The Two New Highest Ranked Compounds For Lifespan Extension According to the ITP | 40 - LTW #7

[@jonathonmills3563]

Highlighting Astaxanthin and glycine would be more viewer useful since both met statistical significance and are readily available to the average person

[@theancientsancients1769]

How much Astaxanthin do you take a day?

[@jonathonmills3563]

@@theancientsancients1769 8mg

[@jamesmcintyre3456]

A person does not live by astaxanthin and glycine alone. 🎉 I know President Garfield proposed eliminating the patent office in the 1880s saying there was nothing left to invent, but...

[@ChessMasterNate]

@@theancientsancients1769 I take 10mg a day of Astaxanthin, plus whatever is in my diet. I eat Salmon once or twice a week. I take glycine too. Random dose currently. I was taking glycine, TMG and collagen peptides, at fairy high dose, and they fixed my joints. I don't know how much my maintenance dose should be.

[@bill9989]

Matt, thanks for all your videos. You are my goto guy for longevity. Today, you spared me the expense of AKG. I already spend a significant amount on other interventions, specifically rapamycin, metformin, taurine, astaxanthin, gly-nac, and others.

[@HvdHaghen]

AKG was tested, but not CaAKG, nor AAKG. Also a different dose could be effective, or it could be effective in humans. Remember the mice live in a very sterile environment and mostly die of cancer, so not of heart and arterial diseases.

[@roba.8907]

@@HvdHaghen100% Agree. AKG has a very short half life, but Ca AKG at doses of 1000 mg daily has a long duration of action and been proven to be very effective in human Antiaging trials with reduced methylation of DNA, etc. Rejuvant has done one of the trials and it improving markers by approximately 10 years. It’s also available elsewhere in high quality at a company called Do Not Age.

[@jamesf7933]

@@roba.8907 I remember seeing a statement a few years ago by Ponce de Leon Health that AKG has to be sustained-release (like Ca AKG) in order to be effective; they said arginine AKG, I think, does not have the anti-aging benefit. So the absence of a lifespan benefit with plain AKG seems like it should have been expected. However, if the mice eat a little bit chow many times throughout the day, should that give an effect like sustained release?

[@hristosstrihas4010]

I think this type of video is extremely useful. Unfortunately, the topic of health and longevity has always been plagued by a great deal of misinformation. I am glad that there is now an effort to provide objective and unbiased information. Many thanks!

[@BarryBPruett]

I like the deep dive into ITP and other robust testing. Would be nice to see summary of which protocols are likely to work for humans i.e. maybe look at human testing results that confirms some of the ITP results which are associated with mean and/or max life extension.

[@espinosalexis]

ITP is flawed! Feeding protocol sickens mice metabolism on-purpose by two insults. Insult1: Ad-libitum is too much food. Insult2: Chow is too bad food. Successful agents are only those that can fight back some of the metabolic problems created by those two insults. Not surprising anti-diabetes drugs are showing such "promise". ITP needs to invest 1-year budget in finding two right things. Right1: correct amount of food to no hurt mice metabolism. Right2: correct whole food omnivore diet to not hurt mice metabolism. Only then can ITP find real longevity molecules and not just those that fight back a bit of the metabolic damage caused by those two sickening insults.

[@espinosalexis]

Just take a look to mice weight! I simply can't understand how you are happy to study longevity molecules with fat and metabolically illed mice! Can't you see that you are not screening for longevity molecules but for fixes to these two absurd on-purpose insults given to the mice! Yes, I understand this still relates to the American population which is sadly being hit by these two insults too (95% of Americans being metabolically I'll). But, then, you should change the objectives of the ITP to: we want to find a pill that can help Americans without changing the amount nor the crappiness of the food they eat!

[@espinosalexis]

Same applies to dogs. Dog chow is crap!

[@bostaurus1]

You raise an interesting point!

[@jds02153]

🤡

[@jonathanberry1111]

@@espinosalexis Yes, and mice are dying of Cancer not old age generally, so it is very much not a test on aging independent of things that can address these various issues. Also one of the best ever, or maybe best ever results in mouse lifespan on Rats was giving then not a constant medium dose but a massive dose periodically delivered then stopped for a period, which is the C60 Olive Oil study, bodies tend to build tolerance to interventions delivered chronically and it seems that pulsed antioxidants in massive amounts can be beneficial in a way that it isn't delivered regularly.

[@kaceeboxers3580]

Watched your video earlier on the UK data concerning estradiol, if I recall , 5 different variations of estrogen were in the top 10. So, puzzling to me, and I had to listen twice to fully understand, why these mice studies showed no additional longevity in female mice and even slightly shortened lifespan. It is understood not all mice studies correlate to humans, as for instance, rapamycin has demonstrated. All very intriguing. You explain this data in such detail and it is fully appreciated.

[@Samucacamilo]

This is awesome. I have been using ITP data as my guiding light for any experimentation decision and the deep dive on this years/2020 findings was great. MOAR.

[@peterz53]

Matt. ITP results could be of more useful if human equivalent dose would be published with results. Also, for positive results, it would help to have test run again using a feasible dose. If I recall correctly this was a problem with the 2019 astaxanthin study in that dose used was very high in human terms, being a lot higher than typical supplements or what can be obtained in diet. So we really don't know if lifespan needle will move in humans taking in normal supplement amounts.

[@anirecapped.]

Divide mice dose by 10 (should be closer to 12 but 10 should be fine)

[@epigeneticnerd4244]

Hello Matt and his crew. I have patients on rapamycin and wondering if you guys are still collecting data on rapamycin users and if so, where would I direct these patients to help contribute?

[@jimparker3376]

Yes. I would also like to see. I know the dog study, the Covid immune response,gingivitis . I think Brad steifeld is doing a study.

[@supermanman6460]

It’d be be cool if there was a clips channel for the podcast. I don’t have time to listen to the fullbroadcast.

[@optispan]

We will be launching 10 minute highlight clips and shorts very soon so stay tuned! - Tara

[@supermanman6460]

@@optispan thanks awesome!

[@ryan_the_red_4907]

Great detailed explanation of ITP

[@stonebridge7710]

My guess is that ITP has opted not to test Methylsulfonylmethane (MSM) for a variety of reasons. I cannot imagine that no one has proposed it (GRAS, extensive research, cheap, etc). Perhaps because sulfite donors haven't worked on lifespan yet? I'd wager the healthspan data (via proteomic stability) could be very valuable to many people - but I'm not the decider ;-)

[@Tron-Jockey]

Many of us on Metoprolol were intrigued by recent information on Rilmenidine and would like to switch. Can you address Rilmenidine in the future?

[@wpmitra7251]

I think Acarbose works better than canagliflozin. ITP also said it extends lifespan. Fewer complications too.

[@MusixPro4u]

ITP results are the super bowl of the longevity scene.

[@HvdHaghen]

I'm very interested in an ITP test of rosemary acid because it is consumed in high amounts in Acciaroli in Italy and also on Ikaria in Greece, both known because of the longevity of the inhabitants. This could be caused by the effect of rosemary acid on vascularisation. Does anybody know how the necessary request for the ITP test has to be done?

[@JaySeitzPhD]

www.nia.nih.gov/research/dab/interventions-testing-program-itp/supported-interventions

[@przemkowaliszewski3290]

Before you extend life by about 10%, you should explain what the ultimate goal of the extended existence for those "lucky" persons should be!

[@joeblow1748]

agree im not here to piss in the ocean.

[@Nelis1324]

Why? Use your own imagination.

[@newyorkskier]

I sense a hint of disapproval of the data coming out of Sinclair lab although I agree that his method of disseminating scientific data can raise an eyebrow even though it increases awareness of the potential of health span augmentation. Also, there is a huge body of data liming sirtuins to improving healthspan (at least mechanistically) and probably lifespan although one can criticize the therapeutic compounds used to modulate sirtuins

[@chunglau266]

Would like to see more itp studies on optispan

[@orion9k]

21:50 that looks like the exact same grapth they used, for the Tourine mouse experiment 🧐

[@Roberto-cg2gr]

Any research on GKI with health span?

[@BradleyWHall]

can i use Mounjaro with Jardiance (SGLT2 inhibitor)?

[@SilverFan21k]

For the algorithm 😎

[@thx1136]

Hope x203 gets submitted.

[@workingTchr]

Keep in mind that longevity isn't the only valid metric. There are supplements that can _improve_ this or that condition and make like more pleasant (or bearable, depending on your POV) for the time you have.

[@fidrewe99]

Why do they test drugs before testing specific foods and their synergies? Longevity starts with nutrition.

[@Dr_Mandler]

We know that finasteride in males increases estradiol levels, could this be a benefit of finasteride without having to add exogenous estradiol or estriol?

[@nicholasarapis]

Hey! I had the same thought. I take Finasteride for hair loss reasons and I've seen some studies linking it to longevity. I will prep an episode with Matt about this topic. From what I've seen, after puberty DHT doesn't serve a purpose and it potentially could be advantageous to reduce your levels. That's just my speculation. Stay tuned! Nick

[@jamesf7933]

Super interesting. Anal-retentive question. If the mice are a cross between four genetic strains, does the cohort consist of four to sixteen different genetic types, and if so, is the genotype of each mouse known? If so, it seems like the results should be reported stratified by genotype as well as composite results.

[@FatherGorgony]

Thank you very much. Very interesting. And what about Taurine?

[@optispan]

Matt shares some thoughts about taurine here: kzbin.info/www/bejne/m56adpWtbZaiqtk - Tara

[@davidwoods1622]

Has the ITP tested C60 or methanol Blue?

[@jeffthetutor9825]

Methylene blue. Methanol will kill you, or in small amounts, make you blind

[@noahlovotti7722]

Remember that future longevity treatments will be primarily in the form of therapy rather than drug.

[@gregsingh9751]

Is any study done on Taurine molecule & if so what was the result.

[@optispan]

Matt shares some thoughts about taurine here: kzbin.info/www/bejne/m56adpWtbZaiqtk - Tara

[@aficionado7178]

urinary track infection?

[@bobbobson4030]

Hi Matt, read your paper recommending the comparison of intervention Vs best case control (900 days median) in lifespan studies. What would be the equivalent best case number for 90% survival for control mice?

[@mikespector2]

Are any human males taking 17 alpha estradiol?

[@y.g.1313]

Noise.

[@SoulDelSol]

Are people similar to mice

[@optispan]

In some ways yes, in many ways no. An example of an important thing to consider in choosing the right model organism are whether mice get the same diseases of aging as do humans (as opposed to having those diseases artificially induced). Ideally we could test interventions in organisms that track human biology and aging as closely as possible, but we have to consider cost and other practical considerations. - Tara

[@arthurmario5996]

will people never stop buying snake oil?🤣

[@europaeuropa3673]

Not for me. bye.

[@roanaur7518]

What is your opinion on Sinclairs information theory of aging? DOI: 10.1038/s43587-023-00527-6

[@Krunch2020]

Sinclair seems like a huckster. None of the work from his lab can be replicated.