Just a quick note on your modifications section: the Zn dust and Ph3P are technically added in equal equivalence, but it’s noteworthy that you only use half the Ph3P that you would otherwise use without the Zn dust (for example, normally it’s 4 eq of Ph3P but with dust it’s 2 eq of both). Good video! 👍
@ChemWis2 жыл бұрын
Thank you
@venkateshgopula4904 жыл бұрын
Nicely explained... #VenkateshGopula
@konstantinkonstantinov70783 жыл бұрын
Could this react with ketones as well?
@ChemWis3 жыл бұрын
No
@konstantinkonstantinov70783 жыл бұрын
@@ChemWis Why it is wittig reaction after all? I mean only the first part (not adding base).
@ChemWis3 жыл бұрын
This is because of less electrophilicity of ketonic carbon compared to aldehyde and also the Ylide formed during this reaction is less reactive.
@kendalldoer54662 жыл бұрын
It actually has less to do with the reactivity and more to do with the mechanism. If you have a ketone you can’t get deprotonation by the n-ButLi to form the last pi bond in the alkyne. It is shown in the video differently but typically the mechanism is drawn with deprotonation and kicking off the Br, with acid work up for the lithium