COVID-19 Update 19: ACE inhibitors and COVID-19

Hypertension is one of the most frequent coexisting chronic conditions among patients with COVID-19. Some experts have suggested that antihypertensive medications, such as ACE inhibitors increase a person’s risk of severe outcomes to SARS-CoV-2 infection.
More and more data are now accumulating that they are perfectly safe and should not be stopped. In this update, we’ll look at several published articles that demonstrate that ACE inhibitors and ARBs were not associated with worse outcomes or increased mortality.
#medmastery #coronavirus #COVID19 #sarscov2 #coronaviruschina #coronavirustruth #coronavirusdeaths #WHO #wuhan #infection #pandemic #publichealth
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Links for reference:
www.nejm.org/doi/full/10.1056...
jamanetwork.com/journals/jama...
www.ncbi.nlm.nih.gov/pubmed/3...
www.acc.org/latest-in-cardiol...
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More updates by Dr. Wiesbauer:
COVID-19 Update 1: How to tell if a pandemic is likely to occur or not-R0 and the serial interval: • COVID-19 Update 1: How...
COVID-19 Update 2: How to stop an epidemic - Herd immunity: • COVID-19 Update 2: How...
COVID-19 Update 3: Symptoms of COVID-19: • COVID-19 Update 3: Sym...
COVID-19 Update 4: Clinical characteristics of COVID-19: • COVID-19 Update 4: Cli...
COVID-19 Update 5: Estimating case fatality rates for COVID-19: • COVID-19 Update 5: Est...
COVID-19 Update 6: Seasonality: will COVID-19 go away in the summer?: • COVID-19 Update 6: Sea...
COVID-19 Update 7: This is probably the most important picture of the whole Coronavirus-epidemic: • COVID-19 Update 7: Thi...
COVID-19 Update 8: Zinc and chloroquine for the treatment of COVID-19?: • COVID-19 Update 8: Zin...
COVID-19 Update 9: Hydroxychloroquine and azithromycin for the treatment of COVID-19-Review of study by Didier Raoult: • Hydroxychloroquine and...
COVID-19 Update 10: Is COVID-19 an airborne disease? Will we all need to wear face-masks against SARS-CoV-2? • COVID 10: Is COVID-19 ...
COVID-19 Update 11: How exactly the coronavirus becomes airborne. • COVID-19 Update 11: Ho...
COVID-19 Update 12: Attack rates of COVID-19 depend on face-to-face time spent with infected persons: • COVID-19 Update 12: At...
COVID-19 Update 13: Randomized Controlled Trial of Hydroxychloroquine in Patients with COVID-19: • COVID-19 Update 13: Ra...
COVID-19 Update 14: Are children contributing to the spread of COVID-19? • COVID-19 Update 14: Ar...
COVID-19 Update 15: Can we disinfect and reuse N95 masks?:
• COVID-19 Update 15: Ca...
COVID-19 Update 16: Effectiveness of surgical masks for prevention
• COVID-19 Update 16: Ef...
COVID-19 Update 17: How an app can get us out of lockdown
• COVID-19 Update 17: Ho...
COVID-19 Update 18: When are patients really infectious?
• COVID-19 Update 18: Wh...
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Useful resources:
For checking daily developments of cases, deaths and more:
gisanddata.maps.arcgis.com/ap...
www.worldometers.info/coronav...
Other useful resources:
Journal Watch:
www.jwatch.org/na51020/2020/0...
New England Journal of Medicine:
www.nejm.org/coronavirus
Github collaboration:
github.com/midas-network/COVI...
CDC:
www.cdc.gov/coronavirus/2019-...
WHO:
www.who.int/emergencies/disea...
Nucleuswealth:
nucleuswealth.com/articles/up...
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Speaker: Franz Wiesbauer, MD MPH
Internist & Founder at Medmastery
LinkedIn: / franzwiesbauer
PubMed: www.ncbi.nlm.nih.gov/pubmed/?...
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Please Note: Medmastery's videos, medical lectures, medical illustrations, and medical animations are for medical education and exam preparation purposes, and not intended to replace recommendations by your doctor or health care provider.

[@robertschlesinger1342]

Interesting and worthwhile video. Please post a sequel video as more definitive research appears.

[@kathleenwilligreen8505]

Very good news it is Excellent video well done 👏👏👍👊🌠🙏😇🌎🌍🌏📼

[@cookies3691]

thank you for the references!!

[@chuteboxegod]

I started on Lisinopril and all of my covid symptoms came back after being symptom free for 5 weeks. Now a month after trying lisinopril which I am no longer taking I can barely get out of bed for more than 30 min. Im dizzy, light headed, brain fogged, weak and lethargic. Anxiety is really bad as well. They are saying its long haul covid, but I was fine till I tried lisinopril. Not sure what to do, something is wrong with me.

[@drdannegoita]

Awesome. That's good news. Thank you. Is there a German version of this video, too?

[@derrickarthur2295]

You probably dont care but if you are stoned like me during the covid times then you can stream all the latest movies on instaflixxer. Been watching with my brother for the last days :)

[@aaravbrodie7891]

@Derrick Arthur Yup, I've been using InstaFlixxer for since december myself =)

[@doctorvimalkatarmal4704]

nice video

[@pauldunne5230]

I wonder if excess calcium is a variable? I’m sure some ace inhibitors are also calcium channel blockers and look at the symptoms from excess calcium and compare them it’s uncanny

[@kevinfisher7032]

As someone who’s taken an ACE inhibitor for many years I’m particularly interested in this aspect of coronavirus study.. I’m glad to hear that research is underway to study the effectiveness of ARB’s against the disease. I find it puzzling that ARB’s have, so far not been shown to reduce coronavirus' effectiveness. One would think that a drug specifically designed to block the ACE receptor would reduce the ability of the virus to enter the cell. ARB's would be seem to be a perfect treatment as they have been tested for decades.

[@joantendler6518]

From my reading on this subject, ARB's certainly seem to be a good treatment. In major contrast, though, ACE-inhibitors cause the buildup of bradykinin, which then causes the exact same symptoms of COVID-19, as side effects! You might be interested in my video on this subject, because it focuses on the role of ACE-inhibitors, and their build-up of bradykinin, in contributing to severe symptoms and even death. There are many studies that supposedly prove that ACE-inhibitors are safe, but they always group them together with ARB's, which actually protect against these symptoms, so they usually find no effect at all-they cancel each other out. kzbin.info/www/bejne/aamvoGunpb1mnac

[@ahm7944]

ACE inhibitors decrease infections as they bind to the receptors preventing the spike protein from covid binding

[@Plastik13]

4:40 They could not find high level of Angiotensine 1-7 on patients taking ACE inhibitors, there is no more angiotensine 2 to be converted to angiotensine 1-7.

[@dockilat5576]

That is my question, how come there will be a need for ACE2 to be more expressed if there is a block by ACE inhibitors to for form Angiotensin2. Thus no increase of the 1-7 was found.

[@ivodepivo21]

Angiotensine 1-7 is not the only parameter that provide Clear answers. So when Science says, owh angiotensine 1-7 was normal on patients Taking ACE inhibitors it doenst mean Anything yet. Severe covid patients showed High levels of bradykinin levels. Bradykinin is brokendown mainly by ACE-1. ACE inhibitors inhibit ACE-1 function and there for stimulating ACE-2 Expression. High bradykinin, is high ACE -2 Expression and low ACE function. All covid related symptoms, especially on IC patients are related to High ACE 2 Expression AKA ACE/ ARB inhibitors, like small blood clots in the Lung vessels. Low blood pressure. Suggestion induces Medicine toxicity? And only covid virus can Enter cells that express High levels of ACE-2 Expression. Funny fact is that the virus covid particles seen in covid infected people alter gen Expression of ACE-2 by reverse transcriptase. Covid virus lowers the Expression of ACE-2 function, and severe infection of covid is only seen in people that Express High ACE-2 function and low ACE function.

[@cosmetolo-joyclassroom6573]

Has anyone here had the virus while on an ace inhibitor? What was your experience?

[@amandacoles5932]

My mother and her husband are on an ace inhibitor. Both did get covid. They both had extremely mild symptoms. One had fever for two days and they are in dialysis. Other had a cough only.

[@Akira-nw4jl]

all this science is exellent and perhaps very accurate but it all depends on how well you interpret these findings. there are about a dozen different medications that work differently in trying to reduce hypertension. hypertension is not a disease but a symptom of something else. for this reason ace inhibitors and the other medications will not work definitively. the underlying cause of hypertension should be the key.

[@ivodepivo21]

@@wk8000 the are many reasons why the body is favouring Higher Blood pressure over Normal Blood pressure. All though the symptom ( High blood pressure) is a Signal of the body to mantain A certain level of homeostase. When the Glycogalyx of the endothelial is compromised, blood circulation flow is compromised. There must be a Balance between vasoconstriction and vasodilation. For vasodilation the body needs to produce NO2 so blood flow and Oxygen Delivery is maintained. But NO2 when not controlled in a reduced form can Act like a radical molecule. This is normally regulated by the Glycogalyx. When Glycogalyx is compromised the body can not maintained Normal blood flow and favors Higher blood pressure to maintain a compromised blood flow circulation. By just give pills to Lower blood pressure and do Nothing about the cause of High blood pressure, you are telling Evolution (our body) to shut up. Now does this Sound like a good idea? I believe this we be mostly not a good idea. Why? Because I've you suppress symptoms with medication, and these medication you have to take for the rest of you're life, like ACE and ARB inhibitors, other serve symptoms Will emerge after some time. This is what a call a Universe Law. Supressing symptoms can save Lives in acute situations, but it's way better to understand why chronic symptoms occure Inside the body and what the intelligent Mechanism is behind it. A compromised Glycogalyx has many reasons, this is for every person Different. But there many Things people can do to optimize the Glycogalyx. One is, direct Sun Light on the skin. In the Summer for 15/20 minutes A Day is a good start.

[@bjoernmueller2160]

Bitte nochmal in Deutsch, parallel. Danke! 👍

[@evab2132]

Which Big Pharmaceutical company financed this video?

[@waptek2]

ok so how much did they pay you .50 ?

[@joantendler6518]

Yep! You can tell when they carefully avoid the only relevant issue of the increase of bradykinin with the severe symptoms, which ACE-inhibitors increase, causing angioedema, while ARBs are protective because they don't increase bradykinin. Instead, he reviewed studies that put them together as risk factors, even though ACE-inhibitors are the problem, while ARBs protect, so you get an overall protective effect or no effect. Avoid ACE-inhibitors-change to ARBs!

[@annunacky4463]

The ones owned by Trump supporters...

[@joantendler6518]

@@annunacky4463 Actually the top recipients of Astrazeneca, which is pretty much responsible for the pandemic (although all pharmaceutical companies share in this), are Biden, Buttigieg and Sanders. See this video for some actual facts: kzbin.info/www/bejne/aamvoGunpb1mnac

[@jimjones8268]

the truth is hidden

[@218philip]

Pure bs.

[@waptek2]

aaaaaaaand you are payed how much

[@hyderali9909]

Very Nice, informative and encouraging. Thanks