DNA Damage Response

[@Biswajitminecraft]

Just finished Hidden DNA Potential on shirlest and it's incredible how much insight is packed in there. My mindset and lifestyle have shifted dramatically. This should be on everyone's reading list!

[@IyyappanSathya-bj5er]

Thank you so much

[@aditipatel9585]

Thank youu

[@bikasshit4328]

shirlest have some really good stuff

[@NameJeff-XD]

Get some B17 proteine, give the body what it needs and it will repair itself.

[@simpleidea2825]

Thank to all those doctors and scientists that enable us to understand our complex body and also saved millions of peoples.

[@mr_derpaderpy4107]

doctors dont discover diseases or find their cures, scientists do

[@artemack9358]

@theeditor1072what for?

[@ritu-p6013]

@@artemack9358 to give us brain and all knowledge

[@Rikka_V1]

I hate those scientists because now as students we need to study all of it. How tf did they discover these anyway. They should had just focussed on politics to save people instead.

[@Goutham1826]

@@Rikka_V1 you should be 9

[@danielpopadic4314]

I love how you can explain such difficult to comprehend topic to people with 0 health knowledge by using animations , if I had to learn it from book or just text I would waste hours trying to picture 🖼️ the movements in cells

[@outofthebox9699]

Yeah and it just randomly evolved, just like Smart Phones.

[@sahasra_loveyourself_]

Yes fr

[@derickd6150]

@@outofthebox9699 Ahhh right and we also just randomly found dinosaur bones that the same science that made this video also tells us is millions of years old, not to mention various shaped skulls dating back hundreds of thousands of years. You can't pick and choose which parts of science you believe

[@outofthebox9699]

@@derickd6150Get lost sick punk, ur brain is too dumb to understand what I said.

[@el_chico1313]

@@outofthebox9699 ur stupidity just randomly evolved like a byproduct of nature u clown

[@alienspecies6872]

As a biology student I can say this is amazing.

[@outofthebox9699]

Yeah and it just randomly evolved, just like Smart Phones.

[@vunknownvictory]

I hate that I can understand in KZbin, but not in class😅

[@bittertruth4847]

@@outofthebox9699 sound as logical as god allowing marriage between a 6 year old and a 54 year old 🤡

[@Dyson2024]

As a maths students this amazed me also

[@UV_Lightning]

@@outofthebox9699 Yes, through billions of years of trial and error.

[@anuskaroy7640]

God bless all doctors, nurses and good scientists

[@blueshoregaming1591]

I love how you said "good scientists".

[@as_if]

Good doctors, good nurses

[@Lousy_Bastard]

Plenty of bad medical professionals about this planet at this present time, who will never be forgiven for what they have done.

[@ariankhan8371]

@@as_if before good doctors and good nurses You should say good scientist than say doctors and nurses Scientist test science before doctors than doctors apply that tested science on patients Big salute to scientists who pulled humanity from pandemic

[@thakursakshi_997]

Good teachers are also in the line of blessing🙌

[@kookimers6809]

This is all we need...well done!! Even non medical or bio student/person can understand these easily

[@rgw5991]

men get cancer too. sheesh.

[@colbyandbrennen3543]

The human body never fails to impress me learning through animations like this

[@wakzies]

SHOW YOUR HUMAN BODY 🔥🔥🔥🔥🔥🔥🔥🔥🔥🔥🔥🔥🔥🔥🔥🔥🔥🔥🔥🔥V

[@JoshCaiLovzu]

0:50 homologous recombination repair... the solution is just jaw-dropping

[@indiabiologyexplains5013]

It's also essential in CRISPR cas9 editing

[@unitedstatesirie7431]

Chlorine Dioxide pulls away the ELECTRONS from the Cancer cells. No harmful effects to body parts. This is the hidden cure for all types of Cancers.

[@mihaelwolrk2143]

@@indiabiologyexplains5013 One question, with CRISP you can change your hair from curly to straight.

[@3alaiyer]

Indeed, God is the best of creators.. We’re not even aware all these things are going on in our bodies

[@unitedstatesirie7431]

@@3alaiyer if you want more cure details send me you e-mail address.

[@BillKinsman]

My mother, grandmother and sister all have this gene mutation. I may in fact have it. It is incredible to know what happened now. It is hard to believe how much progress has been made in the past 50 years.

[@alexshapiro9841]

The only thing hard here is your stupid brain

[@UnpluggedAi]

kzbin.info/www/bejne/iaixiWWdiMeaqdE

[@Donotdisturb12441]

I just love how to make it easy and explain each and everything (it's causes and treatment)

[@dis9078f]

As an engineer student I find it absolutely mesmerizing

[@ZenithalPoint]

Everytime I see this sort of video, I feel like continuity of my existence as a lifeform itself is some kind of miracle and I could die any second in afterward

[@happinessallover]

Not a biology student but understood what these people explained.

[@alexshapiro9841]

no you didn't, FOOL

[@happinessallover]

@@alexshapiro9841 LMAO DED.

[@monolinny1817]

@@alexshapiro9841 kzbin.info/www/bejne/iIqnqpKkocyca7M

[@lucienkennedy1997]

@@alexshapiro9841 Stop gatekeeping

[@bibaRU]

​@@alexshapiro9841what is hard of getting it? If DNA isn't getting repaired cell becoming a cancel cell.

[@nimishnandedkar9278]

Our body is so fascinating . Respect for my body is increased after this video ♥️🔥

[@tphone6717]

Not for the Maker?

[@_emminowithoutl4995]

@@tphone6717 don't exist...(wait are u talking about parents?)

[@tphone6717]

@@_emminowithoutl4995 you have a surprise waiting

[@outofthebox9699]

Yeah and it just randomly evolved, just like Smart Phones.

[@salmanwatto6214]

@@_emminowithoutl4995 what about the ultimate maker ( also of our parents )

[@WriterWriter4]

I bear witness that there is no god but God, alone without partner.. Glory be to God and praise be to Him

[@gibbogle]

Tottaly stupid comment on a scientific video.

[@ramunasstulga8264]

To which God do we pray? Allah? Jesus? Holy cow? You name it!

[@xinking2644]

I can't explain how useful these video are for me to understand this complex theory. thanks, million times!

[@mathewjoseph2237]

This would have made high school biology class so much easier to understand.

[@ttsuter87]

Hopefully this type of learning helps further our understanding of these conplex topics. Visual learning is crucial for so many people.

[@ramunasstulga8264]

Oh bro if you are struggling to understand high school material then university material will be incomprehensible

[@mathewjoseph2237]

@@ramunasstulga8264I actually have a few degrees and a certificate of completion under my belt. Also, you lack a vast amount of knowledge and intelligence. Smart people appreciate those that can actually appreciate this type of material. Also, smart people don’t need to use the word “bro” when dealing with, and describing, something as complex and complicated as cancer. Cancer is extremely complex and complicated to cure. It shows that you really shouldn’t make extremely mindless statements. This is not high school science. This is honors biology. I have taken such a class. But, cancer was not discussed.

[@OmBirajdar]

Understanding biology by animation is genius

[@emperordrone1159]

thankyou for being so much better than several other explaining this

[@Nymus3D]

You are so welcome! We do our best! :)

[@computerheadman1601]

The animation and explanation made it easy to understand, great vid 👍

[@noble2694]

Man the animation is so sick and beautiful. Thank you very much.

[@up5619]

If this is an ad, it would be the type I would actually watch.

[@LoneFifteen]

All of this technological advancement, and my mom still died after being given the same treatment that they've been giving patients for fifty years. We need to push treatments like this to more people who need them and make them more wildly available.

[@juliandiaz1457]

A todo el mundo

[@toota1052]

😢

[@noname8354]

Bro tysm for making this video. I'm going to be writing a literature review on PARPi and BRCA1 cancers so this video helped explain everything in a very simple way

[@ranjanasah5619]

The way of explaining this topic, is just amazing 🌼

[@OtlotlengNtshabele-u5k]

This is really impressive, and as a biology student I now understand the diseases that might affect cells of DNA and the prevention process.

[@brukujinbrokujin7802]

People dont realize that DNA is language of the Gods.

[@Inspiration.U]

Very informative..learning in innovative way..really explained well in best ever experience..commendable and appreciable!!

[@rubiks6]

You cannot tell me this is not designed by an incredible mind. The work of God is clearly seen here in the various DNA repair systems.

[@TejramKamble-h3i]

The insights in Hidden DNA Potential on shirlest are mind-blowing. Ever since I read it, I've been implementing its principles in my daily life. It's a must-read for anyone looking for real change.

[@amiramiro8843]

Thank you for that amazing and easy explanation of this ❤️❤️❤️❤️

[@SGArt9675]

I've been on a quest for personal growth, and discovering Hidden DNA Potential on shirlest was a game changer. This book has influenced every aspect of my life. Can't recommend it enough!

[@marcelnowakowski945]

Absolutely fascinating! Thank you for this awesome animation!

[@TrondHelm]

Brilliant video, awe inspiring.

[@Nymus3D]

Thanks so much!

[@mmd123king6]

@@Nymus3D do they have a copy of the dna from the PCR or they just copy whatever was damaged from the dna?

[@mmd123king6]

@@Nymus3D thank you so much for making this veidio ❤❤❤

[@fullentertainmentbyat4067]

kzbin.infocD7vOkhYZpA?feature=share

[@rubiks.cube0008]

Such designs so complicated and seem to be moving on its own with such delicate and amazing feats yet humans concludes that this is the result of random elements and dust clustering on its own with the help of time, lightning, heat and light is enough to produce such intricate work of arts.

[@terryliu9015]

does anyone else find these things so fascinating? to me it feels like a fairy tale where everything just works out perfectly

[@gibbogle]

Not all the time. People are constantly dying of cancer.

[@allenjiang7017]

As a science history and biology student (even though I have more lessons) this is amazing.

[@Aviink]

These calm me down for some reason and so do "How It's Made" vids.

[@dr.devendrasharma6367]

Simply Beautiful in every aspect, from science to animation.

[@sahilraj2355]

Bro why do you have only 11k subs you deserve 11 million.🥺

[@misskakouei6638]

that was an amazing show, many thanks for your attempt to prepare it🙏💖

[@XY-yg1ci]

really helpful!!! better than textbooks

[@thakursakshi_997]

Thanks for this beautiful explanation 💓

[@Algebrainiac]

This is amazing! Props to the animators. Amazing explanation

[@jasonvoorhees8899]

Please put such videos in a playlist.

[@BamiAndCheese]

I was actually busy studying on this EXACT subject for biology, so I appreciate this video *

[@nirbhay_raghav]

Although it is not that simple as stated in the video, I loved the animation and narration.

[@noname8354]

Ofc it's not that simple we're talking about biology here. That said, this is a very good summary of what happens and proves a great foundation for people to learn more if they want to

[@cibeleanjos3051]

Thank you for video I am student of nurse and these video animations help me of lot🙌

[@droctowiz5968]

I don't understand why the healthy cells can repair the double strand (BRCA1) when the patient has hereditary malfunction which caused the tumor in the first place

[@XavierAway]

Thank you for not dumbing it down

[@masoomshabir7221]

Love this video I'm happy knowing treatment for the deadly cancer. This is science of next level

[@chynnadoll3277]

How great Thou art, indeed Heavenly Father❤❤❤❤❤❤

[@cks2020693]

easily 10 hours' worth of grad-school medical knowledge explained in under 4 mins

[@jyotigupta7821]

I loved the way of her explanation by 3D demantions

[@Tarik360]

Super fascinating, normally I'm not Squamish but somehow this makes me uncomfortable seeing the DNA get damaged.

[@ashudhaliwal9524]

It's super amazing to understand the concept of biology ♥️❤️🥺❤️

[@mathisnotforthefaintofheart]

I find cancer one of the most scariest diseases. And I have adjusted my diet accordingly. Lots of fruits and veggies, very little red meat (and meat in general), fish and eggs are fine. Once a month soda, rest green tea and water.

[@kjj26k]

The only thing more insane than the complex specificity of cellular biology is that we are able to, from our human scale, be that specific down there in the micro world.

[@PortableKonfidence]

Extremely clear and understandable. Thank you

[@Heroesflorian]

I can't help but think that explanation is missing a crucial part. It says some patients lacking double strand break repair functionality due to their inheritance is what causes the cancer, but then proceeds to state that the ability to repair double strand breaks is what prevents all the non-cancer cells from dying as well. Without additional information, those two statements feel a bit contradictory to each other: An issue caused by the inherited lack of an ability is fixed based on trusting in the very same ability the lack of which caused the issue, and killing anything with a lack of that ability.

[@edenleave2054]

Wow this explained it better than my medical school

[@letstalkourself]

I love it what ur going to explain how magic is this i didn't understand this magic when I am in class

[@sandrori]

Awesome repair mechanism! It is hard for me to believe that it evolved by chance - randomly...

[@ithasbeenwritten222]

oooo Agreed It does my heart good to find a comment like that here. ❤️ i have collected lots of goodies like this one at ithasbeenwritten.com on the creation page

[@MODEST500]

yeah becoz u dnt need to believe in it religiously as the science isnt settled yet . Modern day theory of Neo darwinism does a decent job in explaining the survival of the fittest but does a poor job at explaining the arrival of the fittest and Origin of Life , btw dnt be get taken away , Neo darwinism is not the only model of explanations , their are many other models who are never known enough and never talked about becoz academia's fanatic Religious devotion to Darwinism alone. this is just one aspect of Cellular biology and i dnt have enough faith to bank all of it on chance alone , for those who have it , Good for them.

[@bluellamaslearnbeyondthele2456]

Surely it didn't. What evolved first, the PARPs repairing the genes or the genes producing the PARPs and all the other parts of the cell? I mean, there's some irreducible complexity right there...

[@EddyKorgo]

You are right. It didnt evolved randomly. But systematically. Like puzzle.

[@ridwan6695]

Its not by chance it is Allah who gives life and death and this is the truth if you will then believe and if you will then disbelieve

[@lifeisbeautifulcountryside9261]

Just recently this february my sister in-law passed away due to this cancer...we have done everything the doctors tell us bit nothing happy it became more disastrous ,So painful and heartbreaking for her kids who still baby.😭😭😭😭😭

[@abdomenebadellah]

first : Amazing animations second : which software you use to make such ones?

[@crnttox]

blender

[@abdomenebadellah]

@John Wick Thank you☺

[@abdomenebadellah]

@@crnttox Thank you☺

[@shadysaar]

Nymus 30 in motion

[@mariaavini9163]

Sono passati sei anni e cosa è cambiato? Io vedo intorno a me molta più gente di prima che muore di cancro😢. Vicini di casa, amici e tanti giovani.

[@Gamer-xk8bk]

It is really hard to believe that this stuff exists in our body. As a hater of Biology, i can say that this is pretty amazing.😀

[@lingo4770]

Hi Gamer

[@hirotashi5950]

how can you hate biology? what did biology ever do to you?

[@vdofficialchannel9841]

@@hirotashi5950 It gave me Boringness

[@scrambo6182]

@@hirotashi5950 technically biology did literally everything they've ever experienced

[@luisangelcanedo6249]

​@@hirotashi5950 From the moment I understood the weakness of my flesh, it disgusted me. I craved the strenght and certainty of steel. I aspired to the purity of the blessed machine. Your kind cling to your flesh as if it will not decay and fail you. Even in death I serve the Omnissiah.

[@MODEST500]

you aall are so good at ur JOBS damn !!! May God bless you and reward you for your work . stay safe .

[@terozak4140]

Wait ... Cancer appears when several self destruction "data" has been damaged, the DNA has more then just one protection mechanism.

[@autismunion]

Perfect!! God bless you

[@Nymus3D]

Thank you Anwar!

[@autismunion]

@Imperial Terra it is just figure of speech, I dont believe in god either

[@_emminowithoutl4995]

@@autismunion lol

[@_emminowithoutl4995]

@@autismunion me neither brother

[@gibbogle]

Nutso.

[@zoem491]

The graphics are amazing 😮

[@3dgar7eandro]

Wow 😲😳 or bodies and biology are actually amazing!!!

[@areebaaziz6796]

Now I come to know that how breast cancer arises and repaired you have explained very well

[@Hannodb1961]

How amazingly we were designed.

[@gibbogle]

We were not designed, don't be foolish.

[@Hannodb1961]

@@gibbogle Anyone who knows anything about the function of biochemistry, and believes that it all just created itself without a designing mind, believes in magic and has blind faith in the religion of materialism. Life were obviously designed.

[@gibbogle]

@@Hannodb1961 If anything is magic your god is. I do know a bit about biochemistry. Evolution is hard to understand, but supernatural non-material entities are impossible.

[@ttsuter87]

This is all amazing but how these proteins know that’s there job to repair DNA is amazing to me. How the is a subtle chemical process that causes this specific action is amazing. DNA is a wonder.

[@strong_241]

Glory be to God, the best of creators ✨

[@mahadevaswamymahadevaswamy2313]

The way Hidden DNA Potential on shirlest has changed my life is unreal. It opened doors I didn’t even know existed. Wish more people knew about this gem. Must read for anyone on a journey of self-discovery!

[@kritimishra7038]

how come BRCA is active in the normal cells of the affected individual?? isn't he receiving the PARP inhibitor to kill cancer cells arising due to lack of BRCA function?

[@stanly1543]

stellar graphics!

[@-RightWay-]

Thank you Most helpful video 👌🏼👌🏼👌🏼

[@ok-ns7ri]

POV: you're the first to fall asleep at a sleepover (rookie mistake)

[@colinmerritt7645]

Our bodies are amazing!

[@realitycheck7176]

Indeed god is best creator.

[@vaishnavisingh9433]

Wow what a logical technique to get rid of Breast Cancer.

[@morganh0421]

These organisms are living quite an interesting life!

[@雪アンアン]

My mother has a breast cancer, and i rly hope for a treatment soon!

[@dairms]

Wow, this is absolutely fascinating.

[@manjuyadav6948]

This is the best video🎉😊 0:29 0:29

[@nasanidgoirnightspring1359]

imagine a foreign construction engineer comes to save the day of those defect cells

[@ag-bk5wf]

Amazing how the body works.

[@duyenbui9879]

Wait a minute! You said the BRCA in "this patient" is already not working (hereditary mutation). This should also apply to "normal" non tumor cells in this patient as well. So the 3:02 part where "these cells still have active BRCA1 proteins" is totally contradicting the first part of the video.

[@Tom--Ace]

I spotted that too, was wondering if I was alone

[@kritimishra7038]

exactly!! it's a blunder

[@CY1RG]

3:03 i thought the patient has BRCA1 mutations? why are the surrounding cells still having active BRCA1?

[@МариамЗссам]

i think , in the begining all cells got active BRCA1 , then when one cell gets mutation, it becomes infected , other cells gradually started to get infected. for example let's assume the total number of cells are 50 cells , and one cell got mutation , after some time , 5 cells will get mutation and there will be 45 healthy cells , then after some time 10 cells will get mutation and 40 cells will be healthy and that 's on , i'm not really sure about it but that is what i think , please google it to make sure

[@edmunda9573]

exactly, that was my first question. patient has a detective BRCA1 mechanism (which causes cancer). doctors then disable her PARP mechanism. that leaves patient with no cell repair mechanism. wth. please, explain for ignorant

[@melissa3401]

I was wondering that too. If it's hereditary that means your BRCA1 is broken from the very beginning. Or is the second allele still working causing a form of mosaicism? Also, is BRCA1 specific for breast cells?

[@Zer-py2dk]

This just proves that the human body is smarter than the human itself

[@melan0SK]

This is more than 5 classes our professors try to put lot of stuff into our brains

[@deeprollingriver52]

We should all be amazed and revere our bodies.

[@upendarkumar-on9ks]

Background music.. exited..❤️

[@-BigIi-]

The Creator is amazing... truly God Almighty.

[@ExploringworldwithSWAT]

Underrated channel 😔

[@brendataylor1467]

Very well explained easy to understand Thank you .

[@jonayedrejaul7681]

That explanation is really great🥰

[@shivbaviskar2582]

I did not understand this topic But after watching this video I understood everything🎉