Dr. Matthew Hill: How Cannabis Impacts Health & the Potential Risks

In this episode, my guest is Dr. Matthew Hill, a professor of cell biology and anatomy at the Hotchkiss Brain Institute at the University of Calgary and an expert on the biology of cannabis. We discuss how cannabis affects the brain to produce its psychoactive effects (feeling “high”), including altered time perception, focus, memory, appetite, and stress.
We discuss how THC vs. cannabidiol (CBD) affects the brain, the effects of different routes of cannabis administration (e.g., smoking, vaping, edibles), high-potency THC, and whether cannabis is addictive. We discuss if there is a link between cannabis use and the development of psychosis, anxiety, bipolar depression, or schizophrenia.
We discuss whether CBD has clinical benefits in regulating stress, promoting sleep, and treating certain diseases. We also discuss if there are real and consistent differences in the biological effects of different cannabis strains, if cannabis impacts hormones, and the uses of cannabis for the management of pain, stress, Post-traumatic stress disorder (PTSD), anxiety, and nausea.
Listeners of this episode will get an up-to-date understanding of what is currently known about how cannabis affects the brain and body, including both its potential benefits and risks.
Access the full show notes for this episode at www.hubermanlab.com/episode/d...
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Dr. Matthew Hill
Hotchkiss Brain Institute: hbi.ucalgary.ca/mist/team/res...
University of Calgary academic profile: profiles.ucalgary.ca/matthew-...
Publications: scholar.google.ca/citations?u...
Lab website: www.hill-lab.ca/
X: x.com/canna_brain
Timestamps
00:00:00 Dr. Matthew Hill
00:00:00 Sponsors: Eight Sleep, LMNT & BetterHelp
00:07:16 Cannabis, THC, Cannabidiol (CBD), Terpenes
00:12:08 Psychoactive Effects, Cannabis “High”; Time Perception
00:16:55 Cannabis & Brain, CB1 Receptor, Endocannabinoids
00:26:19 Endocannabinoids Types: Anandamide, 2-AG
00:33:46 “Munchies”, Cannabis & Appetite
00:42:17 Sponsor: AG1
00:44:06 THC & Anandamide, Pharmacology
00:52:37 THC & CB1 Receptors, Intoxication & Appetite
00:58:57 Cannabis & Focus, Memory
01:04:09 Routes of Administration, Concentration, Cannabis Research
01:15:12 Self-Regulation, Inhalation & THC, Tolerance; THC Concentrates
01:22:25 Sponsor: InsideTracker
01:23:36 Addiction & Cannabis, Cannabis Use Disorder
01:31:30 Cannabis Legalization & Use, Edibles & ER Visits
01:36:48 Oral Consumption, Edibles, Dosing & Time Course
01:41:12 Drug Testing & Cannabis, Exercise
01:46:04 Cannabis & Hormones, Gynecomastia, Sperm Quality
01:54:37 Cannabis & Pregnancy; Selling Recreational Cannabis
02:04:07 Vaping
02:07:05 Psychosis, Anxiety & Cannabis
02:17:17 Cannabis, Psychosis, Schizophrenia & Genetics
02:30:45 Cannabis Use & Schizophrenia, Manic Bipolar, THC Potency, Nicotine
02:40:37 Schizophrenia, Cannabis Legalization
02:45:06 Cannabis Strains, Indica, Sativa, Subjective Effects & Expectancy Bias
02:57:00 CBD, Pediatric Epilepsy, Adenosine
03:07:22 Entourage Effect; Placebo Effect, CBD & Doses
03:19:12 Cannabis Health Risks, Cardiovascular Risk, Schizophrenia
03:27:08 Cyclic Vomiting Syndrome & Hot Shower
03:31:30 Cannabis Benefits: Pain, Stress, Anxiety, Post-Traumatic Stress Disorder (PTSD)
03:40:18 Cannabis & Anxiety, Anandamide & Stress Response
03:45:55 Scientific Discussion, Clarification & Advancement
03:49:47 Zero-Cost Support, KZbin, Spotify & Apple Follow & Reviews, KZbin Feedback, Protocols Book, Social Media, Neural Network Newsletter
#HubermanLab #Science
Title Card Photo Credit: Mike Blabac - www.blabacphoto.com
Disclaimer: www.hubermanlab.com/disclaimer

[@hubermanlab]

Thank you for watching. If you enjoyed this topic and episode, please click the "like" button and subscribe to our channel here on KZbin. Thank you for your interest in science! -- Andrew

[@poopyspike]

I was wondering if you have anything on varicose

[@ANDREIKIMJONGSUN]

Hi! kzbin.info/aero/PLLFew4xL_sZcLK2SkmLSxXuf-As2fZWTB&si=yhBUVCDz6rXC1EJh

[@lindamon5101]

Weed is so overrated.

[@Ranas-qm8vn]

for me personally it heightened my focus to another spectrum but i used to always forgot the thing that i want to focus upon, that's why i stopped.

[@agentorange9586]

As a daily smoker. I love these.

[@jopo7996]

Dr. Hill and Dr. Huberman in a joint effort to weed out misinformation.

[@ALANGREENSPAN420]

😉😎

[@FullTwos]

Haaaaaaa that's punny

[@youtubemom497]

This should be good because they are both ✨highly✨educated!

[@Lazarsebaolar]

Dope comment. Highly appreciate the bluntness. Shows that you don’t have to get your opponent stoned, even if the argument gets lit.

[@ehza]

😂

[@TheThugNasty]

Let me roll a joint so I can lock in, and listen to this interview

[@healthisawealth999]

Haha 😂

[@lukaspfortner6753]

Absolutely the best focus methodology to get through this whole pod: pack another bowl💚

[@SILERSECT-kc2tq]

What are the odds? The day I decide to stop smoking, this pops up. What a blessing.

[@seanmcgonigle1182]

It's not just keep token bro

[@elliottrichardson8213]

@@seanmcgonigle1182don’t try and drag other people down with you

[@SickGamingSkill]

Literally! The timing is perfect.

[@fluck3r147]

Literally same and then the science said it isn't bad 😅😅

[@sighfly2928]

Allen Car’s Easy Way (Cannabis version) makes it very easy to quit. Highly recommended. You don’t need to use any willpower. Just listen/read it while sober and it will do the rest for you.

[@erveyvazquez8842]

32 yo here. I quit 7 months ago for different medium term purposes. Now I'm at a point where I can stay sober for the rest of my life after a decade of hard smoking. I feel more awake and energetic, and I feel like I can drive myself into that "high" state of visual appreciation without being intoxicated. It's cool to know both worlds.

[@pitchwife7573]

i'm 32 too and recently kicked alcohol (three years without a drop now) but still smoke a lot of weed, and feel pretty good about it

[@Art_Enthusiast]

32 also here. I love weed and won’t ever quit.

[@Jackdaniels19894]

Congrats bro

[@MrPando72]

@@erveyvazquez8842 I been sober for 5 months and feel like it's been a waste of time. Much rather been smoking weed

[@serragrkm]

Same here! I’m 31 and quit 7 months ago after using daily for almost 10 years. It’s true what they say - you get things done. Your mindset improves significantly, meaning your cognitive processes become sharper and more optimistic. Over time, you experience deeper and more restful sleep, too. It was a difficult process in the beginning, but the rewards are definitely worth it.

[@nickjassoiii]

I started with edibles at 15. 100 mg’s consistently. 250 mg’s. The high was euphoric. Then it was into pens throughout high school. I would hate being in class without being high. I discovered joints and would smoke my day away every single day. Bong rips. Every single day. Then onto dabs. Rigs, e rigs jumping between flower and dabs daily. It wasn’t until huberman pointed out you want to shoot for 2 smokes a week. I realized I was smoking about 70-80 times a week. Every time I would feel stress or discomfort or pressure I would run to that crutch. Please don’t be like me in my past: please get help, help yourself. Face reality sober. Exercise and learn sober. It’s worth it. I’m only 9 days without weed. Since being 15 I’ve been smoking out of compulsive habit. It can be done and i have faith that I’ll never turn back.

[@nickjassoiii]

Perhaps indulge, do not over indulge as I did. I found that euphoria and ran with it endlessly.

[@kloozman]

You were definitely masking some other problems you need to deal with if you were using that much herb

[@ezio954ppl]

almost definitely you will go back. but that will be the stumble, from which you should try and recover. Dont give up, just because you gave in

[@EdTube-pk1hg]

dab and smoke daily suffer with severe adhd , .....it helps ....the end 😊

[@down-the-rabbit-hole]

When I use to smoke awhile back, I found it very easy to only smoke 2 or 3 times a week. I would only use it as a reward system. I would only smoke if I crushed whatever weekly goals I had for myself, but I wouldn't smoke if I had a lazy and un-productive week. I guess it's like Beer. I mean I I could have 2 or 3 beers a week and never ever have the threat of becoming an alcoholic. No addiction is good and weed is the same way. Used every now and then it's perfectly fine and won't hurt you. But yea if one becomes a stoner, trying to numb pain etc, then yea they need to flat out quit.

[@IAMMASKARADE]

What I love most about this conversation is there are several times where it’s clarified and admitted that there isn’t enough evidence or data to suggest certain conclusions. In this space so many people talk in absolutes while having very little to prove it.

[@TrixxPlay]

Very true. In Germany for example many people try to suggest that cannabis is worse than alcohol, because we have such a heavy culture in drinking. They have literally zero clue about weed.

[@cantina.records]

​@@TrixxPlay Hello neighbor, same in Poland. Drinking alcohol is a cultural norm, and smoking weed is considered as something that will melt your brain. I see some progress, but it will take at least one generation to shift it to a level that Netherlands have.

[@TheMistyfyingOne77]

These things aren’t uncommon. They come up with theories. Theories are not facts. They are ideas created by intelligent people to help give some form of an answer to things unknown. Their ideas & theories change often. They think they know then, they don’t know then, they do know. It’s a cycle that continues to move forward like everything else. 🌞

[@KustardKing]

Thank you.

[@pietlebrun5943]

The problem with pot is that over time, it kills ambitions in a person. And if you smoke weed and think you're successful and ambitious, if you quit, you'd be multiple times more successful and ambitious. After you go through withdrawal, of course.

[@codymunciemusic]

1 month sober from Marijuana and 525 days sober from alcohol. The best decision I’ve made in my entire life

[@jbartmontage6737]

Gay 😂

[@jbartmontage6737]

@@SaviorMoney-777 Happy Gay it is.

[@jbartmontage6737]

@@SaviorMoney-777 Government worker much saviormoney? Pretty new profil

[@jbartmontage6737]

@@SaviorMoney-777 Government workers are very gay.

[@jbartmontage6737]

@@SaviorMoney-777 You are the biggest gay of them all

[@TerpsNtacos]

I’m 45 y/o and looking back been growing my own clean meds for the last 10 years. I can’t imagine a day without Mary Jane.

[@CarlHungus-y1t]

That is pathetic.

[@1jazzyphae]

Same just not on the growing but I'd love to. Weed saved my life. I got off of the narcotics, opiods, I got through my surgery without any pain killers. It literally saved me from dying of gastroparesis. People gate on what they don't understand. It's amazing for depression and anxiety too

[@TerpsNtacos]

@@1jazzyphae People hate what they don’t know, very true. Nothing beats being calm, cool, collective unlike most people nowadays: low EQ, closed-minded, addicted to medications. Clean cannabis heals. Especially FECO

[@icecold3426]

@@CarlHungus-y1t Nah you are.

[@user-fs8zm2qo5c]

"That's just like, your opinion man." ​@@CarlHungus-y1t

[@aspiresk8boarding]

Quitting weed was extremely stressful for me. I basically lost my mind for a couple months. Extreme anxiety and nausea especially in the morning. Panic attacks from absolutely nothing. Waking up every night feeling hypoglycemic and needing to eat to get back to sleep. That was enough for me to never want to touch the stuff again. Your neuro chemistry can adapt to the stuff in weird ways where without it I had to figure out how to exist again. It took months but I’m back to normal and my overall mood and outlook on life has improved so much. The negative rumination has minimized. I was hitting the bong throughout the day everyday for many years

[@areebahshakeel2409]

how long after quitting did your need to eat to get back to sleep at night end? Asking because my husband is the same and it has been 3-4 months since he quit (or so he says) but still does this at night and still has munchies.

[@joebillage3578]

That likely wasn’t correlated to cannabis. You should visit a GP even though you feel better now.

[@itsmftime727lol]

​@@joebillage3578what's a GP

[@J533]

@@joebillage3578nah its a real thing. He probably has CHS (Cannabinoid syndrome). I also have it, just unlucky i guess. I have “quit” smoking 10+ times in the past 3 years and without fail, i have extreme nausea and dry heaving in the mornings, usually pretty bad for a week or so.

[@J533]

Cannabanoid hyperemesis syndrome*

[@Spuddy10]

Surprised this guy actually showed up after being so condescending and abrasive on Twitter. Good on Huberman for being the bigger man in this situation and handling it with the utmost professionalism.

[@Spuddy10]

@@Alex-cw7xf I don't disagree, but there's a right and wrong way to go about that. He went about it in all the wrong ways, yet Huberman still graciously invited him on his podcast is my point. He has never claimed to be a de facto source of information and is open to being corrected.

[@Alex-cw7xf]

​@@Spuddy10 It's not what Huberman claims that I find concerning, it is the overall effect of his authority on his audience often without effective pushback that is the problem. Huberman was clearly out of his depth on the subject, and it's refreshing to hear it from the horse's mouth firsthand from someone who studies this topic on a daily basis. Huberman has a wealth of information but I would much rather it stay topical to what he has experience with firsthand because health recommendations are nothing to f with. Put it to you this way, if I went to culinary school to study how to be a pastry chef but one day wanted to podcast about barbecue and somehow I mix up different regions and their rubs/sauces, I wouldn't be suprised if I get roasted (pun intended) by some pit master who has been grilling their whole life. It would be silly for me (pastry chef) to then clutch my pearls. Just because I know how an oven works doesn't mean I can grill. I agree there is a time and a place for civility, but not when you are spouting off completely garbage interpretations of data based on your own subjective biases regarding a topic.

[@zeb_reynolds]

yeah dude seemed like a huge fucking prick. i will give him props for going on though and not just talking shit

[@AnneAlready]

I don't follow Twitter/X but this guest seems a LOT less eloquent than most guests. I couldn't listen - even if he had good info to impart he had a puffed up, aggressive undertone.

[@JMU365]

I was wondering why it seemed tense 😮

[@Finite8614]

🎯 Key points for quick navigation: 00:00 *🌿 Introduction to Cannabis and Dr. Matthew Hill's Background* - Introduction to cannabis, its historical use, and modern popularity. - Overview of cannabinoids, focusing on THC and CBD. 07:19 *🧠 Psychoactive Effects of Cannabis* - Description of psychoactive effects including euphoria and altered perception. - Differentiation between THC and CBD effects. 12:49 *⏳ Time Perception and Cannabis* - Effects of cannabis on time perception, including temporal distortion. - Mechanisms influencing perceived time intervals under the influence of cannabis. 19:55 *🧠 Understanding endocannabinoid signaling* - Endocannabinoids, like anandamide and 2AG, regulate neurotransmitter release through retrograde signaling. - CB1 receptors are crucial in this process, found on most neurons except dopamine neurons. 24:21 *🌿 The role of endocannabinoids in euphoria and dopamine regulation* - Endocannabinoids indirectly influence dopamine neurons by modulating inhibitory control. - CB1 receptors in the ventral tegmental area can enhance dopamine release, impacting motivation and reward. 30:25 *🏠 Anandamide and 2AG: Tonic vs phasic roles* - Anandamide acts as a tonic regulator, maintaining baseline neural activity levels. - 2AG serves a phasic role, responding to increased neural activity and regulating synaptic plasticity. 38:55 *🍔 THC's impact on appetite and motivation* - THC increases appetite even after satiation. - Animals under the influence of THC will work harder for food rewards, showing increased motivation. 42:25 *🥦 The role of AG1 as foundational nutrition* - AG1 provides foundational nutrition with vitamins, minerals, probiotics, and adaptogens. - It supports energy levels, digestion, and overall well-being. 44:17 *🧠 Increasing endocannabinoid activity without THC* - Methods to boost endocannabinoid activity experimentally or therapeutically without THC. - Comparing THC's partial agonist effect on CB1 receptors with endocannabinoids like anandamide. 57:51 *🌿 Cannabis and Food Seeking Behavior* - Cannabis intoxication can induce food-seeking behavior similar to the response seen in fasting. - Users often crave high-calorie foods like those high in carbs and fats to replenish energy stores. 59:03 *🧠 Cannabis and Psychological Effects* - Cannabis affects focus and memory differently depending on the individual and context. - Anecdotal reports suggest some people use cannabis to enhance focus despite potential impairments in certain memory tasks. 01:05:57 *🚬 Routes of Cannabis Administration* - Inhaled cannabis (smoking) delivers THC rapidly to the bloodstream and brain, typically within 2 to 5 minutes. - Differences in administration routes (smoking vs. edibles) significantly affect onset speed and subjective effects. 01:16:55 *🌿 THC titration and potency concerns* - THC potency has increased significantly over the decades, leading to challenges in titration. - Higher potency cannabis and concentrates can make it difficult for users to regulate intake effectively. 01:22:40 *💉 Insights on cannabis addiction and dependence* - Cannabis can lead to dependence and potentially meet criteria for a use disorder. - The concept of addiction versus dependence in cannabis use is nuanced but significant. 01:29:34 *🚓 Legalization and societal perceptions of cannabis* - Legalization of cannabis has shifted public perception from illicit drug to regulated substance, akin to alcohol. - Despite legalization, societal views on cannabis safety versus legality remain complex. 01:36:45 *🍪 Understanding the unique risks of cannabis edibles:* - Cannabis edibles, due to their delayed onset and prolonged effects, often lead to unexpected intoxication. - Standardizing dosing units for edibles, similar to alcohol units, is crucial for public safety and consumer understanding. 01:41:28 *🕰️ Duration of cannabis in the body and its impact on drug testing:* - THC's lipophilic nature allows it to accumulate in fat cells, leading to prolonged presence in the body. - Exercise and weight loss can release stored THC, potentially causing unexpected positive drug tests. 01:46:15 *🧪 Effects of cannabis on hormones: Insights and contradictions:* - Cannabis's impact on hormones like testosterone and estrogen is highly variable and not fully understood. - Studies show conflicting results regarding cannabis's role in aromatization of testosterone into estrogen. 01:55:03 *🤰 Cannabis use during pregnancy* - Discussion on varying statistics and concerns regarding cannabis use during pregnancy, - Factors influencing reported numbers include self-reporting versus verified blood levels, 01:56:36 *🤢 Risks and motivations for cannabis use during pregnancy* - Motivations for using cannabis during pregnancy, often related to managing morning sickness, - Comparison of cannabis use versus traditional pharmaceuticals like thalidomide, 01:58:55 *🍻 Education and responsible cannabis sales* - Advocacy for mandatory education for cannabis sellers similar to alcohol servers, - Concerns about misinformation and lack of education among cannabis dispensary staff, 02:04:13 *🌿 Different methods of cannabis consumption* - Discussion on harm reduction strategies for cannabis consumption, - Comparison of oral consumption, vaping, and smoking methods, 02:07:26 *🧠 Cannabis, THC, and psychosis* - Exploration of the relationship between high THC cannabis use and psychosis, - Distinction between acute drug-induced psychosis and chronic psychotic diseases, 02:14:10 *🧠 THC's impact on anxiety and excitatory transmission* - THC initially reduces anxiety by quieting down excitatory transmission. - Increasing THC doses can saturate CB1 receptors on inhibitory neurons, leading to an amplification of anxiety. 02:15:32 *🚫 Rare occurrence of psychotic responses to cannabis* - Psychotic responses to cannabis are rare and typically make headlines due to their unpredictability. - Cannabis-induced psychosis is more likely in individuals with a predisposition or vulnerability. 02:19:00 *🧬 Cannabis use and schizophrenia risk* - Cannabis use is associated with an increased risk of schizophrenia initiation. - Individuals with schizophrenia use cannabis at higher rates than the general population. 02:23:20 *🔄 Debating cannabis as a causal factor in schizophrenia* - The debate around cannabis causing schizophrenia centers on statistical associations rather than definitive causality. - Variations in schizophrenia prevalence across different cannabis consumption cultures suggest complex interactions. 02:33:29 *🧠 Understanding the debate on cannabis and schizophrenia* - Debate centers on whether cannabis causes schizophrenia or is used more by those prone to it. - Evidence from Scandinavia suggests low cannabis use but similar schizophrenia rates. 02:34:39 *🌿 Cannabis use and bipolar conditions* - Discussion on the relationship between cannabis use and bipolar disorder. - Genetic and hereditary links between schizophrenia and bipolar disorders. 02:36:16 *📑 High-potency cannabis and its implications* - Examination of arguments regarding high-potency "skunk" cannabis. - Analysis challenges linking potency to schizophrenia risk. 02:39:03 *🤔 Biological predisposition and cannabis use* - Exploration of why individuals prone to schizophrenia might prefer cannabis. - Discussion on the broader factors influencing substance use in schizophrenia. 02:42:04 *🌐 Public perception and policy implications* - Critique of public perceptions linking cannabis use to schizophrenia. - Impact of media and research on public health perceptions. 02:53:24 *🌿 The influence of terpenes on THC-induced anxiety,* - Terpenes like lemine can modulate the anxiety-inducing effects of THC. 02:57:23 *🧠 The therapeutic potential of CBD in epilepsy,* - CBD, historically bred out of cannabis for higher THC content, shows significant efficacy in treating pediatric epilepsy. 03:00:21 *🌱 CBD's scarcity and its medical implications,* - CBD is naturally scarce in cannabis due to historical breeding for high THC content. 03:12:16 *🌿 CBD efficacy and dosing considerations* 03:17:22 *🚫 Challenges and skepticism regarding CBD* - Despite widespread use, clinical studies have yet to find significant efficacy of CBD at low doses (10-20 milligrams). 03:19:25 *⚠️ Potential health risks of cannabis use* - Cannabis smoking poses risks for lung damage, although evidence for lung cancer is inconclusive compared to cigarette smoking. 03:31:10 *🌿 Cannabis health risks and syndromes* - Cannabis can potentially lead to schizophrenia, bipolar disorder, cardiovascular issues, lung damage from smoking. 03:31:51 *🩺 Medical uses and benefits of cannabis* - Medical uses include appetite stimulation, glaucoma treatment, nausea reduction, anxiety relief, and chronic pain management. 03:33:02 *🩸 Cannabis as a pain management tool* - Cannabis alleviates pain by reducing the emotional response to pain rather than acting as a strong analgesic. Made with HARPA AI

[@mr_green33]

wow, impressive. thank you. if you did all this sober, respect. i would need adderall to write all this out😂😂

[@mikethefenceguy]

Don’t you know… AI is good cause it’s sober

[@DL-rl9bd]

Cool, thanks!

[@theorivas1]

Wow, very useful. Thank you.

[@jordanc8375]

Im 36 and have smoked for many years. But ive never been an all-day smoker. I rip a cone at 830 every night to take the edge off. I have a family and a busy, reasonably well organized life.

[@CoolStoryBro455]

Yes, you got to moderate it. I find the comments funny where people tell their story of non stop weed smoking for years and then quitting. You would feel sick from anything if you do it all the time. Working out is good for you but non stop? Weed is to be used as a tool, in moderation.

[@squirrel9760]

Like thats really any better

[@andymeissner8727]

I’ve been a daily user for about 8 years now. For so long I would attribute cannabis to a lot of my ability to do certain things or handle certain things or situations and my ability to functionally operate at an extremely high level. With work, coaching, parenting, exercise, etc… After listening to the first 90 minutes of this it’s become clear to me that these things I’ve been able to learn, accomplish, and strive for have nothing to do with cannabis and that it is the case that it enhances everything I’m doing. I think a deeper understanding of how my ego works and the way my mind operates when it comes to certain things is what allows for me to avoid the pitfalls of most heavy use individuals. And even have the ability to go a day, or multiple days without using and it won’t affect me the same way it would someone else who is in the same bracket of use. I love conversations like this because it really highlights how vastly different this amazing plant can affect people on an individual level. I’m very excited to hear the rest of this conversation. Cheers family

[@AdewaleAromokeye-rx1dn]

I really appreciate this comment! Very useful to contextualize subjective experiences with respect to each unique individual!

[@Gnu58431]

I've gotta ask- how did you develop a deeper understanding of how your ego operates? I've never quite understood when people say to just 'detach' from an unpleasant or emotionally- provocative situation, and I assume it is to do with a better understanding of ego (as opposed to 'dissociating').

[@andymeissner8727]

@@Gnu58431 great question and I apologize for the late reply. I’ve been studying emotions and personal development and the ego for over a decade now. I’ve been in very deep meditative states on psychedelics and it was in those states that I was able to observe my thoughts from an outside perspective where as in the past I was identifying with them and thought it was me thinking them. When people are saying detach from those type of experiences it’s usually disassociating. However it’s not impossible to be involved in a situation that invokes those feelings and not let it break you all the way down. It’s a tricky topic but I think it’s well worth the effort to learn about. If you have any other questions or if I didn’t answer you the way you wanted lmk

[@Gnu58431]

@@andymeissner8727 that's really helpful, thank you. Some of the topics of your study overlap with some significant issues I've been recently struggling with mostly as a result of some traumas. I have been doing a bunch of CBT but I'm not sure it's proving super effective for me and I'm interested in exploring adjunctive therapeutic solutions. If you might have any pointers or know of particular websites books papers etc that could be useful for someone struggling with I suppose emotional dysregulation/ distress tolerance flowing from trauma, stunted personal growth etc, I'd be very grateful for your advice. The meditative psychedelic experiences sound intriguing and intimidating at the same time! There's certainly a lot been said about psychedelics & therapeutic value, in addition to mdma and ketamine I think they are also running medical trials on. I suppose there is a lot of nuance to ensure an appropriately therapeutic psychedelic experience.

[@mediocreTyler]

I smoke multiple times a day! It would be silly for me not to listen to this one. Thanks Dr H, looking forward to your book

[@rightnearthebeach]

Same

[@nofacee94]

same

[@microfx]

same! already learned a lot!

[@hanaf1231]

I enjoy a little after work, but it sure makes me sleepy. Always wondered how different bodies and brains process it to be able to smoke early in the day and not be in bed by the afternoon! Enjoy.

[@nofacee94]

@@hanaf1231 have an afternoon nap then... or especially after a heavy meal you might feel sleepy.

[@ibrahimdiallo3836]

Listened to this twice, once sober and a second time completely baked. I must say definitely absorbed it more the second time.

[@billespy2183]

Burnt in neural circuit aka ur fried

[@calebford6318]

That’s literally impossible

[@dillmill7698]

Absolutely possible

[@cristianjohnston3083]

​@@calebford6318It definitely is not. Huberman talked in the first weed podcast how weed can help you lock your focus in on certain things

[@Starseedcc]

I get it

[@BrownGeorge-pw2xo]

I started smoking cannabis years ago as a teenage, switched to cigarettes. Spent my whole life fighting Cigarettes addiction. I suffered severe depression and mental disorder. Got diagnosed with cptsd. Cigarettes addiction actually destroyed my life. Not until my mom recommended me to psilocybin mushrooms treatment. Psilocybin treatment saved my life honestly. 6 years totally clean. Much respect to mother nature the great magic shrooms.

[@Dukeson-p7g]

No doubts shrooms are 100% blessings from nature. Indeed nature's little miracles

[@Ronkaja]

Hey mates! Can you help with the source? I suffer severe anxiety, panic and depression and I usually take prescription medicine, but they don't always help. Where can I find those psilocybin mushrooms? I'm really interested in treating my mental health without Rxs. I live in Belgium don't know much about these. I'm so glad they helped you. I can't wait to get them too. Really need a reliable source 🙏

[@SusanaGomez-mp8sk]

Hey! Yes Dr.alishrooms

[@NicoleCtirad]

Mushrooms are very medicinal. This is why anybody familiar with psilocybin and any other kind of fungi will tell you, "They are alive." They have a very ancient wisdom. To my experience, all mushrooms have always said, "Pay attention to your life. How you think, how you feel, and what will you do with the information that you always knew, but now are seeing in this point of view." This is why mushrooms are so respected in tribal cultures. This mental health treatment works for me too. Half micro doses do the trick for me. At least a few days at a time with lengthy time in between. Never addictive. Thank you for sharing this point!

[@Wimruther-hk4zn]

How do I reach out to him? Is he on insta

[@SeleckPlays]

By the way, if you read the X thread, you'll find that this podcast started from a toxic string of comments including Dr. Hill's reply. The ability for Dr. Huberman to look past the way in which Dr. Hill initially responded to the thread gives me great respect for Dr. Huberman. Personally, I don't understand how anything productive comes from X - the number of "people" (bots?) who are simply there to tear down Huberman's good faith hard work is astounding.

[@Andrew-ri5qo]

Hill certainly came across as arrogant, conceited and egotistical.

[@12thDecember]

Xitter's usefulness as a means of sharing information has reached the point of rapidly diminishing returns.

[@sterlingmillhollon2520]

I would argue that Hill is a bot. I read his tweet after I heard the controversy. He was acting like a child.

[@Grceboss]

Lmaoo yeah i saw this and wondered if this was the dude who was fighting on twitter

[@dtown5id]

I thought him being a literal expert on the subject, his comment was warranted if Andrew was giving false information. If he didn't reply in such a way, Andrew would have ignored it and we wouldn't have this great episode.

[@toomuchdiesel]

Absolutely loved this episode! I'm an Infantry Veteran ('02-'07) and I use cannabis for my combat PTSD and tinnitus. It makes the tinnitus from 23 IEDs turn into background noise. It prevents me from having nightmares and helps manage daytime anxiety especially around crowds. But I honestly think it's the combination of cannabis, learning my sleep chrono type and adjust my life to it, getting my morning sun light, running 3x week, lifting 3x a week and all the other protocols I've learned from the Hubermanlab Podcast have really made me feel better than I ever have. So a HUGE thank you Dr. Huberman and Dr. Hill for helping me understand the science behind my favorite medication and recreational drug.

[@ReenteringTheNewsCycle]

I guess we stoners are the minority listening to this pod. Love you Hubey and all of us listeners. Hope everyone has a beautiful day

[@EfTheQuiet1]

As cannabis user daily for over 15 years, this is an immediate listen

[@pukuipz]

Great to hear. Starting to listen now. Are there any key points you found interesting / actionable, maybe important to you personally?

[@EfTheQuiet1]

​@@pukuipzit was interesting to hear that no strain will test above 30%. I've seen some strains advertised at over 35% which I was always skeptical about but I now know to be really question that fact about percentages. Also, not all testing is honest. I've honestly never shopped by THC percentage but rather Terpenes and the percentage. I still have over an hour left of this episode but that so far really stuck out to me

[@pukuipz]

@EfTheQuiet1 word up. I'm not at that part yet, but i imagine it's true that no flower is above 30% THC. I relate and like to think you're a real smoker because you're going off terpenes and percentages rather than just thc - that's the move for consistency in quality. Side note- I notice strains that have very high thc %'s tend to have low terp %'s. 🙏🏼 bless up, lmk if anything else stands out

[@dimakurkin8201]

@@EfTheQuiet1so is weed good or bad?

[@Vayanovic]

@@dimakurkin8201it has benefits and harm. The harm outweighs the benefits. In order to avoid the harm you cannot use it recreationally.

[@JackTheRabbitMusic]

Mr. Mackey taught me all I need to know about drugs. Thank you, South Park.

[@About17Camels]

Same here, mmmmmmmmmkay lol

[@Willyyyyyyyyyyyyy]

Drugs are bad mmmkay

[@lighthouseproductions.8386]

Drugs R behd mkay. You shouldn’t do drugs

[@fucuszullanti7877]

Funny because the medical marijuana episode is what actually got me off my butt to buy weed for the first time at 13

[@raymondjarrell5396]

Chef taught me everything

[@Beakerandgreg]

This turned out to be one of my favorite Huberman guest episodes. Great and challenging conversation between this two. I appreciate Dr. Hill taking the time to share his expertise.

[@rockhard9]

I really wish we could spend some more time discussing the differences in effects caused by edibles versus inhalation. As Dr. Hill mentioned this is hard to ascertain but this is why I'm interested in learning what we know so far.

[@shaneyawlover]

To my understanding, they did. The biggest difference is the first-pass metabolism converting most of the THC to 11-OH-THC. The difficulty is in directly comparing doses to effect for inhalation vs oral consumption

[@EndyPenddyyy]

As someone who start smoking at 18 senior year to age 21 almost everyday, i stopped cold turkey on june 1st 2024 for im enlisting. - I was never addicted but everything in the podcast was so helpful to keep me from craving if I did.

[@madelinemiller5871]

It feels like in this episode it’s extremely hard to find any definitive statements or even *informative* nuance, clicking through the timestamps and I feel like I’m not learning anything

[@sovrnindividual]

Agreed

[@ForRealSwagmaster]

Agreed. There are tidbits of pure fact here and there, but it seems like we have a long way to go in cannabis research. I consume it multiple times a week and really struggle with withdrawals; mostly headaches, irritability, and anxiety. I personally use edibles mostly because of the lung impacts of smoking and the brain fog the next morning after edibles can be bad even after low doses. I am an anxious person without weed, and I’d say weed makes my anxiety sometimes lower and sometimes higher than my sober baseline. There are a lot of factors that go into it. I’ve thought about running a trial on myself and doing, say, 90 days using it semi-regularly (I’ve never been a daily user) and 90 days sober and charting my mood, energy, anxiety, etc each day.

[@ljjdsee]

I am disappointed by this episode for this reason, and guests like this make me appreciate even more so how Dr. Huberman can translate his wisdom into a fluid conversation I can understand and benefit from. What a rare skill for a scientist!!

[@ForRealSwagmaster]

@@MadMan14782 I went 45 days at the beginning of this year, which I’d think would be enough for someone using cannabis 3-4 times per week, but I could see it taking longer.

[@Grassisgreenism]

This is how it often goes when experts actually stick to the science and refrain from overstating the evidence. Huberman’s mo is to draw clear and interesting conclusions from single and often woefully under-powered studies. It makes for great content, but it is not science.

[@Jeeplee_rc]

Anyone else smoking while listening? While ive smoked for 10+ years pretty much daily. There is DEFINITELY negative effects.. i myself at points have realized its more of a habit than a "relaxing" thing. Its important to understand your personal relationship with weed and the negative habits it may form. And i ALWAYS treat the plant with respect and gratefulness while consuming. Very interesting information in this one.. as with everything, MODERATION IS IMPORTANT. PEACE to my fellow stoners and those who don't partake!

[@aew234]

btw this plant is now mostly available in adultered forms such as concentrates tinctures waxes most is created in labs and far from the natural plant it was 30 years ago i find it hard to come to terms with people using the word plant to refer to todays cannabis its like saying poppy seeds instead of opioids and coca beans instead of cocaine Most THC today s high potency therefore lab synthesized into something completely un natural derived from cannabis plant

[@Starseedcc]

One love, cannabis saved my life ❤

[@karstenkailer4669]

I vape one or two vaporizers every evening after everything is done - work, family, socialising. I‘m a vinyl-collector and like to listen to records when I‘m high. Music just sounds and feels better.

[@gbrlzvtt]

yesss I'm with you bro

[@squirrel9760]

Yeah your hooked

[@kat1701]

Thank you for this newer video. As a someone who is 4 months dry but a regular cannabis user, ive really been hoping for some updated content around it.

[@Autonomous_Don]

How come so many of us quit around the time this was released? What in tf is going on? I’m staying of cannabis still, but good to know

[@Siticmon]

This was a great episode and I'd like to thank dr. Hill for coming in to talk about this. We all get carried away sometimes and it especially shows in things that are near and dear to our hearts. I'm sure this experience with Andrew has been a great learning point and maybe next time this happens he will react in a very different way. We can all learn from how this episode came to be, it's inspiring. Thank you both ❤

[@happynjoyousnfree]

Please continue with these long, informative videos. You are such a treasure ❤ I've learned so much from listening and recommend this channel all the time.

[@dimoire]

I quit on June 1st this year, stoked to listen to this episode!

[@altin314]

Huberman is all class. This guest has been extremely unprofessional and insulting toward him on Twitter. Funny how people act differently face to face.

[@blary5298]

Why has he been insulting/what is he saying?

[@tigrisboi]

What he say?

[@MrCBTman]

No, he was responding to Huberman’s terrible videos about cannabis.

[@aaperry1]

Andrew was on Lex Fridman's podcast last week and talked about ongoing friction with someone in the online community surrounding cannabis but didn't mention his name. I'm guessing it's him.

[@jbartmontage6737]

This guest is a total retard. He lies and lies, what a joke!

[@IselaAvila]

I'm that person that skips the first few moments of the episode to get to the "goods". So when I dug in and heard this guest sighing on some responses early in, it made me feel - different from the other episodes. Now that I heard the full episode and connected the dots this is the heavy critic Lex and Andrew spoke of, this all makes sense. Dr. H, I love and admire how much you showed complete respect for someone who said things that I'd say were more than a "healthy discussion online". Hats off to you- great discussion. ❤ from EPTX

[@reddrift3022]

I have to say, I came to this video after listening to the episode on spotify and have to say, as problematic as the relationship started on Twitter, this was probably my favourite episode ever. Dr Hill is extremely grounded and knowledgeable. I hope to see you bring him back in the future and put the rocky start behind you guys.

[@brunodangelo1146]

I quit weed around two years ago. Best decision I ever made. I feel motivated and I am extremely productive every day. It's down to the individual. But if you smoke regularly and are also depressed, consider stopping even for a while.

[@Test7017]

Missin out

[@brunodangelo1146]

@@Test7017 smoked for years. Did other drugs like LSD too. I haven't missed being high a single day.

[@brunodangelo1146]

​@@Test7017 I've smoked w for years. Even done harder psychedelics. Haven't missed them a dingle day.

[@jbartmontage6737]

Now you are a productive worker. Congrats.

[@brunodangelo1146]

@@jbartmontage6737 I am my own boss, I'm productive to myself. I am a content creator on YT, TW and other platforms. I am happier than ever.

[@shermanhoman6666]

I listen to this podcast twice on my commute to work. The information density was amazing. I do wish Hill wasn't so condescending, there is enough that we don't know about neurobiology. Huberman is a class act.

[@marksinger1278]

I'm sorry but how much he glossed over the various cannabinoids was atrocious.

[@hayleightilton4543]

I was a research coordinator on the Vandrey study on THC/CBD metabolic drug interactions! It was a beast, but the findings were so interesting and it's so cool to hear it mentioned by Dr. Hill!

[@str8gigachad124]

I have read the criticism of the Cannabis video. Tysm for adressing it and having another expert on the show!

[@techytitann]

thank you andrew huberman for the knowledge you are giving to us for free of cost and its really changing my life in a postive way and lots of love from india

[@sew1what]

IT doesn't quite the voices... IT just makes them get along 😂❤ thanks!!! Great information 🙏

[@brandoncraig4668]

Thank you for coming together and making this episode. One of the best and most informative podcasts I’ve ever watched.

[@JesseChisholm]

I finally had a chance to sit and listen to this. I can definitely attest to the benefits, and trickle-down benefits of weed and its impact on PTSD and nightmares. The quality of life improvements have been immeasurable, and as spoken about in the podcast, there’s no desire to continue to medicate throughout the day and find it’s fine to wait til the night to take the dose. I grew up firmly anti-drug of any kind, but now, I owe a huge part of the positive shift of my life to the impact it’s had at curbing the horrific symptoms of PTSD.

[@ZusTruth]

“Does Huberman not know because he has never done it? Well, that’s my own business.” 😂

[@aaroncrandal]

To be fair, this is a guy who hides his tattoos to avoid distracting from the science. The "my business" is maybe a poor use of words since it infers privacy. But withholding his own use or lack thereof would be in keeping with his intention to provide an unbiased presentation of the facts.

[@ZusTruth]

@@aaroncrandal I love his podcast. I learn so much for free. 😁😂

[@danny.halstead2181]

He pretty much has to have done it since he has talked about doing acid as a teenager and geting stuck in a elevator during prom.

[@Grizzzly.]

12:14

[@billycrunches8117]

He openly talks about his participation in mdma studies and testing peptides and androgens but god forbid he ever mentions his cannabis use

[@gorrvaskr5963]

I can attest to the chronic throwing up, I have been smoking day and night everyday for the last 4-5yrs, without any tolerance break. It almost always starts in the morning or after work because it's a short period of time that I didn't smoke, it hasn't gotten to the point where I legitimately throw up but I can just open my mouth and salivate for straight up minutes all coming from my stomach. Sitting in a hot shower helps it instantly. After watching this, I'll be quitting even if it ends up as a tolerance break this was a huge wake up call for me. Thank you, Andrew and Matt.

[@azazel1234]

I can definitely back you on this. The vomitting started in the morning when I had it and didn't stop till I ended up in hospital on a IV drip as I had lost over 1.5kg in water from sweating and throwing up. I found out about the shower saviour the second time it happened because I had the worst fever and everything felt cold and my skin was so sensitive. Decided to get in the shower and it immediately stopped the nausea. I haven't had it since and I have continued smoking though I hope to quit one day... Not for me but for my daughter as I wouldn't want her seeing me smoke

[@drxzt]

It doesn't sound like CHS. CHS is much more intense and can land you in the hospital. I used to feel the same way in the mornings-gagging until I smoked, also unable to eat, and losing my appetite. I skipped meals and smoked instead, even though I used to eat well and get the munchies from smoking. Over time, I lowered my dose because I was overdoing it. I went through cold sweats, and when it got too much, I'd take a hit. Now, I eat every couple of hours, and my appetite is back to normal. I try not to skip meals anymore to avoid messing up my system by smoking and numbing my hunger.

[@gorrvaskr5963]

@@drxzt same here, I immediately cut my intake by half so far and I'm already realizing how much I was crutching it from smoking everytime before meals, work and bed. Personally my biggest problem is when I'm at home with the silence of not doing anything, I'll smoke and watch KZbin until the day is gone. Starting to realize that weed makes you feel okay doing nothing or anything which is dangerous to dreamers.

[@CoolStoryBro455]

Take a substance every day and you get sick? Its the substances' fault!

[@drxzt]

@@gorrvaskr5963 I get you 100% I been struggling with the same kind of thing and I'm not entirely out of it, like I said, I just fixed my appetite and got back again into calisthenics this week, so it's helping but I still consume, and still waste a lot of time on places like KZbin. I don't necessarily think it's bad to watch informational stuff like this but spending hours on yt gets you overstimulated and eventually feels like a waste. It can also get complex cause im pretty sure now that im bipolar and even though I picked up weed years ago because it felt like it helped a lot with anxiety and similar symptoms now I feel like im starting to be aware about me having hypomania episodes and also what you were just talking about, I hyperfocus/fixate on whatever im doing and when being home that becomes KZbin.

[@petestone1011]

I've been using cannibis for the past 10+ years. These podcasts help me. Thankyou Mr. Huberman

[@marrero667]

Yeah!! Vaporizer better, CBD is better, more than (15.0 CBD) to (0.40 THC in total)

[@cjoynt84]

Good job Hubs! Appreciate you bringing an opposing opinion on the show and updating your knowledge on the subject.

[@aditimascarenhas5608]

Huberman was very kind to him, he was very rude on Twitter, and I feel like he should have apologised better.

[@MIOLAZARUS]

Andrew knows he could beat his ass if he ever needed and he is also smarter 😂😎

[@Youttubeuser20932]

@@MIOLAZARUS glazing hubes a bit hard there buddy lmao

[@MIOLAZARUS]

@@Youttubeuser20932 How could I not. He is so beautiful 😂🤣❤️

[@xansangwa4202]

Thank you Andrew Huberman 🙏🏾

[@scotchbarrel4429]

Just finished, that was a long one, but well worth the effort. The ending to this one was nice, grown men showing respect for eachothers differences, good stuff Andy, thanks mate 👊😎

[@happyglass8698]

Thank you both for this important dialogue. This is why I love science. This is a murky topic and any light shed on it is very much appreciated. Very maturely handled and gives a wonderful demonstration of collaborative problem solving. I appreciate you both

[@vanessab6605]

Thank you! I love Cannabis and have used it forever I'm so grateful for the research. ❤

[@ehsanmon]

I personally suffered from cannibas induced psychosis which lasted for a few years. I consider myself lucky that I got through it and did not go completely insane.

[@tayla3934]

Same

[@jsuss98]

can you elaborate a little bit more on your story?

[@mattepton5731]

Thank you Dr. Hubermann and Dr. Hill !

[@olgazavilohhina6854]

¡Hola Profe! Extremely informative episode. Thank You for all Your hard work and care for all of us.

[@martinr2040]

I quit a few months ago after years of usage when it became legal in my country and i have never felt better in my life ❤

[@codymunciemusic]

It’s not easy, proud of you! Currently 1 month clean from Grass

[@Willyyyyyyyyyyyyy]

Why is weed so bad, yet alcohol has been legal for decades?

[@hyperadapted]

@@Willyyyyyyyyyyyyy its not about alcohol.

[@chiefsinner1680]

We have been made immature by propaganda

[@sterlingmillhollon2520]

Happy for you!

[@Alx-L]

Hi Andrew, Thanks for another lesson in science, but overall, thanks for a great lesson in practical humbleness and a constructive way to deal with diverging views.

[@GeoAnya]

Dr. Hill brought so much to the table! Thank you both!

[@jamesritter4813]

Hubberman i love the way you put togther your content. I love the wide spectrum of content relating to the mind, body, and soul! Your nsdr! Came across this while trying to get use to working night shifts. It was a life changer to my mental health!

[@kiarapullen4298]

Those first two weeks after quitting smoking heavy is terrible

[@mark-pz7yx]

The sweating and no appetite woooooooooo boy

[@musicjewell9329]

Good luck you got this

[@nokateno]

The nightmares, stomach probs, irritability..

[@KevinL-ih9rl]

You got it . Once you make pass a month you literally forget about cannabis and you realize you’re better of w/o it trust

[@28mouse85]

I smoked around 3.5/4g per day. Every single day for over 10 years. Didn’t have a single day without smoking in those 10 years. And i quit in January this year. Not once did i experience any withdrawal or loss of appetite or the inability to sleep. Quite the opposite infact. Straight away my sleep improved and i had a better appetite

[@liamweavers9291]

As an instrumentation engineer, the elephant in the room, is the lack of standardised testing for cannabinoids. You could take the same plant to different labs and get completely different results. You can take the same plant to the same lab as different samples and get different results. Older varieties of cannabis tend to have a more mixed cannabinoid profile than modern varieties because they didn't specifically know about THC. This meant that plant selection was very much more about the subjective experience and plants were selected on this basis. Unfortunately, they're now selected based on inconsistent lab reports that highlight THC and CBD only. Cannabis should be considered an experience, much like food (It is a plant after all and did form a staple part of many cultures diets) - does it smell nice, does it taste nice, how does it make me feel? Your body knows what it likes and will tell you. With regards to expectancy bias, that only goes so far, for example, you could tell me that an oyster tastes lovely and is really good for me and it may give me that expectation... But I've tasted oysters and they're like salty fishy snot 😂

[@NathanNGM]

I'm SO impressed with how gracious and open Huberman is with this gentleman. Hats off to them both for actually doing this podcast!

[@TheLastSecretGarden]

I've been a daily cannabis user for about 15 years. I have never had any issues - especially since legalization here in Canada, where I can now purchase high CBD-to-low-THC flower. The flower I use on a daily basis is about 7% THC to 11% CBD. The only time I ever experience any issues is when I venture into the 20-30% THC zone (very very rare, but the anxiety is instantaneous). What an interesting podcast all the way around, thank you so much.

[@marksinger1278]

Did you notice how little they both seemed to know about CBD/CBC/CBG/CBN?

[@etc15100]

About 2 weeks out from quitting use after 6 years of daily, heavy smoking. It’s been tough but this episode gives me strength

[@Youttubeuser20932]

What about this episode gives you strength or incentive to quit?

[@spartin86]

I workout often after smoking, and I've never had issues performing. I've ran 10 miles after smoking without issue. I continue to partake and workout and show improvement with strength.

[@wielkizordon]

Beginner

[@sinephase]

that makes you an outlier

[@Mikaeel84]

Imagine how good you do without it. Unless you quit and cross reference your results with previous ones you will never know.

[@theman2223]

That’s because it helps you breathe better. Australia’s best ever Olympic swimmer smoked prior to training. It opens sacks in your lungs that’s why they use it for treatment for people with asthma

[@user-om4ki3mb5s]

​@theman2223 yup it in my experience it improves oxygen uptake and improves performance in repeat explosive, sports such as 7 aside football

[@stevebob240]

I saw this discussion on Twitter, I am so happy that discussion has become such a positive, important conversation!

[@JIPPVideo]

Thank you for this! I appreciate it in my journey to learning more about what affects my body.

[@ericsisk1]

I have so much respect for Dr Huberman. Having this kind of discourse without cancellation or character assassination is much needed everywhere these days. It took a humbling act to make this happen on his part given the way this guy reacted on X. Dr H will be remembered long term. Not sure about those who argue on X/Twitter.

[@alexcoombe3377]

Yeah, I was appalled when I actually went and read this guy’s comments on the X thread. Absolutely blown away at how humble Huberman is to have someone on who I’ll say was a total asshole going after Huberman as a person/podcaster instead of just talking about the science. Huberman has my great respect

[@twkr]

Legend.

[@SeleckPlays]

I've experienced "hangover" effects the next day on edibles, where my head aches and I feel groggy. I don't experience that with flower. I also developed a significant tolerance when using edibles, which resulted in titration issues for me. For these two reasons, I no longer use edibles.

[@MattWeber]

Yea him talking about how easily you can over consume due to the delay in feeling it, is important with edibles especially (starting at the 1:15:00 area)

[@lateefevans3598]

I think part of it comes from how long the ride is and is the user adequately hydrating too. Say for example, take an edible late at night and pass out maybe a couple hours after you take it, maybe not adequately hydrated through the night

[@hyvatystavat]

Loved this talk. More podcasts about cannabis - even more widely and more debates. Thanks Andrew!

[@annamarsch6091]

Great to see this episode after the rather ungly exchange on x. The guest is clearly very passionate and knowledgeable on his topic , i am one hour into the episode. i am missing a bit clearity in the presentation of the subtopics. will watch it to the end though.

[@USRXSSRARMY]

thank you andrew huberman for providing us such great informations

[@sanchessr]

Weed gave me panic attacks at 15 years old and it has been an absolute blessing. Learning how to manage unwanted thoughts and become keenly aware of my mortality have helped me gain an edge in life and it’s all thanks to this drug. It is to be respected and used as a tool. It’s given me context and a reference point for negative mental experiences. I can’t imagine having never done weed and developing sudden panic disorder without any context or coping mechanisms.

[@wlfrcn]

very very good mentality.

[@brandonbeacham5404]

Exactly how it was with me ^^

[@jabr0nicus]

I had a panic attack disorder as a uni student and only managed to chill my shit out with weed and meditation. Granted I had to dial it back once I left school but I genuinely would have dropped out cause it was becoming truly unmanageable. Moderation is everything folks!!! Dont let any substance control your life, whether it's weed or coffee or anything else.

[@TheExplosivezzpw]

I was a heavy cigarette smoker from 13 to 20 and I tried weed to help quit cigarettes. I managed to quit cigarettes (that I loved deeply!) and I quit weed too to avoid replacing the addiction. I’ve settled on smoking a joint every once in an a while and it’s always good!

[@trungkiennguyen7655]

Dr. Matthew Hill is brilliant! His description and nuanced understanding of the mechanism of many biological systems is greatly appreciated. I learned many new things about Canabis. Personally, I think the issue on Twitter was just a misunderstanding. Dr. Matthew saw edge-cases/nuances in some of Andrew's Statements, Andrew gave information but didn't go too deep into nuances to make this podcast fit non-technical audiences. Both are high-minded approaches, sparking new public benefit! Thank you to both for making this episode. Many information are relevant to me. Edit: Just noticed the Sativa vs Indica topic. Time to Google to see who's right.

[@anFy81]

I remember in the early 2000.. I had an exam coming up - the day after a party I started to study and after reading an entire page I couldn't recall anything I just worked through. that was when I realized that if I want to get through college, I have to stay away from cannabis. Sadly.

[@BlazeIsBOSS]

sounds like you didnt have a strong tolerance. maybe dont smoke the only joint u ever smoked the day before you study lmao.

[@twenty6ixteen]

@@BlazeIsBOSS ​ eh I used to smoke morning to night for months and the head fog was so real I couldn't recall anything I did the previous day.

[@theman2223]

Funnny you say that I’m the opposite, if I study on cannabis I absorb everything and it is so much more interesting. I get wowed by everything I read and I become so much more passionate about it.

[@anFy81]

​@theman2223 I am pretty sure it also depents on your specialization.. I can imagine it's great in any field that requires creativity - in my case it was law and the learning of legal paragraphs and dates/numbers of court decisions.. so yes

[@theman2223]

@anFy81 Makes complete sense! For me it doesn’t matter what field or subject but also for me law is so boring that if I smoked during study I would sleep for sure and that good affect would not take place hahaha I take my hat off to you for doing what you do, your a champion!

[@maxwellragland4903]

Everyone talking about the controversy but it’s clear that there’s no bad blood and these are just two professionals who want to inform the public, I greatly enjoyed watching the way they responded to one another and how they sequentially moved the conversation forward

[@Owl-of-Minerva]

Robust discussion. Learned a lot. Had a few misconceptions about phytocannabinoids, edibles, and cbd. Many thanks, much appreciated.

[@cholakicha]

Those mammoth podcasts will cure me of my podcast addiction. My attempts to keep up are obviously unreasonable.

[@gian7707]

You both deserve our utmost respect and appreciation in so many ways. The thirst for accurate knoweledge and just the 'WANT' to help people, moves me in a way I can not put into words.

[@LDPink60]

My friend was diagnosed with schizophrenia at around 18 probably triggered by cannabis but as CBD came into the market she now can use cannabis therapeutically in the right CBD/THC ratio very effectively as an essential medicine. She is now in her 30s.

[@ecmobb8749]

Bs that is way more likely to be genetic!

[@rhumandlove393]

It's not like sugar and type 2 diabetes. Consuming cannabis doesn't give you schizophrenia.

[@EmilioBellomo]

Huge cannabis user! Thank you for never pushing personal views on the subject and always sticking to data

[@Dylan-jn3dq]

Honestly one of the best episodes . I like more in depth pharmacology and mechanisms which the other one didn’t really have

[@sendscho2260]

wow the amount of detailed knowledge of the guest is impressive

[@Knowledge_is_Power911]

im lighting a joint right now to listen to this ! thx

[@christao.3070]

I love Huberman, appreciate the exact way he presents his unbiased information, and the honesty, openness, and willingness with which he responds to the reactions and includes the knowledge (and some disparaging opinions) of other experts and specialists. Dr. Hubermab is a model for humility. I have not read all the comments so I apologize if this a repeat, but I was disappointed that they briefly discussed the shocking statistic regarding the incidence of cannabis use during pregnancy, and Dr. Hill said the impacts “are many” - they said the specifics of other drugs, but did not go further into the impact of cannabis use to a developing fetus. If the prevalence is that high, I think it’s important to be very clear about the negative impact using this drug during pregnancy can have. Dr. Huberman, can you please recommend any resources for simple, up-to-date, trusted resources on this topic? THANK YOU FOR YOUR SERVICE 🙏🏼

[@brandonpeveler4121]

That’s insane I was just looking for this video last night! 😉

[@kokoBuSiLiCa]

Wow what a timing, I just prepared my J and this is exactly the episode I needed!

[@hyperadapted]

let us know how much you recall from the episode ;)

[@iamrinakatofficial]

lmao

[@SteinBergsson]

Is this THE doctor, who acted like an "rude teenager" on social media?

[@jbartmontage6737]

He is a idiot on cannabis.. He lies and lies...

[@hyperadapted]

"dr."

[@Andrew-ri5qo]

Yes

[@BlowinFree]

He’s the big sh agg er

[@sarahbrome5564]

@@SteinBergsson He’s trying to hide the “rude teenager “ part of himself, but it’s still obvious.😂

[@Wavygravvy]

Couple hits at night goes a long way, I got diagnosed with diabetes 2 weeks shy of 15 years old. My night time anxiety was pretty awful, and falling sleep was tough. Totally coincidental, when I tried it eventually in college at 21, I started finding my nights to be relaxing, euphoric and introspective after some cannabis. 37 now. I do stay mindful of lung irritation for the long haul, but truthfully keep usage to less than a bowl pack. We all need a lil something in this life.

[@silviojosebreginski2978]

From Brazil: I appreciate all videos

[@corbindallas3220]

I really like Huberman's ability to stay objective and not inject his biases into the discussion so the conversation is not tainted for the listener

[@Youttubeuser20932]

You can't be serious. Did you even watch his first cannabis video, or his comment sabout vaping being "disgusting" with Chris Williamson?

[@corbindallas3220]

@@Youttubeuser20932 no I didn't. Also refering to this podcas only, so if he did in other maybe he decided to do this one different. Also vaping is gross imo.

[@Youttubeuser20932]

@@corbindallas3220 1. He injects his bias into a lot of topics, in the form of overhyping anything potentially "scary" in his mind. 2. What's "gross" or disgusting about vaping? Unhealthy =/= gross Blowing a cloud of cotton candy flavored vapor isn't disgusting, at all.

[@corbindallas3220]

@@Youttubeuser20932 read top comment more closely referring to this podcast only. ......

[@Youttubeuser20932]

@@corbindallas3220 he does it on his podcast episodes too. This episode he was nervous that this guy was going to call him out again so he just asked questions instead of making string claims like on the first weed episode

[@Ghizlanh]

Thank you Andrew ❤

[@ItsBrendaBlanco]

I love how, regardless of the fact that Hubz is a scientist himself, he allows the guest to develop thoughts and explanations without interruptions, adding only when necessary to further expand or lighten the mood even further. Absolute pro.

[@yaseenathar4758]

Dr. Huberman can you make a video on how to read and understand what does macronutrients mean, like the difference between trans fat,saturated fat,monounsaturated etc. All of them. Your videos are really informative and I learnt many things from them and feel grateful that you share knowledge which would have been otherwise unknown. Love your work. Keep prospering.

[@13hubi13]

I've been a stoner for 13 years, and I'm 32 now. I used to smoke weed with tobacco, only using a bong, every single day. My routine was starting the day with a bowl and ending it the same way. But I didn't just smoke one bowl, I'd always smoke at least 3 or 4. Last year, I got busted, so I took that as a chance to quit smoking. I always wanted to stop but couldn't because I loved it and quitting was always hard. I spent a year mostly sober and started vaping again when I got COVID. With my Mighty vaporizer, I only needed about 0.07g a day, and that was just to sleep. I was very skinny then, around 60kg at 1.81m. During that smoke-free year, I gained about 17kg, looked really good, and even built some muscle. Then, I decided to smoke a bong again. It was disgusting, but that didn’t stop me from smoking more often. Now I'm back to smoking from morning to evening, and I don't feel good. I think about quitting every day, but when I get home, I just smoke a bong again, or when I'm with friends. Now I've lost about 10kg and am down to 65kg. Almost all the weight and muscle I gained during my sober year are gone. This is the main reason I'm going to stop again now. I just can't eat with my extreme usage. When I quit smoking, I could eat like a normal person for the first time in 10 years.

[@BuMyBeLlY]

Good luck 💪🏿

[@nikolaih7478]

take every day as an opportunity to step in the RIGHT direction

[@josephnahous5751]

Those backy bongs are the worst to quit. Currently trying to do the same.

[@rezvaneh.faraji]

find the right ppl who can support you, don’t hang out with friends who smokes, unfortunately or fortunately, having the right ppl around yourself for quitting any addiction is the first and most important step, make your environment healthy, otherwise yoy just can’t, yes you need to sacrifice sometime, but if quitting is something that you think about it every day, it WORTH it!

[@CarlHungus-y1t]

Sad.

[@graymattr4013]

I stopped smoking weed in October of 2022, on my 37th attempt. You CAN do this and you CAN change and you WILL grow

[@Gnu58431]

This was a fascinating discussion and I thoroughly enjoyed the exploration of the contemporary understandings on various perspectives of this potent plant. One of the points made towards the end of the discussion was its benefit in survivors of trauma, in both alleviating anxiety (perhaps by recalibrating Anandimide levels) and reducing REM sleep thereby stopping nightmares and improving sleep, lower overall anxiety and better quality of sleep. For those that do not find a litany of prescription medicines to be helping them with their trauma distress (and those medications often come with their own side effects) I suppose it's a question not of drug-seeking behaviors but what works best for a patient's results and overall quality of life. Perhaps intermittent low dosage can help short term to aid longer term recovery?

[@graymattr4013]

@@Gnu58431 if you can moderate your marijuana intake it’s an amazing plant. If you’re like me and have to smoke all day everyday and become a drug addict it sucks.

[@amandawilson1426]

Holy cow. What an amazing conversation. So much respect for both. I wish I knew half you what you do

[@jasbassi6983]

Smoke twice a week (probably half a joint over the two days) and have been doing so for about 7 years. Never felt any negative side affects - physically fit (6x a week training/soccer); happy; driven; practised as a lawyer for several years. Maybe its on a case by case basis and how much one smokes in a week?

[@d_chatz8353]

Good for you