Glycolysis

[@patrickwmed]

Dirty, I recently passed step 1 and I just wanted to come back and tell you how much I appreciate you. There were many questions I got right on my test because of your pearls of wisdom and awesome Dirty Med mnemonics. For those studying for step 1, I cannot recommend this channel highly enough. Please please please watch as many of his videos as you can and memorize the mnemonics. They really do work!!

[@annsophia9503]

needed this! mine is in 2.5 weeks. will watch as many as I can

[@fatimamuhammad3606]

​@@annsophia9503 How was it?

[@annsophia9503]

@@fatimamuhammad3606 ended up with covid which kinda derailed my studying and then clerskhips started right after so just taking step 2 only (I'm a do student).

[@fatemaha7453]

Just started med school and this guy is awesome!

[@frogprincessss]

Congratulations!

[@ogwangfrancis3608]

You are chosen by God to save medical students or biochemistry students. After attending three lectures of glycolysis and gluconeogenesis I didn't understand but your few minutes videos have made me understand. Long live

[@maxbilo6191]

1:08 Glycolysis Overview 3:15 Entire Glycolysis Pathway 4:04 Glucokinase 4:59 Hexokinase 6:49 Rate Limiting Enzyme (PFK-1) 7:44. PFK-1 Regulatory Mechanisms 10:45 PFK-2 Regulatory Mechanisms 12:20 Pyruvate Kinase 12:53 Glycolysis Overview Final Chart

[@turrlerabbit4884]

Thank you so much for this. i'll definitely donate the second i stop being a broke student

[@squishymallow851]

Same ❤

[@shalimar1050]

Hopefully you aren't broke anymore

[@1004hl]

I was so confused about the fructose 2,6 bisphosphate part until I watched this video. It cleared up all my confusions within a couple minutes. Thank you so much for your videos and saving me hours of frustration!!

[@marial1217]

When Dirty said "love you" at the end, I felt that. Love you too SO MUCH lol. Thank you, Dirty. I've gained a new appreciation of Biochemistry (and tbh, medicine in general) thanks to you. You're awesome.

[@JustinMoreira]

You inspired me to come up with this one. Difference in the relationship between hexokinase and glucokinase: "Hexokinase asks for Help"

[@jax40001]

and Glucokinase Gives help

[@luabastos1493]

Your videos have proven to be not only simple but also highly comprehensible, allowing me to successfully pass my biochem test. Thank you so much!

[@daughteroftheking3220]

I wish we could give you all our tuition. You are literal God-sent to us to save us from misery, mental-breakdowns,and final cramming for a test. Thank you doesn't even do you enough justice!!

[@sunshine-bj8ih]

You were called to teach. Thank you!

[@zukagavasheli9262]

you have no idea how thankful i am of yours, on behalf of all medical students thank you for these easy explanatory videos.

[@somiomer3503]

Thank you so much dude. When I get to the US I'll definitely donate a lot because you helped me A LOT! YOU'RE THE BEST.

[@innominadojustis2224]

I try Physeo, Prixorize, USmle rx express videos, BnB, but it was YOU : OUR USMLE KING DIRTY MEDICINE who explain it simple and easy, GOD BLESS YOU i want to be like you👏🏻👏🏻👏🏻👏🏻

[@Mariamhamwi]

Did biochem videos feel sufficient to solve biochem well?

[@srana5049]

Thank you so much dirty medicine. I recently passed my step 1 exam and all your videos were of great help in my step 1 journey. Thanks

[@muzamara]

Is the real deal similar to UWorld, Free 120 or NBME?

[@NateMcGrath-l6q]

This playlist is better for biochem than boards and beyond or anything else out there. Absolute legend, thank you.

[@umairjaved4755]

The min I pass my steps , I'll start donating IA....Thank u so much brother♡

[@avslayfar1231]

have you donated yet?

[@bengreene6293]

I just have to say I wish I had found your page so much sooner! I am studying for step 1 and Biochemistry has been absolutely killing me. I have spent so many hours studying it, and I feel like I had nothing to show for it. Nothing would stick because I would get bogged down in all the extra. A friend of mine with similar struggles suggested I tried your page, and now I have a renewed hope that this is possible. Thank you so much for your work. I look forward to continuing this series!

[@vincefox8]

You literally read my mind! Searched for glycolysis on your channel before bed, didn't find it, was sad, and then woke up to a brand new video on exactly what I needed!! Thank you!!

[@dramgcastillo]

I promise that when I get my licence in the US and get a job or match, I will unite to your channel and pay... tanks for these. You and Ninja Nerd are saviors

[@elsielc6826]

almost thinking of giving up medicine, not until i discovered your channel. Thanks Dirty!

[@DirtyMedicine]

You can do it!

[@uniteUsk]

your 15min lesson just saved me in biochemistry. Thanks man your a life saver

[@nasrudinabdi1635]

You have done great service for humanity. God bless you

[@Mayavee617]

Thank you , you are a life saver. To the point as always, I can’t thank you enough!❤ Wish for the best in every aspect !

[@rajmukhopadhyay4837]

This is an excellent video with excellent analogies that makes it super simple to understand. One extra detail to note here is that Pyruvate Kinase can also be activated by F16BP (+ feedback). I believe this was mentioned in Kaplan MCAT Biochemistry.

[@Skyguy19]

Not all heroes wear capes, you're one. Thank you

[@nikowlll]

you really helped me to understand this better than i ever imagined. i’m struggling reading its module bc our prof did not manage to discuss this due to quarantine & thank you omg you’re a life saver!!

[@evelynn3941]

God bless you, you're the only youtuber that makes it easy for me to understand.

[@yuta2349]

This channel is seriously the best for understanding topics of med school

[@najumudhina.m.k3966]

PFK 1 & PFK 2 part is best explained. Awesome superb🤗🤗

[@lailaaljazairia7884]

Thank you so much for these videos you have no idea how many students you are saving

[@BryanBjay]

GOD BLESS YOU!!!! This is all that I need. Just what I need to know!

[@dvperez14]

I am not sure what you are doing now in life, but you are such a blessing! God bless you , protect you and keep you safe and nourished in the years ahead in Jesus name. You are such a blessing and I am actually loving this instead of HATING it like i used to!!

[@waybeyondtheblue434]

your videos are a gift from heaven!! I'm a student from germany, and sadly there are very few good videos in my language on this topic, and yours help me so so much!! Keep up the good work!

[@lindembergsilveirafilho1842]

Your explanation is simply outstanding. Thank you

[@lovedazzle95]

Dirty thank you so much. You a literally saving my life right now.

[@edgarmartos6016]

It is also high yield to know that conversion of glyceraldehyde 3 phospate into 1,3 biphosphohlycerate needs NAD+ as cofactor of glyceraldehyde 3 phosphate dehydeogenase. This is something that has been asked in uworld in the context of alcohol ketoacidosis where there is NAD depletion (due to NADH acummulation) or LDH deficiency, where you are NAD depleted, as in normal conditios the conversion of pyruvate into lactate uses NADH and finally converts into NAD to be used in this specific glycolisis step. In this 2 scenarios you would not have NAD, thus glycolisis can not procede anymore as there would not be any cofactor for G3P dehydeogenase, explaining why patients with alcoholic ketoacidosis and LDH Deficiency have hypoglycemia.

[@diandrad406]

After 7 years, I finally understand Glycolysis!! Blessss

[@kshanikdayaram3984]

i think i might name my firstborn after you thank you so much

[@b.u.8709]

@V LOOOOOOL!!!

[@kiruthikabalasubramani8874]

One person who focus on clear understanding and of course on dirty exam questions... 😂...Thank u so much

[@yana-marisaedwards1765]

Thank you so much for your videos! I know you've heard this before but you just saved me!!

[@kayallen7603]

Hexokinase is the main enzyme while glucokinase is the back-up enzyme.

[@michellechavez970]

You’re the best! I wish you were my professor, thank you for your help!

[@aletheiathreskeia1844]

How I wish these kinds of channels existed 10 yearas ago when I was still a medical student....

[@mspinkdomi]

Damn I'm in crunch time mode freaking out and this just made me understand this shit in less than 10 min 1.75x speed love you dirty

[@kayallen7603]

The process by which sugar/starch is used to make fuel to power the body and the body's organs.

[@peskyseagull]

Oh yes, Daddy Dirty going high yield

[@justinarnold3951]

How did you manage to make understanding 2,6-BP sooo easy?!?! What a life saver

[@sole23md]

thank you for posting this, stuck in the house trying to learn from harpers is much harder than this! great help

[@andreainzaghi7373]

I love to re-name it "pyruvate ADP kinase" because it does NOT take away a Pi from the ATP but from the substrate; it is a confusing name

[@Francesco-xp8ne]

What I fail to understand here is that under other resources it also lists Glucagon as an inhibitor of Pyruvate Kinase alongside ATP and Citrate which appears counterintuitive. Do they not exist in complete opposite sides in terms of the availability of glucose and energy?

[@stephaniea.7156]

Thank you! Do you already have a video on gluconeogenesis?

[@Supapacer2025]

Thanks for making this very easy to understand and remember.

[@tableit7667]

You're an AMAZING TEACHER!!!

[@SK1MD]

This is so great!! Thank you so much!! God bless!!!😃❤

[@TheRealBlackPanda]

This dude is the plug for all things biology

[@drjeniferpreethi9305]

God bless this channel

[@VampireDiariesBiebs]

thann you for the entire biochem playlist!

[@alaanasr6327]

Hi, Thanks alot for your content. do you have pdfs or slides?

[@ramshamahmood6413]

Thank you for breaking it down, and making it easier for me to understand. Love your work!

[@tonykeys95]

Please dirty if you can make a purine synthesis/salvage pathway video that would be amazing

[@DirtyMedicine]

This is on the list to be done soon

[@wisercommunication4791]

Amazingly explained ! Thank you so much

[@shabbirahmad7015]

my dude you are so freaking amazing

[@yogeshbhusal8945]

Sir you make video regarding cranial nerves with test?

[@chiahsuantsauo8375]

Didn't know that fructose 1,6-bisphosphate gets converted into both DHAP AND glyceraldehyde-3-phosphate. The DHAP gets converted to glyceraldehyde-3-phosphate by triosephosphate isomerase so that means there's TWO glyceraldehyde-3-phosphate per glucose molecule. WHY'S that important? well it explains why glycolysis produces net 2 ATP excluding the NADH produced in the cytosol which needs the malate-aspartate shuttle or the glycerol phosphate shuttle, mitochondria, and oxygen to produce energy. The books say glucokinase/hexokinase and phosphofructokinase uses 2ATP total phosphoglycerate kinase and pyruvate kinase produces 2ATP total that would result in a net 0 ATP IF there was only one glyceraldehyde-3-phosphate. Knowing now that there is two glyceraldehyde-3-phosphate produced we know that 4 ATP is produced which means there's a net 2 ATP produced. Knowing exactly why and how glycolysis produces 2 net ATP in normal circumstances, this explains why RBCs which produce 2,3-BPG bypassing phosphoglycerate kinase when there is severe anemia or hypoxia results in a net 0 ATP from glycolysis. This also makes the ETC video make sense when you explain the net ATP produced from glycolysis, to pyruvate metabolism, to oxidative phosphorylation.

[@felipesolares]

Quick question: is there a recommended order to watch the biochem videos? The playlist seems to have them in a strange order.

[@bhavanigaddameedhi8870]

you're just awesome and thanksss for making the most tough parts easy

[@shriyamahapatra]

Sir urs explanations are just awesome... Respect for u sir🙏

[@SunilKumar-lt2ln]

Sorry if I m wrong But sir I guess pyruvate kinase is inhibited by ATP, acetyl co A and alanin

[@Rayray.johnson00]

Very informative, much appreciated

[@zachary.ramsumair]

rate liming and regulatory enzymes . WOW thanks

[@gentlegenius6778]

Really helpful Thank you sir God bless you

[@shreyaveldurthy]

You are a life saver! Thank you so much

[@Mariamhamwi]

Do you think your biochem videos + Uworld is enough? I will watch all your biochem videos and study them thoroughly. I have my rotations so I have to be time-efficient with my studying

[@HamzaBuzdar-m2o]

Which book is used as reference book

[@michaelsrowland]

Does the pyruvate then enter the citric acid cycle

[@nived8476]

PFK 2 (F-2,6-BP) makes glycolysis TWICE as fast

[@oxell4925]

Do you have a video on GLUT transporter disorders?

[@zilanayhan7864]

Thank you for a nice and clear lecture!

[@amolsglenal]

Is it use full to high school level?

[@christinac1195]

i wish everyone taught like you~ big picture first! thank youuuuuuu

[@filizozmisirrgw9606]

You are God sent!!!!

[@sahibklol]

Great video! Thanks!

[@dr.fatemaomran3105]

Perfect teaching ever

[@missbailey7280]

I love your videos I have been struggling to get the big picture of everything and have watched a ton of videos I should have found this earlier 😢😢 thank you ❤❤

[@Mariamhamwi]

Wow no way... I never expected to understand biochem instead of just memorizing. TYSM!! hoping I pass my step 1 this novemeber :)

[@SteveSaxony]

did you pass? was there a lot of biochem? thanks mariam

[@dr_yoube]

@@SteveSaxony I didnt do it haha… Im gonna do it next year.

[@kidaz]

In starvation (high glucagon), tissue (not liver) need ATP via glycolysis right? Doesn't glucagon inhibit this (PFK2) then? How does tissue get ATP then?

[@chloesworld2083]

Thank you so much for creating these videos! It's honestly a great help for Biochemistry students like myself. :)

[@lidiateshome819]

Ur awesome! How you easily break down concepts is mesmerizing!!

[@sanverse6807]

Sir you're here saving lives ❤❤

[@sajankahlon7273]

How we get biochemistry notes pdf?

[@yumnatariq587]

thank you so much for these videos. i sucked at biochem. may be i'll suck a little less now.

[@monika246]

Now please do video on glycogenesis🙏

[@eldok7616]

which book i should study in ?

[@sadiakanwal1064]

Awesome sir,gud job

[@FYkjDefh]

I wish I could see these things maybe it would make sense then!

[@yana-marisaedwards1765]

HEY EVERYONE! LET THE ADS RUN FOR THIS CHANNEL! IT'S THE LEAST WE CAN DO!

[@whitecoatandmore1744]

Please upload gluconeogenesis!!!! Thanks a lot for not making biochem a nightmare for me!

[@stevejonan]

Great job, very useful lecture

[@Orange_nightingale]

u r doing Gods work....

[@az71003]

thank you dirty , really appreciate your videos