Dr. Peter Attia Changed His Mind on Metformin

Please check out the original interview here: • Dr. Peter Attia, MD - ...
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[@Kuttanwarrior]

CONGRATULATIONS FOR YOUIR CLASSIC BOOK TITLED 'OUTLIVE"!!

[@tarapruett4664]

Thoughtful content. Thank you. 😊

[@TopgunB]

He is also pro statins and thinks raised LDL is always detrimental and that statins are great so despite his in depth studies he sometimes does not see the woods for the trees.

[@roblovegreen]

The. body is such a complex self balancing system. Nothing beats proper nutrition, exercise and sunlight in regards to health and longevity.

[@daveb8449]

Agreed.

[@treal512]

Love these conversations so much. Was really hoping the last questions would come up and they did. Looking forward to hearing more about this in the future! Thanks Tim and Peter.

[@antichris78]

2:35 probably the best short explanation of Zone 2 I've heard.

[@zibtihaj3213]

How do I know tor sure I am in zone 2… let’s say if I am doing stationary bike ? Thx

[@bayareamacaddict]

Please discuss Berberine

[@TheKidneyDoctor1982]

The average half life of Metformin is 8 hours, probably you should adjust the time you’re taking Metformin and when you’re exercising so they won’t antagonize each other and you could reap the benefits of exercise and metformin. Besides, right now, the studies are still divided, nothing conclusive yet.

[@mbdulka]

That recent study was 43 people, no controlled diet, no controlled previous health taking into consideration .. in effect, useless.

[@ChrisBaker-i6z]

Does Berberine use the same mechanism / have the same effect on mitochondria?

[@aminreviews2311]

It is unclear whether metformin actually inhibits the mitochondrial complex I in the liver at clinically relevant drug concentrations (see 2020 review by Ling He). The mechanism by which metformin decreases the responses to exercise may be related to other effects of metformin, which are many. For example, the decrease in muscle hypertrophy observed with metformin could be from AMPK activation, which berberine also activates. The bottom line is that we only know a little about how metformin affects the benefits of exercise, and we don’t know if berberine also does this.

[@emotuy08]

I quite agree. When Im on peak at working out and take metformin - I feel shit and recover slower

[@mbdulka]

Anecdotal. The study for exercise with/without metformin was like 43 people ... useless. I've been on it for a year, and I feel fine. Maybe I'm not getting as big visually as I would without, but I'm just as strong.

[@emotuy08]

@@mbdulka Where you already at peak performance when you took the metformin?

[@ewaluchter-wasylewska763]

I have nów neuropatia after shingles. Nów I have Got info that metformin makes avitaminose B1 and B12 which metformin has made. Therefore IT is not so positive medicine! Is'nt?

[@bobcocampo]

Best is to exercise better than Metformin

[@jasonpatrick-x1k]

Berberine? Opinion?

[@robynhope219]

Some don't have the energy.

[@cheepchicken]

Big in the bodybuilder world

[@nwobob]

Well you could use metformin to drop your glucose a bit overnight. But a much more pleasant a guaranteed path for me is to have a couple glasses of wine. I appreciate alcohol is a human tissue toxin and carcinogen with no safe dose. Yet I have done a lot of lab testing around this. If I have adequate fasting intervals and no low glycemic carbs my liver function is spot on. Just a thought on a very narrow bit of human physiology, the answer for which will not come for our population in my lifetime likely and for me will.determined by my time and manner of death.

[@healthtips8041]

Great comment, thank you for sharing!

[@Peshur]

There’s is no free lunch with any supplements.....Tim Ferriss

[@bobcocampo]

Does it mean that Metformin causes Sarcopenia?

[@Permuh]

No, it just halts the effect from exercise

[@bobcocampo]

@@Permuh Exercise improves muscle 💪

[@bobcocampo]

Please discuss SGLT2 inhibitors?

[@dhhavs]

Whats the latest news on metformin in 2023?? Can non diabetics take it for anti aging???

[@elizabethk3238]

Did you not listen to the video?

[@dhhavs]

This is a year old video, I asked about the most recent findings on metformin use in non diabetic people.

[@wisemansaid5009]

I've recently started taking metformin for anti-aging my sexual health was great but improve even further i know there are studies about decreasing sexual drive. Maybe decrease of dopamine but I had very very high levels of dopamine which causing problems but this drug has decreased little bit and increased my serotonin by inhibiting bcaa levels which compete with serotonin making enzymes which makes me last longer significantly because my diet is high in tryptophan also insulin resistance can inhibit conversion of tryptophan into serotonin which metformin supress it depends on person to person like people with rosh of Parkinson disease not advised to take this or maybe with dopamine increasing drug at different times

[@elizabethk3238]

Google it. Stop waiting to be spoonfed.

[@jocs8824]

​@@wisemansaid5009it might eventually increase dopamine where it's needed as problem serotonin receptors start down regulating on long term Metformin, allowing dopamine to rise in different brain regions.

[@mpoharper]

I take metformin because of my mucosal melanoma. I have a genetic mutation that calls for this.

[@cheungfranklin3543]

MD surgical registrar 😉

[@EMedNation]

This is not a longevity agent at all. It doesn’t work.

[@dawnwilliamson4660]

Metformin

[@j-uk2189]

Take metformin, lose muscle!

[@russhyn]

This guy also stood by covid vaccines lol gotta wonder how reliable his advice actually is!

[@bozomonster]

Knowing that I will doubt everything he has to say.

[@viktor4gub]

Pqp.. mais um antivax idiota no mundo

[@craftsmanctfl3493]

Standing by Covid vaccines saved millions of lives.

[@bodhitree1128]

Really?

[@SALVATl0N]

🙄