Coronavirus Pandemic Update 63: Is COVID-19 a Disease of the Endothelium (Blood Vessels and Clots)?

COVID-19 Update 63 with critical care specialist Roger Seheult, MD.
Dr. Seheult explains the theory that seems most plausible to us here at MedCram.com: That COVID-19 is primarily a disease of the endothelium (the single layer of cells that line blood and lymphatic vessels). This hypothesis helps explain the increase in cardiovascular complications from COVID-19: strokes, myocardial infarctions, thromboembolism (pulmonary embolism, DVTs, and other blood clots), as well as many critical patients who do not appear to have classic ARDS symptoms (and have relatively normal lung compliance etc. as observed by the research of Dr. Gattinoni in Italy and others). A deep understanding of this theory requires a review of some foundational biochemistry including the electron transport chain and ATP - the energy currency of the body.
Links referenced in this video:
Johns Hopkins - coronavirus.jhu.edu/map.html
Worldometer - www.worldometers.info/coronav...
CDC and Lag Time - wwwnc.cdc.gov/eid/article/26/...
American Journal of Physiology - journals.physiology.org/doi/f...
Some previous videos from this series (visit MedCram.com for the full series):
- Coronavirus Pandemic Update 62: Treatment with Famotidine (Pepcid)? • Coronavirus Pandemic U...
- Coronavirus Pandemic Update 61: Blood Clots & Strokes in COVID-19; ACE-2 Receptor; Oxidative Stress • Coronavirus Pandemic U...
- Coronavirus Pandemic Update 60: Hydroxychloroquine Update; NYC Data; How Widespread is COVID-19? • Coronavirus Pandemic U...
- Coronavirus Pandemic Update 59: Dr. Seheult's Daily Regimen (Vitamin D, C, Zinc, Quercetin, NAC) • Coronavirus Update 59:...
- Coronavirus Pandemic Update 58: Testing; Causes of Hypoxemia in COVID-19 (V/Q vs Shunt vs Diffusion) • Coronavirus Pandemic U...
- Coronavirus Pandemic Update 57: Remdesivir Treatment Update and Can Far-UVC Disinfect Public Spaces? • Coronavirus Pandemic U...
- Coronavirus Pandemic Update 56: What is “Forest Bathing” & Can It Boost Immunity Against Viruses? • Coronavirus Pandemic U...
- Coronavirus Pandemic Update 55: How COVID-19 Infection Attacks The Immune System & Differs From HIV: • Coronavirus Pandemic U...
- Coronavirus Pandemic Update 54: COVID-19 Antibody vs. PCR Testing; When to Relax Social Distancing?: • Coronavirus Pandemic U...
- Coronavirus Pandemic Update 53: Anticoagulation; Can Mechanical Ventilation Make COVID 19 Worse?: • Coronavirus Pandemic U...
- Coronavirus Pandemic Update 52: Ivermectin Treatment; Does COVID-19 Attack Hemoglobin?: • Coronavirus Pandemic U...
- Coronavirus Pandemic Update 51: State by State Projections; Ultrasound to Diagnose COVID19 Pneumonia: • Coronavirus Pandemic U...
- Coronavirus Pandemic Update 50: Dip in Daily New Deaths; Research on Natural Killer Cells & COVID-19: • Coronavirus Pandemic U...
- Coronavirus Pandemic Update 49: New Data on COVID-19 vs Other Viral Infections (Ventilator Outcomes): • Coronavirus Pandemic U...
- Coronavirus Pandemic Update 48: Curve Flattening in California, PPE in the ICU, Medication Trials: • Coronavirus Pandemic U...
- How Coronavirus Kills: Acute Respiratory Distress Syndrome (ARDS) & Treatment: • How Coronavirus Kills:...
Many other videos on COVID-19 (coronavirus outbreak, coronavirus symptoms, influenza, coronavirus epidemic, corona virus updates, coronavirus vaccine, boosting the immune system, vitamin D, vitamin C, Zinc, Quercetin, NAC, n-acetyl cysteine, Insomnia, PPE, hydroxychloroquine, ultrasound to diagnose COVID-19, coronavirus New York, COVID-19 and the epithelium/blood vessels) and other medical topics (ECG Interpretation, strokes, thrombosis, pulmonary embolism, myocardial infarction, hypercoagulation, hypertension, anticoagulation, DKA, acute kidney injury, influenza, measles, mechanical ventilation, etc.) at MedCam.com
Speaker: Roger Seheult, MD
Board Certified in Internal Medicine, Pulmonary Disease, Critical Care, and Sleep Medicine.
MedCram provides videos to a variety of medical schools, education programs, and institutions (please contact us at [e-mail] if you are interested)
Media Contact: [e-mail]
Media contact info: www.medcram.com/pages/media-c...
MedCram medical videos are for medical education and exam preparation, and NOT intended to replace recommendations from your doctor.
#COVID19 #SARSCoV2 #Coronavirus

[@spydude38]

I feel like I'm witnessing the beginnings of an understanding of something very important to mankind.

[@frankozz8699]

you said it. for real virus has dogged mankind for long time. this is fundimental research that may go a long way at understanding extremely complex biology and virus interaction that maybe a new field of medicine/science take place that end the pandemic problem in humans and animals once and for all. This whole thing has been beyond fascinating.

[@seed_of_the_woman]

what does it mean?

[@BT2RC]

@@seed_of_the_woman It means that virology is a very complex thing and can have a profound effect on the human race. That is why there are virology labs all over the place studying the subject...for good and unfortunately evil.

[@TheOlzee]

Yeah, big fancy words have that effect

[@spydude38]

@@TheOlzee Its not the "big fancy words" it is the understanding of what they mean. For many, that is beyond their level of comprehension. Thankfully, many others choose to take the time to listen, comprehend and learn. I can only imagine what would have happened to Jonas Salk if he were trying to develop a vaccine for Influenza or Polio today.

[@shaikan0]

Dr. Seheult, you're an absolute boss sir. Your lectures, medical explanations, and analysis are second to none. You are able to turn highly complex topics into simple enough concepts so that non-professionals such as myself can learn and make sense out of such complexity. You're an outstanding educator, researcher and I can see the passion you posses for your vocation. Never stop making these presentations, you're doing amazing work. Thank you!

[@rla1000]

Joel Chaparro, agree, all was well.... until this one....... lol, by the 18 minute mark, I was all glassy eyed

[@fernfokes7749]

I like his presentations with wheels. I know ...stupid (me) but it kept me focused.

[@easternwoods4378]

I'm just a dumb engineer but I can listen to smart people all day

[@zogzog1063]

Well put, in turn, sir.

[@lmcdougall70]

Couldn't agree more, as I've writen above...a most gifted, generous and knowledgeable teacher - a master craftsman and humanitarian.

[@iangoddard5915]

Literally the cutting edge of medical sciences, right here on MedCram!

[@yhc5318]

Absolutely well said! This dr is absolutely amazing! I'm so blown away that my mind is fatigued. I don't have any type of medical background but I see the concept and ideas form thru his explanations. Incredible man!

[@grevberg]

Where else?

[@flash6261]

LITERALLY!!!!

[@NJ-wb1cz]

Pretty sure you meant figuratively

[@trimetrodon]

Ian Goddard Didn’t Ian Goddard, the famous usenet Ian Goddard pass away? I remember that Ian and he was a good man.

[@yhc5318]

Now that I understand the language? Not even close but he explains it in a way where I can see the outline. Omg... dr. Seheult is amazing! Why is he not on every news channel!!! What is wrong with this world where we have to be fed dr. Oz instead of de. Seheult??!!

[@marianogilglz9049]

because this pandemia is a tool for something else, if not doctors like him will be working with their government to get rid of the virus, maybe this not even happen in the first place.

[@onegurl9]

Because the following of Dr. Oz isn't intelligent enough. And the media is corrupted by stupidity and not nearly smart enough to get someone this intelligent to have a show and actually teach something of use.

[@marianogilglz9049]

@@onegurl9 Remember tha media and politicians are servants to the people with power, they are not dumb, they just follow orders, I can not imagine what goes to Dr Seheult mind when he sees the President talking about this disease, very brave of him for not even mention politics.

[@DarkMetaOFFICIAL]

Some Heros just do good, they don't need fame : )

[@DarkMetaOFFICIAL]

But yes I agree completely!

[@toastrecon]

I've learned more in a few videos on this channel than I did in a couple weeks in college basic biology.

[@pattysayssew3609]

Plus more fun. And so interesting!

[@robotempire]

A G I have had the same experience but i think it has more to do with the fact that now, this info is tied to something that directly impacts your life, more than quality of teacher. Just a more direct interest yanno? For me at least this info now feels unbelievably important

[@onegurl9]

There's no one that does it better. HE IS THE BEST. LITERALLY!!

[@yhc5318]

@@pattysayssew3609 and he seems to have an artistic bent to his diagrams too. Honestly if I had to cram that much info together it would end up look like a jackson pollack painting.

[@user-uk9oq9cg6t]

you will find more in this interview kzbin.info/www/bejne/jJXMpH2YmLiaq8U

[@zestefraicheur]

Greetings from France ! Someone at the univeristy told me : "how do you recognize a good teacher ? when, at the end of the course, you have the feeling that you are super smart because you have understood everything he said".So Dr Seheult you are a veeeery good teacher !

[@aminkeykha5546]

Recent kawasaki -like presentation places emphasis on the fact that covid 19 is a vasculitis like disease. your presentation is marvelous❤️

[@mtbin2]

Amin keykha and Children with Kawasaki are shown to be largely Vit D deficient. pubmed.ncbi.nlm.nih.gov/25994612/ pubmed.ncbi.nlm.nih.gov/19138739/

[@aminkeykha5546]

mtbin2 Also vit D helps in transcription .

[@SR-dm5lh]

@@mtbin2 it is interesting if the Covid19 had anything to do with that... Can that fact the Vit D plays a roll in regulating Renin and Angiotensin I. Basically meaning that the body runs out of Vitamin D faster at people who are infected by Covid19? if that's the case, makes a lot of sense to load up on those IU.. 4000IU should probably be a minimum recommended intake not the minimum www.ahajournals.org/doi/pdf/10.1161/JAHA.114.001417

[@alainpannetier2543]

@@SR-dm5lh Yes. doi.org/10.1136/bmj.m1548

[@mtbin2]

All good points. Really this is all pointing to Covid presentation to be largely due to Vit D deficiency. This recent study showing statistically significant correlation with Vit D levels and severity of Covid19 symptoms basically says it all: vitamindwiki.com/Critical+COVID-19+was+19X+more+likely+if+low+vitamin+D+-+April+15,+2020 Something has to account for people not getting one darn symptom yet testing positive

[@pragooutube]

I just HAD to pause the video just to say, again, THANK YOU for what you're doing... we really don't deserve your expertise.... thank you! I feel truly indebted. 🤗😃👍

[@BulldustHHH]

It's not a question of deserve. Having spent a few years as a lecturer it is clearly a calling for some. I can guarantee our dear doctor is motivated by doing these presentations and it shines through. This is what good will looks like.

[@1contrarian]

I wish I had a biology teacher like you in school. Thank you!

[@markrice41]

You make complicated biological concepts understandable to the lay person.

[@denniskatinas]

This.

[@garryw1974]

Yep

[@onegurl9]

As a lay person, I've never understood anything so detailed in EVERY medical description as I have your videos. YOU ARE THE BEST!! Having you teach us that are not educated in this field makes us understand this virus and what it does to the human body. There is no one out there that does it any better than you. I watched someone who tried recently...NOT!!! It didn't work, I was lost and uninterested. Thank you for explaining with your diagrams and the care that you give to us. You have made it possible, and so easy to understand. WE APPRECIATE YOU AND EVERYTHING YOU DO TO HELP US UNDERSTAND THIS VIRUS DURING THIS MOST DIFFICULT TIME IN ALL OF OUR LIVES. WE LOVE YOU TOO!

[@yhc5318]

@@onegurl9 which channel are you referring to? If you don't mind sharing that info. And I absolutely share your sentiments.

[@chrisa2847]

Please don’t test me on anything he said 😳

[@TheZyzyzyzyzy]

Wow. This lecture reminds me my biochemistry lessons on the nursing college. I'd been sruggling to pass the exam and I was completelly lost. If I'd had these lessons in those times... I'd be much more into the biochemistry. It is very adventurous journey to go through your lectures, doctor. Thank you for your teaching.❤️🙏🏼👍🏻 Can't wait to see another lecture.

[@akaroui9227]

Dr. Seheult what you are doing is extremely important in this difficult time. It reassures people who are not in the field, people who are frustrated, people around the world who lost hope. Your videos inform your peers and inspire students and other researchers.I vote that this community as well as specialists recognize you as one of, and possibly the champion of the fight against this terrible pandemic. I adore your way of pulling scientific papers and creating conversations between your observations, your interpretations, and the work of others that already went through peer reviews. Your discussions make a lot of sense. You always keep a small margin of doubt until you verify the idea. That is the way excellent scientists follow. Please continue this good work.

[@lmcdougall70]

Perfectly stated...the doctor is one of a kind - a great great teacher and humanitarian, something rare in a scientist as brilliant as he.

[@billytheweasel]

"Please bear with me" - This guy is such a gift. I've taken NAC for years to support Glutathione production.

[@keepfeatherinitbrothaaaa]

I've never paid more attention in my life. This is more exciting than any episode of The Wire.

[@Randy_Gentry]

I hope this series ends well; then, next season is canceled.

[@yhc5318]

@@Randy_Gentry amen! And brilliantly stated.

[@mamindhive]

n01ded tbh staring at my ceiling is more exciting than all of the wire

[@Wonster00]

Impressive lecture...the 1st half explaining the oxidative cycle is worth the "price of admission", lessons with knowledge that can be useful for a lifetime.

[@Medcram]

Glad it was helpful!

[@yayita2024-n5c]

​@@Medcram Chlorine dioxide (ClO2) has been used for over 100 years to combat all types of bacteria, viruses and fungi successfully. It acts as a disinfectant, since in its mode of action it turns out to be an oxidant. [1# BiologicalEfficacyList ] It is very similar to the way our own body acts, for example in phagocytosis, where an oxidation process is used to eliminate all kinds of pathogens. Chlorine dioxide (ClO2) is a yellowish gas that, to date, has not been introduced into the conventional pharmacopoeia as an active ingredient, although it is used on a mandatory basis to disinfect and preserve blood bags for transfusions. [2# Alcide studies on blood disinfection] It is also used in most bottled waters suitable for consumption, since it does not leave toxic residues; besides, it is a gas that is very soluble in water and evaporates from 11ºC.The recent Covid-19 coronavirus pandemic demands urgent solutions with new approaches. Therefore, chlorine dioxide (ClO2) in low-dose aqueous solution promises to be an ideal, rapid and effective solution. All too often, the solution is in the simplest of ways. The approach is as follows: on the one hand we know that viruses are absolutely sensitive to oxidation and on the other hand, if it works in human blood bags against viruses such as HIV and other pathogens, why would it not work organically against the coronavirus? Chlorine dioxide removes viruses through the process of selective oxidation in a very short time. It does this by denaturing the capsid proteins, and then oxidizes the genetic material of the virus, disabling it. The application of chlorine dioxide (ClO2) orally or even parenterally is a different approach that has been studied by Andreas Ludwig Kalcker for more than thirteen years with a result of three pharmaceutical patents for parenteral use. andreaskalcker.com/wp-content/uploads/2020/04/chlorine-dioxide-against-coronavirus-v2.1.pdf lbry.tv/@SomosLaDulceRevoluci%C3%B2n:e/Chlorine-Dioxide-for-Coronavirus-Covid-19_-A-Revolutionary-and-Effective-Approach-(Andreas-Kalcker):f Here is link to a small clinical trial on covid19 using ClO2 orally clinicaltrials.gov/ct2/show/NCT04343742?id=NCT04343742&draw=2&rank=1&load=cart And this is link to 3 patents for parenteral application. patents.google.com/?inventor=Ludwig+Kalcker+Andreas For more info andreaskalcker.com/en/

[@ryanleiderman9622]

@@Medcram "Resveratrol reduces intracellular reactive oxygen species levels by inducing autophagy through the AMPK-mTOR pathway."

[@falconcarwash435]

Man, you are awesome! I’ve been following this channel awhile now and am impressed and inspired everyday. Your graphic representations are beyond helpful for me! As a nurse, and human, I want to say thank you for all your efforts, KZbin and otherwise, in combating this virus!

[@robwindsor6373]

I appreciate these videos Dr. Thank you for shining a light upon the medical facts.

[@JohnTischler]

Dr. Seheult deserves an international honor for his communication of complex biological processes to the average person. While I don’t completely understand him based on a single viewing, some of it sticks. Understanding reduces fear and his communication of these processes gives colleagues the tools to better treat patients and scientists the tools to advance research. .

[@animenanet]

I'm a nurse from Portugal. Shared several of your videos with my doctor friends and I must say it all makes sense! You are a marvelous teacher. We are all together in this fight!

[@jessicadaniels8169]

Always look forward to hearing your updates! Thanks for taking the time to do these even while being a full time Doctor. I’m an ICU nurse in NC and I’ve been watching your videos for years.💜

[@TheZyzyzyzyzy]

God bless you! Stay healthy and strong!

[@TuneintoLearning]

Again, THANK YOU FOR YOUR HONESTY, WELL PUT TOGETHER, NON FEAR DEMEANOR AND TONE, NON SENSATIONALIZED content meant to merely to incite fear/hatred/anger. You have the most well presented content and portrayal of our current situation, as well as the etymology and process's of Covid-19. STAY SAFE, AGAIN, THANK YOU FOR YOUR HARD WORK AND EFFORTS AT THESE CRAZY TIMES, YOU DON"T GET PAID NOR PRAISED ENOUGH.

[@DdrtAddh]

This is the only channel i mark videos with a 'like' before seeing the video. Thank you Dr. Seheult 🙏🏻

[@lmcdougall70]

Wrll, folks, I've mentioned this before...Dr. Seheult is a genius.. Had he been my profesor in university Arts and Sciences, I'd have probably leapt into science and been a fanatic. Here I am, an 82-year old Jungian therapist, former professor of literature and mythology, absolutely spellbound - learning something brand new and above all, understanding a great deal of what Dr. Seheult is describing. He is an absolutely gifted teacher - and where he finds the time to do all this is beyond me. I'm filled with gratitude for his dedication, expertise and determination that we all understand what's behind this deadly virus.I await each new episode with excitement! Imagine!!

[@huddy335]

The human body and it's detailed function is truly amazing.

[@dougf1249]

That “Ohhh i see” moment when you said what covid19 does to ace 2 in reference to the rest of the diagram. I’m no where near medically inclined but I understand this perfectly. Man i learn more from these videos than any medical press release. Why can’t we get you up to explain things to the country? Dr. Seheult, I cannot thank you enough for these videos!!

[@stephaneabramowicz4658]

Absolutely incredible presentation, you've done it again Dr. Seheult! Congrats! Many thanks from Belgium.

[@Medcram]

Thanks for your support and watching from Belgium!

[@ryanleiderman9622]

@@Medcram Resveratrol reduces intracellular reactive oxygen species levels by inducing autophagy through the AMPK-mTOR pathway.

[@tonypezzolo9432]

This episode is like Dr. Seheult's opus. A wonderful example of what a great mind can do with consistent and careful observation and conjecture.

[@Medcram]

Thank you for visiting us at www.MedCram.com At our website, browse all of our videos and CLEAR explanations of over 60 medical topics. We also offer CME/CEUs for medical professionals, medical programs, and institutions. All links referenced in this video are in the video description. Quick links to our previous updates on the coronavirus pandemic: - Coronavirus Pandemic Update 62: Treatment with Famotidine (Pepcid)? kzbin.info/www/bejne/eqWzqJmfnc-sqLs - Coronavirus Pandemic Update 61: Blood Clots & Strokes in COVID-19; ACE-2 Receptor; Oxidative Stress: kzbin.info/www/bejne/aGOln2ugqKx8a5Y - Coronavirus Pandemic Update 60: Hydroxychloroquine Update; NYC Data; How Widespread is COVID-19? kzbin.info/www/bejne/nJ-Vqp5riMd6n9k - Coronavirus Pandemic Update 59: Dr. Seheult's Daily Regimen (Vitamin D, C, Zinc, Quercetin, NAC): kzbin.info/www/bejne/hH6VcmWug7GKiJY - Coronavirus Pandemic Update 58: Testing; Causes of Hypoxemia in COVID-19 (V/Q vs Shunt vs Diffusion): kzbin.info/www/bejne/pICXqZqZfsaDm6M - Coronavirus Pandemic Update 57: Remdesivir Treatment Update and Can Far-UVC Disinfect Public Spaces? kzbin.info/www/bejne/aIaXdXSHaNCdiNU - Coronavirus Pandemic Update 56: What is “Forest Bathing” & Can It Boost Immunity Against Viruses? kzbin.info/www/bejne/hpinm4l7paqCmrM - Coronavirus Pandemic Update 55: How COVID-19 Infection Attacks The Immune System & Differs From HIV: kzbin.info/www/bejne/bn_Jl413fKp_fck - Coronavirus Pandemic Update 54: COVID-19 Antibody vs. PCR Testing; When to Relax Social Distancing? kzbin.info/www/bejne/oZjdd3SajtyMgq8 - Coronavirus Pandemic Update 53: Anticoagulation; Can Mechanical Ventilation Make COVID 19 Worse? kzbin.info/www/bejne/pWnEeGlprs6aoKM - Coronavirus Pandemic Update 52: Ivermectin Treatment; Does COVID-19 Attack Hemoglobin?: kzbin.info/www/bejne/p5SZh4ltqspnmac - Coronavirus Pandemic Update 51: State by State Projections; Ultrasound to Diagnose COVID19 Pneumonia: kzbin.info/www/bejne/e2iwppmJa8mhgNk - Coronavirus Pandemic Update 50: Dip in Daily New Deaths; Research on Natural Killer Cells & COVID-19: kzbin.info/www/bejne/nKrEZ42trcibbpo - Coronavirus Pandemic Update 49: New Data on COVID-19 vs Other Viral Infections (Ventilator Outcomes): kzbin.info/www/bejne/q5Ksq51pqJijaqM - Coronavirus Pandemic Update 48: Curve Flattening in California, PPE in the ICU, Medication Trials: kzbin.info/www/bejne/gH-QaZV9d5aWgq8 - Coronavirus Pandemic Update 47: Searching for Immunity Boosters & Possible Lessons From Spanish Flu: kzbin.info/www/bejne/fmKveZqvm7WDh5o - Coronavirus Pandemic Update 46: Can Hot/Cold Therapy Boost Immunity? More on Hydroxychloroquine: kzbin.info/www/bejne/e3e1qKGem7yLrtE - Coronavirus Pandemic Update 45: Sharing Ventilators, More on Sleep, Immunity, & COVID-19 Prevention: kzbin.info/www/bejne/fWLdpHhvlJ1on5Y - Coronavirus Pandemic Update 44: Loss of Smell & Conjunctivitis in COVID-19, Is Fever Helpful? kzbin.info/www/bejne/d2XIpmCelNSql6s - Coronavirus Pandemic Update 43: Shortages, Immunity, & Can a TB Vaccine (BCG) Help Prevent COVID-19? kzbin.info/www/bejne/gqKuqHR_ft5gg9E - Coronavirus Pandemic Update 42: Immunity to COVID-19 and is Reinfection Possible? kzbin.info/www/bejne/p2WzamSMp8uDfdk - Coronavirus Pandemic Update 41: Shelter In Place, FDA Investigates Hydroxychloroquine for COVID-19: kzbin.info/www/bejne/noHdZn6unK6SgZY - Coronavirus Pandemic Update 40: Ibuprofen and COVID-19 (are NSAIDs safe?), trials of HIV medications: kzbin.info/www/bejne/moWZnnuflJ2Ja6c - Coronavirus Pandemic Update 39: Rapid COVID-19 Spread with Mild or No Symptoms, More on Treatment: kzbin.info/www/bejne/d4XSd2uFarlrbNU - Coronavirus Pandemic Update 38: How Hospitals & Clinics Can Prepare for COVID-19, Global Cases Surge: kzbin.info/www/bejne/g6DMpKV5idpjibs - Coronavirus Pandemic Update 37: The ACE-2 Receptor - The Doorway to COVID-19 (ACE Inhibitors & ARBs): kzbin.info/www/bejne/Z6e9dYmYprebr68 - Coronavirus Pandemic Update 36: Flatten The COVID-19 Curve, Social Distancing, Hospital Capacities: kzbin.info/www/bejne/rKjaYqF_ftSko9k - Coronavirus Pandemic Update 35: New Outbreaks & Travel Restrictions, Possible COVID-19 Treatments: kzbin.info/www/bejne/rHaXkH-pm9mBga8 - Coronavirus Epidemic Update 34: US Cases Surge, Chloroquine & Zinc Treatment Combo, Italy Lockdown: kzbin.info/www/bejne/i2ipYpakjNqjb68 - Coronavirus Epidemic Update 33: COVID-19 Medication Treatment Trials, Global Testing Remains Limited: kzbin.info/www/bejne/g56ahqWQmtpgbZY - Coronavirus Epidemic Update 32: Important Data from South Korea, Can Zinc Help Prevent COVID-19? kzbin.info/www/bejne/e5bLYWhqYq2rZ7c - Coronavirus Epidemic Update 31: Mortality Rate, Cleaning Products, A More/Less Severe Virus Strain? kzbin.info/www/bejne/bYqsY6eFpLuJps0 - Coronavirus Epidemic Update 30: More Global COVID-19 Outbreaks, Vitamin D May Aid Prevention: kzbin.info/www/bejne/nZ7UmHqtiZuVrZI - Coronavirus Epidemic Update 29: Testing problems, mutations, COVID-19 in Washington & Iran: kzbin.info/www/bejne/jpuokpaLrtVnrLs - Coronavirus Epidemic Update 28: Practical Prevention Strategies, Patient Age vs. Case Fatality Rate: kzbin.info/www/bejne/p6anipWVrZpneq8 - Coronavirus Epidemic Update 27: Testing accuracy for COVID-19 (CT Scan vs. RT-PCR), California Cases: kzbin.info/www/bejne/roLal6iAnK9sotE - Coronavirus Epidemic Update 26: Treatment Updates, Stock Markets, Germany & San Francisco, Pandemic? kzbin.info/www/bejne/mIeUdI2uf5KorLc - Coronavirus Epidemic Update 25: Vaccine Developments, Italy's Response, and Mortality Rate Trends: kzbin.info/www/bejne/i3rQhImegbGYfbs - Coronavirus Epidemic Update 24: Infections in Italy, Transmissibility, COVID-19 Symptoms: kzbin.info/www/bejne/rXfSm2WCZ7GjhKM - Coronavirus Epidemic Update 23: Infections in Kids & Pregnancy, South Korea, Spillover From Bats: kzbin.info/www/bejne/gHjLqHR9nqahgNE - Coronavirus Epidemic Update 22: Spread Without Symptoms, Cruise Quarantine, Asymptomatic Testing: kzbin.info/www/bejne/haLTeamBZb10ers - Coronavirus Epidemic Update 21: Antibodies, Case Fatality, Clinical Recommendations, 2nd Infections?: kzbin.info/www/bejne/b3O8kqytfrmLj80 - Coronavirus Epidemic Update 20: Misinformation Spread, Infection Severity, Cruise Ship, Origins: kzbin.info/www/bejne/gZKXaYiQeamtgrs - Coronavirus Epidemic Update 19: Treatment and Medication Clinical Trials: kzbin.info/www/bejne/anmuaoR7rpZ-gJo - Coronavirus Epidemic Update 18: Cellphone Tracking, Increase in Hospitalizations, More Sleep Tips: kzbin.info/www/bejne/rHaXoXWhqNGkiZY - Coronavirus Epidemic Update 17: Spike in Confirmed Cases, Fighting Infections with Sleep (COVID-19): kzbin.info/www/bejne/rZ3FfmmMi9CJkK8 - Coronavirus Epidemic Update 16: Strengthening Your Immune Response to Viral Infections (COVID-19): kzbin.info/www/bejne/p6K9inidh6qokJo - Coronavirus Epidemic Update 15: Underreporting, Prevention, 24 Day Incubation? (COVID19): kzbin.info/www/bejne/pWmTZaqras2So9U - Coronavirus Epidemic Update 14: Hospital spread of infection, WHO allowed in China, N-95 masks: kzbin.info/www/bejne/pnXRnnurbd1seZY - Coronavirus Epidemic Update 13: Li Wenliang, nCoV vs Influenza, Dip in Daily Cases, Spread to Canada: kzbin.info/www/bejne/ZobKo4Odf8mtppI - Coronavirus Epidemic Update 12: Unsupported Theories, Pneumonia, ACE2 & nCoV: kzbin.info/www/bejne/fYWWkHRnl8tsprc - Coronavirus Epidemic Update 11: Antiviral Drugs, Treatment Trials for nCoV (Remdesivir, Chloroquine): kzbin.info/www/bejne/ppeqoZd8g62ip7M - Coronavirus Epidemic Update 10: New Studies, Transmission, Spread from Wuhan, Prevention (2019-nCoV): kzbin.info/www/bejne/nYHal5yHnKymfNE - Coronavirus Epidemic Update 9: Fecal-Oral Transmission, Recovery vs Death Rate: kzbin.info/www/bejne/bnnNqmaLm8aHicU - Coronavirus Outbreak Update 8: Travel Ban, Spread Outside of China, Quarantine, & MRSA: kzbin.info/www/bejne/faHFhqKCq9WXedE - Coronavirus Epidemic Update 7: Global Health Emergency Declared, Viral Shedding: kzbin.info/www/bejne/pIiWqaSZfM6XprM - Coronavirus Outbreak Update 6: Asymptomatic Transmission & Incubation Period: kzbin.info/www/bejne/i3jbmIGbl91kpsk - Coronavirus Update 5: Mortality Rate vs SARS / Influenza: kzbin.info/www/bejne/g3-cXoiOqNuDeLs - How Coronavirus Kills: Acute Respiratory Distress Syndrome (ARDS) & Treatment: kzbin.info/www/bejne/pZzKaKinlK2lnrM - Coronavirus Update 3: Spread, Quarantine, Projections, & Vaccine: kzbin.info/www/bejne/iXuliqqLqadradE - Coronavirus Symptoms, Diagnosis, Treatment: kzbin.info/www/bejne/i3SqZKunqch_acU - Coronavirus Outbreak - Transmission & Updates: kzbin.info/www/bejne/b6ewiYahgLGaaKs

[@mvbrown25]

MedCram - Medical Lectures Explained CLEARLY I’ll keep saying it but Citrulline(NO precursor that works in a unique way and bypasses certain processes, REDOX), Alpha Ketogluterate(Krebs cycle, REDOX), and high dose Vitamin C(BH4, REDOX)

[@laurieannJake]

MedCram - Medical Lectures Explained CLEARLY I'll be there!!

[@joeythehat9]

Great work on this video, Doctor. I would not be surprised if they removed it for containing too much accurate data.

[@lwmstern]

a logical question would be if unregulated ag2 is a key modulator of ROS , then why wouldnt an ACE inhibitor be helpful ? this would essentially block the creation of AG2 . Majority of patients with CAD , htn ckd are presumably taking an ACEI as it's first line treatment for HTN In those with CKD, DM. Additionally used in CHF. Maybe Dr Seheult can shed more light on why it would or wouldnt be helpful ?

[@rafael.frigori]

Hi dr. Seheult! A superb vídeo. Please discuss how ACE2 inhibitors would be advisable (or not) in this context. Thanks!

[@mattfields2033]

Another fantastic presentation. Why couldn't you teach me in college? I learn so much and so easily from you. Please keep up the great work.

[@moebeddah2288]

I've read that there have been instances of high iron concentration in the bodies of patients suffering from Covid19. Can this be that because of impairment of the SOD function via the lack of ANG 1-7, Catalase is the only mitigating factor in combating Oxidative Stress? Thus, the high iron levels due to Catalase being the only game in town, so to speak. I'm a retired truck driver, so you all go easy. It's truly a credit to Dr. Seheult's concise and thorough presentation that allows a layman such as myself to comprehend the insidious nature of this disease. I'm looking forward to the Webinar tomorrow. I'll be the old, quiet guy in the back row. Cheers!

[@bho-lj1jk]

Moe Beddah Hey, Moe, save me a seat. We can swap old timie trucking stories after class.

[@moebeddah2288]

Konglim Khoo - Thank you

[@yasminedey8612]

The high levels of iron, suspected to no longer be in the hemoglobin, are being absorbed by the ferritin, which could explain why the the ferritin levels might be higher. Read here: www.jewishpress.com/news/us-news/ny/scientists-study-coronavirus-attack-on-hemoglobin-test-new-treatments-with-old-standbys/2020/04/10/

[@moebeddah2288]

Yasmin Dey - Thanks for the link. As a result, I think I have a better understanding of the process.

[@yasminedey8612]

@@moebeddah2288 To find out more on the Coronavirus, you might also be interested in the DW (Deutsche Welle in English) channel: kzbin.info/www/bejne/g5q6lJ5tZc2XkLs

[@joebarcelona]

You probably saved some lives with the making of these videos. Highly accessible and instructional, complete with references. Great.

[@andrewkeller4453]

Doc, I studied exercise physiology in grad school a decade ago. I wish you would have been one of my professors. You do a great job of making complex systems understandable for viewers of all backgrounds. Here’s a appropriately distanced 3,000 mile fist bump from NC. 🤜

[@longhealthyjoyfullife]

"The rationale for vitamin C in sepsis [and for that matter in COVID-19] is strong. Humans are unable to synthesize vitamin C, while animals acutely increase its production during stress to protect cells against the overwhelming production of reactive oxygen species (ROS) causing endothelial and mitochondrial injury with subsequent organ failure [3]. In animals, the endogenous vitamin C production is inversely correlated to the cortisol response. Higher cortisol responses are associated with poorer outcomes, which may be attributed to higher severity of illness, but also to vitamin C deficiency [4]. Vitamin C is our central antioxidant, which directly scavenges free radicals, prevents production of ROS, and restores other antioxidants, reducing endothelial permeability and cellular apoptosis. Furthermore, vitamin C is a neuroprotector, immunomodulator, and cofactor for synthesis of vasopressors. Increased vitamin C consumption and reduced recycling lead to abrupt hypovitaminosis C (≤ 23 μmol/l) and deficiency (≤ 11 μmol/l) as measured in 88% and 38% of the patients with septic shock [5]. Recently, the largest randomized clinical trial (RCT) of intravenous vitamin C in septic patients until now, the CITRIS-ALI trial, showed a 16.5% lower mortality in the vitamin C group compared to placebo, while the primary endpoint deltaSOFA-score after 96 h was negative [1]. Mortality curves parted from day 2, which may be due to early circulatory stabilization by vitamin C [2]. Many comments on this trial addressed the methodological problem due to the exclusion of deceased and discharged patients from the deltaSOFA-score. Given the early mortality reduction in favor of vitamin C, recalculation with assignment of the worst SOFA score to deceased patients and the best score to discharged patients will undoubtedly show less organ dysfunction. So, the results of the CITRIS-ALI study support the promising role of adjuvant high-dose intravenous vitamin C for septic patients. The CITRIS-ALI trial differed in two important aspects from the groundbreaking before-after study of Marik et al. which showed a 30% absolute mortality reduction, but had the limitation of not being randomized [2]. First, the i.v. dose of 200 mg/kg/day vitamin C (i.e., 16 g/day for 80 kg BW) was higher than the 6 g/day of the HAT-therapy. Second, vitamin C was administered as monotherapy and not in combination with hydrocortisone and thiamine (HAT-therapy, based on the hypothesis that hydrocortisone and thiamine have potentially synergistic effects with vitamin C). Although the positive results of the CITRIS-ALI study on mortality question the necessity of co-administration of hydrocortisone and thiamine when vitamin C is dosed sufficiently high, notably 66% of patients in CITRIS-ALI study received corticosteroids... The optimal dose of vitamin C is unknown, and systematic dose-finding during critical illness has not been performed. However, several facts are known. First, the antioxidant capacity of vitamin C is dose-dependent and direct radical scavenging capacity is maximal at a plasma vitamin C level > 175 mg/l (1000 μmol/l), more than ten times normal [6]. In addition, other functions like immune modulation, inhibition of bacterial replication, and neuroprotection are dose-dependent as well. Second, intravenous dosing is necessary, because enteral uptake is limited [3]. Third, intravenous vitamin C doses of 2-3 g/day are needed to normalize plasma concentrations and sustained therapy is needed to prevent reoccurrence of hypovitaminosis [7]. The dose-concentration relationship is linear, so higher doses yield proportionally higher plasma concentrations [7]. Plasma concentrations > 1000 μmol/l can be obtained with 10 g i.v. vitamin C/day [7]. In the only dose-effect study in septic patients, the higher dose of i.v. vitamin C (200 mg/kg/day) improved organ dysfunction more than the lower dose of 50 mg/kg/day. A recent meta-analysis found a reduced mortality with medium-dose vitamin C (3-10 g/day) in critically ill patients, in contrast to low (

[@joyfisher8008]

Another tough one for me to follow but thank you for the info & the link! Will increase my vitamin c even more.

[@tulsissurfboard6094]

This particular lecture will go down in history as one of his best. So great!

[@spectator59]

I've watched quite a few of your videos, and I have to say, this is one of my all-time favorites. Wonderfully clear and articulate. Thank you!

[@motofreak75]

Thank you for spending so much time on these videos. The amount of time that goes into each video you post is a lot (I know)

[@jenne808]

I hope you will post the webinar so that I can listen to it later. I would love to hear it because I have followed all of your posts in order to figure out how to deal with my own personal health situation. (Bad as it gets, high risk, elderly, multi-generational household). I don't feel ok about taking up a space which might go better to a medical professional. Because of your posts, we are doing everything we can to reduce risk, my favorite post what the 'what I do when I get home to not bring the virus into my house'. It makes me feel better everything I bleach wipe my light switches. Zinc is daily....

[@desolation0]

When he said "back to medical school and refresh some basic things" I was not expecting "The mitochondria is the powerhouse of the cell."

[@Harveychiro]

OUTSTANDING presentation Dr. Seheult! You always do a marvelous job but you knocked this one out of the park! Clear, concise and easily understood! Looking forward to the next in this series.

[@unknownuser8446]

Believe me sir you can not get enough praise for being in the front lines...alongside others You are a true hero .... Thank you ....

[@Medcram]

Thanks a ton

[@danieljohnson309]

I don't comment much on the 'net' but I've been following these Medcram Vids and this one, which I managed to follow even tho I am not currently in the medical industry, is just unbelievably good. Incredible clarity and thanks for **another** great video.

[@user-qf6yt3id3w]

This is the best channel on KZbin right now. Really interesting stuff.

[@CaraSusanetta]

Doc, you are such a good teacher. I am LOVING this series. Thanks to you and your colleagues for making this so understandable.

[@impek667]

Knowing this is frightening. However, with knowledge comes power and your research is nothing short of incredible! I can't thank you enough for keeping up your continued work on fighting this disease!! Your videos are amazing, I have never studied medicine and still you manage to explain everything in a way that normal people such as myself can understand this. Stay strong Dr.

[@petek7033]

You sir are inspiring the next generation of doctors, scientists, biologists and educational enthusiasts alike! I absolutely love this channel, from all the way in Cape Town, South Africa - I thank you for your exceptional service!

[@lawrencetanner7958]

Dr. Seheult, I am grateful for your efforts. I've never been to med school, so this is all a stretch for me. But the lucidity of your explanations is, perhaps, without comparison. You and your colleagues are doing wonderful work. I am thankful. Do, please, be careful in your ICU. Wouldn't want to lose you.

[@Medcram]

Wow, thank you!

[@bradstephan7886]

He is such a clear instructor. I sure wish I had these videos during my accelerated nursing program!

[@reinerwilhelms-tricarico344]

Wow! I had to watch this twice but I think I got the gist of it. This is truly mind boggling to see this complexity, and you’re an excellent teacher.

[@Medcram]

Wow, thank you!

[@rudyalan2440]

This Doctor needs to run the WHO, he is on top of everything! Lets put an expert who is in everyday practice in charge. Some one that is on it, everyday! Not some incompetent bureaucrat sitting in an ivory tower far removed from the real World. Dr. Seheult is my Man of the Year! He loves medicine, I can tell!

[@JigmeSwag]

Pre-med here, I really enjoy how the basics of biochemistry is being applied and explained beautifully

[@greylaga.anser4ultd15]

This whole lecture series is doubly important. 1) It serves as a historical record of the disease in terms of actual progression and in terms of understanding. If we'd known this in January... but you have to 'earn the learn', unfortunately. Terrible though this is, we are at least fortunate to face this in 2020, rather than the poor doctors with their techniques and understanding who had to face Spanish Flu in 1920. 2) It's so clear as explanation. As a physicist, I'm hooked. I'm watching real time science evolve to target the issue of our times. An amazing achievement!!! Thank you Dr Seheult!

[@Salopovpaz]

Thank you Dr Seheult for your generosity. God bless you

[@comet1072]

Wow, this is so interesting! Thank you for explaining this clearly, it sure does start to tie a lot of loose ends together

[@djJinjiny]

i have been watching every single med cram since like update 16 . thanks to this organization I am now ready to take biology and .....and I'm excited about it!!! thank you!!

[@thomism1016]

Jeanie Mac Go for it and I hope you consider coming into medicine in due course as well. 👍🏾

[@lseh4720]

I once believed I was somewhat intelligent, until I tried to understand everything Dr. Seheult explained here. I had to watch it several times. If medical school were completely online with videos, I think I might be able to graduate; otherwise, so much goes over my head the first time. So glad to be able to watch this. People, why are you wasting time watching the Orange Menace for 2 hours daily, watch this channel instead for two hours. You’ll come out so much smarter. Thank you Dr. Seheult.

[@Oso-es6tx]

Thanks again for taking the time to make another video to keep us inform.

[@PinkAmadeus]

Thank you for this immensely relevant content!

[@ephraimdunn8745]

I also have utilized you lecture 37 for my basis of understanding the disease. Started patients on spironolactone with good results!

[@cindyjohnson5242]

Dr Dunn, what is your basis for the spironolactone? Can you explain please?Is it to prevent electrolyte loss? Are you using it to treat CV or as prophylaxis? Or just general practice?

[@violetg7315]

Awesome, this lecture took me back to metabolism class as a Food and Nutrition major in college. I love the names of superoxide dismutase, glutathione peroxidase, especially, their important effects on oxidation of cells /free radicals. Catalase included of course. Thank you!

[@Medcram]

Thanks for sharing!

[@phillee2814]

Thank you Doctor Seheult for the immense work you are putting into assembling all this information in a digestible form, ON TOP of your full-time job fighting this horror at the point it is most desperate. I'm simply soaking up these postgrad level studies right on the leading edge of biochemistry and the mechanisms of infection and damage from a disease, which you selflessly provide free to us and the whole world. I'm miraculously managing to follow them, despite a background (In IT, so at least I'm used to logical thought and ongoing education) far removed from the medical field (although I've always been science nut, a trait inherited from my grandfather). The closest I've ever been to studying medicine was understanding my own sicknesses and treatments (unfortunately many and varied), basic first aid (I used to do voluntary work as a motorcycle road race marshal, so have been the available body to assist in some trauma management) and studying for my flying exams. You manage to explain in ways which simplify the complex and even allow me to make predictions of the direction this is leading in. I may be smart (my medical records say I am), but without an explanation presented logically, I'm lost! I think there are probably far more smart people out there who simply have not been given the chance to show it than is commonly believed. You are providing that logical explanation, and in a way that even those outside the medical field can follow! Definitely worthy of the Faraday prize, and if and when it is turned into a paper for peer review and published (which it should be - you are making logical steps which tie so many other papers together and then apply them in a new way), it could easily become the definitive text on how to manage and treat the virus effectively, and be worthy of the Nobel prize for medicine, given the global desperation for such a management protocol. But first we've got to beat this little bastard of a virus, and thank you for your work in the trenches actually applying all this to those who need it most.

[@jasonlasalle4054]

Fascinating. Dr. Seheult is a great teacher!

[@Jaehova26]

I've been waiting on these up thank you ♥️

[@pnkbiankii]

Delightfully easy to follow for me, whose biochemistry background and understanding are so thin. Thank you so much for your patient, thorough explanations of these processes and their implications in disease emergence.

[@90bideven]

wow, you deserve a medal for how much time and effort you put into these videos!

[@Floortile83]

Can we nominate you for a nobel peace prize?

[@angelalalley7593]

Floortile83 He deserves the Noble one too!

[@ElvisTranscriber2]

I don't know if the criteria for the Nobel prize would apply here, but certainly a Faraday Prize is ABSOLUTELY in order. The Royal Society of London Michael Faraday Prize is awarded for "excellence in communicating science to UK audiences". Named after Michael Faraday, the medal itself is made of silver gilt, and is accompanied by a purse of £2500.

[@cathielamson9232]

The one for medicine, of course.

[@ELee-zv5ud]

@@ElvisTranscriber2 Yes, what has to happen to nominate someone? He is communicating to UK audience as I"m sure some people form there are following this. But does it have a more limited restricted definition, such as, within the UK?

[@ElvisTranscriber2]

@@ELee-zv5ud Yes, you are right. In the eligibility criteria (see link below) the tenth point is: 10. The prize is open to citizens of the British Isles or a Commonwealth country, or those who have been ordinarily resident and working in the British Isles or a Commonwealth country for a minimum of three years immediately prior to being nominated. But I'm sure there is an American equivalent (possibly more than one prize) The eligibility Criteria can be found in: royalsociety.org/-/media/awards/Faraday-eligibility-criteria-2020.pdf?la=en-GB&hash=11E885E95F6AE7CB7828BCCC5EB9BFE7

[@girlgeniusNYC]

Dr Medcram - this explains why 85-90% of people on ventilators don't leave the hospital alive. "We'll have to go back to medical school"? Never been there. Thanks Dr Medcram for making me smarter!

[@sdziewa]

Holy Crap!!! I have been watching your video series since day one....This makes sense and hope it can lead to an effective treatment. Thank you for you invite and tremendous research efforts.

[@davidcottrell1308]

wow! as usual, so clear. Thank you so much....this all makes so much more sense...every day it gets clearer and clearer what is going on....

[@mortisha8693]

Whew! I’m glad there wasn’t a quiz after this lecture.

[@liinahm3201]

This is beyond amazing, thank you so much Dr.

[@gregcampbell7034]

Ive learned SO much from these updates, thank you eternally. Even though I’m fascinated by the sciences, I actually failed secondary school (high-school) science. My only failing grade! My academic & professional background is creative (& communications), so it’s be a stretch is a stretch for me to understand every detail, but the way it’s explained I’m able to follow and come away so much more informed. Been watching for the last month and it’s SO exciting and satisfying when you refer to past videos that I keenly watched on repeat to try & learn more & more. It’s making me want to go into medicine/biology/something! Thank you again 🙏🏼

[@lyandoli24]

This man is saving lives through this communication and awareness. Thank you.

[@TheShumoby]

First to thank you for excellent content!

[@Medcram]

Thank you for your support!

[@taresy6789pp]

@@Medcram but then your saying endosome ph release can not be prevented by increasing ph in the OH hyroxy atom theory does not work

[@blastradiu5]

OMG. I love these presentations and I'm not even a medical professional.

[@jonathanantoun1367]

You are awesome Dr. Seheult. Certainly, you give great explanations about all your topics to ensure most people understand the medical/scientific terminologies. It is impressive that you can find time to create this videos after managing your patients' health. Thank you

[@markrichards8020]

Agreed - I work in a pharmaceutical co as a lawyer and I find the medically qualified professionals all very arrogant and patronising but you explain complex concepts so well than any reasonably intelligent person could understand - thank you for all your amazing work - fantastic Mark Richards

[@Asynca]

Every time I watch a biochem lecture I'm amazed that we exist!

[@laurieannJake]

Gosh I need CME for all this too!! Brilliant lecture Thx!

[@nealmonda9690]

‪Dr., please consider posting a list of latest best practices for supporting optimal immunity (with disclaimer) at the end of each video? Great work deserves a wider audience. folks will pass simple advice along.‬

[@buttercup3ish]

you are the best of teachers!! thank you for explaining for us everyday folk

[@proverbsthirty-one6531]

This was a lot of good information for a layperson like me. Seems we need something to protect Ace 2 before it impacts the rest of the process. Of course i know nothing, but I appreciate these lessons.

[@bobp5776]

In response to your post, "Seems we need something to protect Ace 2 before it impacts the rest of the process" (good thought) Monoclonal Antibodies targeted to bind to the virus's ACE2 latch,Preventing the Virus to bind to ACE2 , have been developed by Centivax and Distributed Bio LLC and a few other company's. Centivax's Antibodys ( www.centivax.com/monoclonals ) if all goes well, can be distributed as early as Sept.

[@teri2466]

Is oxidative stress what we non-medical people call "inflammation?" Thank you so much for this information, doctor.

[@tomterific390]

Excessive ROS production is indeed part of the inflammatory process. What complicates it is that LOW levels of ROS, from sources such as the mitochondria and NADPH oxidase, are part of normal cellular physiology, serving a signaling role, switching activities of key enzymes on and off by reversible redox reactions. Hydrogen peroxide is heavily involved in such normal signaling. Under normal conditions, the levels of ROS are kept under control by SOD/catalase and the glutathione redox system he mentions here. But if these cellular antioxidant systems' capacity to maintain ROS at physiological levels is exceeded, then you get oxidant stress. And that can trigger inflammation. Even inflammation plays a normal role in host defense against pathogens, and as an initial step in the the repair process after an injury, and as part of that normal response, there are steps to tamp that inflammation back down once it's no longer needed. Like excess ROS, it's when inflammation gets out of control that problems arise. Finally, inflammatory cells themselves, e.g. macrophages, neutrophils, actually do their thing by generating ROS--it's part of how they attack invading pathogens. Unfortunately, other things can trigger an inflammatory response besides an invading pathogen, and if that inflammatory response becomes dysregulated, diseases can result. Most of the big diseases plaguing Western society these days--cardiovascular disease, cancer, arthritis, inflammatory bowel disease, type 2 diabetes, autoimmune disorders, ischemia-reperfusion injury, etc. all have ROS-associated inflammation at their root. This has been recognized for decades now, and it is a huge area of research interest in biomedicine.

[@kyjo72682]

No. Oxidative stress is damage which is caused to cells by these "reactive oxygen species" molecules. en.wikipedia.org/wiki/Oxidative_stress Inflammation is a protective reaction of the body and the immune system. en.wikipedia.org/wiki/Inflammation

[@aminkeykha5546]

Tom Terific ✔️

[@Saltydogwilm]

Sarah TJ inflammation is a single type of oxidative stress due to the immune response activating neutrophil and macrophage cells which kill pathogens by producing ROS.

[@ELee-zv5ud]

@@tomterific390 Thank you for this explanation.

[@grevberg]

Amazing to be able to explain something so complex so simply and clearly, kudos!!

[@janierodriguez3017]

Thank you so much for sharing your studies. This is amazing! Dr. Sehelt, your an excellent teacher and doctor.

[@art-sm2uv]

Melatonin is endothelium protective and a potent antiinflammatory, boosts the body's natural antioxidant system such as catalase, SOD and glutathione, is a highly potent antioxidant on its own that can scavenge ROS & RNS, is protective of mitochondria and mitochondria activity, increases ATP production, helps prevent reduction of ANG 1,7 and is a potent antiinflammatory among many other potential health benefits! Please do a report on melatonin as it might relate to Covid-19!

[@wendyperkins4417]

art 100% this is why children are not presenting with CV, they have very high melatonin...very interesting xxxxxxxxxxxxxxx 💖👩🏼‍🌾🦋🎨

[@ultimohombre7498]

Could you repeat the part that comes after " Welcome to another covid-19 Med Cram update" ?

[@marynguyen6417]

The brilliantly intelligent doctor! You have connected the dots , it made so much sense. This also demonstrated the relationship between metabolic health and infectious diseases. A lifestyle which lowers oxidative stress on the body (eg. keto diet and intermittent fasting) would counteract these oxidatve stress, or at least lowering the baseline, thus putting the body in a much better position in responding to the disease. THANKS! I am your fan !

[@okidok4155]

Thank you so much for going back to Biochem. A refresher course for most of us.

[@lauriemarch4123]

God bless you and your staff for your brains....retaining all this knowledge, and simplifying it down for us .whew! 😬 We are complex and wonderfully made . Wow

[@yhc5318]

I hope when all the students go back to school they become inspired thru this trial to seek out the science, technology, engineering and mathematics field like never before. Our country and this world is getting a front seat view of how absolutely critical and important those fields are to all of humanity.

[@DawnDiggetyNoDoubt]

Thanks for all the great info.

[@debbiebailey9557]

Thank you! Thank you! Thank you! Doctor, your efforts to educate all who will listen are wonderful. I appreciate the no nonsense, no hype presentation of your research. It's truly like a breath of fresh air for my mental health!

[@ELee-zv5ud]

Retired prof. (educational psy.) Dr. Seheult is an extraordinarily skilled instructor. In the top 1 % . I’ve seen the best over the past 30 years from around the world. This lecture in particular demonstrates that. I want to thank you and your team.

[@Medcram]

Thank you for the kind feedback!

[@markkirui8348]

wow..suddenly alot of my med school biochem makes sense. An awesome presentation.

[@Evergreen64]

I've also heard that giving intravenous vitamin C can possibly help. Might this be because it is a powerful antioxidant?

[@Freeedy]

These lectures are brilliant learning whilst I've been stuck at home in lockdown. Thanks to Dr. Roger and all at Medcram for imparting all your knowledge and experience.

[@blackbart99]

Where were you when I was in college? Man I really could have used a teacher like you. Great lecture...I used to think this info was way over my head...but not anymore. I got it...I really do. This is the best thing on the web right now.

[@Medcram]

Happy to help

[@destitute8493]

If vitamin D is protective against CV, wouldn't that help explain the disparity of outcomes between black and white patients (dark skinned ppl have less vitamin D)?

[@HectorMoreno]

Destitute yes!

[@bernardocantu77]

Their ace2 makeup is different as well. Blacks are not to take ace 2 inhibitors.

[@ELee-zv5ud]

Also many white people are deficient in Vitamin D as well. In winter anyone in northern places -all of Canada, northern US until you get really far south, northern Europe, Russia etc In the summer you have to have 15 daily minutes of enough skin e.g., arms and leg exposed (without sunblock) lol. Most Australians are Vitamin D deficient because they were encouraged to use sunblock all the time ! So everybody take a Vit. D pill.

[@browndotflop]

Bernardo Cantu yes - my thesis involved looking at the attentuation of blood pressure during exercise in pts with hypertension taking ACEis - definite difference in the black subjects compared to the white subjects.

[@alainpannetier2543]

You mean, like in this study www.bmj.com/content/369/bmj.m1548 ?

[@BayAreaTraveler]

This is such an awesome review. It's like being back in undergrad again in my Biochem course at UCLA!

[@cotepm]

Amazing the way you describe hard to understand science and medicine and you give access to regular people understanding of what is happening and all that live as it unfolds. Always good to explore other avenues and see if this could ultimately be a solution. You are truly a great doctor and a great teacher. Salutations de Montréal.

[@itrick58]

Your medical explanations/ lectures are solid and clear! Thank you for your time and effort to create this content! Subscribed!