Claisen Condensation Reaction Mechanism

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Great explanation Sir, Would it be possible for you to make more videos on alkylation, acylation, adol reactions, beta elimination and related rxns, heterocyclic synthesis and reactivity Pleaseee They way you explain is very clear.

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[@kaviyarasanm7133]

Sir Why ethoxide ion not attack Alpha corbon in in the first reaction?

[@jyji6976]

why hydroxide can attack carbon directly but not when it was Eto? (Eto attacked alpha hydrogen first)

[@bailassandijani3788]

Because Eto is not sterically hindrance so it will not added to carbonyl group at first

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[@kalyanikudalkar5037]

Hello, can you please explain perkin condensation too?

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Awesome

[@revathin7292]

Will the Ester part hydrolyse into alcohol if we have 2eq of hcl?

[@rahullovesthepayne8690]

why does it attack the alpha-hydrogen only? And also, why ethoxide is a good leaving group?

[@sandeepsinghbisht3489]

EtO- is weak base and also there is no other better leaving group than EtO-

[@electro8032]

Can you make a video on perkin's Condensation,Please.

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[@JoeyVX]

Can HCL be substituted with sulfuric acid?

[@JoeyVX]

@@asmaakram250 yes thank you, I was able to understand perfectly, a stronger acid can replace a weaker acid only in this reaction they are using HCl and I wanted to know if sulfuric acid a weaker acid can be used instead of HCl not the other way around. So for instance I would be using sulfuric acid to form the ketone. I think it can be used instead only it would require a larger quantity of sulfuric acid over HCl I presume

[@ivantimofeev2233]

yes, and it actually would be better a stronger acid gives a better kinetic constant but be careful with the concentration of the sulfuric, in my experience, going over 70% chars the reagents (basically reduces all organic compounds to elemental carbon, which is not great)

[@JoeyVX]

@@ivantimofeev2233 I appreciate your comment, thank you for your input. The good thing is that the reaction takes place in an aqueous soln. and the sulfuric acid would be added slowly but I guess it would be best to pre-dilute the sulfuric acid before addition. I actually ended up trying sulfuric acid and it worked, it was performed at mg scale just as proof of concept and it worked great. Took quite a lot of sulfuric acid, I was surprised.

[@fiaahuja]

Why does it needs to match?

[@bailassandijani3788]

why the LDA didn't react directly with carbonyl carbon at first but it react first with alpha hydrogen?

[@anjaleitner9171]

LDA isn't nucleophilic

[@sandeepsinghbisht3489]

Because Acid -base rxn happens at a very faster rate. Then Nu attack

[@saiei]

Nice

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Organic chem is my major and reaction mechanism is my worst nightmare pls help me

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Interesting

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