CRISPR Cas9: Will it Cure Aging? - Talk by Oliver Medvedik at D.N.A. Conference

[@LifespanIO]

If you wish to *help us end age-releated disease* please visit ► www.lifespan.io/hero Join the conversation on our ► Discord Server: discord.gg/HwTX7gR and ► Subscribe: kzbin.info

[@freemusicarchives7557]

Very exciting times to be alive. We are about to witness and participate in a major revolution.

[@DimitriBoyarski]

Free Music Archives Could be a very shitty time to be alive. Knowing what is possible but dying just before we get there.

[@wuvliving8083]

Only if the science moves fast enough man! You should come join us in the linked community in my reply above :), we are spreading the word online and increasing awareness big time!

[@stardolphin2]

True. No matter when it happens (even if tomorrow), there will always be somebody who will just barely 'catch the boat' so to speak, and somebody who will just barely miss it. That's true of any life saving development. I recall the late VP Hubert Humphrey once joking that he didn't want to be the last man to die of cancer... I'm 63, and believe that those in my age range are on the ragged edge of making it long enough. It could go either way. All I can do, is what I would do anyway. Take the best care of myself that I can.

[@DimitriBoyarski]

Robo Tamza I think if we really focused on it we'd be there in 5. But we'd far rather focus on killing each other and our environment than worry about shit like immortality.

[@thearchive26788]

Dimitri Boyarski in 5 years?

[@PhilosopherRex]

I'm going to have to watch this a couple more times. Good stuff!

[@elaine1034]

It's horrifying. What do you think is in the Moderna vaccine?... it's mRNA!!

[@PeeedaPan]

I love that he went relatively in depth

[@sofiasanchez4663]

Amazing talk. Though I would've liked to hear more specific examples of how CRISPR could cure aging. Thanks for sharing this knowledge :-)

[@christopherobrien5005]

17:58 augmentives - antiaging compounds

[@michaela2634]

The average lifespan of humans in nature was _technically_ 35 but that was only because of the ridiculously high infant mortality rate. For those that made it to adulthood the average lifespan hasn't changed much - most people died in their 60s, 70s, or 80s.

[@brewhog]

Give the man a glass of water!

[@Gangularis]

Seriously.. really making it hard to listen to.

[@hanspanzer]

all that technology but can't supply water. that's how deep humanity has fallen.

[@Max-zv1bu]

This technology is very exciting. But we are still waiting for its successful practical use to cure diseases. Hopefully the human test in China will give good result.

[@MayurPanghaal]

The genie is out of the bag.I saw supply companies selling crispr kits online.

[@richiemylove5825]

What about the one in America?

[@SpaceHawk13]

Cats come out of a bag, genies come out of a bottle.

[@JohnSmith-di8hp]

+SpaceHawk13 umm it was actually a CRISPR engineered Cat Genie...

[@bluejackscanada]

I hope it does amazing things.......My Neighbor however who is involved in Medical research says CRISPR does not have any commercial benefits. I hope he is wrong. He seems more negative than most reporting discoveries on you tube.

[@Mornys]

29:49 Audience member: "My question would be: is it possible to look at young person's genome and create a backup of the data, and as the person ages and the genome degrades, you put the old stuff in there of the back up with CRISPR or similar technology." I''ve also thought that quite a few years ago, way before CRISPR in its current form was discovered, but I figured... correct if I'm wrong... that the degradation doesn't occur similarly in all of the cells in one's body, but that mutations are in different places in different cells. I figured that since reading genome gets easier and easier it eventually wouldn't be that big of a deal to read one's genome several times from different cells, then overlap the data and then based on several samples hopefully be able to figure out what the DNA used to be despite of some mutations. Like if 9 samples have some specific section of the genome reading one way and only one differs from it, then you could be fairly sure the 9 samples which agree with each others have the original unmutated DNA in them and the one that differs is mutated. Have I understood this right? After that the presenter is then talking about "It's like data equivalent of having your umbilical stem cells frozen. In this case it's like saving the epigenetic data rather than the stem cells themselves." Does that mean that the meaningful degradation is not just about mutations, but which genes were switched on/off when the person was young versus to how they're switched when the person is old? Maybe we don't need to do that for every person individually, but just take large sample of random young individuals and check which genes they tend to have switched on/off when they were young? Maybe we can then switch the same genes on/off in genome of an older person?

[@jonjon11882]

Yeah this does seem like one very reasonable way to tackle the problem of aging. I think also however that we have to keep in mind the fact that the way aging works (from what I understand) is also based on a programmed genetic elements that CAUSE the aging phenotype directly, the question is how, is it a protein ? what molecular gene product or regulatory sequence is being interfaced that is causing the downstream cascading of degradation that comes with aging? Mother nature seems to have given us a death warrant along with life. With this in mind, is it a more practical and effective approach to target those set of genes with CRISPR like editing technologies? and like you said, not all cell types have the same epigenome, we have to ask ourselves about the differential epigenetic varations associated with each cell and connect that to aging. TLDR: this looks like it's going to take a while to figure out, and we might die before we find out how lol

[@bw10097428]

Seems like this could be easily tested in a mouse model. Have you come across this anywhere? Maybe in the short term we should focus on how to "reset" our genome instead of trying to figure out how it all works. All in good time.

[@milianedik]

Speak and speak but have not gone from experimenting with animals in more than 25 years, is that perhaps we must wait another decade, how much longer have people suffering from genetic diseases, even when we have to endure.

[@Gangularis]

Can we please get this guy a glass of water?!!

[@eileentoh7160]

I hope it will help ! !

[@googledev566]

_Please add English subtitles, not auto-generated_

[@gregorysagegreene]

***** "There's no physical reason why we can't." ***** ... Wow! Our knowledge has progressed to the point where we can forsee this! Yamanaki Factors are what's missing from this lecture wrt anti-senescence.

[@redwatch.]

Does anyone know how all the relevant brain cells would be targeted with corrective vectors to counter the deleterious effects of epigenetetic changes? In other words, how do you get to them, specifically?

[@anthonydunn729]

Targeting something like brain tissue using something like CRISPR, I've heard, is made possible through the RNA side of the molecule. It's all injected into the blood, and I guess it might bump into all the cells in your body, but only the cells with the right segments of DNA will be interacted with. Which is probably really complicated because all the cells in your body have the same DNA, they're just, epigentically different... More or less exposed or 'readable'

[@aqueento]

i totally have a question, so if the crispr system works with all DNA is it possible to take the genes that plants have to photosynthesis and use that to our advantage in humans? I wonder if maybe that could somehow help with aging as well.

[@Kenny-tl7ir]

No. That will mean turning your skin green.

[@anoopsagar8911]

​@@Kenny-tl7irI am groot 🤬

[@gbennett58]

I wish he had been able to explain some of the jargon he uses. Without that, it is really difficult to follow what he is saying unless you already know the material. This combined with his verbal machine gun approach to lecturing leaves much to be desired.

[@god_damn9661]

at 8:35 he says smth like "...this is the original antivral software literally so thats not even analogy.."!

[@BrandonSLockey]

hahahaha yea that was funny

[@shapes9495]

yes what the heck!

[@wokecults]

Love the talk. Lots of info. Thanks!

[@sarahkerr6049]

fam, im sarah kerr and you just beat doge! you are the new meme!

[@TechCarnivore1]

That anime characters face looks like Voldemort.

[@wokecults]

it's actually a doll of Yui Mizuno, from Babymetal. I'm a fan of the band. The doll looks better when you see the entire picture babymetalfan.blogspot.ca/2015/02/yuimetal-chibi-figure.html

[@TechCarnivore1]

Mikiko Jane Yeah, I know of them already. I just think they should give it a nose haha.

[@wokecults]

I didn't notice that until you mentioned it. Now I keep looking for the nose haha

[@problematic7993]

He looks great for 90. I wonder what is his secret?

[@nubianking2018]

I truly enjoy..the detailed info...

[@sagesolomon8070]

Sign me up for stopping aging.

[@aolcb]

I would volunteer as well

[@whatthefunction9140]

this is so huge. epigenetics is everything.

[@sheraawrr2009]

The video and explanations are overall good,but the pictures you used are quite complicated and could be replaced with better ones,but yea that was actually good thank you

[@MrApplewine]

Just tell me if CRISPR Cas9 can be used to turn on telomerase in all our cells and thus cure aging.

[@y.g.1313]

haha- I just thought the same thing !! Thank you for sharing your idea. I find it astonishing that in gazillion of 'super-scientific' presentations from G.Church, J.Doudna and many other 'luminaries' , TED talks, Davos etc nobody has yet identified this obvious gaping omission in their reasoning. (or maybe they are working on it secretly ;-) Advanced educated consumers - like you and me (smile) - are going to power the world of science forward, which is why one of the main initiatives of lifespan.io is 'crowdsoucing'. And we 'ain't seen nothing yet'- the power of gathering bright ideas from internet users is just getting started to be harnessed. The unfortunate point is - our comments here probably will not be noticed by the likes of George Church or Jennifer Doudna - that's why I will have to start my own VC financed biotech. I got tired of waiting for those 'geniuses' to deliver what matters - meaningful robust healthspan extension of super-centenarians (since all the younger groups can achieve this, no dbouts, faily easily, if they do all the right things). It seems the 'geniuses' now spend more time in courts fighting over potenital gravy-train of 'patents' and fundrasing for their own startups, rather than moving the real science forward. **Cheers**

[@mjoscifi]

George Harris - well said. Proud of you for taking the initiative, it sounds like you both are on to something very promising.

[@JDEZ512]

I also am thinking ok after 3 billion years were finally here, nobody seems to have a sense of urgency to expand lifespans like oh ok I'll just die. I guess can't sway all the minds of men but we know and move forward trying. Millions of souls will thank us later.

[@ron1313]

One would think we could redirect our 20 trillion budget of which 10 trillion goes to defense, to at least spend 1 trillion on curing aging. There are some promising treatments in the meantime. Some researchers are using Planarian worm DNA & others (Dr. Riordan) are doing stemcell treatments using umbilical cord blood. So one could fast, eat keto & do calorie restriction until they find a cure. "Planarians are also an emerging model organism for aging research. These animals have an apparently limitless regenerative capacity, and the asexual animals seem to maintain their telomerase levels throughout their lifetime, making them "effectively immortal

[@ron1313]

​@@y.g.1313 Did you start a fund? What's the minimum investment?

[@smorrow]

Did the guy at 31:50 say Super Nintendo?

[@boop9000]

SENS technology will create regenerative therapies to extend human life beyond 200 years

[@bluejackscanada]

Interesting. If you are still alive 200 years from now though, would they not have new therapies in 2216 that would allow you to live even longer? Unless of course you get hit by a Google driven truck. LOL!

[@boop9000]

true

[@sebastianpye9328]

Yes Aubrey de Grey calls it Longevity escape velocity

[@AgingsAProblemFPS]

Let's become immortal.

[@boop9000]

@@AgingsAProblemFPS let's do it.

[@mulanszechuansauceisthemeaning]

I can't wait to see further development of Crispr Cas9

[@sashagertzina5558]

Vanga said about that in 1991

[@carmenmoldoveanu4897]

So is for good or for bad?

[@JorgeRamos-xw6dy]

So is pharma against this technology?

[@simicpetar]

What about the dangers of this kind of gene editing. Since the research is getting cheaper and faster, therefore more accessible to people. What if someone accidentally, or on purpose gives this ability to cut and alter genes to viruses ? In other words, can this defensive mechanism of bacteria become an offensive mechanism of bacteria and viruses ? And what about the emotional state of a 1000 year old human, if taken into consideration the amount of trauma they would endure in 1000 years ? Is there some sort of ethical committee that will monitor this new technology ?

[@arlle6235]

From the religious point of view I would say that Adam lived for 930 years, so i dont think there is a problem

[@junaidur-rehman3457]

Petar Simic Scientists such as Jennifer Doudna who are the pioneers of the CRISPR technology agreed to have a meeting in December 2015 regarding the ethics and issues regarding CRISPR-Cas9. I watched a speech she gave and she mentioned how she thought the technology would be used in human genomes within the next 10 years. It's a scary thought because the responsibility with breakthroughs such as this is immense. Imagine that responsibility falling into the wrong hands. The results could be devastating

[@simicpetar]

Well since you think ethics are just "standing in the way" of progress, can you sincerely tell me your exact age Mr. Zivkovic ?

[@Rohankumar-dd2ss]

If u do not want to live then sucide

[@nubianking2018]

Let us investigate this more.....go forward in living desease free...

[@johnvandenberg8883]

Wouldn't it be much more helpful to give us a good view of the slides presented, instead of continuously zooming in on this guy?

[@jackcambric8480]

We need biological 3d printers and crispr Titanium bone replacent.

[@PeteNalty63]

If there areclinical trials to study this in live humans, sign me up.

[@Ketofit62]

Do you like these educational videos Austin Odd work?

[@andycrabbe100]

Yeah but does it cure aging?

[@dinomiles7999]

AI is here to stay and improve our HEALTHspan . We must stop SELF Dastrutive Behavior . We are ALL addicted . Bryan Johnson, Blueprint... Show me the data. See you in 2500. Love you all .

[@problematic7993]

finna get my crispr kit and make my own virus

[@velavanlaack9134]

By looking at the speaker, dare to say, no hasn’t cured ageing

[@hehbol]

Cure aging? Since when is a disease?

[@fahrenheit9646]

Degradation of DNA integrity over time is responsible for most age-related declines in performance and health. Age is something we can solve.

[@jonasantley2139]

tre if knowledge of good and evil and the tree of everlasting life once man eats from the seccond surely he must be destroyed. quote god in genesis hooah. were all fkd now man

[@alanmoore9734]

Want to live forever? Talk to Christ.

[@MelissaR784]

Only for the billionaires. While the rest of us will be turned into obedient workers.

[@alanmoore9734]

I'm going to marry a girl with enough dog DNA to remain loyal.

[@beyondspace4088]

😂

[@jacobstaten2366]

The spit making noise in his mouth is very distracting.

[@TELEVISIBLE]

Think of lots of asshole will never die ! I feel sick

[@TheSpicyPotatoe]

Hahahaha they aging tech will be for politics and first class .

[@TheSpicyPotatoe]

+Jon Cognac don't compare our primitive technology to something that will make you immortal. Such a simple minded statement

[@TheSpicyPotatoe]

+Jon Cognac lol yeah but we had no idea the potential of the Internet . We are prepared to keep this tech away from the public for a LONG TIME . Probably for another 50 years or 70

[@TheSpicyPotatoe]

+porquilho that was a terrible analogy. We were irresponsible back then and atomic bombs are not hard to spot . Immortals can easily mask their identity.

[@paulfitton8276]

Monsanto ,tried to buy it,but was stopped by then Pres. Clinton, saying...."this is for the people ! "What 's happening now, but if a foundation isn't formed we'll lose it

[@TAKEmeTOtheMORGUE]

Aging can't be cured since it is not an illness.

[@professorscambuster3063]

That's just factually incorrect and I'm disappointed people have let you get away with such a statement for a year without correcting you.

[@gcoon760]

be careful I think this is why people will desire the mark of the beast? We arenot God.

[@healthyskepticism7703]

We are trying to make this world a better playce, something your God was unable to do for 2000 years...

[@jacobstaten2366]

We are simply using the tools God gave us.

[@udaykadam5455]

@@jacobstaten2366 Is GOD again pulling stuff out of his ass?

[@jacobstaten2366]

@@udaykadam5455 if you're going to post something, you should try and make sure you can intelligently articulate whatever point you think you have.

[@jackcambric8480]

We not God but God gave us the code and intellect for a reason.

[@imagination7710]

Aging is not a disease.

[@kingwillie206]

That is debatable, but the fact that aging causes diseases isn't.

[@imagination7710]

No shit

[@sebastianpye9328]

No, but it causes most of the worst and most common diseases

[@stardolphin2]

Technically, no. But like a broken arm or other trauma, it *is* a physical condition worthy of treatment.

[@warioland523]

It's a disease that is a risk factor for other diseases.

[@TPerm-hj4sf]

Fake news

[@professorscambuster3063]

Rejuvenation biotechnology is very much real.

[@udaykadam5455]

Fake person, must be bot...