Cliff Brangwynne (Princeton & HHMI) 1: Liquid Phase Separation in Living Cells

[@mazin627]

This was great. I came across a term called liquid liquid phase separation in a paper, didn't understand but thanks to this video I now have some insight. Thank you.

[@rickfearn3663]

Cross pollination between physics and biochemistry is so very exciting!!! Thanks for opening our eyes to these exciting developments. Question is what will the future bring? Thanks Dr. Brangwynne.

[@benjaminjoshua6235]

Very great lecture. Looking forward to more videos.

[@ankitbioinfo]

Very nice talk. Finally I landed here after hearing the talk of Tony hyman, Frank Julicher and Eric Dufresne.

[@paul3116]

Fantastic talk! Just a small detail I'd like to add: I wouldn't define the Golgi apparatus as 'a funny name', it comes from Camillo Golgi, an italian scientist who discovered this organelle.

[@jamesdriscoll9405]

You have to admit, it's a little funny that he's known for his little apparatus. Seriously, mad props to the pioneers of cellular biology! And whatever it takes to memorize all of this crazy crazy stuff!

[@katenicholls5301]

Thank you SO much for your clarity and for the generosity of your time. I am fascinated.

[@ansonoconnor2035]

This video was fantastic. Great explanations and great lecturing.

[@anonviewerciv]

Macromolecules as liquids. (15:30) 7:17 21:51 Organelles without (phospholipid) borders.

[@王祥-k5l]

membraneless organelle will change many the molecule biology concepts, thanks Cliff Brangwynne

[@soudaminisahoo8935]

This is indeed helpful to understand LLPS (liquid-liquid phase separation) from a physics point of view.

[@mehdisharifitabar7745]

Hi Cliff, fantastic talk! . thank you

[@xXRandomPianoXx]

28:38 You said that with a low interaction parameter (high temperature) the system remains in a high entropy/mixed state. And as you raise the interaction parameter, the system will favor phase separation. But the sign on the y-axis is indicating the opposite. In other words, based on the graph, it appears that a low interaction parameter drives the system into phase separation, and so on... Could it be that the interaction parameter is relative? (ie. low interaction between heterogenous molecules (phase separation) vs. low interaction between homogenous molecules (mixed state))?

[@shrishtiwari7750]

Excellent Lecture. Thanks for clearing the basic concept.

[@davidgurarie6712]

These are novel and important idea. Thanks for nice intro.

[@samingzadeh4494]

Loved it. Thank u Prof. Brangwynne!

[@thefalcon217]

What effect does milli meter microwave raditation have on liquid phase seperation, given it can increase hydroxy radicals in water?

[@captainquinine]

this talk was super good

[@moofaca]

Thanks for the great talk!

[@RanjitDe]

Very helpful for a beginner like me. Thanks.

[@davidkincade7161]

Great stuff!!

[@sukuraluoriver9813]

thanks

[@weiwang7446]

wish I could give 1000 thumb up

[@jamesdriscoll9405]

Everbody gangsta until the phase change

[@Echodonut]

Coo

[@x04x0n1c]

You're a soft squishy robot, not me

[@jatigre1]

I wonder when biology is finally going to admit and understand that without a "spirit" / "IS-BE" there is no life animating-organizing force behind life-forms

[@davidkincade7161]

See “intended evolution”- there is a “life force” as the substrate to physics and chemistry.

[@patldennis]

Huh?