Cystic Fibrosis Mechanism and Treatment | HHMI BioInteractive Video

[@iwo612]

My child was diagnosed six years ago and I’ve never seen anything with visuals that are this clear and with such succinct explanations. The CF clinics should use this for newly-diagnosed patients.

[@SunilKumar-zs5vh]

Sorry but can i ask how is your child now ?

[@CFlifestyleFoundation]

This is an amazing visualization of what is happening inside the body of an CF patient. Thank you.

[@andrewwarner3187]

Your videos are absolutely beautiful. Well done on the quality, keep these up. My students receive wonderful visuals with the help of your animations.

[@Vee-v3k_]

hats off to those editors who made this for us !

[@parast09]

the visuals are mind boggling

[@ryan3.082]

This is the best, most succinct visual explanation of CF I've ever seen. Thank you!

[@biointeractive]

You're very welcome!

[@mjdmjd02]

videos like this are why i love medicine !

[@marielat.fuentes1090]

Just like this, understanding CF has become easier. Thank you!

[@sirmeowthelibrarycat]

😺 Remarkable development in understanding this dreaded condition. Education and intelligence combined to great effect!

[@fusion2x]

This is a very clear explanation of CF! Thank you

[@biointeractive]

Glad it was helpful!

[@LilyGurungMomogurung]

awsome animation!

[@NovaBio]

Great explanation

[@CosmoH0103]

Great explanation with beautiful visuals.

[@biointeractive]

Glad you liked it!

[@Sanquezo]

Cant believe people would hit thumbs down on this

[@fxbiani]

Probably because they were forced to do this, lol I was, but I thoroughly enjoyed this and really appreciated the high quality images in it, so I'm not one of them!

[@thatsme2347]

Because this video is TERRIFYING

[@bello-adeotinasirat1961]

But none did

[@dwreborn9077]

Cleared my concept🙏🏻😆

[@samahnour5423]

wow , well-explain video!! keep up the great job!

[@biointeractive]

Thanks a lot!

[@snehakumari5136]

Wowwwww👍👍👍👍👍 loved it

[@5602KK]

Incredible visuals

[@tazl624]

What an amazing animation

[@rgvn5]

What a nice video OMG

[@findsomethingonearth8667]

👏👏👏👏👏👏👏👏👏 nicely explain 🙏

[@samgnanaraj]

amazing animation

[@justsomeone2001]

Thank you so much! I’m doing a level bio and visuals help a lot with understanding ❤

[@skrame01]

It's amazing the human body works at all.

[@meowm3426]

wow, thank you :). I read half of two papers about CFTR and still didn't get how it's regulates water, because the paper was too in depth about signaling cascades and localization in apical membrane. I still didn't get how it regulates water. But, I just found the answer from this video, through osmosis and salt regulation. I'm too dumb to remember that aquaporin should exist everywhere in membrane and yeah, salt attracts water. And water can pass through this channel right?

[@RK-ep8qy]

water will go through the aquaporins not the Cl- channel/CFTR. and yes the slightly positive hydrogens in water are attracted to Cl-

[@RubyKumari-mz4co]

Wonderful animation...

[@monikabhardwaj8036]

Awesome explanation..

[@monicadupont9606]

Thank you for this video. 🙏

[@kikibear12146]

Amazinggggg videooo!!!!!

[@emmameubank]

Researchers tested over 200,000 small molecules to see if any of them would bind to the CFTR protein. Then for each small molecule that had some binding ability, researches chemical synthesized different variations of that molecule and tested them. They identified a drug that when taken by patients with a certain type of CFTR mutation, binds to the CFTR protein, opening the channel and allowing improved ion transfer. This increases chloride ion flow and maintains a watery, clear mucus, which helps the cilia move more freely and reduces the risk of bacterial infection.

[@keithp6699]

Kaftrio?

[@LoreNigo]

Thanks a lot! The video is very interesting and educational. I wanted to know if it is possible to subtitle it in Spanish.

[@biointeractive]

It is definitely on the short list of resources that will be translated to Spanish. I don't have a timeframe for when that will happen, but it is in the works.

[@rogozencojasmin9298]

I have CF and there is no available cftr modulator for my mutations 😭😭😭😭😭

[@ritikabounthiyal6427]

Just fabulous

[@Dreamgirl310]

I am suffering with severe cystic fibrosis, nasel polyps and lung infections.. I need the medicine that is made after research on this.. Can you provide me?

[@alainamead8705]

Anisa, have you talked with your doctor about Trikafta? It was just approved for 90% of CF patients and has shown incredible results!

[@ramidimahenderreddy38]

Tobramycin bid...u want ping me

[@iwo612]

I’m so sorry you’re going through this. It all depends on your mutations, and you would need to discuss with a CF doctor. CFTR modulators is what they are called. The mental health side effects from the drugs were so bad we had to take our daughter off.

[@cheerybellerellegue8309]

Hello and good day.. I am Dr. Chaey Rellegue of DepEdTV Philippines. I would like to ask permission if we can utilize some contents of your video for educational purposes for our senior high school learners? Thanks and more power

[@biointeractive]

Our materials are free to use for educational purposes. All videos and other resources are freely downloadable from our website: www.biointeractive.org/

[@cheerybellerellegue8309]

@@biointeractive Thanks you so much.. More power to all of you.

[@Krishnaaaaaaaaa]

Please upload more videos

[@DeniseAngel-d9w]

THANKS ALOT

[@spypipi2714]

Ty nicely understood

[@njanimeluvr723]

Great animations. But the drugs name? Find out in the next episode of Dragon ball Z Jk it must be ivacaftor or lumecaftor if you wanna know

[@lilsinny]

Epic

[@هالة-ش3ب]

Great

[@ShortVideos-cv7vj]

so why Cystic fibrosis Have Stomach Problem And Why They take Medicine Before every meal?

[@maindortv7427]

The cause is exudation of fibrin in different organs and tissues that cause that. If we focus on removing the excess mucus on those body tissues, I think that’s when we start noticing some change on the body. By consuming the nutrients needed like potassium chloride because I think, no new fibrin can be created without potassium chloride. By bringing more potassium chloride.. we are bringing back the balance on the body. Because when potassium chloride is not available in the body, the nature will try to take potassium and chlorine in any parts of the body and then that’s when the unbalanced get in the body. Many diseases start creating for no reason. I think aquatic herbs are one the best nutrients carriers like bladderwrack, Irish seamoss and many more. Then you have to follow those blooming flowers. They re going to heal you. Lilly of the valley, comfrey, elderflowers and many more.

[@ovuvuevuevueenyetuenwuevue1158]

Human body is amazing

[@kentheengineer592]

Keep in mind the way you get bacterial infections is caused from your own microbiome as apposed to environmental issues

[@sabrinahassan4580]

Wait ..so the water will move into the cell?

[@tandemdwarf745]

Yes, the lack of chloride transfer leads to the cells absorbing water via osmosis.

[@tranghuyen-qu1ij]

the video image is too poor, you need to fix it more

[@fadwa_4]

Thhhhhaaaaaannnnnxxxxxxxxx

[@Jaykidd7]

We got all the way to the end for you not to tell us what drug will help us😂

[@muhammadhanzla9631]

❤️

[@FollowTheKnowledge]

Why not tell us what the drug is called 😅

[@faq2468]

Mr Burns Biology anyone?

[@ju6284]

we all should drop our religions and gods and worship those people who always make molecules like that !! no joking !

[@theredneckdrummerco.6748]

cool cgi bro

[@SharonThompson-q9b]

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