Why Peter Attia Changed his mind on METFORMIN

Is metformin a magic pill for longevity? Peter Attia's self experimentation with this glucose lowering drug is all about following the latest research.
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*This content is strictly the opinion of Annette Bosworth, MD. Our content informs and educates viewers. Medical advice is not given on this channel. Your personal physician gives the medical advice and treatment specific to your situation. Dr. Boz channel only educates. Consult your doctor or qualified health professional regarding specific health questions. Neither Dr. Bosworth nor the publisher of this content takes responsibility for possible health consequences of any person(s) receiving this educational content. Ask your health advisors before beginning any nutritional supplement or lifestyle program.

[@user-xj5xp6qz5g]

Once I found out Attia was a fan of statins and other pharmaceuticals I stopped paying any attention to him.. it told me all I needed to know about his depth of knowledge and understanding.

[@grayrabbit2211]

My GP has actually never written a single script for a statin in his practice. Then again, he spent many years in a research lab before heading off to medical school, so he actually has an understanding of how the body really works.

[@Initium1000]

You sound ridiculous because you’re not medically trained and not a single person cares about what you say.

[@deirdrewalsh1134]

My Father used to say over and over to me -…”remember if in doubt, the answer is NO” As far as Mainstream medicine is concerned, it’s pretty good advice.

[@mfaracing]

Totally agree. In a word: wisdom.

[@area51z63]

My father always said, do not take your medical advise from doctors who lost their license for committing fraud like Annette Bosworth did

[@robertstancliffsr9575]

I began taking metformin when I was 35 I am 80 now and still taking it. I take 2000 mgs daily and have no kidney damage, no low B-12 or any other side effect, except possibly in the last few years, constipation. On the other hand, that could also be just getting old. There is a reason for the old people and prune juice jokes. It's easy to fix with a stool softener or laxative as needed. I am also 5 years older than the next oldest member of my immediate family lived to be. I have no idea if metformin has anything to do with that. I still take it and see no reason to stop............Excellent drug for me that allowed me to eat more of what I like with no problems. I still do pushups and other exercises and try to walk daily, although nowhere as far as is recommended. So far so good. My blood test results are always good...... Something else I do "wrong" and have since "Tab" came out in about 1950 is drink a diet soda or two almost every day. I like them and see no reason not to. If the artificial sweetener is going to kill me now 80 is a pretty good run, and right now I am doing fine.....

[@user-jp3cc6qs1q]

Bless you.

[@hu6860]

I took Metformin from 2016 to 2021 and it damaged my kdney that caused me skin rashes almost all over my body. It was killing me slowly. Then because of skin problems, doctor advised me to take statins which really I thought Im going to die soon. Ive did a Big U TURN. From Dr. Tan, I started listening about the low carbs diet which can reverse diabetes. Then start listening to different doctors. Finally on June 2022, I decided to stop these meds and do the LC, ketogenic and fasting. Its nearly 2 years now, thank God Im still alive. Not perfect LC or ketogenic but I reduced carbs, sugar, bread, pasta or any foods that contains sugars. Feel energetic and positive. Now, Im back again to low carb after holidays. So far I can even walk 2-3 hrs a day without getting hungry

[@georgeporter5665]

I loved your presentation, making complex Topics understandable. I also appreciate shorter videos like this. Thanks

[@DoctorBoz]

We are trying … I sure like to talk -- so this is amazing how short we got this!!

[@ariston5433]

I have been on metformin Er for 7 years. I was getting diarrhea from it at the 2000 mg dose but since I have cut it back to 1500 mg a day that does not happen. I just went to my Dr. and all my bloodwork was good. I eat right watch my portions, exercise and take care of myself. I am 70 and walk an hour a day and when the weather is bad I walk on my treadmill, I am of normal weight and not obese. I have had high blood pressure since I was 20 years old and weighed 99 lbs. I had hyperthyroidism in my 30s and had to have RAI on my thyroid. So now I have to take Synthroid. Between my thyroid , menopause, I gained weight and was unable to lose any weight so my endocrinologist put me on metformin ER. I immediately lost 8 lbs by doing absolutely nothing. It helped control my appetite too. I wish I was one of those health food superstars that doesn’t let a single processed food molecule touch my lips and only the purest Alpine spring water fill my glass. I do watch my portions, watch my carbs and try to stay away from processed foods. My blood work came out normal no bad cholesterol or high triglycerides, my glucose levels are good too. I hardly ever get sick with anything so I feel fortunate.

[@Sandra.Viewer]

“The master key of knowledge is, indeed, a persistent and frequent questioning.” - Peter Abelard

[@rogerbird5665]

Peter Abelard said that about 700 years ago. He is absolutely correct when it comes to external, objective matters. We call it science now. When it comes to internal, subjective matters, what St. Augustine of Hippo said about 1600 years ago: "Knowledge and experience comes from persistent faith."

[@alant383]

@@rogerbird5665 Hmmmm .... not sure that faith is an objective source of scientific knowledge, or how to use it .... Our understanding seems to have changed (thankfully) in the last 1600 years.

[@rogerbird5665]

@@alant383 Science is fantastic and appropriate for objective matters. There is no substitute. But for subjective matters, it isn't worth shit. If you disagree, tell me all about consciousness, where it comes from, how to make it, what it is made of, how we improve it (keep in mind WW1 and WW2, etc.).

[@alant383]

@@rogerbird5665 Consciousness is the subject of psychological study, We could argue how scientific that subject area is at great length. There is no doubt that psychology is at least partially an analytical science. But subjectivity is by definition a matter of opinion or at least a person's viewpoint. And everybody is entitled to their PoV - imo. :-)

[@rogerbird5665]

@@alant383 Trivialize it even though without it NOTHING EXISTS.

[@BeckyJB]

❤love this example! About 20 years ago I refused metformin. I began not eating sugar and started eating whole foods. ❤ apparently that wasn’t enough because today I’ve gone keto for great results. I am reaching for longevity. ❤❤❤❤thank you again Doctor!!!

[@e.j.oneworld6649]

What is your ApoB level? With Keto for over 10 years, mine was 178! And it’s a major factor risk for atherosclerosis according to Peter Attia….

[@JasonActualization]

​@@e.j.oneworld6649Peter has yet to discover that ApoB in and of itself is not causal of atherosclerosis.

[@zibtihaj3213]

Exactly … mine is 87 and I am trying to lower it also ( not on Keto )

[@loneranger7573]

@@e.j.oneworld6649 If your thyroid hormones arent up to snuff, your lipos will be off. Check your thyroid, and consider HRT as well if you are over 50, male or female.

[@christinehebiton4126]

Look into Dr Ken Berry

[@mariejones7136]

I take berberine which lowers my glucose along with keto diet and I use it since I'm cancer survivor..It works .I also fast .

[@bseidem5112]

Scientists have discovered the ivermectin cures 15 common cancers.

[@jeffreyjohnson7359]

Berberine does essentially the same thing as metformin, but it is less effective because it isn't absorbed as well. I take both.

[@mathieskoljasuszkiewicz242]

Me too. And sauna and cold showers weekly. Green tea, curcumin and many other supplements and herbs

[@rancancookcanoy9768]

Another great video. thank you. My doctor wanted me to take Metformin, but I decided to reduce my carb intake to less than 20 carbs per day.

[@DoctorBoz]

You win

[@colinmacdonald5732]

Is that the same as limiting yourself to 20 Oreo cookies?

[@colinmacdonald5732]

Is that the same as limiting yourself to 20 Oreo cookies?

[@colinmacdonald5732]

Is that the same as limiting yourself to 20 Oreo cookies?

[@colinmacdonald5732]

Is that the same as limiting yourself to 20 Oreo cookies?

[@MrBrianDuga]

I appreciate the translation of Peter Attia's technical language.

[@MartyRaaymakers]

Thanks for making this easier to understand. Good video 😊

[@Floating.Swords]

I learned something new and valuable today. Subscribed!

[@leslietascoff9784]

Fantastic! Thank you for summarizing the reason that Attia stopped Metformin. I heard him talk about it but it sounded more complicated. Your explanation was perfect for me! 😎❤️

[@DCGreenZone]

Berberine potentially for PC. >>Yeah, after taking Metformin, I felt the the affects on my heart and stopped after a day or two and that was in my early 30s. Now Berberine has helped my heart and I can feel the difference. Both being pretty apparent. Berberine is a way better choice than Metformin. What’s interesting is that I have been taking bio-available Berberine 500mg 2X per day. I have literally not been sick with even a cold whatsoever since I’ve been taking it daily for over a year 🤔

[@jameschesterton]

It is insane how doctors are taking prescription drugs without fully understanding the implications.

[@user-xj5xp6qz5g]

Once I found out Attia was a fan of statins and other pharmaceuticals I stopped paying any attention to him.. it told me all I needed to know about his depth of knowledge and understanding.

[@09mubarak]

same @@user-xj5xp6qz5g

[@oldwaltonian2476]

@@user-xj5xp6qz5g A very good move on your part, I would say. We need to stop getting sucked in by these 'doctors' and their constant 'see-sawing' over what pharamcuetical drugs and 'natural' supplements we should and should not be taking for optimising our health.

[@Rob-vl1vc]

What's so unusual about people taking medications that haven't been proven safe long term? It happens over and over and over again. Doctors prescribe them every day.

[@whitGGG]

Thank you for explaining in a way that we can understand.

[@danielhancock6188]

I have been on metformin for 10 years as a type 2 diabetic. As I have learned more about the metabolism, I have been reversing my diabetes. I'm still on medicine, but my A1c was 5.5. But metformin has made me B12 deficient. I am working hard with my diet so that I can eliminate metfomin. I believe it is slowly killing me because it has caused me to be anemic.

[@George-lz6ue]

A single teaspoon of dried yeast flakes a few times a week significantly boosted my B12 levels.

[@terfalicious]

@@George-lz6ue And it's yummy! I put it in my yogurt in the morning - gives a nice, nutty taste!

[@user-if8qq7xv2d]

I think you should be able to come off Metformin now with that GREAT A1c number. Congratulations! What A1c score is your doctor looking for before taking the Metformin prescription away?

[@hevesat1920]

@@George-lz6uewow, that is amazing. I heard about it from Dr. Berg but did not know it was so effective

[@danielhancock6188]

I don't know what A1c my doctor is looking for. I was on 6 different prescription drugs. I am now down to 2 - metformin and gllipizide. I was told I could drop my blood pressure medicine. I am moving in the right direction.

[@George-lz6ue]

Really helpful advice Dr Boz, and love the straight to the point. Thank you.

[@uberpekes]

The only real things I care about doing for health are 1) Eating healthy (which is a minefield of debate) 2) Lots of cardio (more low intensity but high included as well) 3) Strength training 4)7-8 hours sleep 5) Time restricted eating. Those are my 5 pillars I guess. And there are most certainly other things you can do but imo the science/doctors recommendations change (this vid is proof) too frequently.

[@forester057]

Avoid things that spike blood sugar above 120. More beef. Less veg with their defense chems.

[@jeffreyjohnson7359]

Although I do some TRE, it's not really showing benefits in studies aside from reducing calories. Another important thing, which I don't really do, is stress reduction, for example through meditation. Also, a few key supplements, like Omega 3, D, and perhaps a multi (there's a lot of others that have some evidence).

[@dr.sabircholas6074]

Thank you Dr annet for this insight. I think we have to wait more for future studies. Im a pulmonologist do you think a state of Latic acidosis could be beneficial as weight training produce lactic acidosis and is it helps in some pathways that promotes health and likely longetivity .

[@meatdog]

So does Berberine do the same as metformin in blocking the O2 and producing lactic acid????

[@Lulu-kt6gr]

A little less oxygen to your muscles is not going to hurt you and might even help. As long as you’re not feeling extra tired, you’re fine. Adjust your dose if you are tired.

[@Glorymole-pv2gt]

Wouldn’t even a little less oxygen to your muscles negatively affect athletic performance ?

[@seascape185]

@DrBoz I have COPD it’s very bad . I’m asking is all my work in carnivore for nothing? I mean sometimes there is not enough oxygen to go to the mitochondria? I’m 112 but ii was 136 . I’ve never been that heavy but I was fat 155 ate cRbs alcohol smoking . Thfen I havnzeatrn carbs for 15 yrs or alcohol.stop sun and smoking .Anyway what can I do to know ?Thank you for all that you’re doing. 😊

[@ioioiotu]

@@Glorymole-pv2gt You can either have maximal athletic performance or maximal longevity, just ask steroid users :)

[@dr.shadmbbsdphmasco]

Berberine is better than metformin

[@audis4bb]

I'm a biochemist and the problem I have with Peter Attia is that he loves pharmaceuticals, including statins. Statins has significant side effects, including but not limited to increased risk of type 2 diabetes and Alzheimer's and he's still recommending statins in spite of this. He never mentions Niacin which works just as well with none of the side effects. Some common side effects of Metformin include nausea, vomiting, diarrhea, stomach discomfort, and headache disorder. Berberine works just as well with none of the side effects. If I didn't know better, I wonder if he is a consultant to some pharmaceutical company like Scott Gotlieb, former FDA commissioner with revolving door and big paychecks from Pheifer. Attia does not like saturated fats and spews the big Agra propaganda that saturated fat is bad and PUFAs are good this is just incorrect. Check out: Shawn Baker, Paul Saladino, Anthony Chafee. Anyone that pushes pharmaceuticals as opposed to natural alternatives I'm very leery of.

[@lagarde2011]

I've always had high cholesterol though I've never been close to being overweight and I (usually) have a decent diet, exercise, etc. A couple years ago I had a blood panel done and the total cholesterol was 280 with a high LDL being the driver. GP told me to start on statins but I said I wanted to try niacin and I pointed out that my triglycerides were very low so I wasn't worried. GP told me that niacin "doesn't work" and he's never had a patient suffer side effects from statins. Hard to believe, but whatever. He seemed not to understand the implications of the triglyceride numbers. I took niacin for 4-5 months before getting a new panel which showed my total cholesterol and LDL each down around 40 points. Mind you, I hadn't made any real changes to my diet, though the niacin does suppress appetite, which was a happy surprise. Despite the results, the GP still insisted that I start on statins. I changed doctors.

[@AstwoodF]

Niacin does work, but it depends on how low you need to lower your LDL. Not defending Peter here, but in his book, he doesn’t really disparage Saturated fat, and he says that the studies are inconclusive on PUFAs and MUFAs. Given the literature out there, his recommendation is to favor MUFAs.

[@user-xj5xp6qz5g]

Once I found out Attia was a fan of statins and other pharmaceuticals I stopped paying any attention to him.. it told me all I needed to know about his depth of knowledge and understanding.

[@mey7579]

Niacin has plenty of side effects as a family member of mine found out the hard way. He had skin flushing, a rash, and stomach issues.

[@user-xj5xp6qz5g]

@@timbo8366 ur weird

[@galinarovensky3921]

Thank you so much for the detailed explanation. Do you believe Berberine is as dangerous as Metformin, in terms of reactions? Could you provide any information or opinion about the use of Berberine?

[@gabygutierrez8366]

Hmm I have taken Metformin for over 14 years due to PCOS, and I love how it balanced my symptoms…. And it helped me to get pregnant and everytime I stop taking it my symptoms start again…. So I got back to it…

[@patricktrussell7465]

What is PCOS ? Nice abbreviation .

[@Ant88889]

I heard something even on mainstream that metformin use showed increased danger. I will look it up. Just the side effects were not just the problem. New studies showed other dangers.

[@isuriaravinda8211]

Appreciate your descriptive short video. Metformin caused muscle camps as well.

[@jorgegonzales9815]

Disappointing Dr. Boss to hear you are/were a fan of Attia. Guess nobody is perfect. After listening to many of his videos I don't listen to him anymore. He seems unable to explain issues without a lot of medical mumbo jumbo which I think makes him sound arrogant. Thanks for your friendlier more down to earth explanations that we can use to keep healthy.

[@kathy5438]

Dr. Ben Bikman also has a lot to say about NOT using Metformin and the issues and problems associated with using it.

[@ariston5433]

I have been on Metformin Er for 7 years. My endocrinologist waited several years before putting me on it. I could not lose weight no matter how much I tried . I have hypothyroidism due to RAI being given to me for hyperthyroidism. I was on antidepressants for many years and then menopause hit me and I was hungry all the time no matter how much I ate. I have since quit the antidepressant, and have cut down on the metformin. I watch everything I eat , exercise every day. I went to my Dr. two weeks ago and my blood work came out normal on everything. The Dr. told me that my weight is fine too. I really do not want to get off off the Metformin because I do not want to be hungry all the time. Sorry I am one of those defective horrible people who has to take meds for my thyroid and blood pressure ( I have had high blood pressure since I was 21 years old and even had it when I weighed 99 pounds. I wish I could be one of those perfect people who could just pop a vitamin and be healthy food superstar.

[@Eldorado66]

@ariston5433 first of all, it's important to acknowledge the incredible resilience and dedication you've shown in managing your health conditions. You've been attentive to your body's needs, making adjustments as necessary, and that’s no small feat. It's truly commendable that your recent blood work shows everything is normal and your doctor is satisfied with your weight. This is a testament to your hard work and careful management of your diet and medication. Please don't be too hard on yourself by thinking of yourself as "defective" or "horrible." It's crucial to remember that our bodies' abilities to process foods and supplements are largely dictated by our genetics. Each person's body has its own unique needs and responses, especially when it comes to managing conditions like hypothyroidism and blood pressure. The fact that you require medication doesn't make you less than anyone else-it simply means you're taking the necessary steps to care for your health. You're doing everything right by monitoring your health, staying active, and listening to your body's cues. Keep focusing on your health and well-being, not on an idealized notion of perfection. You are strong, capable, and worthy of self-compassion. Continue to advocate for your health as you've been doing, and take pride in your journey. You’re not just surviving; you're thriving, one step at a time.

[@OptimizeYourHealthPhD]

Wise choice!!! Ray Peat nailed this down decades ago...! RIP Dr. Peat

[@boromirofmiddleearth557]

interesting video. thought about taking metforminbut didn't. don't take statins. doing a sardine fast right now. As a Norwegian American I prefer King Oscar wild caught brisling . Doing well! start weight 275 lbs down to 272 lbs on 2nd day. looking forward to doing your program Dr Boz!

[@simonwiltshire7089]

Waiting for Peter to change his mind on statins.

[@APEXCARNIVORE]

this guy cannot even grow his own hair😂

[@y00t00b3r]

@@APEXCARNIVORE lol We're gonna be waiting a long time for Peter to change his mind on statins. He's hypnotized by "established" "science". Dr. Boz is being really charitable towards Attia.

[@PudgyCurmudgeon]

"Science evolves by being challenged, not by being followed" - Gary Fettke, orthopedic surgeon and Low Carbohydrate Healthy Fat (LCHF) advocate. Peter ought to have a chat with Gary.@@y00t00b3r

[@Krunch2020]

Yes, he’s self experimenting with something different every few years. He thinks Apo-B is the largest predictor of atherosclerosis. I think it’s metabolic disease. Peter has done keto and Omad with fasting for years so he has considered various viewpoints.

[@griffinharvey3910]

Wow! I'm really surprised to learn he's in favour of statins! Even I know better than that, and I'm not a doctor! :-D

[@stufen11]

Wow, Dr Ted Naiman said this a number of years ago. I have never known him to be wrong. Nice video Doc.

[@DoctorBoz]

Thanks! Glad you enjoyed it

[@hmmm..2733]

I gotta say…you’re equally as nerdy as Attia and his gang….That’s why we love you!!

[@tedjackson426]

Thanks for the video. Small point, but ETC's are located on the inner mitochondrial membranes or cristae, not the Outer membrane as you stated.

[@wesleycardinal8869]

Interesting. My wife recently went on to metformin at our request. She has MS and I was encouraged by a study from Cambridge Uni in conjunction with researchers from the Uni of Melbourne that found a reversal of damage in rat studies with fasting and metformin. I would have liked to see her take on fasting and I have Dr Boz's book on the Keto diet and her mum. But she's not interested in serious fasting, and I can't change her mind. But the fact that metformin was also shown to give the same benefits was encouraging. It's still early days for her and we will have to wait and see if there's any improvement.

[@user-if8qq7xv2d]

Berberine, an OTC supplement has been proven in studies to be as effective as Metformin, or better, without all the side effects of Metformin.

[@loneranger7573]

Consider this and do your own studying: Many women go into remission from MS during pregnancy. Why? becuase of high levels of Progesterone. Progesterone helps build Myelin sheath. if you live in the US, you can get Progesterone cream at any drugstore. or order online. I take it as part of my HRT. 200 mgs Prometrium.

[@suemcdermott5230]

Have you researched Dr Roy Swank’s diet? No fasting but very low fat diet. Scientific results for 50 years were mostly very positive.

[@amberelizabethjensen4489]

Estriol, (E3), has been shown to reduce MS Plaques in the Brain. It's OTC in the USA. Purchase at Health Food Stores.

[@war-painter]

@@loneranger7573 - Make sure she doesn’t have breast cancer in her family. Everyone loves to say “ just take HRT” but it’s very easy to get breast cancer and I have several family members who died after doing HRT.

[@bill9989]

I take metformin and I'm not diabetic nor pre-diabetic. Here's why. Before metformin, my fasting (morning) glucose stayed around 90. After metformin, my fasting glucose is around 84. Alzheimers disease is sometimes called Type 3 Diabetes. I don't want Alzheimers disease. The association between AD and prolonged high blood glucose is very strong. Furthermore, do a little mental exercise: Search "metformin and X" where X is any ailment, disease, or condition you think of. The results are very positive for metformin. Finally, Lactic Acidosis is a rare but well known danger for metformin. However, taking Vitamin B12 usually reduces or eliminates that danger. Obviously, I take B12. It has a fairly long half life in the body so I take it a couple of times a week.

[@DoctorBoz]

Metformin lowers blood glucose … the price you pay is to grind on your mitochondria- the sugars are lower … but not because you’re healthier … they are lower because of what you’re doing to your mitochondria… Alzheimer’s is called Type 3 Diabetes because of the tax your body pays from the elevated blood sugars and the ensuing grind of your mitochondria. My approach = lower the sugars without the med.

[@bseidem5112]

A Doc in AUS cured ALL his Alzheimer patients whether in a facility or in a private residence with a strict keto diet (Dr Berg, KZbin).

[@mfaracing]

@@DoctorBoz You are the best!

[@bill9989]

@DoctorBoz But there are other reputable medical and longevity experts who say the mitochondria stressing that you advise against, is actually a positive in that it either strengthens the mitochondria or induces it to make more (or both). Similar to the stressing effects of exercising. Edit Update: I'm a 74 yr old male. My A1c is 5.1 and my Insulin is 7.6 (less than 18.4 is considered optimal). Since I started metformin I've lost 20 very stubborn lbs and got my BMI down to "normal."

[@garnerblair5179]

Lack of folate and b12 will cause issues with methylation and homocysteine. Take a look at homocysteine and dementia. Not good .

[@greggbambu411]

I'm sticking with metformin for anti aging. It keeps glucose and insulin low. Thats a great thing for longevity.

[@robertstancliffsr9575]

I'm 80 now and have been taking metformin for type 2 diabetes for 45 years. It has caused me no problems. Not going to say much about the longevity effect I hit about 90......but, I am currently 5 years older than the second oldest member of my immediate family lived to be............

[@nancykowalczyk2070]

Please don’t assume most of us aren’t interested in the deeper scientific knowledge…….its what I’m MOST appreciative of learning.’

[@newyorkskier]

I also like Peter Attia's shows. He is quite analytical. But I have to say I word of Nir Barzilai over Peter's on this particular topic. When it comes to muscles, I must admit Peter knows the literature well and also has some novel observations of his own

[@MasterofPlay7]

what do you think of methylene blue? it makes the mitochondria works more efficiently

[@1607rosie]

I tried metformin a few years back I hated it everytime I took it I got diarrhea. Luckily I went on line and to see if there was anything else I could do. I learned being on a low carb diet worked. It been tough road but I keep working at. I can keep it around 5.5 -5.7 a1c. So if your on it you don’t have to be. I firmly believe low carb is the healthy way to eat.

[@frankh.5378]

Diarrhea is only for few days. If you go over week or two, your body gets used to it. I have been taking it for last 2 years daily (500mg)

[@PierreDybman]

I a t'ai Berberine, an a no tie ect

[@ioioiotu]

There was also the alternative of slow release metformin that has a much lower chance to cause diarrhea.

[@MarkHolmes]

@@ioioiotu I take 1000-1500mg of metformin ER (extended release) per day and have never had diarrhea issues and I've been taking it for at least 15 years

[@StarvingMyselfToLIFE]

So. How does he or anyone determine what damage may have been caused down stream because of this disruption of a normal bodily function and how to repair it. Taking a foreign synthetic drugs to prolong the life of a any living species doesn't seem logical on its face, but what do I know?🤔

[@Boilerking76123]

Metformin was the first diabetes medicine that gave me stomach cramps and diaries. Had to quit it after first week

[@user-if8qq7xv2d]

It's poison.

[@war-painter]

I was in love with it for the first 18 days and 9 lb weight loss, immaculate regularity every day on time until three days ago when bloating and constipation hit me. Now the weight I lost is coming right back! This is so unfair when I don’t feel like eating, I’m soooo bloated and miserable. Awful drug.

[@pomanprod]

My running performance decreased after taking metformin for 6 months. Specifically I had trouble doing sprints. I read that it reduces mitochondria formation so I stopped metformin. I take berberine instead.

[@jn3750]

Annete, have you ever published any peer reviewed articles?

[@dfgroup]

After watching this I wonder if the way methylene blue bypasses this fist hook up and delivers more to the fourth in the process, if this negates this metformin issue. Any thoughts?

[@outerbanks854]

My niece...the nurse....is worried about my keto/carnivore diet...she want me to consider TMAO....testing

[@musicofnote1]

I just stopped taking Metformin, had been taking it since around 2014. I took it together with Berberine and got the same blood sugar results as without. Now, as i wrote, I stopped taking it when I started taking 2gr of Myo-Inositol/D-Chiro-Inositolat each meal and before going to bed. Blood sugar rates are holding steady. Not going down but also not raising. What I'm really curious about, is what its long time effect on LDLs will be. I reduced my Ezetimib/Rosuvstatin-Mepha 10 mg/10 mg by 25% when I started Myo-Inositol/D-Chiro-Inositol. We'll see in the end of June. BTW, I am doing this with knowledge and approval of my GP.

[@ukestudio3002]

Articulate, informed, well meaning .. thank you.

[@PetePuma25]

Dr Boz is my favorite. She is smart and beautiful, the perfect combination for my health education.

[@silversulu]

I wonder if Berberine has a similar impact, given that it's also a mitochondrial impact very similar to metformin.

[@sbarros78]

Such a beautyful woman ❤

[@C2B1303]

creepy commentary

[@theancientsancients1769]

Is this the same case for Berberine?

[@Linda-xr8zw]

As a prescriber, if someone needs to start medication for high BG what would be your first choice? Metformin has always been encouraged as a first line med. I appreciate the information in the video. I under stand Keto works , albeit by varying degrees from person to person. But some people do not have the means to initiate keto lifestyle changes for a host of reasons.....

[@YeshuaKingMessiah]

U can do it No excuses

[@y00t00b3r]

you mean people have a host of reasons for not initiating lifestyle changes that are available to everyone.

[@Linda-xr8zw]

@@y00t00b3r well as an example, some people are opposed to eating meat and dairy for religious or political reasons. Keto is not going to work for them.

[@y00t00b3r]

@@Linda-xr8zw Avocados, olives, macadamia nuts, pecans... It wouldn't be easy, but it would be worth a try. You can't help the un-helpable. You might have to resort to metformin if switching to a whole foods diet was not adequate.

[@jobrown8146]

People need a motivator (for me it was learning that you can go blind and get kidney damage) as well as education (learning the various methods that are available so they can choose). If people don't know that it is possible to remit diabetes by changing what they eat then they aren't being given choice. If they are educated and then choose not to change their diet then they have made an informed decision. I remitted my diabetes in less than 3 months just by changing to low carb. When I was diagnosed with diabetes, my GP wanted me on metformin, a statin and also see a dietician (in Australia). I said no to the drugs and that I would try diet first and told her that you only change one thing at a time. At the follow up appointment when I got my blood test results I said to her that I hope from now on she suggested diet before drugs. If I had taken the drug/s and changed my diet I think that the drug/s would have been assumed to have made the difference or contributed to the remittance and I would possibly have ended up on them for life. ALL DRUGS HAVE SIDE EFFECTS.

[@mrhomely]

Any options on berberine for lowering A1c?

[@Soliaipix]

Would it have helped to take B-12 with the Metformin?

[@robertstancliffsr9575]

Yes..........

[@joannekerr8839]

I'm a T2 diabetic and I've been taking a small dose of metformin (500mg) every day - would this size dose, going on what you're saying above, be contributing even in a small way to me feeling tired/lethargic every day ?

[@l.s.3066]

Stop taking Metformin for a few days and see how you feel, then you can draw your own conclusions.

[@e.j.oneworld6649]

What’s about Dr.Attia’s belief on ApoB??? Is it still credible????? I started taking PCSK 9 for my ApoB which is 178 this month…..

[@paulywalnutz5855]

something about it upregulating your insluin receptors after a short duration lead me to believe that if you didnt have diabetes, a short stint on metformin could be good used sparringly

[@gyaniadmi2347]

Thanks for this information 😊👍

[@danielwiederkehr5163]

so, should a diabetic take or not take metformin? is there an alternative?

[@ioioiotu]

Sure a complete block of the electron transport chain will cause death, but there are good reason to believe a partial block prolongs life as an exercise mimetic and hormesis.

[@yveshenry1978]

Hi Doc, any mention of Berberine's mechanism of action? It seems to have many benefits with no down side. If Berberine can control blood sugar as well as Metformin, why would anyone take the latter?

[@MarkHolmes]

I have tried Berberine vs Metformin. Didn't do a thing for me, so I'm a bit suspicious of all of it's so-called "benefits"

[@JackieUnfilteredASMR]

Is berberine ok???

[@justincase5272]

My doc prescribed 4 Metformin a day. No way! Diarrhea. So I take 1 a day, along with 2 Berberine. Same results.

[@insidebabashead8591]

My mother was in a Glucophage (which is now called Metformin) clinical study. After 3 months, we were told to immediately discontinue it. Her previously perfect kidney function had been seriously compromised. I have two friends with the same problem. Yet I dont believe the mfr has ever acknowledged that potential serious side effect.

[@Calidastas]

"It might not have done what we thought it was doing" should be the motto of the medical industrial complex.

[@mauriceupton1474]

The citric acid cycle. Very critical.

[@charlieyang2613]

Do you have a video on Ozempic?

[@lindah629]

How do you do keto without a gallbladder??? Thanks 😊

[@marilyn6905]

Inquiring minds anxiously AWAITING your comment on Peter Attia's decision to STOP FASTING...& his estimation of his 20# MUSCLE LOSS over 5 yr Fasting practice with ??? associated Benefits.

[@jimb3457]

Yea....he does look a little wimpy, kinda like David Sinclair and he takes metformin.

[@sampotter4455]

Shouldn't the common sense starting point be: don't take any drug unless you have to?

[@infersage1329]

I went to a weight loss clinic and they prescribed me, Metformin. I ended up being allergic, I guess because my feet swelled up and broke out in hives.

[@lilareed2320]

Dr Boz…ok so if im doing keto and now carnivore…how is it that my aic is 5.7 and on carnivore its 6.0. My naturopath wants me on barberine or metformin. Ive lost 40lbs - why is BS still high when not taking in carbs?

[@zvikaso]

Maybe due to gluconeogenesis.

[@x-techgaming]

Amazing brown eyes 😍

[@lpgoog]

How about Metformin and reducing chances of getting LONG COVID?

[@michaelberman3648]

Will berberine result in an increase in lactic acid production as well?

[@war-painter]

Will berberine help to lose weight/appetite or will berberine cause constipation and bloating like Metformin? I can live with occasional diarrhea, although that was never really an issue.

[@paulettestancil5986]

Wow

[@quake2u]

You seem to know in detail how cells of the body work, so I've had a life long chronic fatigue problems and would like to know what causes such a problem.

[@MobyShamu]

Don't ask Quack youtube doctors for advice.

[@MarkHolmes]

@@MobyShamu what makes you think Dr Boz is a quack or any of the others? (Dr Ekberg, Dr Ken Berry, Dr Eric Berg, Dr Jason Fung, etc etc)

[@Herbert_Knavs]

Lactic acid or lactate?

[@BLR1GBattlemaster]

Didn't they also show that Metformin decreases exercise tolerance? I'm sure it's related to the lactic acid build up issue. That's why I'm hesitant to take it.

[@joseph72588]

Some don't take Metformin on exercise days.

[@unixnerd1]

If a T2 diabetic is able to properly manage their blood glucose levels through diet (low-carb or keto) and exercise, would you say it's better to be off the Metformin, or still take it for the extra marginal gain?

[@y00t00b3r]

why on god's green earth would you take a medication if it weren't necessary?

[@jobrown8146]

All drugs have side effects. I've got high LDL 300 after changing to low carb and refuse to take a statin, which has been recommended by my cardiologist and my GP (telling me that I am at a high risk of heart disease), yet I am now metabolically healthy and have a coronary calcium score of 0.

[@slay2525]

I take Metformin for a 90 day cycle maybe once a year. Not for diabetes, only longevity. I mix up my stack just to keep it fresh.

[@KayFlowidity]

3:00 👌👌👌 4:15 Lactic Acid

[@DMx4839]

I'm a 70-year old Type 2 and have been on Metformin for 22 years, non-stop. All I know is that it helps. I have no set diet other than avoiding sucrose and products with sucrose/sugar in it. So, I'm no expert at all. But, I'm as strong as an ox (I think) and experienced no complications at any time as a result of my condition and from Metformin. I exercise only periodically (on for 6 months, off for 2-3 years) and the only time I put on belly fat or have any bloating is when I drink fruit juice. Yes, I experimented with it to confirm the hypothesis. So, perhaps I need to learn more why Metformin is described as such a problematic product?

[@bill9989]

It's not. It's saving your life and reducing your chances for Alzheimers Disease. Keep at it.

[@Lulu-kt6gr]

@@bill9989I think so too. If it’s lowering oxygen a bit, well we know that oxygen is an oxidant, which is why over-exercising is counter- productive. Attia is smart but he’s just guessing and probably wrong with this call.

[@bill9989]

@@Lulu-kt6gr I posted in more detail on this video. I think you'd enjoy the info if you can find my post.

[@kerrywebb4565]

Someone please explain my painful pituitary gland

[@TopgunB]

Well lets hope Peter Attia changes his mind about LDL and statins as well.

[@elaineevans7126]

Check what out?? Is there a second part to this?

[@DoctorBoz]

There is an end screen to watch I actually think we have not published it yet … hang tight

[@Leonardokite]

So what are your thoughts on methylene blue? It's a very old drug that has been rediscovered to do some amazing things in your body in low doses. Primarily it works directly with the mitochondria to increase ATP/energy. It even works in the brain. It looks very promising. I plan on trying this starting next week.

[@ianstuart5660]

Have heard amazing benefits about it!

[@nancymc4154]

I'd love to know what she thinks, I bought some lab /food grade MB a few months ago after reading an impressive book about it but have been afraid to take it 😅

[@ianstuart5660]

@nancymc4154 maybe try very tiny amounts to start!

[@Leonardokite]

@@ianstuart5660 Indeed, definitely smart to start at the low end and work your way up.

[@DoctorBoz]

I love the research on Methylene blue

[@zippytippy]

I took it for 30? Years. In the end it made me so sick. Attacked my Liver and my mouth got so sore.

[@alphacause]

Whether you agree with Dr. Attia or disagree with him, he exemplifies an attitude that more people should have. Don't be wedded to your beliefs. Constantly refine your conclusions and practices based on new findings when they have the weight of the evidence behind them. Very few things can be more admirable in a person than the willingness to admit when one is wrong.

[@McsMark1]

Dr Boz, please note the sound of your voice in this video and the sound in the video from 6 years ago that you link to at the end of this video. The difference in the 6 year old video, is much easier to hear your words (crisper & cleaner) vs this video (muffled or somehow slightly distorted). Probably where & how you recorded this video vs the previous video.

[@greggeaton4351]

In lieu of your thoughts on Metformin, & understanding that Berberine is a "poor man's" version of it, what are your thoughts about Berberine?

[@KJB0001]

Dr Boz, should we (nonDiabetics) stop Berberine then as well Also, in Biology 1301 in college, I faked it past the Kreb's Cycle chapter, thinking 'when will I ever need I know this" Ha!!!

[@DoctorBoz]

I would not take berberine for the same reasons I don’t take metformin

[@MarkHolmes]

@@DoctorBoz as a LADA diabetic, would you take metformin (something I've done for some 15+ years) or would you take insulin? My c-peptide is at 1.1, fasting insulin at 3.2. GAD autoantibodies on the high end of the range. So I'm still making a small bit of insulin and I eat low carb and take 1000-1500mg of metformin ER per day. Should my endo doc be encouraging me to take insulin to preserve the few remaining beta cells I have left? I get mixed opinions. (hba1c around 5.8)

[@lizkeith1356]

BIG PHARMA MUST BE BROUGHT TO HEEL.

[@polyanthesis]

People with MECFS can have low HbA1c, no diabetes and high lactic acid (along with pain and other symptoms)

[@harryhoesch3793]

Sure seeing a lot of I was wrong content. I'll save the time the first time now.

[@murrayduffin6241]

Now check the long term effect of metformin on cognition>