Dantrolene & Calcium Channel Blockers (CCBs)

This video explains the mechanism and indications for the ryanodine receptor antagonist. This video also explains the mechanism and indications for dihydropyridine and non-dihydropyridine calcium channel blockers.

[@dryaminivs7852]

I was looking for Malignant hyperthermia and this gave me a wholesome understanding.

[@physiopathopharmaco4190]

Thanks for the feedback!

[@collho]

This was such a clear and succinct explanation. Fantastic

[@hussain55019]

Your passionate voice and loving way of teaching.

[@hussain55019]

Sir please clear my confusion what i understand is that in skeletal muscle the CR RyR1 is activated mechanically by DHP receptors in T tabules while in cardiac and smooth muscle calcium has to enter the cell and then combine to the receptor of ST to release Calcium.Am I right?

[@jamesgriffitts5652]

Thanks Brother Baker, coming in clutch!

[@sashahanna3792]

Excellent video!

[@radio-teb2018]

great explanation. Thank you :)

[@minzzal]

Awesome, thank you fukcing lecturer in my school doesn't say anything in terms of the antagonistic actions and told us to find

[@AMWE-gh7ti]

Informative...

[@禿頭叔叔]

Thanks dude！ My teacher didn't tell me so much details!

[@physiopathopharmaco4190]

You’re very welcome thanks

[@Ukjackie73]

Hi, I really love how you have done your video, especially the patho section - is there any chance I can use from 1.47 - 1.59 on Dantrolene for my uni assignment please? I can't get my powerpoint animation to work :(

[@rubbers3044]

Why does giving a calcium channel blocker with dantrolene leand to hyperkalemia?

[@physiopathopharmaco4190]

Decreases calcium inside cells so more calcium in the ECF which corresponds to blood levels so there are higher levels in the blood Also the combined action may inhibit the Na/K pump so again more K+ in the ECF which again corresponds to higher blood levels