btw love your content 😘

[@dvdossbsvskfbdvav]

yeah, it just makes a bit of HCN as a side product, it'll just evaporate off so no need to separate it

[@gutschke]

When you start with KCN, don't be surprised if you are making HCN...

[@davide2555]

​@@gutschke if the reaction doesn't include any acidic workup you don't produce it (luckily 😂) I'm really surprised he just mentioned the production of HCN without saying anything more 😂😂

[@JackFrawley101]

I'm pretty sure even the layperson knows "Potassium Cyanide" means "professional in controlled environment, do not attempt at home"

[@jackingwads7513]

​@JackFrawley101 never underestimate a stupid person's lust for money

[@nickgardner6340]

I can still remember watching myself, from the street corner, riding a bike, while riding a bike and watching myself on the street corner..... Don't smoke angel dust, kids..

[@minmuseve5567]

or you will watch yourself riding bikes

[@RevShifty]

I remember lifting my knee up to my ear to step up on a sidewalk, because I'm it felt like I was only 6 inches tall. Then somewhere before my foot touched the sidewalk, I became 50 feet tall and almost fell down from dropping my foot that far. Angel dust is definitely a terrible drug. And I generally love drugs.

[@MRblazedBEANS]

I have had similar experience with ketamine

[@deremjool8043]

​@@RevShifty I found it quite pleasurable, I experienced a similar "scaling" effect. I would reach out with my hand and it would suddenly be like 50ft long, and bring it back to my side and it would almost feel like it was gone. The feeling was very "buzzy", there is a quote from someone I don't remember, describing the experience of a newborn as "blooming buzzing confusion", and this is quite apt to the experience of PCP.

[@SurnaturalM]

I didn't smoke it, I used to sniff it.

[@soop597]

I dont know why i expected a taste test at the end of this

[@og-zerocool6285]

Glad I'm not the only one who thought that.

[@derenjoy3r]

This is some groundbreaking shit in terms of youtube chemistry, love to see it and also that you explain your mistakes so us chemists can learn from them and not make them ourselves

[@californium-2526]

Making [REDACTED] powder, only on KZbin!

[@filterexel8018]

I typically use the "dissolve the NaOH in H2O first" trick exactly because of situations like this. Even finely-prilled NaOH takes forever to dissolve and change the pH of a solution.

[@kuni45]

It's the only way a lot of the time, but when you're doing a liquid-liquid extraction after it really sucks to double the volume. Especially when the freebase is freely soluble in water

[@refluxcatalyst7190]

When I (didn't) do it, I used potassium cyanide to form the nitrile intermediate instead of the sulfate. I'm guessing using morpholine, you have to form the sulfate first? The phenyl grignard reacts directly with the nitrile to give you your product arylcyclohexylamine, if you use piperidine. The first sulfonation step wasn't necessary for that.

[@multiarray2320]

"didn't" xD

[@geordifrere]

Going through the bisulfite adduct allows you to avoid generating stoichiometric HCN with strong acid during cyanohydrin formation, which is a major hazard since HCN boils at 26 °C and would be fuming invisibly from the reaction mixture. The bisulfite adduct forms a small amount of the ketone through its equilibrium and the bisulfite ion acts as a mild acid to form small amounts of HCN over time and/or protonate the final cyanohydrin. Small amounts of carbonyl and HCN means few side reactions and minimal poisonous gas generation.

[@kpunkt98]

I was wondering this. Guess my comment is obsolete now

[@refluxcatalyst7190]

@@geordifrere with piperidine, you don't use a solvent. You add cyclohenanone and piperidine neat, then add stoichometric KCN. The entire thing solidifies into the nitrite intermediate.

[@joedirt1965]

I know when mixing insoluble powders with liquids (cocoa powder + soy milk) I add a very small amount of liquid to the powder initially to wet it so it does not clump up (then I add the rest of the liquid). In your case I say use a pre-made solution of base since the base is soluble. I assume your base clumped up and got coated with something that prevented mixing.

[@dvdossbsvskfbdvav]

this is actually how I make my hot chocolate, it mixes much nicer if you make up a paste with the powder first before mixing in the rest of the milk

[@Sniperboy5551]

I watch MRE videos and everyone says the exact same thing

[@nicholasneyhart396]

​@@dvdossbsvskfbdvavI was concerned that you guys used soy sauce for like a solid 10 minutes because I misread the top comment.

[@MXXR35000]

@@dvdossbsvskfbdvavas a pastrychef , I can confirm adding 1/3 of the liquide to a powder or a thicker consistency makes it easier to emulsifiate/mix

[@A1ko_]

You do not expect to see a full Arylcyclohexylamine synth every day on KZbin, good shit

[@billyhendry8369]

Yeah I'd assume most people don't even know how many and how popular analogues of PCP are. I get the click bait but somehow only with all the 3-meo-pcp, pco, o-pce 3-ho-pcp etc. The claims of "crazy powder never came back" Still it's great people learn about this, a shocking amount of people have never heard of a dissociative drug in their life.

[@A1ko_]

@@billyhendry8369 pcplogs are absolutely the most popular rc dissos there are but personally I'll stick to k or klogs

[@YvngKrishna]

​@@billyhendry8369 yeah fs, pcp (and most dissociative hallucinogens) have this huge myth status of making you violent and insane, when most people who have gotten into states of delerium are mainly overdoses. Hell even ket i see people freak out about because its used as horse tranq. Dissos are such an interesting class of drug and arylcyclohexanone chemistry content is kind of obscure to come by and its pretty neat seeing them be brought out like this

[@bigboi9856]

@rockysable20 o- pce is crazy strong and lasts about 16 hours. a 10mg dose will send you to another dimension. Fun stuff

[@Mulmgott]

@@bigboi9856 O-PCE is the best. But It wasn't as strong as you describe (at least for me). It did last for up to 10 hours though. And 10mg was a nice dose that made me slightly manic (or rather unnaturally happy and extraverted). It also doesn't really impair my motor control as much as other arylcyclohexylamines so thats convenient aswell. Deschloroketamine fucks with your motor control on an insane level for example.

[@kuraikobayashiani5990]

Dissociative substance synthesis in a chemistry youtube channel? We're truly living a eventful decade

[@remcovanvliet3018]

You've not seen the high explosives and the primaries being synthesized, yet? Brother... You've SO many watch lists to add yourself to, these days! It's fukn amazing! 🤓

[@letzte_maahsname]

I really hope it never ends. But I'm not too sure about that. Better get them before they all get taken down 🐴

[@rileysimmons9886]

Chemiolis is truly #ourguy

[@slash890]

​@@remcovanvliet3018 u care to share any?😂

[@SLOWBURN0G]

Genuinly, i dont think anyone understands him and nile red are the new wave

[@chemdelic]

We making it on the watchlist with this one🎉🙂‍↕️🗣️❗️

[@mortlet5180]

Nah, I'm still waiting for the Hexanitrobenzene or even an Octanitrocubane synth (yes, I know heptanitrocubane is believed to be more practical, but it's all about the symmetry). That's where the real watchers of lists lie...

[@MELLOWFELLO]

Not funny getting old already

[@KirkHolbrookVll]

it doesn't matter to me what losers are watch, then again I don't jerk off, watch porn or do anything bad, or to be embarrassed of. they can put cams in every room even my bathroom.

[@VoltageNostalgia]

​@@mortlet5180there's that Australian youtuber chemist who's been trying to make some sort of cubane for a while

[@emrysgaming6015]

Eh, it's not currently scheduled, and is sold as a designer drug, or research chemical as it's actually known in the scene of people who buy these chemicals(including me). So it's in a sort of legal gray area, and is only illegal if sold for human consumption. So legal if being produced, and marketed for research and analytical purposes only.

[@mac6na6na26]

I happen to run a shop that has a lot of ex-convicts, and I get to see all their criminal records. Though PCP may not be nearly as prevalent as meth which causes many more problems due to how common it is, PCP easily takes first place for "most likely to cause a violent crime". It's disproportionate, really. Terrible drug.

[@Sniperboy5551]

Dissociatives suck, but I guess some people enjoy them

[@richiehoyt8487]

"Strength of 10 men"...

[@timecode37]

worse than meth?

[@ferretyluv]

I really don’t get the appeal of PCP. Everything I hear about PCP sounds like a nightmare. It’s somehow still popular in Washington, DC.

[@ahmaudarberywasaviolentkle8094]

I suspect it produces an ever lasting high. They're never the same after.

[@МихаилБондаренко-ц4х]

we all are waiting for you to make legal meth analogue

[@HouseBricksDoor187]

Meth is already legal and they put it in Vicks inhalers

[@Brice23]

How many legal amphetamine-like substances exist? Unfortunately where I live they have created blanket laws that ban substances the lawmakers have never even seen or heard of. The drug analogue act. It is draconian and hinders more than it helps. Of course.

[@andrewhooper7603]

Even better, pseudephrine.

[@stevusbeefus]

idk why ppl so obesessed with meth or amph synth considering its been done to death and is boring af imo

[@BioLust]

@@Brice23 It's actually only been employed here in the US less than 5 times. The federal analogue act does not ban as many substances as you would imagine. I am not going to name the chemicals, but oh boy are they there. It is not illegal as long as it is for research purposes. homologous to Phenmetrazine is all I'll say.

[@SomethingImpromptu]

I’ve never liked people referring to psychedelics or dissociatives as “psychotomimetic.” Veeery early on in their discovery, some scientists did kind of dismissively assume “Oh, LSD is altering your consciousness in this extremely complex & hard to characterize way… This must be what it’s like to experience psychosis!” But this is a profound mischaracterization, which is why (at least for most 5HT2a receptor agonists), it’s largely been dropped as we’ve come to understand both psychotic mental illness AND psychedelics better. The fact that people are still inclined to talk about PCP this way probably has more to do with media sensationalism than anything (though I’ve never done PCP & can’t say for sure)- from what I’ve heard it’s really just more stimulating than other dissociatives & therefore not suitable as a tranquilizer/anaesthetic. Beyond that difference… Like, sure, there are people who freak out & have mishaps on it, & I’m not saying people necessarily should be using it, but people freak out & have mishaps on too high a dose of all kinds of things. That doesn’t necessarily mean it was truly comparable to psychosis. I think psychotomimetic is a perfectly reasonable label for deliriants, & really that they’re the class which should’ve been labeled this way from the beginning… Completely hallucinating whole scenarios/people/conversations/animals/shadow people/etc. that aren’t there; hearing schizophrenia-like voices in your head; extreme fear/paranoia; extreme confusion & disorientation/disconnection from reality… These are the very psychosis-like symptoms of deliriant poisoning, or having intentionally taken Amanita Muscaria mushrooms, or diphenhydramine, or whatever- terrifying, awful, nightmarish stuff which I strongly suspect TRULY comes as close to simulating what a psychotic condition like schizophrenia as any chemical can induce… There’s not much else to it- those are the primary effects. You JUST feel like you’re losing your mind & living in a waking nightmare. On the other hand, dissociatives have considerably more interesting content to them, & far fewer of the truly psychosis-like symptoms. I’ve rarely heard or someone taking ketamine, or MXE, or DXM, or even PCP & legitimately hearing terrifying whispering or screaming in their head for hours they they just couldn’t shake off (whereas I’ve heard of people taking Amanita Muscaria extract 1 time in not that high of a dose & experiencing those kinds of symptoms for DAYS or WEEKS afterwards). You don’t have true hallucinations or dissociatives… You may have beautiful closed eye visuals, but that’s quite different from a nightmarish waking dream state where you literally don’t know what’s real & what’s not. I’d place dissociatives more as a middle-ground, because they do have a tendency to induce some delusions (usually just during the experience, which is why the issues mainly come about in cases of addiction/dependency, where someone is taking them all the time & never getting a breath of air from that state & assessing their experiences from a more lucid, rational perspective). Classical 5HT2a agonist psychedelics, IMO, are the farthest from “psychotomimetic” of any of these. I think it really was just ignorance that led to this labeling for LSD & psilocybin & the like early on; keep in mind that it was being applied so early on that we were only just even learning that serotonin had anything to do with mood/behavior- in the very earliest days of the discovery of LSD & it’s effects. It’s very much a vestige of an impoverished earlier state of psychopharmacological & psychiatric research. The effects induced by psychedelics like these may seem very chaotic & overwhelming, especially to the uninitiated, to someone who didn’t know what they were getting themselves into, or to someone who takes an excessive dose for their first time & plunges in deeper than they’re ready for… But upon the kind of deeper inspection that mystics & shamans have been giving these experiences/states for ages, & the kind that psychedelic scientists & “psychonauts” have more recently devoted themselves to, there’s actually a profound & beautiful order to that chaos; the fact that it’s unpredictable & too complex for our minds to easily put in a box, to reduce & identify with some very simple pattern or experience we’re familiar with, doesn’t mean that it’s actually untethered from reality or random or meaningless or in any way equivalent to symptoms of psychosis. And especially as classical psychedelic doses increase (besides n,n-DMT, which seems to go in exactly the opposite direction), you move towards boundary dissolution & ultimately full ego-death & mystical experience… Which is quite wildly different from any kind of psychosis. There’s really no comparison. If anything I think it romanticizes psychosis to compare it to something as favorable as psychedelic experience. Even in the fringe cases where someone has a predisposition to mental illness & psychedelics catalyzed the precipitation of a psychotic state, the psychosis it precipitates is going to be very different from the psychedelic state itself.

[@Quinazolinking]

Ok? So?

[@Eternal1nstant]

Bro wrote a whole bible page.

[@deremjool8043]

​@@QuinazolinkingIt is an important distinction to be made, that most hallucinogens do not meet the classical definition of psychomimetic, "producing effects (as hallucinations or paranoid delusions) that resemble or are identical with psychotic symptoms," specifically the psychotic symptoms part.

[@trevorgrommet4654]

Great info! I have schizoaffective disorder. Used to get real gnarly voices constantly. Very disturbing and bothersome. During IV ketamine therapy, no voices whatsoever. No more depression. Neurogenesis from activating glutamate is the way in my case. I also was put on an atypical antipsychotic that activates 5HT1a receptors and is a dopamine agonist. No voices for months now. The manufacturer doesn’t know exactly how it works, because from what my doctor step mom says, chemicals produced by the brain have so many roles that they are still discovering. Mushrooms are a joy. Never had a bad trip. I don’t do them often though. Not for everyone, of course. Some minds just can’t handle it, whereas mine relaxes.

[@homuraakemi4559]

Took a solid LSD dose one time and I genuinely thought I had triggered a psychotic episode because of the psychotomimetic misinformation. I was pretty familiar with hallucinogens to begin with so I just held on until it started wearing off.

[@giacom312]

Congrats on 100k!

[@kalebmaciver7117]

awesome video, this was informative and quite funny that you could skirt regulations just enough to post this. I am just curious why you chose this route? as opposed to higher yielding cyanide free methods using para toluene sulfonic acid and azeotropic separation of water, do you not own a dean stark trap?

[@Chemiolis]

Only because this was the original method, and to follow closest to Hamilton’s synth

[@Lucawee]

@@Chemiolis Hamilton ended n7 on the quali today, Mercedes is strong now

[@kalebmaciver7117]

@@Chemiolis ahh I see. what synthesis are you planning next?

[@remcovanvliet3018]

@Ren-xl1sq I wouldn't worry about it too, too much, if I were you. He's still just as strongly outclassed in the talent department. *edit for clarification* When I say outclassed, I'm talking about Lewis, of course, not Morris.

[@SayaialahBeliau]

​@@Chemiolisdude pls make other video of pcmo but with basic solution

[@AlistairKarim]

From an average person's perspective, it simultaneously looks like suffering and like some sort of dark magic. I actually appreciate that you post videos even though it's not a complete success.

[@scepticalchymist]

That succinctly describes chemistry studies :).

[@deadlikedisco4726]

"Coz it's trash" Yeah it really is. A very solid analogoue for ketamine in 4-MEO PCP. Same dissociative anesthetic effects, but has a much longer effect with greater chance of hallucinogenic effects. It is very difficult to be mobile once ingested, which isn't great if one has anything to do for about eight hours

[@seetheious9879]

Felt like I was on a raft in a river when really I was in a forest on solid ground. Still made it to the party but barely.

[@hj-hh4gc]

Can only find info on 3 and 4 meo PCP. Is 5 real or a typo?

[@deadlikedisco4726]

@@hj-hh4gc No, you're correct. I meant to type 4. Thank you

[@hj-hh4gc]

@@deadlikedisco4726 thank God you replied cause that sounds like heaven

[@deadlikedisco4726]

@@hj-hh4gc I mean, if you don't have anything to do for a day, turn off the lights, lay down, and get weird.

[@jogandsp]

It's not surprising that you had the problem with the base not dissolving. It makes a basic solution immediately around it which causes the product to precipitate onto it. Next time, dissolve the base before adding it and you won't have that issue

[@Piocoto123]

Nothing quite like a good dissociative anaesthetic synthesis in the morning to begin an excellent day!!! Cheers for Chemiolis!! and for H Morris

[@joecummings1260]

A guy I went to HS with in the 1970's that never did anything but drink decided to try "drugs" by doing a big line of PCP. I remember being at that party but left before anything f ed up happened. Somehow he got home that night and was freaking out and his parents called the rescue, but two cops showed up also. He was trying to fight the cops and from what they said he tried to grab one's gun. (Back then the cops weren't psycho like they are now). He ended up in a locked ward in a mental hospital for about a week. He told me he went nuts when he was at home in his room and the giant mice attacked him

[@TheHippyProductions]

My cousin has a good friend from new orleans who did sherm for a little while...until a girl he did it with in his friend group while they hung out outside decided to climb a lightpole nude, and sat on the bulb part for so long it fused to her hoo-hah. Fire department had to uh...get kinda rough to unattach her. He never smoked sherm again after seeing that.

[@lysy-zn2gg]

Holy, PCP is like the worst possible drug to start with. Even if I'm pretty experienced I wouldn't take it. A small dosage atleast.

[@joecummings1260]

@@lysy-zn2gg I know, WTF was he thinking? He didn't even smoke weed. He did drink a lot of beer though. He must have been drunk as Sh*t and figured YOLO or something. I do remember him doing some crazy impulsive stuff though. One time we were in his Camaro and he was doing like 60 and threw it in reverse. F ed shit up bad, I had to tow him home with my pickup. I asked him why he did it, and he just said "To see what would happen"

[@lysy-zn2gg]

@@joecummings1260 Maybe he wasnt aware of its effects and thought it would work like cocaine or something. Crazy dude nontheless

[@nathanpyle3443]

Back then, people didn't have cell phones to record cops only doing bad things so everybody thinks that cops are bad.

[@1-eye-willy]

ive smoked loads of PCP, and ive never had what is called a "whack attack" but ive seen people freak the fuck out, strip naked, get hit with stun guns with no effect, ive seen people walk into traffic. they were indeed having a "whack attack" but every time ive had it i just felt really good, really high. kind of like a mixture of THC, nitrus oxide, and opiates. thats probably why its so addictive and why people keep doing it regardless of how crazy it makes them act. i think some people dont have the brain chemistry to handle the stuff because some people dont act any different and some people loose their minds.

[@TheBic4]

Yeah I never had these crazy hallucinations people described when I smoked dippers. Worst thing I did was call my mom and asked her to pick me up when I was in a blackout. Perhaps having experience with psychedelics helps.

[@necoluga7950]

WHERE GETING ARESTED BY THE FEDS WITH THIS ONE 🗣🗣🗣🔥🔥🔥

[@ashe1.070]

The medicinal chemistry stuff is extremely interesting! Keep it up! Did you keep the aqueous layer from that neutral solution at the end? If so you easily could have remedied the error, and included the result in the video. All well. Is 5-MeO-MiPT controlled in the Netherlands? If not, that could be an interesting project. You could start from melatonin by conversion into 5-MeO-Tryptamine. Then reductive alkylation with one molar equivalent of acetone, and an excess of STAB-H (prepared ex-situ from borohydride, and 3 equivalents AcOH in THF, or DCE). Followed by the reductive alkylation with sodium hydroxymethylsulfinate, excess Et3N, and STAB-H under similar conditions. Both reductive alkylation reactions can be conducted in a one-pot operation. I think doing these reactions in that order is absolutely necessary to avoid formation of the dimethyl substituted product due to the steric bulk of the isopropyl group. For the same reason, the formation of the diisopropyl product by a second reductive alkylation is unlikely to occur. Furthermore, while this compound is certainly active, I don’t think 5-MeO-MiPT has much value recreationally. If I’m wrong the use of succinaldehyde to give 5-Methoxy-N,N-tetramethylenetryptamine (5-MeO-pyrrolidyltryptamine) would be an interesting alternative. The methoxy group could also be swapped for an ethoxy, or similar group by starting with 5-hydroxytryptophan. Thus, decarboxylation to serotonin, protection of the amino group as an amide (or carbamate), Williamson ether synthesis to give the desired alkoxy group, deprotection, and finally the reductive alkylation sequence would give the desired analog. This gives a large degree of freedom to design a compound that is certainly inactive. For example, 5-Propoxy-Pyrrolidyltryptamine; there’s no way that is active, so it could make for a cool project without legal worries.

[@DaNiKzz]

Wheres the taste test at????????

[@SixOhFive]

When do the 200mg samples drop @ the shop? ;)

[@aunovichkov]

Last extraction you could perform with dcm It nicely dissolve organic bromides But not toluene Then drying, turning back to bromide and recrystallization from EtOH That should work

[@samlazar1053]

PCP has newer been popular here in Europe.mainly because it produces relatively low euphoria and huge hallucinations

[@BigSamWin]

I don’t think pcp is popular by any means but at certain times it was common in the USA

[@theundergroundscientist1312]

Great video and synthesis! Love the content of making compounds of interest :) while casually making HCN as byproduct Just a few notes: - 4:55 Arrow to oxygen atom is redundant since lone el. pair moves to sulfur atom and is not conjugated with S-O pi bond system. - 5:06 Resonance not equilibrium (both structures describe the same molecule). Resonance arrow should be used instead. Congratz on 100k!!

[@kapoink835]

How much would I need to make a gallon? Preferrably in liquid form

[@swagicallovin4107]

Your whole grignard set up just under a normal atmosphere and open to air before the sealing?

[@fromepotter]

Good, now make a gallon of it. I need for my work downtown at an investment firm, mostly land acquisitions.

[@Michael-kp4bd]

How’s the family?

[@fromepotter]

@@Michael-kp4bd well, candice died and I gotta pick up the kids from soccer practice

[@Emil-cj6ey]

How are dealing with HCN fumes? Did you just connect the condensor to a NaOH containing scrubber?

[@Chemiolis]

Into the atmosphere

[@frysebox1]

​@@Chemiolis Nature's trash bin

[@eli_777]

He's leading all the gas into a modified shower

[@bazooka93]

Cloud storage

[@lorenzdellwo4241]

nice video but why did you use HBr to hydrolize instead of HCl?

[@Chemiolis]

Only because of the literature I followed, it doesn’t really matter.

[@SayaialahBeliau]

​​@@Chemiolisu Said diethyl ether can also be use but does the volume is still the same?? (400ml)

[@ZoruaZorroark]

you know it might be good when youtube/google gives one a "please get help" type of message

[@cajampa]

What do you mean KZbin gives you get help type of a message? I have only heard one other person mention this and he was an admitted schizo.

[@ZoruaZorroark]

hmmmm, that does gives me a concern too if that guy was the only other to get that message

[@cajampa]

@@ZoruaZorroark Yeah I would be. But I am also really asking you. What do you mean with those messages exactly. How and where do they appear? And what do they say? Because you even mentions Google, do you mean in the search engine Google or something else? There is a lot of things "Google". For him it seems he would go on unhinged rants so bad, that he claimed staff of KZbin would contact him by sending him emails to talk to him about getting help. And considering how KZbins "moderation" seem to be just an AI bot censoring things. Up until straight up banning your whole life as in Google accounts, if you go too far of the rails. This whole "getting contacted" and it does not happen to anyone else. Seem to me to very possible be connected to schizo delusions in his case. But if it really does in happen in reality, I am very curious how and where it happens and after what kind of interaction you did? And just to be clear, me saying that it does not happen to anyone else. Does not mean it is not happening. I can not know that, but I just know about one other case, and now two with you, reported instance of something like that happening. And you know about the other guys problem. And you are saying this on a video about dissociative substances, so am sure you get why I could suspect and have a reasonable suspicion that it could be that it is a delusion in your case also. We all know how wonky things can get for people who have an affinity for dissociatives. Because most seem to have the reverse problem, that getting any sort of interaction or "support" from KZbin or Google seems to be impossible. Even many channels with millions of subs can't get a any support from a human for example. I just comment a lot and have been in lots of discussions on this plattform about various intricacies on how the limitations works on the comment system we have here. Personally I would find it kind of nice if there really is humans that care enough, to ask us to get help if we need it. But I am afraid reality does not work like that. Just because it seem to be reported so exceedingly rare. And I also don't want to go around and claiming that it does not happen if it really does happen. So it would be great if you could give me more details to figure out if this mysterious contacts, from the staff overlords on KZbin/Google really is a thing they do and how it manifests.

[@ZoruaZorroark]

yes, the google search engine, and the message that i had pop up was very much a bot generated message. maybe next time i see a message like what i got on this video, i should take a snapshot and send it to you or post it on on of the myriad of message boards. chances are, i would just not bother mentioning such a message in the comments the future. sorry if i am coming off as a bumbling idiot who somehow cruised through school in this conversation on where you are legitimately attempting to understand what i have said

[@cajampa]

@@ZoruaZorroark If it is a message you get that pop up in the browser when you are just using Google to search and it happened after you clicked on some link. It is very likely some kind of spam ad for some kind of health services, the Web is filled with such things. And not Google the company trying to send you a message. Because they really don't do it like that. Although the very recently introduced a notification icon where they can send us updates in the Google search just like we have a on the KZbin app and site. If they where to send some kind of a message I bet it would be either thorough email or to the notification thing. I had a friend who was diagnosed with schizo affective disorder. And he would see patterns and get messages from powerful people, celebrities, intuitions and companies all the time. It was all his delusions who made him think that though, he misinterpreted regular things as something much more significant than they really was and saw patterns and connections where they really was non. And he was quite disturbed. I am not saying you are that. Just that it is very unlikely that Google are sending you messages like that. But them again that have some disturbing privacy implications. If Google would be follow and spying on some of us like that. You know what the paranoid say, it is not paranoid if they actually are after you :) The closest I know they do is if you are acting to unhinged is they send you a message in KZbin, telling you can't post messages in some time like 24 hours or a week or something. I don't remember exactly because it have never happened to me. But in some of those discussions I spoke about KZbin comments limitations. There was a bunch who reported having gotten such messages. But no one besides that one guy said anything about get help messages. And because he said he got them to his email and you said you got them in the search site in the browser, that makes it even less likely that it is even the same thing, if it is a thing that originates from Google the company. Anyway if it happen again take a video of it with your phone and ask someone else about it to get a second opinion. Maybe it does happen....

[@skinisdelicious3365]

Me: buys toluene DEA and ATF: rock paper scissors shoot!

[@mortlet5180]

I hope you don't have a dog!

[@jessepinkman1471]

too real

[@chemistrycapital]

Hamilton Morris is definitely watching this

[@jeythegrey]

Whenever you're saying "phenyl" I hear "fennel" which is kinda funny and I can't unhear it, sorry ^^

[@eredgorgoroth]

Never tried the original PCP, but I had an intense relationship lasting a couple of years with its cousins ​​3meo-pcp and 3ho-pcp

[@y33t23]

4:03 *casually*

[@kid_missive]

KCN is well enough behaved, and acutely toxic, but not in a microscopic amount. It's not likely a chronic toxin or carcinogen, so a chemist is probably more likely to be casual handling it (with gloves) than a lot of other things. If you had a small exposure, you could just leave the room and wash up and it would clear from your body very quicklly.

[@straightouttheshed]

i actually have that DEA drugs of abuse book from 1973 and i pulled it out so fast after your mention at 1:57

[@devilapi]

I really love PCP Analogs, especially O-PCE or 3-MeO-PCE

[@paulszeto5741]

You know where to get some?!

[@5150lefont]

I second that. I have not had a reliable vendor since 2019. Could really use one.

[@ianbaine]

I’m no stranger to fun substances but never have I ever come across this fancy molecule available for exchange.

[@sgctactics]

You had me at "subscribe for better yields"

[@mabus42]

Now we just need a proper trip report from Chemiolis. There is no way that you didn't test it, and we know it.

[@fmdj]

PCP's fine and gentle, try 3-MeO-PCPy and rewrite that intro ;)

[@max3eey]

You are a junkie

[@iiiKingLongSwipeiii]

I know right actually PCP is super smooth and on top of it they were going to use PCP as a therapy drug for depression but there hasn't been enough studies on it for its long-term effects so that's why they switched to ketamine

[@Rexwizord]

@@iiiKingLongSwipeiiiand the people who thought they were taking it and instantly found themselves in Mad Max

[@iiiKingLongSwipeiii]

@@Rexwizord I believe that it highly depends on the way it is administered for that to happen for what you said and it also depends on the person's genetics because everybody is different and it will affect everybody different.... Smoking it is very smooth

[@Rexwizord]

@@iiiKingLongSwipeiii the chemical itself it is almost impossible to stop redosing

[@ksarecords8099]

It's not a psychotomimetic it's a dissociative anesthetic

[@dorisnumper6996]

Ketamine is extremely interesting when you research how it acts in the brain and how it acts on deleting trauma based memories causing instant depression relief

[@ilis_5794]

are you fckin serious ? ask that to all my friends in psychatric hospital bc of Ketamine

[@ilis_5794]

and dont give me the argu that it should be controled thats garbage as hell, old scientifics had the same conclusions, can you say why are you studying ketamine ? If you do chimic studies can you focus on other things that making drugs pls we have a lot of schyzo maker molecules, stay focus

[@delilililah]

@@ilis_5794 as a heavy ket addict i cant attest it does not just delete bad memories and instantly make everything better lol

[@strumps9549]

​@@ilis_5794Skill issue

[@drspalding31]

What a time to be alive they allowed how to basically make drugs on you tube before GTA 6 came out

[@kawaiiintelligenceagency3889]

What chemists see: A threeneck flask. What I see: A glass bagpipe

[@1981mrdavid]

Lol. Me: That's a funny looking bong.

[@nagarajpai3120]

That hcl salt may be moisture sensitive and also amount of solvent used was also more, hence yield was less Alternate method is that you can purge hcl gas to the solvent and take amine along with that solvent in another rbf, added hcl gas purged solvent at 0 to 5C, under nitrogen and filter it under nitrogen, dry it in vaccum oven

[@johnthomas2970]

DISSOCIATIVE ANAESTHETIC GANG

[@RaVen99991]

Wait no way you are dutch too, Nice edic : congrats on 100k subs

[@libalj]

this is like an extractions and ire video

[@elietheprof5678]

If we understand its mechanism of action in the brain, would that help in designing better *anti*-psychotic drugs?

[@1981mrdavid]

We do know it's mechanism of action. It inhibits depolarization of neurons. It enters the ion channel from outside of the neuron and binds, (reversibly) to a site in the channel pore, blocking the flux of positive ions into the cell. This causes it to work as an NMDA receptor antagonist.

[@elietheprof5678]

@@1981mrdavid interesting - so then what might an NMDA receptor _agonist_ do instead, in terms of effects on the brain?

[@1981mrdavid]

@@elietheprof5678 It induces a dissociative state. Ketamine, and dextromethorphan also fall into the same class of NMDA receptor agonists. Research on this class of drugs is being studied for their potential mental health benefits. However, clinical trials with phencyclidine (PCP) have shown to cause too many negative side effects and more harm than good. Ketamine seems to be favored at the moment.

[@jerry3790]

I was here before his lab got raided

[@jessepinkman1471]

same

[@patentedorganism1557]

Alright, so when is the methamphetamine synthesis video dropping?

[@andueskitzoidneversolo2823]

Pcp is fun, peyote is better though, .... but you want to know a secret. You can either golden orb spiders and eat them for a strong hallucinogenic effect. I also hear some snake venom does the same If you could isolate what ever compound that it, it might be 100% legal. But as a person with schizophrenia myself please understand schizophrenia is not just hyper mania, I mean yes that's a part of it, but schizophrenia is so much more. It's a huge spectrum.

[@dmtwizard]

Of course Peyote is better. It comes from the earth. They aren’t even in the same hallucinogenic class lol

[@Mulmgott]

@@dmtwizard Dissociatives and traditional Psychedelics for me feel like they are on the opposite ends of the same spectrum. They are similar in a weird way but very different in general.

[@dmtwizard]

@@Mulmgott I agree. DXM and Ketamine for me had a lot less visuals than Psilocybin, LSD or DMT. Dissociatives are more in your head. Granted Ketamine was the most visual one

[@Mulmgott]

@@dmtwizard For me the most visual dissociative I have tried was Deschloroketamine. Psychedelics are hyper visual for me though. I can take 5mg of 2-CB and see fractals on my walls, hands, etc.

[@Ultralight-p3p]

username checks out

[@walterbunn280]

Ehhh.... So I'm not really sure why you would use an oxygen bearing molecule with a Grignard reagent. I'm pretty sure Morpholine will react with magnesium in a grignard reaction. Like, Morpholine looks awfully like a type of Ether. You might be able to do something with a Suzuki reaction, using a borate ester. They even have some Suzuki Reactions that just need copper as it's catalyst. It'd be a relatively unexplored topic.

[@xenomancer1]

I already subscribed years ago and the yields have not improved. I want my money back.

[@oxoniumgirl]

i was thinking the same thing lol

[@Chemiolis]

Plz dont expose me

[@HisNameIsRobertPaulson01]

Were the effects of the finished product acceptable?

[@TreasureHoardingDungeonDwarf]

6:53 *Forbidden Rootbeer*

[@THYZOID]

noice

[@joedamore9350]

This is intresting as hell. Not because of the chemical being synthesized, but because the chemistry of it is fascinating.

[@methyleneblue_]

thanks for the instructions

[@Lucawee]

you're the only one that can use the s word without it being offensive, i love you chemiolis

[@bitterlemonboy]

Can you try making some Benzo RC's. I would be so happy

[@SixOhFive]

No

[@5b_c4ll3d_p4ul]

what a junkie

[@PuffPuffPassinn]

😂😅

[@h3xag0nal]

The way you drew that ketamine structure made me angry. Liked and subscribed.

[@benbernanke7701]

Ok now make MXE And send it to me

[@PuffPuffPassinn]

😂😂 I miss that stuff lol 😢

[@platinumwaiter]

Hate to be that guy, but the mechanism at 5:07 implies an Sn2 attack at the tertiary center which bothers me a lot lol. Why not just make the oxocarbenium via ejection of the bisulphite and have the morpholine attack the oxocarbenium?

[@Quinazolinking]

👌

[@Swiecacyludek]

Very educational film.

[@ErtugrulK]

Three out of four voices in my head agree that PCP is the best.

[@dancoroian1]

More arylcyclohexylamines!

[@grgvv]

I would check the melting point of the final product, to confirm that the precipitate you obtained is indeed PCP HCl (m.p. 233-235°C). Or just take an NMR of it.

[@humanplace1962]

What is the 00:03 image from?

[@Quinazolinking]

DEA drugs of abuse guide 1978

[@humanplace1962]

@@Quinazolinking Okay wow how do you even know this? I can not find the article online, I even asked chatgpt and he wasn't able to help me, do you have the link/file by any chance? Thank youuu

[@Quinazolinking]

@@humanplace1962 It’s government property, it is not available anywhere online or to the public. There are a few copies in university libraries but you have to get very lucky to find a copy

[@amritlohia8240]

@@humanplace1962 Google only finds the 2020 edition (at www.dea.gov/sites/default/files/2020-04/Drugs%20of%20Abuse%202020-Web%20Version-508%20compliant-4-24-20_0.pdf)...

[@humanplace1962]

@@Quinazolinking aaanddd?? where exactly?

[@781TheVbyz]

What if you have a positve reaction and effect off pcp or psychedelics instead of losing yourself you become more superhuman ??

[@Quinazolinking]

First!

[@djrelentle2027]

WE'RE GOING TO LOOSE OUR MINDS WITH THIS ONE🔥🔥

[@Gman193]

@chemiolis when will you be uploading the taste test? Can't wait to see that one 🎉😅

[@nagarajpai3120]

For intiating bromobenzene, you dont want that temparature,with iodine it initiates at RT preventing what happend in heating

[@CDCI3]

8:32 Can you explain what you mean by "hydrolyze all the product"? I don't know what there is the hydrolyze here.

[@Chemiolis]

You’re right, it’s not hydrolysis, just acidification. I said it because normally we use water to hydrolyse remaining Grignard reagent, I just mixed it up.

[@CDCI3]

@@Chemiolis all good, thanks for the reply. Your videos are great. You resources are seemingly beyond any other chemistry KZbinr. I fully expect you to come on some day and say "Well, my company/PI found out I was making these videos with their lab and chemicals, so I got fired and I'm moving into Tom's shed in Australia."

[@swimtwin]

Dissociatives make me feel like im not real.

[@Adrian87104]

The morpholine imine is not in equilibrium with the tertiary carbocation, they are resonance contributors

[@Alexandertygreat]

That benzo bromid you made can be made into K pretty easily? 99% sure that is starting in some newer papers. Great videos

[@pirotechnik.14]

The film is brilliant and professional. I hawe a question, were did you get the morphine?

[@jacquesmertens3369]

Fascinating ! How do you even obtain potassium cyanide? Or is that a common ingredient? Please stay safe.

[@christopherleubner6633]

I would have skipped adding acid, filtered out the excess magnesium, then went streight to base. You would get the cyanide back and have a cleaner pull of your free base. ❤

[@user-zx8oy2jf4d]

Slow clap... HCN - check, grignard solution on the ceiling - check, gaseous HCl without downstream trap - check, PCP - maybe - probably not

[@CDCI3]

The alpha-cyanoamine + grignard reaction is weeeird! Is an alpha-cyanoamine just always in equilibrium with the iminium cyanide in solution?

[@CDCI3]

Or is it tautomerization with the terminal N?

[@CDCI3]

Oh shit, it was literally the next sentence, and I just went searching the internet for it for 10 min.

[@Tripsqueak]

i don't know what i watched but it was stimulating.

[@dansamarco1610]

Oh you poor bastard, you're never going to break your brain with yields like that!

[@RiccioloStyle1990]

This synthesis is gonna kill you before you can make it to the end, if not properly trained. Great video and great demonstration of frequent chemistry issues in a life of a synthetic chemist.

[@Gamert80]

GG on 100k subs! Huge milestone!

[@ScottWoodruff-wh3ft]

I hope you saved your aqueous layer from the botched toluene extraction at the end.

[@FutureAIDev2015]

How did you ensure you got rid of all the cyanide salt from the reaction? Is it by adding a slight excess of the other reagents?