Making Schizo Powder (PCMO)

This is not a tutorial and shouldn’t be replicated. For educational purposes only. This involves an old and dangerous route, used as an example only, not because it is the safest or ‘best’. Reaction releases deadly hydrogen cyanide that can only be contained with an appropriate fume hood or trap.
Intro largely written and idea by Damian (discord: tangramexcerpt)

[@triple_gem_shining]

WE'RE MAKING IT INTO THE MENTAL HOSPITAL WITH THIS ONE

[@lm-rh3qo]

Gonna hit them with the hyper mania. You can fly!

[@kaboom4679]

Come on , voices , we're going home !

[@amogusenjoyer]

​@@kaboom4679what if they are already home 😳. They never left the walls

[@Sniperboy5551]

Dissociatives suck.

[@abreada]

My arm is numb 3 days 3 days 3 days

[@morningstar8187]

Three out of four wall voices agree that PCP is the best.

[@kaboom4679]

I wouldn't know. None of mine speak English , and the one that did , just up and quit without any explanation .

[@gonelucid]

The 4th prefers datura

[@pyro_mania67]

The 4th is having a bad trip and wishes he had some MDMA.

[@mj.l]

@@gonelucid having done pcp and datura, i can confirm that datura creates horror delirium and voices. pcp is a perfectly good drug when used responsibly, but demonised due to prohibitionist racism of the 70s and 80s.

[@quantummechanicalengineeri7016]

Space!

[@Ru-mk8lp]

I think they should invent a kitchen knife that doesnt whisper

[@jeffreydallas6047]

Don't tell them about me...

[@jessepinkman1471]

that's funny as fuck Lmfao

[@Mailmanzkidd]

This is the comment and thread I came for but we’re the only ones that get it because we saw that video of the ex waiting affiliate that did the ween stage dive off his balcony but he still has a nice shaft even though they didn’t replace the rest right. That’s the joke right yinz aren’t actually talking to the cutlery again right? 😅

[@jessepinkman1471]

@@Mailmanzkidd masha allah brother

The voiceover of you saying: "It wasn't an issue and the condenser kept everything inside" while we can see a column of liquid rising in the liebig condenser was extremely funny. We really like to play down near-misses on accidents.

[@deadlikedisco4726]

Yeah that's how things went in my silver fulminate synthesis. Just don't worry about spillover on a hot surface. It's fine. Everything is fine.

[@Thatonefuckinguy]

I mean if it ain't exploding or on fire, then your probally doing it right. (unless you want it to explode or set on fire.)

[@billynomates920]

i don't know what it is in other languages but that 'uhwowowooh' every english speaker half-says, half-chuckles on surviving a near-death incident. 😂

[@christopherleubner6633]

Anyone who has played around with O chem has had the fountain of reacting chemicals at least once. 😂

[@Chemiolis]

I’m too impatient for Grignards and always push it to near-disaster

[@chemdelic]

We making it on the watchlist with this one🎉🙂‍↕️🗣️❗️

[@mortlet5180]

Nah, I'm still waiting for the Hexanitrobenzene or even an Octanitrocubane synth (yes, I know heptanitrocubane is believed to be more practical, but it's all about the symmetry). That's where the real watchers of lists lie...

[@MELLOWFELLO]

Not funny getting old already

[@user-zk4rg1ej3b]

it doesn't matter to me what losers are watch, then again I don't jerk off, watch porn or do anything bad, or to be embarrassed of. they can put cams in every room even my bathroom.

[@komodo420.]

You must be 12 years old

[@tobias_cz8719]

I absolutely love how this guy casually makes HCN as a biproduct and doesnt bother putting any disclaimer. Btw love your content 😘

[@dvdossbsvskfbdvav]

yeah, it just makes a bit of HCN as a side product, it'll just evaporate off so no need to separate it

[@gutschke]

When you start with KCN, don't be surprised if you are making HCN...

[@davide2555]

​@@gutschke if the reaction doesn't include any acidic workup you don't produce it (luckily 😂) I'm really surprised he just mentioned the production of HCN without saying anything more 😂😂

[@JackFrawley101]

I'm pretty sure even the layperson knows "Potassium Cyanide" means "professional in controlled environment, do not attempt at home"

[@jackingwads7513]

​@JackFrawley101 never underestimate a stupid person's lust for money

[@nickgardner6340]

I can still remember watching myself, from the street corner, riding a bike, while riding a bike and watching myself on the street corner..... Don't smoke angel dust, kids..

[@minmuseve5567]

or you will watch yourself riding bikes

[@RevShifty]

I remember lifting my knee up to my ear to step up on a sidewalk, because I'm it felt like I was only 6 inches tall. Then somewhere before my foot touched the sidewalk, I became 50 feet tall and almost fell down from dropping my foot that far. Angel dust is definitely a terrible drug. And I generally love drugs.

[@christianterrill3503]

I have had similar experience with ketamine

[@deremjool8043]

​@@RevShifty I found it quite pleasurable, I experienced a similar "scaling" effect. I would reach out with my hand and it would suddenly be like 50ft long, and bring it back to my side and it would almost feel like it was gone. The feeling was very "buzzy", there is a quote from someone I don't remember, describing the experience of a newborn as "blooming buzzing confusion", and this is quite apt to the experience of PCP.

[@SurnaturalM]

I didn't smoke it, I used to sniff it.

[@californium-2526]

Making [REDACTED] powder, only on KZbin!

[@A1ko_]

You do not expect to see a full Arylcyclohexylamine synth every day on KZbin, good shit

[@billyhendry8369]

Yeah I'd assume most people don't even know how many and how popular analogues of PCP are. I get the click bait but somehow only with all the 3-meo-pcp, pco, o-pce 3-ho-pcp etc. The claims of "crazy powder never came back" Still it's great people learn about this, a shocking amount of people have never heard of a dissociative drug in their life.

[@A1ko_]

@@billyhendry8369 pcplogs are absolutely the most popular rc dissos there are but personally I'll stick to k or klogs

[@KysEcstacy]

​@@billyhendry8369 yeah fs, pcp (and most dissociative hallucinogens) have this huge myth status of making you violent and insane, when most people who have gotten into states of delerium are mainly overdoses. Hell even ket i see people freak out about because its used as horse tranq. Dissos are such an interesting class of drug and arylcyclohexanone chemistry content is kind of obscure to come by and its pretty neat seeing them be brought out like this

[@rockysable20]

@@billyhendry8369 I geeked off hard on one of those

[@bigboi9856]

@@rockysable20 o- pce is crazy strong and lasts about 16 hours. a 10mg dose will send you to another dimension. Fun stuff

[@user-yi1pr5kg2g]

we all are waiting for you to make legal meth analogue

[@HouseBricksDoor187]

Meth is already legal and they put it in Vicks inhalers

[@Brice23]

How many legal amphetamine-like substances exist? Unfortunately where I live they have created blanket laws that ban substances the lawmakers have never even seen or heard of. The drug analogue act. It is draconian and hinders more than it helps. Of course.

[@andrewhooper7603]

Even better, pseudephrine.

[@stevusbeefus]

idk why ppl so obesessed with meth or amph synth considering its been done to death and is boring af imo

[@user-jc3cg7yt2o]

@@Brice23 It's actually only been employed here in the US less than 5 times. The federal analogue act does not ban as many substances as you would imagine. I am not going to name the chemicals, but oh boy are they there. It is not illegal as long as it is for research purposes. homologous to Phenmetrazine is all I'll say.

[@filterexel8018]

I typically use the "dissolve the NaOH in H2O first" trick exactly because of situations like this. Even finely-prilled NaOH takes forever to dissolve and change the pH of a solution.

[@kuni45]

It's the only way a lot of the time, but when you're doing a liquid-liquid extraction after it really sucks to double the volume. Especially when the freebase is freely soluble in water

[@refluxcatalyst7190]

When I (didn't) do it, I used potassium cyanide to form the nitrile intermediate instead of the sulfate. I'm guessing using morpholine, you have to form the sulfate first? The phenyl grignard reacts directly with the nitrile to give you your product arylcyclohexylamine, if you use piperidine. The first sulfonation step wasn't necessary for that.

[@multiarray2320]

"didn't" xD

[@geordifrere]

Going through the bisulfite adduct allows you to avoid generating stoichiometric HCN with strong acid during cyanohydrin formation, which is a major hazard since HCN boils at 26 °C and would be fuming invisibly from the reaction mixture. The bisulfite adduct forms a small amount of the ketone through its equilibrium and the bisulfite ion acts as a mild acid to form small amounts of HCN over time and/or protonate the final cyanohydrin. Small amounts of carbonyl and HCN means few side reactions and minimal poisonous gas generation.

[@kpunkt98]

I was wondering this. Guess my comment is obsolete now

[@refluxcatalyst7190]

@@geordifrere with piperidine, you don't use a solvent. You add cyclohenanone and piperidine neat, then add stoichometric KCN. The entire thing solidifies into the nitrite intermediate.

[@AlistairKarim]

From an average person's perspective, it simultaneously looks like suffering and like some sort of dark magic. I actually appreciate that you post videos even though it's not a complete success.

[@scepticalchymist]

That succinctly describes chemistry studies :).

[@giacom312]

Congrats on 100k!

[@kuraikobayashiani5990]

Dissociative substance synthesis in a chemistry youtube channel? We're truly living a eventful decade

[@remcovanvliet3018]

You've not seen the high explosives and the primaries being synthesized, yet? Brother... You've SO many watch lists to add yourself to, these days! It's fukn amazing! 🤓

[@letzte_maahsname]

I really hope it never ends. But I'm not too sure about that. Better get them before they all get taken down 🐴

[@rileysimmons9886]

Chemiolis is truly #ourguy

[@slash890]

​@@remcovanvliet3018 u care to share any?😂

[@mac6na6na26]

I happen to run a shop that has a lot of ex-convicts, and I get to see all their criminal records. Though PCP may not be nearly as prevalent as meth which causes many more problems due to how common it is, PCP easily takes first place for "most likely to cause a violent crime". It's disproportionate, really. Terrible drug.

[@Sniperboy5551]

Dissociatives suck, but I guess some people enjoy them

[@richiehoyt8487]

"Strength of 10 men"...

[@timecode37]

worse than meth?

[@ferretyluv]

I really don’t get the appeal of PCP. Everything I hear about PCP sounds like a nightmare. It’s somehow still popular in Washington, DC.

[@ahmaudarberywasaviolentkle8094]

I suspect it produces an ever lasting high. They're never the same after.

[@SomethingImpromptu]

I’ve never liked people referring to psychedelics or dissociatives as “psychotomimetic.” Veeery early on in their discovery, some scientists did kind of dismissively assume “Oh, LSD is altering your consciousness in this extremely complex & hard to characterize way… This must be what it’s like to experience psychosis!” But this is a profound mischaracterization, which is why (at least for most 5HT2a receptor agonists), it’s largely been dropped as we’ve come to understand both psychotic mental illness AND psychedelics better. The fact that people are still inclined to talk about PCP this way probably has more to do with media sensationalism than anything (though I’ve never done PCP & can’t say for sure)- from what I’ve heard it’s really just more stimulating than other dissociatives & therefore not suitable as a tranquilizer/anaesthetic. Beyond that difference… Like, sure, there are people who freak out & have mishaps on it, & I’m not saying people necessarily should be using it, but people freak out & have mishaps on too high a dose of all kinds of things. That doesn’t necessarily mean it was truly comparable to psychosis. I think psychotomimetic is a perfectly reasonable label for deliriants, & really that they’re the class which should’ve been labeled this way from the beginning… Completely hallucinating whole scenarios/people/conversations/animals/shadow people/etc. that aren’t there; hearing schizophrenia-like voices in your head; extreme fear/paranoia; extreme confusion & disorientation/disconnection from reality… These are the very psychosis-like symptoms of deliriant poisoning, or having intentionally taken Amanita Muscaria mushrooms, or diphenhydramine, or whatever- terrifying, awful, nightmarish stuff which I strongly suspect TRULY comes as close to simulating what a psychotic condition like schizophrenia as any chemical can induce… There’s not much else to it- those are the primary effects. You JUST feel like you’re losing your mind & living in a waking nightmare. On the other hand, dissociatives have considerably more interesting content to them, & far fewer of the truly psychosis-like symptoms. I’ve rarely heard or someone taking ketamine, or MXE, or DXM, or even PCP & legitimately hearing terrifying whispering or screaming in their head for hours they they just couldn’t shake off (whereas I’ve heard of people taking Amanita Muscaria extract 1 time in not that high of a dose & experiencing those kinds of symptoms for DAYS or WEEKS afterwards). You don’t have true hallucinations or dissociatives… You may have beautiful closed eye visuals, but that’s quite different from a nightmarish waking dream state where you literally don’t know what’s real & what’s not. I’d place dissociatives more as a middle-ground, because they do have a tendency to induce some delusions (usually just during the experience, which is why the issues mainly come about in cases of addiction/dependency, where someone is taking them all the time & never getting a breath of air from that state & assessing their experiences from a more lucid, rational perspective). Classical 5HT2a agonist psychedelics, IMO, are the farthest from “psychotomimetic” of any of these. I think it really was just ignorance that led to this labeling for LSD & psilocybin & the like early on; keep in mind that it was being applied so early on that we were only just even learning that serotonin had anything to do with mood/behavior- in the very earliest days of the discovery of LSD & it’s effects. It’s very much a vestige of an impoverished earlier state of psychopharmacological & psychiatric research. The effects induced by psychedelics like these may seem very chaotic & overwhelming, especially to the uninitiated, to someone who didn’t know what they were getting themselves into, or to someone who takes an excessive dose for their first time & plunges in deeper than they’re ready for… But upon the kind of deeper inspection that mystics & shamans have been giving these experiences/states for ages, & the kind that psychedelic scientists & “psychonauts” have more recently devoted themselves to, there’s actually a profound & beautiful order to that chaos; the fact that it’s unpredictable & too complex for our minds to easily put in a box, to reduce & identify with some very simple pattern or experience we’re familiar with, doesn’t mean that it’s actually untethered from reality or random or meaningless or in any way equivalent to symptoms of psychosis. And especially as classical psychedelic doses increase (besides n,n-DMT, which seems to go in exactly the opposite direction), you move towards boundary dissolution & ultimately full ego-death & mystical experience… Which is quite wildly different from any kind of psychosis. There’s really no comparison. If anything I think it romanticizes psychosis to compare it to something as favorable as psychedelic experience. Even in the fringe cases where someone has a predisposition to mental illness & psychedelics catalyzed the precipitation of a psychotic state, the psychosis it precipitates is going to be very different from the psychedelic state itself.

[@Quinazolineking]

Ok? So?

[@Eternal1nstant]

Bro wrote a whole bible page.

[@deremjool8043]

​@@QuinazolinekingIt is an important distinction to be made, that most hallucinogens do not meet the classical definition of psychomimetic, "producing effects (as hallucinations or paranoid delusions) that resemble or are identical with psychotic symptoms," specifically the psychotic symptoms part.

[@trevorgrommet4654]

Great info! I have schizoaffective disorder. Used to get real gnarly voices constantly. Very disturbing and bothersome. During IV ketamine therapy, no voices whatsoever. No more depression. Neurogenesis from activating glutamate is the way in my case. I also was put on an atypical antipsychotic that activates 5HT1a receptors and is a dopamine agonist. No voices for months now. The manufacturer doesn’t know exactly how it works, because from what my doctor step mom says, chemicals produced by the brain have so many roles that they are still discovering. Mushrooms are a joy. Never had a bad trip. I don’t do them often though. Not for everyone, of course. Some minds just can’t handle it, whereas mine relaxes.

[@homuraakemi4559]

Took a solid LSD dose one time and I genuinely thought I had triggered a psychotic episode because of the psychotomimetic misinformation. I was pretty familiar with hallucinogens to begin with so I just held on until it started wearing off.

[@derenjoy3r]

This is some groundbreaking shit in terms of youtube chemistry, love to see it and also that you explain your mistakes so us chemists can learn from them and not make them ourselves

[@joedirt1965]

I know when mixing insoluble powders with liquids (cocoa powder + soy milk) I add a very small amount of liquid to the powder initially to wet it so it does not clump up (then I add the rest of the liquid). In your case I say use a pre-made solution of base since the base is soluble. I assume your base clumped up and got coated with something that prevented mixing.

[@dvdossbsvskfbdvav]

this is actually how I make my hot chocolate, it mixes much nicer if you make up a paste with the powder first before mixing in the rest of the milk

[@Sniperboy5551]

I watch MRE videos and everyone says the exact same thing

[@nicholasneyhart396]

​@@dvdossbsvskfbdvavI was concerned that you guys used soy sauce for like a solid 10 minutes because I misread the top comment.

[@rob1732]

Just seeing 3 rings arranged like that screams “I will fuck you up”

[@dorisnumper6996]

Ketamine is extremely interesting when you research how it acts in the brain and how it acts on deleting trauma based memories causing instant depression relief

[@kalebmaciver7117]

awesome video, this was informative and quite funny that you could skirt regulations just enough to post this. I am just curious why you chose this route? as opposed to higher yielding cyanide free methods using para toluene sulfonic acid and azeotropic separation of water, do you not own a dean stark trap?

[@Chemiolis]

Only because this was the original method, and to follow closest to Hamilton’s synth

[@Ren-xl1sq]

@@Chemiolis Hamilton ended n7 on the quali today, Mercedes is strong now

[@kalebmaciver7117]

@@Chemiolis ahh I see. what synthesis are you planning next?

[@remcovanvliet3018]

@Ren-xl1sq I wouldn't worry about it too, too much, if I were you. He's still just as strongly outclassed in the talent department. *edit for clarification* When I say outclassed, I'm talking about Lewis, of course, not Morris.

[@SayaialahBeliau]

​@@Chemiolisdude pls make other video of pcmo but with basic solution

[@deadlikedisco4726]

"Coz it's trash" Yeah it really is. A very solid analogoue for ketamine in 4-MEO PCP. Same dissociative anesthetic effects, but has a much longer effect with greater chance of hallucinogenic effects. It is very difficult to be mobile once ingested, which isn't great if one has anything to do for about eight hours

[@seetheious9879]

Felt like I was on a raft in a river when really I was in a forest on solid ground. Still made it to the party but barely.

[@hj-hh4gc]

Can only find info on 3 and 4 meo PCP. Is 5 real or a typo?

[@deadlikedisco4726]

@@hj-hh4gc No, you're correct. I meant to type 4. Thank you

[@hj-hh4gc]

@@deadlikedisco4726 thank God you replied cause that sounds like heaven

[@deadlikedisco4726]

@@hj-hh4gc I mean, if you don't have anything to do for a day, turn off the lights, lay down, and get weird.

[@Piocoto123]

Nothing quite like a good dissociative anaesthetic synthesis in the morning to begin an excellent day!!! Cheers for Chemiolis!! and for H Morris

[@jogandsp]

It's not surprising that you had the problem with the base not dissolving. It makes a basic solution immediately around it which causes the product to precipitate onto it. Next time, dissolve the base before adding it and you won't have that issue

[@Gamert80]

GG on 100k subs! Huge milestone!

[@patentedorganism1557]

Alright, so when is the methamphetamine synthesis video dropping?

[@soop597]

I dont know why i expected a taste test at the end of this

[@djrelentle2027]

WE'RE GOING TO LOOSE OUR MINDS WITH THIS ONE🔥🔥

[@necoluga7950]

WHERE GETING ARESTED BY THE FEDS WITH THIS ONE 🗣🗣🗣🔥🔥🔥

[@dansamarco1610]

Oh you poor bastard, you're never going to break your brain with yields like that!

[@DaNiKzz]

Wheres the taste test at????????

[@ZoruaZorroark]

you know it might be good when youtube/google gives one a "please get help" type of message

[@cajampa]

What do you mean KZbin gives you get help type of a message? I have only heard one other person mention this and he was an admitted schizo.

[@ZoruaZorroark]

hmmmm, that does gives me a concern too if that guy was the only other to get that message

[@cajampa]

@@ZoruaZorroark Yeah I would be. But I am also really asking you. What do you mean with those messages exactly. How and where do they appear? And what do they say? Because you even mentions Google, do you mean in the search engine Google or something else? There is a lot of things "Google". For him it seems he would go on unhinged rants so bad, that he claimed staff of KZbin would contact him by sending him emails to talk to him about getting help. And considering how KZbins "moderation" seem to be just an AI bot censoring things. Up until straight up banning your whole life as in Google accounts, if you go too far of the rails. This whole "getting contacted" and it does not happen to anyone else. Seem to me to very possible be connected to schizo delusions in his case. But if it really does in happen in reality, I am very curious how and where it happens and after what kind of interaction you did? And just to be clear, me saying that it does not happen to anyone else. Does not mean it is not happening. I can not know that, but I just know about one other case, and now two with you, reported instance of something like that happening. And you know about the other guys problem. And you are saying this on a video about dissociative substances, so am sure you get why I could suspect and have a reasonable suspicion that it could be that it is a delusion in your case also. We all know how wonky things can get for people who have an affinity for dissociatives. Because most seem to have the reverse problem, that getting any sort of interaction or "support" from KZbin or Google seems to be impossible. Even many channels with millions of subs can't get a any support from a human for example. I just comment a lot and have been in lots of discussions on this plattform about various intricacies on how the limitations works on the comment system we have here. Personally I would find it kind of nice if there really is humans that care enough, to ask us to get help if we need it. But I am afraid reality does not work like that. Just because it seem to be reported so exceedingly rare. And I also don't want to go around and claiming that it does not happen if it really does happen. So it would be great if you could give me more details to figure out if this mysterious contacts, from the staff overlords on KZbin/Google really is a thing they do and how it manifests.

[@ZoruaZorroark]

yes, the google search engine, and the message that i had pop up was very much a bot generated message. maybe next time i see a message like what i got on this video, i should take a snapshot and send it to you or post it on on of the myriad of message boards. chances are, i would just not bother mentioning such a message in the comments the future. sorry if i am coming off as a bumbling idiot who somehow cruised through school in this conversation on where you are legitimately attempting to understand what i have said

[@cajampa]

@@ZoruaZorroark If it is a message you get that pop up in the browser when you are just using Google to search and it happened after you clicked on some link. It is very likely some kind of spam ad for some kind of health services, the Web is filled with such things. And not Google the company trying to send you a message. Because they really don't do it like that. Although the very recently introduced a notification icon where they can send us updates in the Google search just like we have a on the KZbin app and site. If they where to send some kind of a message I bet it would be either thorough email or to the notification thing. I had a friend who was diagnosed with schizo affective disorder. And he would see patterns and get messages from powerful people, celebrities, intuitions and companies all the time. It was all his delusions who made him think that though, he misinterpreted regular things as something much more significant than they really was and saw patterns and connections where they really was non. And he was quite disturbed. I am not saying you are that. Just that it is very unlikely that Google are sending you messages like that. But them again that have some disturbing privacy implications. If Google would be follow and spying on some of us like that. You know what the paranoid say, it is not paranoid if they actually are after you :) The closest I know they do is if you are acting to unhinged is they send you a message in KZbin, telling you can't post messages in some time like 24 hours or a week or something. I don't remember exactly because it have never happened to me. But in some of those discussions I spoke about KZbin comments limitations. There was a bunch who reported having gotten such messages. But no one besides that one guy said anything about get help messages. And because he said he got them to his email and you said you got them in the search site in the browser, that makes it even less likely that it is even the same thing, if it is a thing that originates from Google the company. Anyway if it happen again take a video of it with your phone and ask someone else about it to get a second opinion. Maybe it does happen....

[@sgctactics]

You had me at "subscribe for better yields"

[@THYZOID]

noice

[@ashe1.070]

The medicinal chemistry stuff is extremely interesting! Keep it up! Did you keep the aqueous layer from that neutral solution at the end? If so you easily could have remedied the error, and included the result in the video. All well. Is 5-MeO-MiPT controlled in the Netherlands? If not, that could be an interesting project. You could start from melatonin by conversion into 5-MeO-Tryptamine. Then reductive alkylation with one molar equivalent of acetone, and an excess of STAB-H (prepared ex-situ from borohydride, and 3 equivalents AcOH in THF, or DCE). Followed by the reductive alkylation with sodium hydroxymethylsulfinate, excess Et3N, and STAB-H under similar conditions. Both reductive alkylation reactions can be conducted in a one-pot operation. I think doing these reactions in that order is absolutely necessary to avoid formation of the dimethyl substituted product due to the steric bulk of the isopropyl group. For the same reason, the formation of the diisopropyl product by a second reductive alkylation is unlikely to occur. Furthermore, while this compound is certainly active, I don’t think 5-MeO-MiPT has much value recreationally. If I’m wrong the use of succinaldehyde to give 5-Methoxy-N,N-tetramethylenetryptamine (5-MeO-pyrrolidyltryptamine) would be an interesting alternative. The methoxy group could also be swapped for an ethoxy, or similar group by starting with 5-hydroxytryptophan. Thus, decarboxylation to serotonin, protection of the amino group as an amide (or carbamate), Williamson ether synthesis to give the desired alkoxy group, deprotection, and finally the reductive alkylation sequence would give the desired analog. This gives a large degree of freedom to design a compound that is certainly inactive. For example, 5-Propoxy-Pyrrolidyltryptamine; there’s no way that is active, so it could make for a cool project without legal worries.

[@aunovichkov]

Last extraction you could perform with dcm It nicely dissolve organic bromides But not toluene Then drying, turning back to bromide and recrystallization from EtOH That should work

[@samlazar1053]

PCP has newer been popular here in Europe.mainly because it produces relatively low euphoria and huge hallucinations

[@chemistrycapital]

Hamilton Morris is definitely watching this

[@MAGATRON-DESTROY]

How about inventing something that cures schizophrenia instead of making you feel like you have it. The world really needs that

[@jameson1465]

It’s called a antipsychotic

[@jerry3790]

I was here before his lab got raided

[@jessepinkman1471]

same

[@Chad-Giga.]

When do the 200mg samples drop @ the shop? ;)

[@theundergroundscientist1312]

Great video and synthesis! Love the content of making compounds of interest :) while casually making HCN as byproduct Just a few notes: - 4:55 Arrow to oxygen atom is redundant since lone el. pair moves to sulfur atom and is not conjugated with S-O pi bond system. - 5:06 Resonance not equilibrium (both structures describe the same molecule). Resonance arrow should be used instead. Congratz on 100k!!

[@methyleneblue_]

thanks for the instructions

[@skinisdelicious3365]

Me: buys toluene DEA and ATF: rock paper scissors shoot!

[@mortlet5180]

I hope you don't have a dog!

[@jessepinkman1471]

too real

[@sharonrigs7999]

Makes me think of that time I was walking on a warm tropical beach, hand in hand with my beautiful wife. Then...the Angel Dust wore off and I realised that I was dragging a broken mannequin around a Wendy's parking lot

[@swagicallovin4107]

Your whole grignard set up just under a normal atmosphere and open to air before the sealing?

[@HisNameIsRobertPaulson01]

Were the effects of the finished product acceptable?

[@kawaiiintelligenceagency3889]

What chemists see: A threeneck flask. What I see: A glass bagpipe

[@1981mrdavid]

Lol. Me: That's a funny looking bong.

[@DavidMueller666]

Generic Delsym chased with some DM cough gels always did the trick for me. Best yet, these products are legal to purchase, possess, and consume.

[@danielsass1826]

It just amazes me that peope figured out how to do all this stuff

[@user-ul6dc4qc4j]

Detachment=Loss of Control

[@andueskitzoidneversolo2823]

Pcp is fun, peyote is better though, .... but you want to know a secret. You can either golden orb spiders and eat them for a strong hallucinogenic effect. I also hear some snake venom does the same If you could isolate what ever compound that it, it might be 100% legal. But as a person with schizophrenia myself please understand schizophrenia is not just hyper mania, I mean yes that's a part of it, but schizophrenia is so much more. It's a huge spectrum.

[@dmtwizard]

Of course Peyote is better. It comes from the earth. They aren’t even in the same hallucinogenic class lol

[@Mulmgott]

@@dmtwizard Dissociatives and traditional Psychedelics for me feel like they are on the opposite ends of the same spectrum. They are similar in a weird way but very different in general.

[@dmtwizard]

@@Mulmgott I agree. DXM and Ketamine for me had a lot less visuals than Psilocybin, LSD or DMT. Dissociatives are more in your head. Granted Ketamine was the most visual one

[@Mulmgott]

@@dmtwizard For me the most visual dissociative I have tried was Deschloroketamine. Psychedelics are hyper visual for me though. I can take 5mg of 2-CB and see fractals on my walls, hands, etc.

[@Ren-xl1sq]

you're the only one that can use the s word without it being offensive, i love you chemiolis

[@tntomega]

i lost you at the cyanide part

[@Zigs_TV]

The first reaction was very satisfying.

[@jimparsons6803]

Interesting and thanks. I recall doing a Grinyard Rx in Organic Chem Lab II, at University. Them were the days. Eventually ended up in plastics and coatings. Even had a US Patent using surfactants to cause conformational nucleation of same. Predictably increase T(g).

[@kpunkt98]

Why was the bisulfite adduct used tho? Don't see the benefits tbh. Can sb explain?

[@SchizoidMastermind]

Taking notes on how to become stronger

[@Adrian87104]

The morpholine imine is not in equilibrium with the tertiary carbocation, they are resonance contributors

[@Tripsqueak]

i don't know what i watched but it was stimulating.

[@darthstarone3532]

This destroys the brain 🧠🤯🧠

[@Pablo668]

Fascinating, but how are you going to test it?

[@davidgreenwood6029]

I wouldn't even want to be in the same room as any of these things.

[@Josezwitterion]

The BEST Chanel orgánica chemistry

[@libalj]

this is like an extractions and ire video

[@patrickfle9172]

Maybe bubbling the HCl through an inverted funnel helps with the clogging problem?

[@annabellethepitty]

No samples like in the rain smell vid?

[@joeyRaven201]

Wait no way you are dutch too, Nice edic : congrats on 100k subs

[@deagle2yadome696]

i used to get dusted a lot, it has its place, it’s a hard drug to control, but extremely unique

[@jasonvoorheis1332]

My popcorn ceiling is always very kind to me

[@ReptileAssylum]

I added some to the kids formula, it actually calmed the little assholes down!🎉

[@mabus42]

Now we just need a proper trip report from Chemiolis. There is no way that you didn't test it, and we know it.

[@y33t23]

4:03 *casually*

[@kid_missive]

KCN is well enough behaved, and acutely toxic, but not in a microscopic amount. It's not likely a chronic toxin or carcinogen, so a chemist is probably more likely to be casual handling it (with gloves) than a lot of other things. If you had a small exposure, you could just leave the room and wash up and it would clear from your body very quicklly.

[@kawaiiintelligenceagency3889]

I've done 3-Me-PCP which is a designer analogue and I can't state the bizzare effects mentioned. To me it produced a feeling of weightlessness, calmth in my brain, euphoria and maybe a somewhat distorted feeling of body but that's all. It was a very nice experience. I took a low dose tho, can't remember how much and just know that drugs are bad mkay?

[@DSOXBLADE]

Have you done one on percocet yet?

[@RiccioloStyle1990]

This synthesis is gonna kill you before you can make it to the end, if not properly trained. Great video and great demonstration of frequent chemistry issues in a life of a synthetic chemist.

[@pirotechnik.14]

The film is brilliant and professional. I hawe a question, were did you get the morphine?

[@kebabrepubliken]

Morpholine can't do an Sn2 reaction on a tertiary carbon. Maybe it's an Sn1 which is favored in polar protic solvent (water for example)

[@jeythegrey]

Whenever you're saying "phenyl" I hear "fennel" which is kinda funny and I can't unhear it, sorry ^^

[@kapoink835]

How much would I need to make a gallon? Preferrably in liquid form

[@curtiswheeler2212]

the same chemical that turns a liquid to a solid like gold for instance?

[@lorenzdellwo4241]

nice video but why did you use HBr to hydrolize instead of HCl?

[@Chemiolis]

Only because of the literature I followed, it doesn’t really matter.

[@SayaialahBeliau]

​​@@Chemiolisu Said diethyl ether can also be use but does the volume is still the same?? (400ml)

[@KennethAkin-me9je]

That shit was some scary stuff and GE dumped a whole bunch of that shit into the Hudson River.

[@fmdj]

PCP's fine and gentle, try 3-MeO-PCPy and rewrite that intro ;)

[@max3eey]

You are a junkie

[@iiiKingLongSwipeiii]

I know right actually PCP is super smooth and on top of it they were going to use PCP as a therapy drug for depression but there hasn't been enough studies on it for its long-term effects so that's why they switched to ketamine

[@Rexwizord]

@@iiiKingLongSwipeiiiand the people who thought they were taking it and instantly found themselves in Mad Max

[@iiiKingLongSwipeiii]

@@Rexwizord I believe that it highly depends on the way it is administered for that to happen for what you said and it also depends on the person's genetics because everybody is different and it will affect everybody different.... Smoking it is very smooth

[@Rexwizord]

@@iiiKingLongSwipeiii the chemical itself it is almost impossible to stop redosing

[@781TheVbyz]

What if you have a positve reaction and effect off pcp or psychedelics instead of losing yourself you become more superhuman ??

[@TheBic4]

Wish it wasn’t so hard to get KCN but I totally get why it is.

[@Emil-cj6ey]

How are dealing with HCN fumes? Did you just connect the condensor to a NaOH containing scrubber?

[@Chemiolis]

Into the atmosphere

[@frysebox1]

​@@Chemiolis Nature's trash bin

[@eli_777]

He's leading all the gas into a modified shower

[@bazooka93]

Cloud storage

[@grgvv]

I would check the melting point of the final product, to confirm that the precipitate you obtained is indeed PCP HCl (m.p. 233-235°C). Or just take an NMR of it.

[@TreasureHoardingDungeonDwarf]

6:53 *Forbidden Rootbeer*

[@Brett-yq7pj]

This is why I love angels

[@johnthomas2970]

DISSOCIATIVE ANAESTHETIC GANG

[@IndianaDundee]

@Chemiolis Would you please make a video explaining the process of making Methadone HCL? The process is easily found, but (at least for me) some of the details of the process are not easily understood. Thank you for considering my request.

[@Quinazolineking]

Considered the request, denied.

[@joecummings1260]

A guy I went to HS with in the 1970's that never did anything but drink decided to try "drugs" by doing a big line of PCP. I remember being at that party but left before anything f ed up happened. Somehow he got home that night and was freaking out and his parents called the rescue, but two cops showed up also. He was trying to fight the cops and from what they said he tried to grab one's gun. (Back then the cops weren't psycho like they are now). He ended up in a locked ward in a mental hospital for about a week. He told me he went nuts when he was at home in his room and the giant mice attacked him

[@onemoreguyonline7878]

Woohoo, 100k subs!

[@sunoncream1118]

the fact that hospital used this that make and ppl hear voice is kinda the same than the car reparator putting you sugar in the tank to see you again...

[@knivesnico8775]

good job!

[@user-sb9zf7ro4m]

Where’s the video where you try it?

[@elietheprof5678]

If we understand its mechanism of action in the brain, would that help in designing better *anti*-psychotic drugs?

[@1981mrdavid]

We do know it's mechanism of action. It inhibits depolarization of neurons. It enters the ion channel from outside of the neuron and binds, (reversibly) to a site in the channel pore, blocking the flux of positive ions into the cell. This causes it to work as an NMDA receptor antagonist.

[@elietheprof5678]

@@1981mrdavid interesting - so then what might an NMDA receptor _agonist_ do instead, in terms of effects on the brain?

[@1981mrdavid]

@@elietheprof5678 It induces a dissociative state. Ketamine, and dextromethorphan also fall into the same class of NMDA receptor agonists. Research on this class of drugs is being studied for their potential mental health benefits. However, clinical trials with phencyclidine (PCP) have shown to cause too many negative side effects and more harm than good. Ketamine seems to be favored at the moment.

[@jojstar4]

whats it feel like