Coronavirus Pandemic Update 52: Ivermectin Treatment; Does COVID-19 Attack Hemoglobin?

[@Medcram]

Thank you for supporting our COVID-19 video updates by subscribing to this channel, and visiting us at www.MedCram.com At our website, you can view all of our videos and CLEAR explanations of over 60 medical topics. We also offer CME/CEUs for medical professionals, medical programs, hospitals, and institutions. All links referenced in this video are in the video description. Quick links to our previous updates on the coronavirus pandemic: - Coronavirus Pandemic Update 51: State by State Projections; Ultrasound to Diagnose COVID19 Pneumonia: kzbin.info/www/bejne/e2iwppmJa8mhgNk - Coronavirus Pandemic Update 50: Dip in Daily New Deaths; Research on Natural Killer Cells & COVID-19: kzbin.info/www/bejne/nKrEZ42trcibbpo - Coronavirus Pandemic Update 49: New Data on COVID-19 vs Other Viral Infections (Ventilator Outcomes): kzbin.info/www/bejne/q5Ksq51pqJijaqM - Coronavirus Pandemic Update 48: Curve Flattening in California, PPE in the ICU, Medication Trials: kzbin.info/www/bejne/gH-QaZV9d5aWgq8 - Coronavirus Pandemic Update 47: Searching for Immunity Boosters & Possible Lessons From Spanish Flu: kzbin.info/www/bejne/fmKveZqvm7WDh5o - Coronavirus Pandemic Update 46: Can Hot/Cold Therapy Boost Immunity? More on Hydroxychloroquine: kzbin.info/www/bejne/e3e1qKGem7yLrtE - Coronavirus Pandemic Update 45: Sharing Ventilators, More on Sleep, Immunity, & COVID-19 Prevention: kzbin.info/www/bejne/fWLdpHhvlJ1on5Y - Coronavirus Pandemic Update 44: Loss of Smell & Conjunctivitis in COVID-19, Is Fever Helpful? kzbin.info/www/bejne/d2XIpmCelNSql6s - Coronavirus Pandemic Update 43: Shortages, Immunity, & Can a TB Vaccine (BCG) Help Prevent COVID-19? kzbin.info/www/bejne/gqKuqHR_ft5gg9E - Coronavirus Pandemic Update 42: Immunity to COVID-19 and is Reinfection Possible? kzbin.info/www/bejne/p2WzamSMp8uDfdk - Coronavirus Pandemic Update 41: Shelter In Place, FDA Investigates Hydroxychloroquine for COVID-19: kzbin.info/www/bejne/noHdZn6unK6SgZY - Coronavirus Pandemic Update 40: Ibuprofen and COVID-19 (are NSAIDs safe?), trials of HIV medications: kzbin.info/www/bejne/moWZnnuflJ2Ja6c - Coronavirus Pandemic Update 39: Rapid COVID-19 Spread with Mild or No Symptoms, More on Treatment: kzbin.info/www/bejne/d4XSd2uFarlrbNU - Coronavirus Pandemic Update 38: How Hospitals & Clinics Can Prepare for COVID-19, Global Cases Surge: kzbin.info/www/bejne/g6DMpKV5idpjibs - Coronavirus Pandemic Update 37: The ACE-2 Receptor - The Doorway to COVID-19 (ACE Inhibitors & ARBs): kzbin.info/www/bejne/Z6e9dYmYprebr68 - Coronavirus Pandemic Update 36: Flatten The COVID-19 Curve, Social Distancing, Hospital Capacities: kzbin.info/www/bejne/rKjaYqF_ftSko9k - Coronavirus Pandemic Update 35: New Outbreaks & Travel Restrictions, Possible COVID-19 Treatments: kzbin.info/www/bejne/rHaXkH-pm9mBga8 - Coronavirus Epidemic Update 34: US Cases Surge, Chloroquine & Zinc Treatment Combo, Italy Lockdown: kzbin.info/www/bejne/i2ipYpakjNqjb68 - Coronavirus Epidemic Update 33: COVID-19 Medication Treatment Trials, Global Testing Remains Limited: kzbin.info/www/bejne/g56ahqWQmtpgbZY - Coronavirus Epidemic Update 32: Important Data from South Korea, Can Zinc Help Prevent COVID-19? kzbin.info/www/bejne/e5bLYWhqYq2rZ7c - Coronavirus Epidemic Update 31: Mortality Rate, Cleaning Products, A More/Less Severe Virus Strain? kzbin.info/www/bejne/bYqsY6eFpLuJps0 - Coronavirus Epidemic Update 30: More Global COVID-19 Outbreaks, Vitamin D May Aid Prevention: kzbin.info/www/bejne/nZ7UmHqtiZuVrZI - Coronavirus Epidemic Update 29: Testing problems, mutations, COVID-19 in Washington & Iran: kzbin.info/www/bejne/jpuokpaLrtVnrLs - Coronavirus Epidemic Update 28: Practical Prevention Strategies, Patient Age vs. Case Fatality Rate: kzbin.info/www/bejne/p6anipWVrZpneq8 - Coronavirus Epidemic Update 27: Testing accuracy for COVID-19 (CT Scan vs. RT-PCR), California Cases: kzbin.info/www/bejne/roLal6iAnK9sotE - Coronavirus Epidemic Update 26: Treatment Updates, Stock Markets, Germany & San Francisco, Pandemic? kzbin.info/www/bejne/mIeUdI2uf5KorLc - Coronavirus Epidemic Update 25: Vaccine Developments, Italy's Response, and Mortality Rate Trends: kzbin.info/www/bejne/i3rQhImegbGYfbs - Coronavirus Epidemic Update 24: Infections in Italy, Transmissibility, COVID-19 Symptoms: kzbin.info/www/bejne/rXfSm2WCZ7GjhKM - Coronavirus Epidemic Update 23: Infections in Kids & Pregnancy, South Korea, Spillover From Bats: kzbin.info/www/bejne/gHjLqHR9nqahgNE - Coronavirus Epidemic Update 22: Spread Without Symptoms, Cruise Quarantine, Asymptomatic Testing: kzbin.info/www/bejne/haLTeamBZb10ers - Coronavirus Epidemic Update 21: Antibodies, Case Fatality, Clinical Recommendations, 2nd Infections?: kzbin.info/www/bejne/b3O8kqytfrmLj80 - Coronavirus Epidemic Update 20: Misinformation Spread, Infection Severity, Cruise Ship, Origins: kzbin.info/www/bejne/gZKXaYiQeamtgrs - Coronavirus Epidemic Update 19: Treatment and Medication Clinical Trials: kzbin.info/www/bejne/anmuaoR7rpZ-gJo - Coronavirus Epidemic Update 18: Cellphone Tracking, Increase in Hospitalizations, More Sleep Tips: kzbin.info/www/bejne/rHaXoXWhqNGkiZY - Coronavirus Epidemic Update 17: Spike in Confirmed Cases, Fighting Infections with Sleep (COVID-19): kzbin.info/www/bejne/rZ3FfmmMi9CJkK8 - Coronavirus Epidemic Update 16: Strengthening Your Immune Response to Viral Infections (COVID-19): kzbin.info/www/bejne/p6K9inidh6qokJo - Coronavirus Epidemic Update 15: Underreporting, Prevention, 24 Day Incubation? (COVID19): kzbin.info/www/bejne/pWmTZaqras2So9U - Coronavirus Epidemic Update 14: Hospital spread of infection, WHO allowed in China, N-95 masks: kzbin.info/www/bejne/pnXRnnurbd1seZY - Coronavirus Epidemic Update 13: Li Wenliang, nCoV vs Influenza, Dip in Daily Cases, Spread to Canada: kzbin.info/www/bejne/ZobKo4Odf8mtppI - Coronavirus Epidemic Update 12: Unsupported Theories, Pneumonia, ACE2 & nCoV: kzbin.info/www/bejne/fYWWkHRnl8tsprc - Coronavirus Epidemic Update 11: Antiviral Drugs, Treatment Trials for nCoV (Remdesivir, Chloroquine): kzbin.info/www/bejne/ppeqoZd8g62ip7M - Coronavirus Epidemic Update 10: New Studies, Transmission, Spread from Wuhan, Prevention (2019-nCoV): kzbin.info/www/bejne/nYHal5yHnKymfNE - Coronavirus Epidemic Update 9: Fecal-Oral Transmission, Recovery vs Death Rate: kzbin.info/www/bejne/bnnNqmaLm8aHicU - Coronavirus Outbreak Update 8: Travel Ban, Spread Outside of China, Quarantine, & MRSA: kzbin.info/www/bejne/faHFhqKCq9WXedE - Coronavirus Epidemic Update 7: Global Health Emergency Declared, Viral Shedding: kzbin.info/www/bejne/pIiWqaSZfM6XprM - Coronavirus Outbreak Update 6: Asymptomatic Transmission & Incubation Period: kzbin.info/www/bejne/i3jbmIGbl91kpsk - Coronavirus Update 5: Mortality Rate vs SARS / Influenza: kzbin.info/www/bejne/g3-cXoiOqNuDeLs - How Coronavirus Kills: Acute Respiratory Distress Syndrome (ARDS) & Treatment: kzbin.info/www/bejne/pZzKaKinlK2lnrM - Coronavirus Update 3: Spread, Quarantine, Projections, & Vaccine: kzbin.info/www/bejne/iXuliqqLqadradE - Coronavirus Symptoms, Diagnosis, Treatment: kzbin.info/www/bejne/i3SqZKunqch_acU - Coronavirus Outbreak - Transmission & Updates: kzbin.info/www/bejne/b6ewiYahgLGaaKs

[@ketinporta4994]

MedCram - Medical Lectures Explained CLEARLY are those deaths inevitable death by themselves or because the overwhelming number of cases prevents quality and immediate care before cases get worse?

[@ChristiansPrayingTogether]

People have been reporting cancers cured and/ or put into remission by using a dog de-wormer medication . When explained as to why this has worked , it is much like the explaination given here . There are too many people claiming this dog de-wormer saved their life - It seems there is something here - some kind of connection that can't be ignored . Thank you 😊 You are the angel of medicine and sooooo grateful for your vids .

[@zeeshawn15]

So if I have Beta Thallasaemia Major? Does that mean this virus doesn't attack me? Because I lack the Beta Hemoglobin chain... lol just curious? I mean wasn't thallasaemia kinda mutated into people's trait due to malaria anyways?

[@FireFilmsMedia]

Thank you so much for your public service! Been watching you guys for a couple weeks now and this is the most informative channel on KZbin right now

[@earlhickey1557]

please use any estimation rather than the chinese reported numbers for reports.

[@flagship1701e]

Let's be clear. this guy Seheult is giving rare and much-needed information EVERY DAY, alongside his regular medical shifts and his MedCram business. He's the ONLY person I have seen that is proposing research-based, time-proven, proactive therapies that have been largely left behind by western medicine to give some modicum of control and hope in a largely out-of-control situation. He gives powerful and valuable starting points for us all to carry forward and do follow-up study on. It's up to us and our unique situation's to decide where and when these can help us. 20 years ago, 25 trips to the library and hours of paid consultation with an average physician MIGHT have exposed some of the useful ideas that this guy posts here for free every day. Some of the petty "but you missed this" is pretty audacious. Thanks again Doc!!!!

[@glenniejunkin1816]

He IS excellent. Dr. John Campbell from the UK is wonderful too.

[@lewgoogle5530]

I agree with commending Dr. Seheult. He is a calm, logical source of good information. The best guy on KZbin, in my opinion. However, I do not agree when you say that he is the "ONLY person...that is proposing research-based, time-proven, proactive therapies that have largely been left behind by western medicine..." First of all, the papers that Dr. Seheult calls to attention are the epitome of western medicine. Western medicine preaches basic science followed by placebo-controlled double-blind studies to establish the efficacy of either newly developed drugs or new uses for already licensed drugs. It is not for "us" to decide "where and when these can help us". If is for us to wait for proper controlled clinical trials and then use the drugs indicated. I say this as an MD, an infectious disease doc, and a molecular virologist with 45 years of experience studying viruses. One would be ill-advised to self-medicate or to think that the paper on Ivermectin justifies its clinical use against COVID19, at this point in time.

[@drtoup]

@@lewgoogle5530 Western medicine should be able to ferret out the bias and prevent the tendency to assume that medical therapies are effective based upon anecdotal evidence. I have been discouraging unnecessary prescribing of hydroxychloroquine to panicked patients. This is clearly a complex problem and Dr. Seheult is helping clinical providers with this much needed information!

[@sdraper2011]

Well said.

[@spacejunky4380]

@@drtoup so are discouraging your patients. And if so isn't this a hipa volation. And if not then why are you even telling people what they should/not do?

[@Warrior-In-the-Garden]

Dr. Seheult: " of course we have to go back to Cellular Biology" Me: "YES!!!!!" So grateful for your hard work and love the way you map it out for us. Wish we had MedCram when I took A&P. Thanks again!

[@luln5122]

hi kelly, just above you....i ask about if drinking too much water would help increase oxygen...do you have anything to say about it

[@tlockerk]

Amen to the bad old days of A&P.

[@Priceless085]

Lul N It’s best to drink plenty of water as it helps to stabilize your body’s lymphatic state and also your blood will get clean from toxins by the filters that water gives, it should help open your lungs oxygen, it’s best to hydrate no matter what, as it aids in replenishment and balances the fluids of our bodies, water is always best for our body no matter what, and as for the oxygen being produced by the water we give ourselves, I would agree and say yes drinking water will provide more oxygen to the lungs and throughout the bloodstream wiping out the toxins we don’t need that day, through the urine and sweating! Be safe and if anyone else that knows about waters benefits, please comment and feel free to correct what needs to be! Thanks!

[@kevindonovan6727]

Does the keto diet have any place in any covid-19 discussion?

[@tuppatube]

What is your stand on ivermectin now, 8 months later?

[@gordontaylor7573]

Roger, you might like to look at Australia. In my state of Victoria pop 6.5 m . Our peak of daily new cases was 111 on the 28th of March, yesterday 21. We are extensively testing, possibly more than officially recommended. Nation wide social distancing with some state variations. Not quite as strict as the Kiwi’s, our build industry still open. Community transmission more prevalent in NSW than here and reason to be vigilant as the curve could swing. In my general practice clinic we are testing in a tent in the car park trying to keep all respiratory presentations separated. You daily updates have been a major source of information to help us plan for the incoming wave. Dr Gordon Taylor

[@sabrinarichey6484]

I believe you all need to take a look at poisoning such as 1080 to kill swine and harmful to humans especially with radiation from 5g towers. You all say conspiracy but science center an explain this plus the usage of 1080 in New York in federal housing district which started on Feb 7th. A slow painful death. Horrible. Check where your country has used 1080

[@ambrenna]

Thank you Dr Taylor for your hard work and dedication. It is because of people like you that Australians will be able to beat this thing!

[@ChristmasLore]

Read somewhere (mhm, KZbin comments level), that Australia has used placenta in some cases? Does that bare any truth?

[@williamsanne20]

Despite the cruise ship fiasco, even NSW numbers have been impressive. However, there is sustained community spread in Sydney so it is still early days. Hopefully, 10 days from now we will have some promising figures for successful containment. Easter and complacency induced by the burgeoning sense of security will be telling.

[@kassrripples3659]

Gordon Taylor Thank you Dr. my family all live in Melbourne and country Victoria. I’ve been watching the situation in Australia closely. I hope to return for a few week visit to see my parents in July ... hoping all this is calmed by then. Do you have connections with Dr Catherine Crofts in New Zealand?

[@myrddrral]

Evening. In our service, we _have_ seen patients with a normal PAO2 and a low (80%) SO2. Moreover, they were completely asymptomatic, with normal chest x-rays and minimal ground-glass images in chest CR scans. Such factors would be in line with the heme theory. There may also be a correlation with blood type susceptibility (which has been observed) if we consider Covid-19 has a hematological component. Seeing as hydroxicloroquine (despite not having it's mechanism truly known) is used to treat other red blood cell intracellular parasites, there may also be some connection to its effect on Covid-19 if one considers the possible hematological connection. I believe it is a path worth investigating.

[@BS73PKE]

What blood types are susceptible?

[@FearIsaLiar]

@@BS73PKE A

[@FearIsaLiar]

Absolutely

[@sabrinarichey6484]

Sickle cell anemia? Perhaps?

[@kassrripples3659]

I’ve been looking for information on how CoVid19 impacts those with essential thrombocytosis...

[@robotempire]

Dr. Seheult you are a public health hero. Your calm & steady delivery, free from unscientific conjecture and political speculation, makes you unique! I recommend your channel every time I talk to someone online who is struggling with anxiety about death rates, zinc ionophores, self-care (sleep hygiene etc.). You are really doing a tremendous public service. The fact you’re also working in the ICU is incredible. Please keep it up.

[@drsdarb7932]

It would help a ton if we all had access to rapid COVID 19 testing so we on the front lines could start preventative treatment early. Waiting a week to know if patients are positive may be too late to keep them from developing severe illness.

[@rashasarandah1695]

drsdarb drsdarb will hospitals take the patient in to treat in the interim without presenting with severe illness in the emergency room?

[@EW-uw7dg]

@@rashasarandah1695 Exactly. I just read a comment about a person in cali whonis struggling to breathe and she called her doctor, he told her to go to the hospital but the hospital told her to go home. I have heard other similar stories from people being sent home and some died.

[@cicibradley2809]

It took 13 days for mine.

[@thebigfist]

Abbott labs has a very rapid test (5-15 minutes) that was approved this week.That should really increase testing, although you still need to go to a clinic, Municipal drive-through test center, Hospital or Physician's office(but with the $7,500 price tag, I know many solo-practitioners offices won't be able to afford to purchase the machine!)

[@Imahappygirl25]

25 years in veterinary medicine and I'm living to see the day that we treat everyone like dogs: cones to keep them from touching their face; crate training for quarantine, and deworming for COVID :D Ya gotta laugh sometimes!

[@sharonnadeau6893]

I just hope people don't take their dogs heart worm medicine

[@girlgeniusNYC]

Don't eat poop! Lol

[@Bit-while_going]

Q: do you know where this pandemic is going? A: Rrrrooof!

[@Imahappygirl25]

@@sharonnadeau6893 You'd hope not because that dose would be too low. The bigger concern is that they don't buy large animal ivermectin off of Amazon.

[@midnightdaemon6844]

You're hilarious! Love your humor! ❤️❤️❤️😄😄😄🤣🤣🤣

[@mozambique5521]

Thanks for taking a look at the molecular biology and findings of ivermectin. Thanks for your continued work in this area and in the ICU.

[@dancoffey3552]

Thank you for the Ivermectin comment. I would expect this is also something that should be tried if our animals/pets get sick with C2 as well

[@rebeccaprice4002]

I wonder if this is why dogs don't get it or at least not affected.

[@jwkelley]

All these interventions seem to be contingent on intervening early but everyone is normally waiting until it becomes life-threatening. People are also being told to not seek help until it becomes severe. Also all the places that have lower death rates seem to be the places that are proactively testing trying to find the virus vs waiting and letting it come to you.

[@litte_chiwi6547]

I am from New Zealand I’ve been following your updates since Day 1. First of all thank you for your videos, I love the clear and concise content suitable for all levels of audience. We are 2 weeks into a 4-week lockdown with only essential services operating. We still have clusters of community spread, but everyone is doing their best to keep the country safe, staying home and saving lives.

[@EricDavidRocks]

Yes, let's have an update since this is in the news.

[@g-style4466]

I don't know if anybody else realizes..... this gentleman is definitely the most intellectually describing of what is actually going on

[@karihostetler4429]

In discounting the hemoglobin binding model, you forget to consider that BOTH alveolar membrane inflammation AND dysfunctional hemoglobin could be occurring at the same time. I think this model explains the severe inflammation - from the free Iron released. It explains the elevated ferritin levels (trying to scavenge that iron), the diabetics who are higher risk than expected (due to already having dysfunctional hemoglobin and high ferritin and high free iron), the lag in symptom onset because the ferritin initially keeps up and the patient is gradually placed in functional anemia. In carbon monoxide poisoning, which also affects gas exchange at the cellular level, a study I read on pubmed by Dogan, et al, cites only a modest increase in lactate by the patients sick enough to need HBO, with the average lactate being 2.3. Before discounting that this could be part of the clinical picture, please investigate it further. I’m not saying it’s the Only piece of the puzzle, but it deserves a valid look. Why is the blood so dark if it is not affected? I’ve heard reports of greenish serum from the iron. Please reconsider. Thank you.

[@nedgermany]

Kari Hostetler smokers have high hemoglobin Lombardy Italy high altitude which causes high hemoglobin Young people have lower hemoglobin Diabetics have hemoglobin issues Vitamin d may be beneficial

[@gbormann71]

It would not explain the normal paO2 vs low SpO2 but might contribute to the low/low case causing a double whammy. It'd be interesting to find out in which patients the virus becomes haemotoxic.

[@jmwyatt33]

My favorite time of the day! Thank you so much for your fantastic and informational updates.

[@Medcram]

Thanks for your support

[@davejoubert3349]

Please ask heaithdata to fix the number UK ICU beds. This seriously damages their credibility. It would also add to our understanding if they showed their historic prediction figures.

[@chillyjdc]

These of course are interesting days. As a 99%-practicing-stay-at-home practitioner (gotta get outside solo occasionally to see the sun and practice my social distancing,) it is very reassuring being able to check out from work each day to see your videos and see what kind of breakthroughs our global bothers and sisters are making. Although I know that Nobel prizes can be controversial, I truly hope that your hard work on the front lines and on the KZbins of the world reward you with something special AT THAT LEVEL. Even if it means knowing that you've informed millions of people in a positive way. Keep doing the good work my friend!

[@sputnut]

You might want to clarify that you can't take your dog's heartworm meds... Some people drank the chloroquin for fish tanks and one died... People don't think sometimes.

[@michaelgonzales1365]

Sad that it’s gotten to that point.

[@lovemetender9979]

Those guys were Trump supporters.... you can't fix stupid.

[@Gummy_Pop.]

CE is a person who missed his hairdresser's appointment...and this is what happened to him.

[@earlhickey1557]

@@michaelgonzales1365 maybe he would have died anyway, so no reason to change anything, everything from this channel was clear.

[@dankuchar6821]

@@lovemetender9979 Don't make this political. That's childish. I'm sure you're better than that.

[@NomenNescio99]

Thank you so much for your videos and for not dumbing down the information you provide. I'm an engineer by profession and training, but in the recent months I have for obvious reasons taken great interest in medicine and I have learned so much from your channel.

[@kathrynrasmussen4763]

Thank you so much for helping further understanding of this virus, treatments, and boosting our immunity. You are an excellent educator.

[@moose9906]

So the question is how accurate are these models going to be given their assumption of people in isolation? They may accurately describe the current situation but once quarantines are lifted, the virus will come roaring back because there is no herd immunity, no vaccine and a high percentage of vulnerable individuals in close proximity. I am not sure what the long term plan is here.

[@BelgianGurista]

We'll not go back to a normal society as we once knew it. Social distancing is here untill "the" vaccine. It'll become the new normal.

[@pierrecurie]

China is running that experiment for us. If they get steamrolled by a 2nd wave, we'll know to be more cautious (assuming our leaders pay attention...)

[@Mybwain]

@@pierrecurie China's reporting is the most trustworthy.

[@CCSABCD]

Herd immunity may be establishing and we don't know, many people get infected and have very few or no symptoms at all, and do not get tested. The time of quarantine plus the time of "returning to normality" could be enough to get enough people infected and naturally immunized, so that new severe cases are not as massive and abrupt, and therefore not enough to collapse the healthcare system. Remember that the "new cases" are only the ones tested, the real cases are estimated to at least double that number.

[@DKucner]

Historically most outbreaks took as long as about 2 years, including Spanish Flu and H1N1. They eventually began to wane and disappear or become endemic like ebola. Covid19 is more contagious than any of those which is a factor that should speed up herd immunity; if this theory is true it should improve much faster than 2 years.

[@sugar_nutss]

I am an engineer and I find your videos easy to follow. This really helps me in gaining the insights which otherwise were beyond my ability to learn. Thank you!

[@weekendwarrior8179]

I'm an RT and I'll like to see some of treatments that have been used, such as ventilator vs Bipap vs high flow (vapotherm)

[@IainMcClatchie]

If SARS-CoV-2 is dissociating iron from hemoglobin, a given volume of blood leaving the lungs at near-100% PaO2 in the plasma would carry less oxygen than in a healthy patient. So on leaving the lungs, PaO2 should be the same but SpO2 should be lower. The fingertip monitor sees the blood after tissues have pulled some oxygen from it, decreasing PaO2 even further, and driving SpO2 down with it. One thing that might confirm the iron dissociation hypothesis is if patients show a shift in the hemoglobin saturation curve between SpO2 and PaO2. If the iron is dissociated I would expect the blood to act as if it is carrying less iron and for the relationship between the two saturations to become more linear. Presumably this could be tested in a lab by repeatedly measuring PaO2 and SpO2 while either increasing or decreasing the total amount of oxygen in the sample blood.

[@balrogrex]

i think, Dr. Seheult says PaO2 is low and that is why he did not buy this idea.

[@Hoenhoff]

I'm struggling to understand how viral proteins would even encounter Hgb. The RBC has no nucleus, so all viral proteins would have to come from virion-delivered proteins without further synthesis, assuming they could infect the RBC at all. Otherwise it's all Hgb being broken down in macrophages or hepatocytes. I'd buy macrophages, but I don't know if their Hgb load would be sufficient to manifest pathology.

[@ppppugh7892]

Zn+2 and Fe+2 battle for absorption within a cell with nucleus (RBC have no nucleus). I wonder if the patients with low SpO2 and PaO2 have been given high Zn doses as a treatment.

[@IainMcClatchie]

@@Hoenhoff Shoot, that's a really good point. Wish I'd thought of that.

[@ironmike303]

Thank you so much for making these updates! As am EM physician I use the information you provide to educate my college and adapt my practice. Best resource on KZbin!

[@werner-de-jong]

Great explanation. I am not medically schooled but understand you clearly. :)

[@GertDHoll]

Medicines company MSD spokesperson Jurgen Theissen tempered the expectations of the drug Ivermectin to fight the pandemic: “Our expert team of scientists assessing external studies of MSD drugs has calculated Australian research results and has concluded that for the same effect in humans, the dose should be at least a hundred times the dose that is currently approved and that we know is safe and well tolerated. "

[@cmgardner2003]

Thank you! Ivermectin is a neurotoxin at high doses. Unfortunately people will start taking their horses dewormer thinking it will "stave off the covid"

[@ojsojs6004]

@@cmgardner2003 Actually there is this recent test result to 1408 people using ivermectin and the result is impressive papers.ssrn.com/sol3/papers.cfm?abstract_id=3580524

[@timothyaustin5101]

Anesthesiologists in my hospital have suggested that the picture is less ARDS because the ventilated patients are not requiring high pressure support suggesting the lungs are still compliant. There has been suggestion that the pathophysiology appears more vascular with multiple tiny PEs and a shunting issue. This being in keeping with diabetes and ischaemic heart disease being particularly prognostic risk factors.

[@JanicePhillips]

How strange. I use ivermectin all the time. I'm a horse owner. It's one of the best all around anthelminthics available over the counter.

[@lolasdogrescue]

@Rocky Fjord feed stores. I just went and got my dog's refill. Use it for heartworms. I'm stocking up just in case.

[@JanicePhillips]

Why "stock up"? And good god no, I don't take my horse's dewormer!

[@JamesThomas-pj2lx]

dogs too.

[@JamesThomas-pj2lx]

@Rocky Fjord tsc

[@paulafreeman-vida365]

No people wait for science dont wreck your body . Dont be a doctor on yourself

[@meme-yc4ks]

*And this is why ferritin levels in blood are elevated in these patients were seeing...*

[@Kayne1b]

Could it also be why women might seem to be less severely affected? Much more common (during reproductive ages anyway) to have low iron/ferritin/iron saturation, also (maybe) faster blood cell production rate. edit: Seheult doesn't seem to think heme destruction is involved (fair enough). I could add though that high ferritin is typical in cases involving inflammation so ferritin specifically could just be associated with that.

[@mattmoo1007]

Thanks Dr. Seheult. Fantastic explanations, as usual.

[@melindabendle6459]

I Thank All The Wonderful Doctores, HOSPITAL are COMPLETELY AWARE OF ALL OF THIS..🎀🇺🇸 THE HOSPITAL IN SANTA BARBARA CALIFORNIA IS THE REASON I AM STILL ALIVE 9 YEAR'S AGO BRAIN SURGERY ALSO MY STOMACH..BLESS YOU FOREVER..🇺🇸🏩🇺🇸🙏😇❤

[@Mum2cuties]

Yes, go New Zealand, stamp-it-out and keep-it-out. We are all working as one, if you can’t work from home you get a financial package. Hopefully we will be back working and quarantining as a whole country.

[@kerisutt7579]

New Zealand is probably only doing so well because they are coming out of a long summer so everyone's immune systems are good, unlike the northern hemisphere who have been hit by Covid-19 mid-winter. New Zealand may be testing more than Australia, Argentina and South Africa but in terms of deaths per population they are are all relatively low because these countries have all just come out of summer.

[@Mum2cuties]

Keri Sutt don’t think so, we have the advantage of being at the end of the world so the virus didn’t reached us with the force of other countries with greater global people movement. We can track most of our cases to overseas introduction, only 2% community spread, so we caught it early and started lockdown before it got out of hand.

[@cedarpope]

@@kerisutt7579 No, read more about NZ, they really were pro-active and jumped on this immediately. And there is new evidence that heat may not reduce this virus much if at all....

[@georgebono7477]

So has anyone looked at the correlation between patients already taking Ivermectin or Coloquine, as a therapeutic for exiting condition (i.e. parasites or malaria), and if they have or have NOT acquired COVID-19?? I.e. do we see a possible prophylactic action/response in populations already taking these drugs??

[@GREENPOWERSCIENCE]

Cattle/livestock farmers are usually exposed to some degree in the south rural areas from handling dosages for horses cows, etc….. and a lot self does randomly to avoid parasites as "just in case thing" to do… I am curious about Veterinarians and COVID-19 cases.. I know of one death reported but wondering because I personally know a few who randomly self medicate ivermectin when they suspect parasite infections….(told me it was common to reassure okay for older pets) Also curious if the rabies vaccine they get out of med school has any effect but many do not keep up with their titers so?

[@blowitoutyourcunt7675]

Anecdotally speaking I've been on ivermectin for the last 18 months for re-occuring scabies (I'm a child care worker) and despite 3 close family members falling ill w covid, I've had nothing more than seasonal allergies. So maybe?

[@diplomat2623]

🤔🤔🤔 That’s probably why Africa is not so bad...

[@blowitoutyourcunt7675]

@@diplomat2623 The spread there will be slower because transport isn't at the level of first world countries and it's much bigger but I think we eventually see spread there as well and it will be bad because they lack medical structure severely.

[@nomore5403]

Africa

[@WeddingDJBusiness]

The country( New Zealand) is pretty much in total lockdown with only essential workers / medical/supermarkets/petrol stations, telecommunications, power, security/police and those that maintain/supply those essential services working. They also recently issued no trips to beaches/out of town etc via car or going to your holiday home for Easter. No international travellers incoming or outgoing and limited domestic air travel. The last two days are beginning to see a reduction in reported cases after two weeks of the intended 4 weeks of these lockdown procedures. It's early days so far so hard to predict how this will pan out but hoping for a total eradication in possibly 2 months.

[@whistleblowerer6527]

We have 990 icu beds in Sweden at the moment and we are continuing to set up more if needed

[@jeremywallace4545]

Do you have any updates on Ivermectin, and it's a effectiveness?

[@lloydreid3936]

Dr. Seheult, you provide such an invaluable service to those of us who know from your KZbin videos on COVID! Thank you! You're also one of the heroes in the COVID pandemic saving lives in the ER! Again, thank you! Watching your videos now for over 6 weeks has led me to watch your other video series, Insomnia, for example, since the anxiety over COVID has interrupted my normal sleep pattern. In perusing other offerings from MedCram, I will be exploring other topics germane to overall health to guide my own personal wellness in the future. I had one year of basic biology, genetics, microbiology, and chemistry in college before realizing I didn't have the aptitude to succeed in the medical field. I had a successful career in business. I mention that because, even though your videos are sometimes highly technical, even with the very limited knowledge of a layman, I'm able to follow and understand them because of your detailed, patient, knowledgeable, orderly, and thorough explanations. I've come to realize what an amazing organism the human body is and the world of doctors and scientists is truly amazing! You rock!!!

[@eddyandthebadcheese2247]

Why is everyone ignoring Taiwan!!?? Taiwan is right off the coast where the outbreak started. Taiwan also had the most flights in and out of the region. Taiwan is also a DEMOCRACY. And how many people have died in Taiwan from Covid-19 ? Five people , maybe Six ?????? Let that sink in for a minute. 25 million people and only 5 deaths so far. Thats equivalent to about 85 deaths for the US population. Once again, Why is everyone ignoring Taiwan?????

[@PinkAmadeus]

Many are not ignoring Formosa, but of course, the WHO and CCP want us to.

[@urishima]

Punctuation marks are solitary creatures that will experience great anxiety when grouped together closely.

[@ecpgieicg]

Calm your horses. No one is ignoring Taiwan. Taiwan got an exclusive segment on PBS for example. But by itself, to be blunt, Taiwan is a tiny island that does not compel much attention to begin with.

[@Lateralmove]

I suggest swapping one controversial topic for another. Does Israel exist? Discuss...

[@Lateralmove]

Palestine exists only if you squint and pretend to care.

[@DrBiohack]

Thanks as always, I am a public Health specialist so I really appreciate having your clinical dimension to support my broader understanding of all the dimensions of this pandemic.

[@carlreller]

speaking from NZ the Prime Minister is expected to announce mandatory 14 day supervised quarantine for all new arrivals.

[@carlreller]

@Patrick Meredith only NZ'ers allowed back. Case-by-case exemptions for humanitarian reasons. Initial returns were >10,000/day which was too hard to manage, now down to

[@rosestewart1606]

in Canada, the provinces are demanding this. like every other measure, the federal government is refusing. Travellers still account for over 60 percent of all cases in Canada. In some provinces, travellers and their close contacts are still 100 percent of all cases.

[@fation.]

They should all be tested too.

[@dreamseeker8045]

Personal experience. Day 1 -I took covid19 probably by digestive contamination. I use FFP3 face mask, but no gloves. Day 3 - positive on RT-PCR Day 6 - light fever 37.6 C, some muscular pain, light headache . I took myself 1 mg/kg body weight ivermectin - 10 ml 1% solution (8 times therapeutical dose for parasites). I have 98.5 kg and 49 years old. Next 4 days no symptoms or adverse reaction. Day 10 - negative first test on RT-PCR. Day 11 - negative second test on RT-PCR.

[@KimFredtoft]

As Niclas writes. The IHME data for hospital beds and ICU beds for the Scandinavian countries are of by a factor of about 10. They estimate that we have about 92 ICU bed available in Denmark. Our current estimate actually sits around 1000 ventilator equipped ICU bed. No idea qhy they got it so wrong, but it seems to be the same for Sweden and Norway.

[@oddgeiraasebo3466]

For Norway the number of icu beds is off by a factor of 5-10 depending on the exact definition of an icu bed. We should have at least close to 500, though some of these will be needed for non-covid patients.

[@demi3115]

It's the same for the Netherlands, it was 900 IC beds, but now there's 2400 available - so I guess they just didn't update the data

[@michaelcharlton8896]

It's the same for the UK. The number of ICU beds they have for the UK is way too few, even for before the pandemic started. It's like they got their data from 1952 or something. They say they will update the information, but you would think that they would be as up to date as possible before publishing a country's page, and actually bothering to get the correct information before they do. Several news outlets have seen the page and are putting out stories of doom and gloom on the back of it, even though it is incorrect when it comes to basic facts, and the data that are given as projections for days past are way off to what the actual data was. Very poor scholarship from an establishment that should know better.

[@KimFredtoft]

I just wrote them an e-mail. We'll se what happens. I can understand why they could be wrong by maybe 50%, but this seems really strange. Maybe they don't understand the metric system :-)

[@Medcram]

I think they are looking at beds available for the pandemic on top of what they are taking care of already. Could be wrong but see.

[@SagittariusArcherVaperkitten]

❤️ Thank you so much for the information you give us, I am no medical professional but you give me hope and confidence in the medical community....you are a Godsend....Love to all...Kim ❤️

[@darkquaesar2460]

i still that it's accelerating, a week ago new york said that their hospitals were nearing capacity. It would make sense that hospitalizations were slowing if they stopped taking in patients, mean while the NYPD are reporting an increase in officer infections, the hospital ships that were supposed to be used for none covid-19 patients are now starting to be used for covid-19 patients, the death rate for NYC and New Jersey are both increasing by about 50 - 60 deaths a day, and emergency workers are still reporting an increase in illness. The CDC chair said that 90% of americans are abiding by the social distancing rules and I can tell you that just isn't the case because they're still closing places that people congregate too in large groups. just the other day fish markets in DC were forcefully closed because people were not following the social distancing guidelines along with a multitude of other areas. I feel like the government is either leaving out crucial data to re assure trump, or to keep people from panicking, it's so wide spread now that meat packing plants and slaughter houses are closing because their workers are getting sick.

[@doroparker1702]

Dear dark qasar, there is a report about a 30year old Ben in the US. His wife called the ambulance for him and they put him on a respirator for some hours. Then they gave him some paracetamol against his high fever and sent him home. He went to bed and next morning his wife found him dead. This is no surprise. When a hospital sends somebody home with a seriously damaged lung and fever due to covid 19, they can as well not treat him at all. All over the world they would have kept Ben in hospital. Everybody knows you need minimum 5 days on the respirator. Plus some testing etc. As long as there is fever the patient is fighting against the virus. In USA there is no treatment if you got no bundle of cash, isn't it?

[@isomur]

When people don`t get help in hospitals and they just die in their homes. The government starts to cover up things.

[@darkquaesar2460]

This looks more like they're trying to keep people from panicking and causing mass chaos while they prepare to handle that kind of catastrophe. It would also explain why the federal government is trying to hoard it's own supplies all of a sudden.

[@sallym6482]

Good points! I also think it's a total mistake for people to continue to order take-out food. Consider the infected cruise ships....people were isolated in their cabins while workers brought food to their door and it was later found out that the transmission of the virus was probably from those working in the kitchens. This virus can hide in asymptomatic carriers for a long time. 'Front-line and essential workers' might be able to prepare food for people, but they are also the super-spreaders. Pick up the take-out food all packaged up nicely and BAM!...you just succeeded in bringing the virus into your home. The virus is definitely a trickster....time to think on our feet and revamp our daily lives. Simply be self-reliant for awhile---your own cook, cleaner, etc, etc. Also a total mistake for school systems to continue to feed children packaged meals...eek! If the virus isn't on the food, it might be on the packaging or residing in the person the parent is standing next to in the food line. I don't know why people keep trying to continue their habits when those same habits are the perfect breeding ground for the virus. You mentioned police officers getting it----I'm now hearing about mass transit workers(bus drivers, etc.) also getting it more than law enforcement. I see the buses in my area (Denver, Colorado) continuing to drive around and I think, "whaaaaat???' Apparently, we are not yet smart enough to outwit the virus....lastly----from cruise ship data, the virus can live for up to 17 days on surfaces. Holy crap!

[@wegder]

I celebrate smart people! They are the only ones that can lead us out of this mess!

[@mr1enrollment]

I have a question, but first a preamble: In the absence of a Federal Government with a clue - we the people need to 'engineer' a method to bring our country back to economic function. First observation: is that people with the antibodies need to be recognized so that they can go back to work and support the economy, provide relief, and contribute to the herd immunity. THEREFORE the entire country needs to have massive testing, and in a similar way to what the German government is doing we need certificates that confirm our immunity via the antibody test. Second: A plan to allow those persons at little risk to return to normal activities needs to be generated. These people may NOT be immune but perhaps at LOW risk. This population will be the younger among us - perhaps those less than 40years old. Certainly there needs to be more than a simple age below which return to work is sensible. Perhaps the absence of co-morbidity, living arrangements that do not risk older populations, etc. Third: A national plan to use blood plasma from the recovered patients to support the lives of those at risk people that come down with the disease. Fourth: My question - which may be too extreme - Would a therapy that includes two steps be possible? A: first develop a method of purposefully infecting a low risk population with a low virus load followed by B: using blood serum with antibodies 3-4 days later to suppress the infection, thus bringing the person to immunity and making them ready for the work force. Personally I am not a medical professional, I am an engineer, I ask questions with the intent of getting people thinking about creative solutions. WE need to do it since the Federal government is incompetent and incapable.

[@terrywaters6186]

If I'm not mistaken Israel's strategy from the beginning was to lock-down and protect their at-risk population and let the rest have at it, get sick and get over it. I'm guessing we aren't capable of doing this in the U.S. is because we can't even track people well enough to control immigration. It's looking like we may have an effective drug therapy now so lifting restrictions can begin soon as long as we keep hospitalizations at a manageable level.

[@banmadabon]

Hi from Italy. I want you to give a look at a peculiar fact that's happening in the province of Ferrara (North Italy Emilia Romagna region, one of the three more hit region in Italy) Doctors observed that in that particular province there are almost no infections. The doctors believe that the people there, having been historically exposed to malaria and thalassemia, have developed a sort of enhanced resistance from contagion. I've listened on this channel about how this virus hits on blood red cells and how maybe antimalaric drugs could help. Maybe there's a link. Not a doctor so I stop here suspecting having already told enough silly things. Big props for your info. You explain things so well that I have a delusion of having nailed a important thing...Maybe is encephalitis affecting my brain...God bless America and especially docs. Hold fast!

[@bridgetfhelm]

Not silly at all. These same observations regarding malaria and are being made in other parts of the world as well.

[@terrydoyle1141]

Great board work, Doc! Makes even technical issues of cellular biology understandable to laypersons. Plus enough clear advice to make any one of these videos well worth watching. Look forward to more!

[@strawberrylemonade7225]

How does pre-existing anemia affect outcomes of Covid 19? I have not ever seen it listed as an underlying condition, but it seems like it would be

[@rashasarandah1695]

H D I’m curious about this too...

[@brunosodre3258]

Italy a lot of cases... peoole with vitamine d low... have corona

[@rfq84]

I'd also like to know

[@jennd7891]

I am anemic along with my recently tested 18yr old daughter. I’ve been keeping up on the MedCram updates trying to figure out our risk. I’d love more explanation on this also.

[@nedgermany]

H D maybe it would actually be beficial

[@jamesriepe7939]

The media wants you to believe that there is no cure or no help. But these scientists and doctors amaze me everyday!!!

[@GetMeThere1]

I think expected "isolation" until June is completely realistic (however wise I might personally think it would be). Here in Bergen County NJ (highest infected county in NJ) I'm already beginning to see a bit more traffic on the roads vs a few days ago.

[@jsweezey6487]

QUESTION: If viruses are sensitive to Ph levels then why not try to use baking soda to alkalize the body of patients to as far as possible (without killing the patient)?

[@antoniourata7195]

If you propose such treatment,know your physiology first.

[@kimberleeadams7731]

I found the following online to answer your question but first I wanted to say there’s been a movement toward self-care, especially among those who distrust the medical practitioners or where healthcare is difficult to obtain. Do we know what seemingly innocuous self-administered treatments patients are using? Effects of baking soda on oxegen and carbon dioxide: The supplemental bicarbonate will push the acid/base buffer equation towards increased CO2 production; however, if the patient’s ventilation is inadequate, the equation will move back towards more H+ production, worsening the acidosis. With a respiratory acidosis, the kidneys try to compensate by increasing H+ secretion, raising the HCO3- concentration, assuming the patient has adequate kidney function. In acute respiratory acidosis, the serum HCO3- increases 1 mEq/L for every 10 mmHg elevation in PaCO2. If PaCO2 remains elevated for three to five days despite compensatory mechanisms, it is considered chronic respiratory acidosis. In this state, the serum HCO3- increases from 3.5 to 5 mEq/L for every 10 mmHg elevation in PaCO2.

[@antoniourata7195]

@@kimberleeadams7731 yes.but basing on your first premise,it will not work. Acid-base balance in renal physiology and management is more difficult than you think.

[@petermontgomery5621]

Recent articles discuss hydroxychloroquine not helping, but they also state they used it as a "hail mary" on very sick patients. I fell this is like stating brakes do not prevent accidents, when they only used them 10 feet before hitting a wall. Are there any studies showing if early use of Hydroxycholorquine with or without azithromycin is helpful if started early on in the infection?

[@rosam.1488]

There was an article of South Korea about giving it to mild patientes and it worked.

[@novodiver]

It would be interesting to know if these patients were also given zinc supplement along with hydroxychloroquine. If the level of zinc in their systems was very low, the hydroxychloroquine wouldn't have any effect.

[@chicagomike]

One of the best teachers in the world. Wow. Terrific writing too!

[@brookandroad]

And you addressed this weeks ago! Is it still protocol to ventilate with traditional oxygen amounts instead of using paralytics to reduce pressure and allow time for lungs to heal?

[@elizabetho395]

Or maybe they need to go to HVOF? Like in NICU? I HAVE seen babies paralyzed when needed for this same reason

[@michaeldruce4536]

Thanks Dr. Seheult. Look forward to your vlogs each day. Clear, precise and summarised as to what is going on. Thank you 🙏 I appreciate you. 🙏🙏🙏

[@mattoney4711]

I bought some Ivermectin a few months back to treat a case of scabies. Ran me like 12 bucks. Just checked Amazon and it's 65 bucks. Crazy.

[@simonepryor382]

@Nuby29 join the group ivermectin MD team on Facebook

[@SAMTELLIS4]

Thank you so much for talking about Ivermectin! Ever since I saw the first article about it, I've been waiting on more information about it.

[@heather173]

So glad you talked about Ivermectin, I use it constantly in my farm and (house) animals, it has a good safety margin in people in parasite control (helped eradicate the Guinea worm!) I'd take it. I'd probably dose me at a pig and one sheep dose. ;) But seriously, this is exciting if it works in Vivo.

[@mirandabri834]

How much is that exactly?

[@katylox2838]

@@mirandabri834 usually it is written on the bottle, to calculate per pound of body weight

[@cotepm]

Merci beaucoup from Montréal. I know that many of my fellow Canadians like your updates and really appreciate all the technical review. I want to salut my kiwi friends from the other side of the Commonwealth!

[@ThereItIs.]

Can you look at high dose vitamin c 1500mg iv tid-qid and how it might relate to the fe++ fe+++ released from hemoglobin by covid

[@antoniourata7195]

That will not work.

[@ypcomchic]

Ok last week I developed GI issues and went to the doctor. They refused to test me for covid19 because I didn’t have any respiratory symptoms. In the past few weeks my head would hurt but it was on the outside like my spinal fluid was sick had pain down my spine too. Was telling my mom it’s not a headache but feels like I have encephalitis - a pressure around my head. As if today I have developed a small mucous cough but I keep taking deep breaths which hurts and hot showers help me to clear it up a little. I wear a mask and gloves and have to mandatorily work. Only two people in office that have gotten sick- one who was working temp in another city and one at my actual office but I haven’t seen her in few weeks. Unfortunately we have to work close together for couple hours each day but we all are wearing masks and gloves. So far no one has gotten sick 🙏. we are all terrified but keep working because we have to.

[@davoforrest5]

Listen to “This Week in Virology” podcast for a helpful discussion of Ivermectin . Gives much more detailed discussion

[@MA-zg2pz]

David Forrest so helpful thanks!

[@Jenisagarc]

Thank you.

[@ChristmasLore]

@Spooky_Mega_Gengar The Belmont , hydroxychloroquine. Forget it.

[@simonxag]

They point out that the dosage equivalent of the in vitro study would be 20,000 (twenty thousand) times the current approved human dose. They also mention that it's a bad idea to take veterinary medicines.

[@cmgardner2003]

@@simonxag exactly! Ivermectin is a neurotoxin- easily crosses the blood brain barrier. I am waiting to hear news stories of people dying from takomg their horses dewormer

[@danstuder4914]

Gov to do list 1. Push treatments trials quickly -> Antibody (CRL) Distributed Bio 2. Upscale antibody testing -> home test kids 3. Upscale 15min testing 4. Categorize people at risk and establish isolation plans and regulations HB Pressure, Obesity, Asthma, Smokers, C-Therapy, metabolic disorder What if they have kids? -> Remote School -> isolate. 5. Roadmap for business for employee work remotely. Shift jobs to remote work. 6. Ramp up PPE production. 7. International exchange of knowledge regarding ventilator usage. 8. Upscale ventilator production -> Better prevent usage of it. Antibody treatment 9. Bring cases down to zero -> Contact tracing (all cells OS app CV19 pushed down) 10. open economy

[@trizthe1]

Sweden is not isolating at all. Even if we have such a low number of ICU beds. It is completely inzane! Also we have a shortage of protection gear for the hospital-staff and also respirators. So deaths will probably be much higher here than predicted on that website unfortunately. /Swede

[@bugbumble3]

Really appreciate your work...have been following you for almost 5 years now.

[@RGSRinc]

Doc, on your point about seeing inflammation and thickening of the alveolar wall (ARDS-like) that argues against the "Sars Cov2 attacks hemoglobin" argument, I thought I read something to the effect that the iron stripped out of the hemoglobin could be causing that inflammation. I'm not a doctor but could that be an explanation that allows for the hemoglobin attack position being proposed?

[@RGSRinc]

@Idylchatter Thank you!

[@tapatapaz]

@Elizabeth Vering Yessss, I'm still waiting for an indication on that.. My frying pan is waiting

[@defacto_8840]

In my humble logic, SARS-CoV-2 being the simplest, it needs a cell machinery to replicate, so it acts directly on the cells mRNA, DNA 🧬 genetic code. It doesn’t add in my mind that it would displace iron out of Heme, as a direct target mechanism. I just feel I am missing something ... :(

[@fireteamomega2343]

@@defacto_8840 I would agree with that statement. It more likely has to do with pulmonary surfactant proteins. Which there are articles on with regards to SARS infection... Specifically pulmonary surfactant protein d which affinitively binds to SARS as an immune response. It's primary function however is to keep surface tension in the alveoli to perpetuate alveolar gas exchange. Less protein means less surface tension means less oxygenated blood. As a result the hemoglobin tends to aggregate and binds more iron likely causing the results you are seeing.

[@adameshag9365]

Iam asudanese doctor in Ksa ,iam indeed very grateful for the effort you are putting to educate us , I sincerely hope your country will soon over come this dreadful pandemic

[@kennaortega3708]

Re: Cytokine storm... What if they were to stabilize the mast cell prophylactically? Then moving forward to actual infection then sort of treat for anaphylaxis along with the other treatments?

[@sdraper2011]

How would stabilizing the mast cell prophylactically be done?

[@Imahappygirl25]

This is interesting. In dogs they give Benadryl and pepcid to prevent the mast cell response but it's difficult to treat once they're activated.

[@kennaortega3708]

@@sdraper2011 Doxypin, or Cromyl Sodium maybe.

[@theferaltaint5065]

kenna ortega THIS^

[@meganplacidi4919]

I wonder if the people that are having cytokine storms due to Covid-19 have mastocytosis or mast cell activation syndrome.

[@kenferrier7751]

Do you have any updated information on the use/efficacy of Ivermectin for treating Covid-19? Thanks! I appreciate all your videos and the insights they contain.

[@ekso6368]

I'm also waiting on an updated video on Ivermectin before the end of this year 2020 into 2021. Meanwhile, IVERMECTIN up in this recent December- month video with testimony from Doctors: kzbin.info/www/bejne/bn-blGmmmaZ-Zpo

[@zillurrahman2927]

Any conclusion about Hydroxychloroquine, Azithromycin & zinc therapy?

[@earlhickey1557]

like before? it works so far, and also take as early as possible.

[@stuartdryer1352]

@@earlhickey1557 Actually there is one small randomized clinical trial (30 patients) showing no significant effect on viral load or patient outcomes. Need bigger studies. (It was not tested with zinc)

[@my2cents2u]

Hydroxychloroquine is an immunosuppressant. If it is used on a patient with a compromised immune system, it could have dire consequences. Basically, it might help you, it might kill you. More testing is needed.

[@patriciahoke4722]

Yes, azithro now requires a PA!

[@garywetzel1094]

Edgar, has incurable TDS, take your blankie and 🍼😂🤣😂🤣✌

[@iruletheworldlucifer1606]

Respect and appreciations Doc ! You really are no less than angel doing researches and reading ones which can benefit human race. Keep in touch regards

[@maxwellsmart9097]

You forgot to mention Iceland, which also has a very low death rate.

[@lubricustheslippery5028]

Iceland have done a lot of testing. Faroes have done even more, The faroes had test facilities to test viruses in salmon they converted to test Covid-19

[@maxwellsmart9097]

@@lubricustheslippery5028 Higher testing does not translate into lower death rates, it helps with other measures to squash the curve which is a different desirable effect altogether.

[@moroccanman1382]

Thanks in Advance for all your effort and your update

[@gabrielb3349]

Love your channel! Have been watching daily for awesome covid-19 updates, thank you. I am a PA in Massachusetts and about to be redeployed to ICU to help with covid positive patients. Really enjoyed you ventilator review. My comment is regarding the potential beneficial effects of colchicine in decreasing the cytokine storm. It has a unique mechanism of action and theoretically makes some sense. Just wondering if you have heard anything about using it in ARDS pts?

[@gloriaredmon-booth6572]

Another day, another excellent update.

[@leilalaraibish798]

Can you do a video please about the two strains of Covid-19 the L and S type, which one is more prevalent, and is it true that the L type might be more aggressive ? and if you get and heal from one type will the antibodies protect you from both types or just the one ?

[@Chomper750]

Long ago debunked.

[@leilalaraibish798]

@@Chomper750 Where ? cause i am seeing it again and again in official pages or talked about by doctors

[@HAL-ol1lh]

@@Chomper750 "de-bunked" implies dubious source - of the Alex Jones variety - but my impression it was legit research.

[@mai-qy9ji]

I heard from a doctor that one type of antibodies protect from both

[@juliobro1]

How about updating about Ivermectin, how it's being used in many countries, including US, and with better effectiveness than Remdesivir (which has dangerous side effects).

[@earnestthompson5136]

Ivermectin !!! This med was around even when I was in med school 25 years ago. It was a test question I think because of its anti-parasitic mechanism of action. I never used it or even saw it prescribed but for some reason , ( maybe because I liked to travel in the tropics :) ),it was one of those test question answers you never forget.....and here it is today as a promising answer to our Covid-19 problem ! Thanks again for the excellent lecture.

[@Muuip]

Dr. Seheult and Team: Role model for pandemic information processing! Thank you, much appreciated!

[@thierry1312]

I ve been thinking about the benefit of finnish sauna you have mentioned before on the immune system. I am not medically skilled so maybe its just silly what i am about to say but what if the beneficial part of the sauna is mostly or partly just the inhalation of hot air into the lungs ? I ve understood that the coronavirus does not like high temperatures a lot. Could it be that when a person is infected in an early stage and doing finnish sauna daily the spread of the infection is slowed down, giving the immune system more time to do its thing.?And if this would be the case how about heating up the oxigen or air that is given to hospitalised covid19 patients or even intubated patients ? If 60 celsius is killing the virus outside the body why would it survive 60 celsius inside the body ? What if an intubated patients air supply for example is heated up to 60 celsius for like a few minutes every hour ? Sorry for my English. Sorry for wasting anyones time if this is just a silly idea from someone without any medical education.

[@torigodwin8321]

Your English is fine. Your thinking is fine. Keep up the good work on both!

[@doroparker1702]

Thierry, please watch this episode again with sauna. The thing is that your blood develops more of - I don't really remember. Either white blood cells or blood epithels, something like that. These blood cells help to fight against the virus. I think when you got the virus and sit in a 90degree Celsius sauna you will just collapse.

[@thierry1312]

@@doroparker1702 1. not necessarely in an early stage.2. I am not talking about putting sick people into a sauna but heating the air that is ventilated into their lungs to kind of kill of the new virusparticals that came out of previously killed cells. Or maybe some kind of Hot air Vapor Inhaler therapy might have the samen effect.

[@jsvendsen6256]

Thierry Wlazlak - in regards to the sauna, it is not only the heating up of the body, but then the rapid cooling down and heating up again. This triggers the innate immune system from what I can remember. Some have suggested looking into the wim hoff method.

[@thierry1312]

@@jsvendsen6256 What you say is assumed yes but i have not seen any hard evidence. But i have seen scientific studies stating clearly coronavirus and any other virus is destroyed by cooking it or even lower temperatures. A finnish sauna easely reaches temperatures above 80 celsius. Thus making you inhale air with temperature above 80 celsius as well. I wonder how the virus can survive this inside the lungs and not in the open

[@CA-td2mx]

What I can't wrap my head around as a US Army Registered Respiratory Therapist... why is Canada fairing soo much better on the uncomfortable worldometer numbers? I can only speculate that they are just better citizens that listen to their government. I hope Dr. Seheult can give insight as to why some non-equatorial countries are doing very well such as Canada where it also happens to be where Dr. Seheult was born, and maybe show what they are clearly doing right with countries that use saunas and hydrotherapy. Maybe it's Canada"s Maple syrup? Jokes aside, I hope to someday work fro you when I hanging up my Army uniform in 3 years as a RT/ECMO Specialist, to practice medicine on these front lines. You are my hero Dr. Seheult with an amazing educational gift.

[@babybalrog]

ref: Nordic Countries. While I was originally hopeful they would show low deaths/1 Million or /cases. I see that as unlikely since they have closed the saunas, and one would need to take the data in windows to see how individual policies affecting things. But since, you may not know you are infected for 5+ days, and it's basically free. Contrast showers have become my new thing.

[@bflippsytrance]

Dr. Anthony Cardillo has been prescribing the malaria drug hydroxychloroquine, in combination with zinc, to patients who are experiencing severe symptoms of COVID-19. "Every patient I've prescribed it to has been very, very ill, and within eight to 12 hours they were basically symptom-free," Cardillo told ABC7 in Los Angeles. "So clinically, I am seeing a resolution." I actually heard about this combination on your channel first, keep up the very informative work! Thank you!

[@thanemorgan3518]

Hasn't this model kind of missed in every prediction so far, and it only looks sort of accurate now because they readjusted it ever few days?

[@golfinguy423]

Not the same model i dont think

[@polygondwanaland8390]

Think of it more like a hurricane model cone. We know vaguely where it will go, but we have to update the model with all new data coming in, which can dramatically change the cone.

[@thanemorgan3518]

@@golfinguy423 On further research... Yes, this is a crap "model". The IHME "model" is a three parameter curve fitting exercise, originally based on the curve of deaths ove time from China. It is the least sophisticated of all of the versions of models out there - it had a big wave of self promotion a few weeks ago, and then for some reason, perhaps optimistic numbers, it got picked up by the White House. The fact that it dropped its projected deaths by an order of magnitude isn't a sign of how things or data have changed (for the better). It is a measure of how bad the original assumption was - we can use China exclusively as a predictive model for each of the US states. They just averaged in Italy and Spain, from what I understand, and that is why the model is so different now. But it cannot be taken as any more accurate. It's basic assumptions about self isolation don't hold true in many US states; they assume they will be maintained through may; and if you dig into the assumptions they use for each state, you find out that they are just flat wrong about the steps many of the states have taken. They claim some states are in full lock down which are not, and others that do have stay at home orders do not in their assumptions. Just as an example, they are claiming New Mexico will peak in a couple of weeks. The much more sophisticated models that consider likelihoods of transmission, hospitalization, and recovery say that won't be until almost a month later. The original estimate from this "model" for New Mexico, before the new death curves were considered, was off by almost an order of magnitude from reality.

[@ggeudraco]

When I checked yesterday, the website containing the model had been blacklisted on the HSCN, who controls the internet connection for most of the NHS here in the UK. I'm not sure whether NHS England considered it dangerously misleading or whether they would prefer that we utilise other methods of prediction, but it is concerning...

[@thanemorgan3518]

@@ggeudraco Wow. Thank you for sharing that.

[@annemacleod1421]

Dr Seheult, when this is over I feel we should have your beautiful explanatory diagrams made available to print onto a canvas to hang on our office walls..... as a reminder of scientific research AND as admiration for your wonderful teaching skills and great drawing ability! 🤗🤗🤗 Thanks for the New Zealand update.... 29 new cases reported today Thursday 9 April ... there is hope. Our one death was sadly a woman reportedly diagnosed with influenza as she had no known contacts with any travellers or their family. We are facing Easter weekend and the message is...stay in your isolation bubble with family and do not travel away on holiday or the Police might intervene!!!

[@pipmorris3628]

Love your updates and have been following from day 1. I wonder wouldn't physiotherapeutic postural drainage, particularly inverted percussion along with bronchodilators and expectorants help in the early days of the infection in the lungs?

[@mirandabri834]

How about this idea...... Giving THEM something that REALLY helps, like the title states?? Why is everyone NOT EVEN mentioning IT??

[@jimgale3101]

My wife is a nurse at a major hospital here in NM and she has fw ed this video series to the hospitals Infection control team....

[@Healthhokie]

Love these videos. Sent the link to my PCP.

[@danteozierim.d.3961]

Excellent description of MOA! Bravo!

[@minaafshar9858]

Hi I am a registered nurse at a hospital in Southern California I am a huge fan of yours and really enjoy listening to your updates, I have a question in regards to the rapid testing for covid 19 which we recent started using at my facility which is great but from what Ive heard from other staff its only 65% accurate which sounds dangerously low, I would love if you would do an update about this and explain more in detail

[@Medcram]

I’m concerned too. Send us the link if you have one to the sensitivity.

[@racol5]

chima chibi I agree. Is this another 'bought the stock, use the stock'? UK health advisor is strong on not promoting ineffective test. For example, 20% of UTI test are false negatives here so symptoms count in determining retesting or treatment. However, there's a percentage of Covid19 infected people who are asymptomatic, and some who have vague symptoms. How many test at 65% efficiency would you have to carry out to be confident. And what would be a 'good' percentage for this test to be useful in flattering the curve? At 65% I'd use up the ineffective stock by testing thrice, I could be wrong but just doing it once seems foolish.

[@fireteamomega2343]

Igm/Igg western blot tests are and always have been useless garbage... False positive negative results honestly you might as well just flip a coin. Not all antibodies are created equal apparently even monoclonal ones. Usually there's to be expected no great quality control. Bioreact separate purify spin down pellet freeze and ship. Then you get a bad cloned batch to test with. Some bind some don't some clump together and you get skewed results. Sometimes you also get like protein binding that occurs and crazy protein bands appear. I could go on and on about why it sucks. It needs to be discarded as testing it's 2020 and just a mess of a thing... I would say further investment to drive down the cost in something like ddpcr is the way to go forward far more controlled and accurate.

[@dikirkland]

As a non-medically trained but avid watcher of your presentations, thank you so very much! I truly enjoy the new knowledge and information you provide. One other “island nation” similar to NZ you may want to watch is Hawaii. Hawaii was very slow out of the gate on Covid19, but now that they are on board, the Gov and his team have instituted strong restrictions and enforcement has started.

[@sapelesteve]

Great update once again Doc! If Ivermectin works to curtail the virus, I was wondering how long it would take to get FDA approval for its use? Also, would it work in the asymptomatic general population to confer some type of immunity to the virus? Just curious..............

[@martijnhotdog]

MMS also for bacteria, viruses, cancer.

[@chriscone916]

couldn't the mental issues be a result of low oxygen levels getting to the brain?

[@scienceofmassage4706]

Dr. Seheult, my deepest respect for you clever analysis. We are going to use this data in our family medicine clinic.

[@ELdASenSei]

Greetings from the Netherlands

[@nicholaslacovara2381]

Please look at the Wikipedia map of Covid19 in Italy compared to the Mediterranean Anemia (Thalassemia) map. People in Italy with Thalassemia seem to have a much lower incidence of Covid19 The Covid19 mechanism again may be related Thalassemia and Malaria resistance.

[@banmadabon]

I paste the post I sent to the doc just 5 minutes ago... Hi from Italy. I want you to give a look at a peculiar fact that's happening in the province of Ferrara (North Italy Emilia Romagna region, one of the three more hit region in Italy) Doctors observed that in that particular province there are almost no infections. The doctors believe that the people there, having been historically exposed to malaria and thalassemia, have developed a sort of enhanced resistance from contagion. I've listened on this channel about how this virus hits on blood red cells and how maybe antimalaric drugs could help. Maybe there's a link. Not a doctor so I stop here suspecting having already told enough silly things. Big props for your info. You explain things so well that I have a delusion of having nailed a important thing...Maybe is encephalitis affecting my brain...God bless America and especially docs. Hold fast!

[@nicholaslacovara2381]

banmadabon Thank you. We are very fortunate in the US to have had the advanced warning from Italy who told the truth about the impact of the virus as opposed to the more limited information from other countries. Thank you and god bless you and the people of Italy!