Specific (Adaptive) Immunity | Humoral and Cell-Mediated Responses

CORRECTION: What I labeled "CD4+" in the diagram is actually the "TCR," which stands for "T-Cell Receptor." The CD4 glycoprotein is a coreceptor with the TCR, but it's not shown in my diagram.
This is how our bodies learn to identify a new pathogen and develop immunity to that pathogen in the future.
🔬For all my science videos and other resources, check out: www.justinmsiebert.com
💻 My youtube channel: / siebertscience
0:00 Introduction
0:48 A Wild Pathogen Appears!
2:11 Phagocytosis and Presenting the Antigen
3:27 T-Helper Cells
4:29 Humoral Response (B-Cells and Antibodies!)
7:07 Cell-Mediated Response (Killer T-Cells!)
9:18 Recap
11:13 More bad acting...
_____
Image used:
“6VSB spike protein SARS-CoV-2 monomer in homotrimer” commons.wikimedia.org/wiki/Fi..., 5-HT2AR, CC0, via Wikimedia Commons

[@halqthedarktemplar]

To add a bit to the cell-mediated response for people reading the comments, the infected cell presents the antigen via the MHC-I (instead of the MHC-II of the APC cells) and the T-killer lymphocyte uses the CD8 receptor for that antigen

[@naylacalvin2507]

Thank you it was actually helpful

[@user-wx8kv8ty3o]

Fantastic lecture and comments.

[@chefmittens3056]

This was insanely precise. I love that you follow such a linear path for something involving a lot of steps at once. Seriously thank you thank you thank you. I've watched a lot of good videos on immunity but yours was the only one to truly make it fully understandable.

[@SiebertScience]

Thanks so much for the kind words! Glad you found it helpful.

[@user-hv6ow1tu6x]

Yes, this is so true thank you😊

[@puneet1173]

Thank you so much. I have spent hours looking for videos to help me on this topic and now you have made it crystal clear in my head. Please continue to make more videos they help so much

[@SiebertScience]

Aw, thank you for the comment! Glad it was helpful!

[@SyenPie]

EXACTLY. This was by far the best video I've found on this topic, presented in such a CLEAR and organized way! This man truly has a gift for teaching.

[@TiaDimi]

I have been researching this topic over the past week for an assignment, struggling to find anything as clear and helpful as this video by a mile. This video literally feels like the best video on the whole internet for explaining B cell and T cell functions and specific immune responses in general. The detail is perfect, the whole video flows. Thank you so much, I really appreciate your work!

[@zygridollero5479]

Thank you so much for doing this! I was having a hard time reading about this topic on my own. It made so much sense :D

[@flygirlkc]

Thank you for the "clear as glass" explanation!

[@SiebertScience]

You're welcome!

[@heatherkrn5200]

This is the most helpful video I have seen on the interaction within the adaptive immune system. Thank you for such a clear explanation

[@darianleduc]

Thank you so much! Adding the etymology of the cell and biochem names is super helpful

[@jennyrios9535]

Reviewing my Physiology notes to take my TEAS exam. I looked through so many videos that were either too complex or too simple. This was perfect! Loved the artwork and the clean separation of processes. Thank you!!!

[@SiebertScience]

You're welcome! I'm glad you found it helpful. Yeah, it's hard to find resources at the right level for a lot of this stuff.

[@chrissvitreoushumour]

awesome explanation. you connected the processes of cell-mediated and humoral immunity really well

[@fimpero994]

I've been trying to get my head around this topic for months now and I stumbled across this video, ive never heard it explained so well and so precisely yet in a way so easy to understand. You're an extraordinary teacher, THANKS!

[@bonner9900]

The best and clearest presentation !

[@arnabray3662]

Thank you so much for such amazing explanation. Definitely gonna nail this topic tomorrow

[@tiffany6376]

I got frustrated learning about immune system, but your video is truly a big help for me to understand it better. Hopefully u will continue making new videos cause I gonna be a big fan of your

[@SiebertScience]

Glad it helped! I plan to keep making more videos!

[@hollyweselowski7442]

thorough and helpful, im an NP student and this was SUPER helpful !

[@marthaschurr7827]

Great video, and such beautiful visuals

[@annguy5563]

This is so amazing, you explain what my 3 hours lectures couldn't in 10 minutes.

[@jo_lenin8990]

Super cool video. Thank you so much. You make it straight forward, interesting and deep at the same time. Best doctor here!

[@mondelwane8592]

I wish you were making videos 4 years ago, my goodness man you are a life saver

[@sagaranilkumar8619]

Oh thanku so much for that wonderful class helped me to understand the topic very much... plz keep going and post more videos..

[@jenniferthomas6592]

This was super helpful! Thank you!

[@hamzaha.al-quaid2441]

Really awesome big picture video. Thank you🙏🧬

[@laurenbaron6820]

Thank you so much! Very helpful video. Love the pictures made it much more clear :)

[@SiebertScience]

You're welcome!

[@v.2435]

This is so concise, Thank a lot Prof. !!!

[@ratanraj743]

You are wonderful ... clear and crisp ... wish youtube present u to the needful learners in the manner how our cells present the antigens for betterment of body :)

[@SiebertScience]

Thanks! I hope KZbin listens to your advice, haha! :)

[@TheTiss1982]

This man needs a medal for this breakdown! I’m passing this exam! Talk about confidence he just gave me

[@user-nw4sp1bp5v]

Nursing student here! Thank you so much for these videos!! You are a hero!

[@akeminnocentosagie5901]

You have definitely help and educate me so so much with your videos. You are the best with the You analyses and make it look very simple to understand. Thank u so much.

[@user-wx8kv8ty3o]

Fantastic lecture and comments

[@karl_fischer]

I have a class test in 4 hours and now I am fully confident that I'll ace that! Thank you.

[@khalidabdulfattahmutwally9286]

Extremely beautiful and beneficial. I love that so much.. please continue

[@pulkitverma8104]

Brother one of the finest video on this topic.....you got my respect 👍🏻🤝🏻

[@carlapaperdoll]

Bless you! Please continue doing what you're doing! You're an angel

[@stephaniemiller5165]

I Spent a week trying to figure this out and u explained it in a few minutes. You are truly a teacher indeed. Can you couple this with the Mac 1 and two? Omg you are good. I have hope now of passing this section of the exam tomorrow!

[@cbri1621]

Your videos have single handedly taught me all of the systems that we need to know for the MCAT! I never took anatomy as its not required for us and when I started studying I had regrets on not taking it, but man your videos on the immune system, digestive, respiratory, circulatory and kidneys have literally taught me everything!!! Your videos are so well put together and so easy to follow I hope KZbin pays you a million dollars a year for your services :) Question about the immune system: So what is the difference between MHC-II and MHC-I? Are MHC-II's only present on macrophages? Seriously thank you x 1000 and I hope to use your videos throughout medical school once I make it there :)

[@user-pc6or2qi2m]

thanks heaps for this video!

[@sarahlee3100]

Please continue making these videos. Once I learned about your channel, I can't stop watching them to learn more! Very concise and easy to digest diagrams (they are also very cute) Thank you so much

[@SiebertScience]

You're welcome! I plan to keep making them!

[@samanthaagneslumapas8479]

Big help 🎉 thank you!

[@celinaleal7692]

Love your videos! I'm doing biomed and some concepts I just cant' understand until you explain it. Also, omg I love Cells at Work too!!

[@taylorguarino1555]

Thank you so much for this amazing video

[@sookieseestruth7573]

This was the bomb. Thank you

[@mulukenm268]

What an attractive and genius way of presenting!! Please continue doing it for other parts of pathology and physiology. You made the subject matter very edible 😀😀😀

[@SiebertScience]

Thanks! I plan to keep making videos 👍🏼

[@sandyable]

so far your videos have been very helpful:) thank you for making it easier for us. although I didn't believe you were sick :x

[@NappyZoeRebel]

Great video!!!

[@emersongill8501]

I'm a very visual learner and the way you drew it all out and separated the different processes! thank you for finally helping my brain understand this topic :) If I get an A on my exam today I can thank you!!

[@SiebertScience]

Glad the videos were helpful. Let me know how you did on your exam!

[@kimmagri181]

Very helpful ! Thank you so much :)

[@SiebertScience]

You're welcome!

[@alperbulut1267]

i didnt had a problem with focusing on your lecture. That's rare for me thank you for the video

[@carolinew1616]

THANK YOU! 🎉🎉

[@vectorie6195]

Thank you so much

[@jonnymercy4528]

best guide ever!

[@lamarjr001]

You’re the best!!🏆🔥

[@TP-mv6en]

This is a great video thanks so much for making it

[@rajabumlaluko2897]

I found it more helpful and easy to understand

[@Jarh9999]

thank you sooooooooo much this clicks so well now

[@SiebertScience]

You're welcome! Glad it helped!

[@ddamme05]

I'm not a Bio major but this is probably the best video explaining anything ever. Helps me understand research I'll have to read for my extra-credit assignment. Thanks!

[@SiebertScience]

Best video explaining anything ever??? What a great compliment! I appreciate it!

[@elle3947]

Took me so long to understand until this short video , so clear :) thanks

[@dejamin876]

Many thanks very good video

[@mohammedshamboul3145]

Thank you You are good medical teacher I watch in youtube

[@gellerhockey1213]

Thank you!!!!

[@AnaMishu]

I always watch your videos before reading a textbook bc most of the time textbook seems very complicated, then I do my quizz assignment with ease

[@milliecroft1200]

I dont think ive ever commented on a youtube video in my life, but this was so helpful i almost did a backflip out of joy, thanks !!!!!

[@JessicaDejesus60]

wow thank you so much!!

[@allround8771]

I've been watching a couple of videos on the Immune System and I could easily admit that you're the Phil Jackson of Immunology. Well, Phil Jackson with a touch of DiCaprio (nice fake acting lol). You've mastered the act of transferring knowledge. Thank you!!!

[@SiebertScience]

Hey, my students tell me my acting is improving! But they’re probably just being nice... Thanks for the comment!

[@eman.hasann3335]

U r one of the best youtuberrrr❤❤❤❤❤❤❤

[@ethancraeynest4183]

very clear and specific video, just hoped you would take about the types of interferones and the "component system" too. This would have helped to be even more complete. Maybe talking about the NK-cells too but overall very very good video

[@martashenker]

NK cells are part of the innate immune system, that's why they are not being discussed here

[@Ahmad_Fawaz]

Can you make vd about the non-specific?

[@croys8608]

Thank you,

[@HamedAlqahtani]

thank you so much

[@osamaelessawy4796]

thank you

[@mollygrigg7005]

I watched the lymphatic system video and now this … and I want to watch the blood one next. For the very first time I’m finding human body systems fascinating. Never had such a great teacher before. I might have gone into medicine if I had had videos like this in my younger life! Now I’m going to use them to teach my kids!

[@SiebertScience]

Aw, thanks for the kind words! Best of luck with homeschooling anatomy this year!

[@user-ck8qz6yb6n]

100% perfect🤞👏👏clear and understandable ♥️

[@SiebertScience]

Thanks so much!

[@Heh18287]

thanks you for this AMAZING explanation, and you should definitely be an actor😂

[@victormulenga4690]

wonderful and help tutorial, I like it

[@SiebertScience]

Thanks for the comment!

[@evamaryanti800]

Not so convincing coughing, but the lecture was amazinggggg. Thanks!

[@SiebertScience]

So you’re saying I shouldn’t quit KZbin to become an actor??? ;)

[@MdR15]

Just Excellent💯💯

[@SiebertScience]

Thank you 🙌

[@aggelikinakou_]

oh my god, thank you so much for this video, immunology is driving me crazy

[@mangajunction8762]

This is good ✨

[@SiebertScience]

Thanks!

[@grrrrr219]

hataraku saibou in the background! It's a good show focusing on body immunology ! 😄

[@SiebertScience]

I was hoping some people would notice that! Great show!

[@eman.hasann3335]

Thank uuuuuuuuu❤❤❤❤❤❤❤❤

[@Yo_Thenics]

What about MHC 1 that present the antigen for T cytotoxic?

[@medianayaseen1610]

I have a question regarding the B cell maturing in the bone marrow i read in multiple sources that it start’s developing in the bone marrow but continues in the spleen to final maturation but i also read it matures in the bone marrow so can you tell me which is true?

[@trinityg8511]

the best video to explain this. I really wanted a clear cut, step by step demonstration and this is incredibly helpful. thankyou!

[@prernapatil6458]

can you just clear a doubt ? How can cells retain specific memory of any pathogen in spite of having average life span?

[@karl_fischer]

they keep dividing into new cells and passing on the information.

[@JarodKientz]

I like the Cells at Work easter egg.

[@SiebertScience]

Yeah, I just discovered the show last week! So good!

[@teresap8428]

The intelligence of our body

[@triggeredbiology4726]

This is for class 12??

[@VennelaReddy-fj3st]

this guy made my life a lot easier

[@andreasvanbrusselen3802]

Goat

[@bili4591]

The problem is, everybody start to modify the truth at the moment of the cross between innate and adaptive immunity so I can’t know what is real or not real ... - The T helper cell learn the shape of the antigen presented by the APC and goes on ? OR - The T helper cell have already learn a antigen specificity at the birth and goes on only if himself and the APC match ?

[@justgremoryy2148]

Cells At Work!! i love that anime!

[@szxnv]

goated

[@alvinsun2346]

very helpful, especially when you have a teacher that doesnt do her job

[@SiebertScience]

Thanks! Glad you found it helpful. Yeah, a bad teacher makes it tough, but as a student you have to find what works for you! (such as finding KZbin videos)

[@haley3730]

APC: the body’s way of wearing the blood of our enemies 😂 Those cells literally decapitate the invader and WEAR it’s body to alert other cells!! How cool is that!!!

[@samanthadebruin1467]

would Humoral mediated immunity be how we build immunity through vaccines???????///

[@SiebertScience]

There are several different mechanisms for different types of vaccines, but understand this type of immunity is kind of the first step in understanding how those work.

[@johnyannelli2480]

I would be very careful if you listen to this and use it to learn immunology. It is oversimplified. For example, CD4 does not define specificity nor does it recognize antigenic proteins. This is mis-leading. Be careful.

[@SiebertScience]

Thanks for pointing this out! I added a correction in the description: "CORRECTION: What I labeled "CD4+" in the diagram is actually the "TCR," which stands for "T-Cell Receptor." The CD4 glycoprotein is a coreceptor with the TCR, but it's not shown in my diagram."

[@pardeep.ksharma9136]

everything was convincing :)