Chronic Inflammation - T Regulatory Cells (Lecture 4)

Chronic Inflammation - T Regulatory Cells (Lecture 4)
An important lecture in the chronic inflammation series. T Regulatory cells (TRegs) and their function. Let's review this promising area of immunology.
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Disclaimer:
This video is not intended to provide assessment, diagnosis, treatment, or medical advice; it also does not constitute provision of healthcare services. The content provided in this video is for informational and educational purposes only.
Please consult with a physician or healthcare professional regarding any medical or mental health related diagnosis or treatment. No information in this video should ever be considered as a substitute for advice from a healthcare professional.
A good reference diagram in the book:
FIGURE 15.6 Mechanism of action of CTLA-4. A, Cytotoxic T lymphocyte antigen 4 (CTLA-4) expressed on regulatory T cells (Tregs) or activated T cells can inhibit the activation of responding T cells on the same antigen-presenting cells (APCs) (in trans). B, CTLA-4 on regulatory or activated T cells binds to B7 molecules on APCs and removes these molecules from the surface of the APCs, making the B7 costimulators unavailable to CD28 and blocking T cell activation. This action of CTLA-4 is able to suppress immune responses best when B7 levels are low, enabling CTLA-4 to out-compete the lower-affinity receptor CD28.
References:
Textbook: Abbas, Abul K.; Lichtman, Andrew H.; Pillai, Shiv. Cellular and Molecular Immunology E-Book (p. 94). Elsevier Health Sciences. Kindle Edition.
URL list from Wednesday, May. 31 2022
DrBeen: Medical Education Online
www.drbeen.com/
Targeting IL-2: an unexpected effect in treating immunological diseases | Signal Transduction and Targeted Therapy
www.nature.com/articles/s4139...
IL-2 administration increases CD4+ CD25(hi) Foxp3+ regulatory T cells in cancer patients - PubMed
pubmed.ncbi.nlm.nih.gov/16304...
IL-2 administration increases CD4+CD25hi Foxp3+ regulatory T cells in cancer patients - PMC
www.ncbi.nlm.nih.gov/pmc/arti...
IL-10-Dependent Amelioration of Chronic Inflammatory Disease by Microdose Subcutaneous Delivery of a Prototypic Immunoregulatory Small Molecule - PubMed
pubmed.ncbi.nlm.nih.gov/34305...
Chronic Inflammation - StatPearls - NCBI Bookshelf
www.ncbi.nlm.nih.gov/books/NB...
Inflammation - Wikipedia
en.wikipedia.org/wiki/Inflamm...
Cytokines and Chemokines at the Crossroads of Neuroinflammation, Neurodegeneration, and Neuropathic Pain - PMC
www.ncbi.nlm.nih.gov/pmc/arti...
Frontiers | Toll-Like Receptors, Associated Biological Roles, and Signaling Networks in Non-Mammals | Immunology
www.frontiersin.org/articles/...

[@janemerrittmckenna2386]

Thank you for all you do! These past 2 years would have been pure torture without your information!❤ You were who I listened to. My doctor knew nothing!

[@rachelmolina3995]

I love that cartoon! Fabulous! Thanks!

[@tommyjablonski3281]

So much more to learn how God made the body.God is the greatest scientist Smen

[@samhart3897]

Dr Been explains things in a way that is understandable to anyone who has little medical background and no background that would motivate study of the subject.Really good.Wish government advisors would watch his lectures

[@tink_b.u5190]

You’re a genius Bro… THANK GOD FOR MAGNIFICENCE

[@libbie2525]

Fascinating! Thank you so much for all your work.

[@brendadelcarmen7907]

Thank you for all the excellent information and your time. All your talks make me think of the mastermind who created these mechanisms. There must be a creator behind them, Almighty God that is, whose intelligence is beyond our imagination, All Glory goes to him and the fact he has given people like you the intelligence, patience and love to study and understand these processes so that simpler minds like mine can understand and meditate on who created us and how magnificent the human body is and works. Knowing all of this and how the body is prepared to fight to keep it healthy and the balance that is involved only gives me hope that God will fight for humankind to eventually live a life without illnesses some day soon, especially for all those injured by imperfection and Covid among other diseases. Thank you very very much for your time to teach us.

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[@kenernstzen2407]

Brilliantly presented 👏👏

[@rachelmolina3995]

Thank you for good information.

[@vassargirl1752]

Terrific video, thank you Dr. B. As an aside, what camera are you using now? Fantastic. Also: sugar (fructose from fruit as well) causes massive inflammation. Many are clueless. Intermittent fasting, strategic calorie restriction--powerful weapons/protection against.

[@NoName-jr2eo]

FASCINATING ‼️ I don't know what more I could possibly say about it!

[@zenaalialmohtaseb8340]

Wow it's my first time seeing you're video literally I can't stop think you so much I full in love with immunity today ❤

[@DrBeenMedicalLectures]

You are very welcome. Glad you liked the talk.

[@garywillis5790]

Beautifully explained!

[@bhagwanlaldangi4137]

Excellent presentation

[@TeacherMom80]

We LOVE you, Dr. Been! 🤗 Thanks for being wonderful you! 💖🕊️🙏🏼

[@tommyjablonski3281]

Dr.beem u r truly.blessef to understand our body's fun too d

[@pattyrooney1323]

Thank you Dr.

[@gabriellapetrarulo4443]

Thanks a lot Dr. Syed. Really........

[@marloes8726]

Two more superb lectures from the Chronic Inflammation series. I share your excitement and appreciation for our complex and precious immune system. A system not fully understood in all it's complexity. I especially liked this lecture nr 4, with the T Regulatory cells which were only identified in the 90's! Needless to say I watched all 4 lectures twice, trying to memorize everything 🙈

[@djelalhassan7631]

GREAT

[@leoniegray6404]

Thank you again for sharing important info. So glad youre here. Also 'cake or death' by Eddie Izzard was hilarious

[@jean-marclasalarie8100]

wonderful How did you dig out all that stuff ?

[@michaelruffinelli6757]

Chronic inflammation smell test reduction persistent, I hear about an Italian doctor that give 1mg of interleukin (not sure maybe the 2) par day, plus 2 day a week ok Keto diet 2 day of intermitting fasting, omega 3 1000mg a day, q10, resveratrol. What do you think? Thank you for the great video part 2 (stunning I'm wondering how it could be in a Cartoon animation with your cool draw) Video cam Feedback : The video contrast is to high, also color correction need to be done more natural :D, I suggest to use C-log for optimized your video.

[@alireid5874]

The important questions: does spike protein (natural or vax induced) dysregulate T regulatory cells? If so, is it transient or permanent? What can be done to re-establish homeostasis? I would look for heretical docs who treated HIV/AIDS patients in the 80's and 90's with non-conventional means. They are the ones that understand immune dysfunction

[@tink_b.u5190]

Turmeric,ginger, black pepper in orange juice 🧃

[@tommyjablonski3281]

Could sam made virus disrupt these cells functions on Purpose to hurt. Us?

[@th4tsfilthy]

100% its a bioweapon lol. they knew and lied every step of the way..

[@th4tsfilthy]

the v is worse then covid. crimes against humanity trials are starting up. seek the info out. msm will never tell us!

[@preciousissah7395]

Gain of function funded by democrats done by fauci and push by bill gates

[@logic7374]

let's talk th17/il17 and MS

[@DeanOSupremo32]

What can we do to combat chronic inflammation or reset immune cells that are dysfunctional?

[@alireid5874]

Intermittent fasting/autophagy, grounding, sauna.

[@DeanOSupremo32]

@@alireid5874 Thank you for the response. I've heard of intermittent fasting triggering autophagy. What is the mechanism for grounding and sauna?

[@Kmatey]

Is it not Transforming growth factor β (not tumor growth factor)