Chronic Myelogenous Leukemia - CRASH! Medical Review Series

[@woloabel]

Hematology: Chronic Myelogenous Leukemia (CML). Ax: Translocation 9/22 Genetic Mutation (Liquid Neoplasia: BCR-ABL Translocation) or The Philadelphia Chromosome Translocation. SSx: 1) Constitutional Symptoms 1) Fatigue (Anemia), 2) Night Sweats, 3) Low Grade Fever, 4) Splenomegaly is Possible, 5) Leukocytosis (Elevated WBC Count at Greater than 150,000/mcL. 6) Median Age of Diagnosis is 55. 7) Prognosis is good if treated early. Dx: 1) Incidental CBC Suspicion and Clinical Pathological Correlation, 2) Peripheral Blood Smear (PBS) and HIgh LAP, 3) Bone Marrow Biopsy (BMx) for a Definitive Diagnosis Locating the Genetic Mutation (95% Specificity). DDx: 1) Leukemoid Reaction (Leukocytosis due to Infection or Chronic Disease) with a High Leukocyte Alkaline Phosphatase (LAP). Tx/Mx:1) BCR-ABL Inhibitor (Imatinib), 2) Bone Marrow Transplantation (BMT). Cx: 1) Leukostasis (Sx: Blurred/Loss of Vision, Priapism, Decreased Cognition and Respiratory Distress. Leukocytosis of Greater than 300k Per microliter. Tx: Leukopheresis/Exchange Transfusion); 2) Blast Crisis (Sx: Acute Anemia, Thrombocytopenia, Immunosuppression; Dx: BMB with 20% Blasts or Greater; Tx: BMT or Chemotherapy). Goodness, my first CML Diagnosis! Just Kidding, it was a Leukemoid Reaction due to Autoimmune Pathology. MD Paul Bolin, Es Geht gut. Prost!

[@justinclark2763]

Thanks for the videos. I appreciate that you separated the Leukemia lectures into individual videos opposed to one larger video. It makes it easier to navigate while studying.... Did you complete or plan to record Myeloproliferative d/o's (PCV, Essential thrombocytosis, or myelofibrosis)? If so I might have missed it. Thanks again.

[@ayoungmuslimgirl]

U R amazing!! I am sitting next to a cozy fire listening to all the hema lecs u made in preparation for our Med II final.. I hate hema tbh.. But ur awesome.. A bit on the slow side though, but that makes me capable of doing things while listening to ur lecs 👍👍👍👍👍👍 Thanx a lot.

[@doaadahboor7778]

Philadelphia chromosome is also present in ALL ; however , in ALL it is not favorable mutation . Here in CML , its presence is considered favorable . Thank you sir !

[@samikshabhomle8975]

To learn more about Leukemia and its treatments, you can consult Dr. S. K. Gupta. He is one of the best hematologists in India. If you can't visit his hospital, Dr. S. K. Gupta has a facility for video consultations too. Visit their website for consultation or for a second opinion regarding treatment.

[@DrDinooshDeLivera]

Fantastic! Thank you so much.

[@ashokbansode4831]

Very good instructions

[@oussamamasri5515]

you said that basophilia is common in leukemias.. are you pointing out at the staining or at the cells? do the cells stain more basophilic? or do we have increase in basophils?

[@BackbenchersRevolution]

Osama Masri basophilic cells of wbc not those who stain

[@HafizahHoshni]

Awesomely informative and perfectly explained! Thank you so much! 😊😊 20/7/2019

[@Inyaking]

Thanks, Doc.

[@funwithme6959]

Fantastic sir

[@BackbenchersRevolution]

thanks a lot sir

[@jobayethossain6354]

very good

[@colemanadamson5943]

Yeah right.......I developed CML when I was 32. So stick your 55.

[@pwbmd]

That number is an average.