Corey Fuchs reaction

[@ThorirLenvik]

Great information!

[@ChemWis]

Thanks for watching!

[@varshalondhe3722]

Nice explanation

[@ChemWis]

Thanks and welcome

[@kendalldoer5466]

Just a quick note on your modifications section: the Zn dust and Ph3P are technically added in equal equivalence, but it’s noteworthy that you only use half the Ph3P that you would otherwise use without the Zn dust (for example, normally it’s 4 eq of Ph3P but with dust it’s 2 eq of both). Good video! 👍

[@ChemWis]

Thank you

[@venkateshgopula490]

Nicely explained... #VenkateshGopula

[@konstantinkonstantinov7078]

Could this react with ketones as well?

[@ChemWis]

No

[@konstantinkonstantinov7078]

@@ChemWis Why it is wittig reaction after all? I mean only the first part (not adding base).

[@ChemWis]

This is because of less electrophilicity of ketonic carbon compared to aldehyde and also the Ylide formed during this reaction is less reactive.

[@kendalldoer5466]

It actually has less to do with the reactivity and more to do with the mechanism. If you have a ketone you can’t get deprotonation by the n-ButLi to form the last pi bond in the alkyne. It is shown in the video differently but typically the mechanism is drawn with deprotonation and kicking off the Br, with acid work up for the lithium

[@priyanshisharma3578]

Sir aap bahut achha padhate ho

[@ChemWis]

Thanks for the complements!

[@Vihan12345]

Great 🙏🏻

[@thaleshpal5421]

👌👌👌👌👌