Dr. Peter Attia Pt 2 - Hormones, Ozempic Weight Loss, Insulin Resistance, & Testosterone Replacement

Peter Attia, MD, is the founder of Early Medical, a medical practice that applies the principles of Medicine 3.0 to patients with the goal of lengthening their lifespan and simultaneously improving their healthspan. He is the host of The Drive, one of the most popular podcasts covering the topics of health and medicine. He is also the author of the #1 New York Times Bestseller, Outlive: The Science and Art of Longevity. Today we're sitting down with Dr. Peter to finish our conversation from Monday and discuss all things nutrition, how things like alcohol affect your body, and everything you should know about supplementation.
TIMESTAMPS
00:00 Importance of Emotional Health
03:26 Understanding the Roots of Negative Behaviors
05:34 Bridge to Recovery
12:16 Addiction and Alcohol
16:01 Alcohol and Research
17:04 Insulin Resistance
27:59 Glucose Regulation and Insulin in the Body
30:22 Insulin Resistance: Causes and Effects
39:51 Semaglutide and Metformin
51:22 Semaglutide and Weight Loss
53:12 Terzepatide and Long-Term Risks
56:41 GLP1 Inhibition and Cravings
58:14 New Drug for Weight Loss
59:05 TRT and Hormone Replacement Therapy
1:01:44 Decreased Libido in Relationships
1:03:09 Testosterone and Low Libido
1:06:38 Testosterone and Androgen Receptors
1:07:39 TRT, HCG, and NAD
1:09:33 NAD, Oral Precursors, and Supplementation
For Detailed Show Notes visit TSCPODCAST.COM To Call the Him & Her Hotline call: 1-833-SKINNYS (754-6697) This episode is brought to you by The Skinny Confidential This episode is brought to you by Westin Hotels At Westin hotels, there’s amenities and offerings aimed to help you move well, eat well, and sleep well, so you can keep your well-being close, while away. Find wellness on your next stay at Westin. This episode is brought to you by Betterhelp BetterHelp is online therapy that offers video, phone, and even live chat-only therapy sessions. So you don’t have to see anyone on camera if you don’t want to. It's much more affordable than in-person therapy & you can be matched with a therapist in under 48 hours. Our listeners get 10% off their first month at betterhelp.com/skinny . This episode is brought to you Primally Pure Primally Pure has harnessed the power of natural ingredients in their complete line of non-toxic beauty products. Visit primallypure.com and use code SKINNY at checkout for 15% off your order. This episode is brought to you by Delola Spritz Visit DelolaLife.com to find a store near you that carries Delola and follow @delola on instagram to learn more! Please enjoy responsibly. This episode is brought to you by Beekeepers Naturals Beekeepers Naturals is female-founded and the products are clean and effective, third-party tested for all pesticides, and the brand is dedicated to sustainable beekeeping and helping save the bees. Get 20% off your first order at beekeepersnaturals.com and use code SKINNY at checkout. This episode is brought to you by Armra ARMRA Colostrum strengthens immunity, ignites metabolism, fortifies gut health, activates hair growth and skin radiance, and powers fitness performance and recovery. Visit www.tryamra.com and use code SKINNY at checkout for 15% off your first purchase. Produced by Dear Media.

[@TheSkinnyConfidential]

Make Sure To Check Out The First Part Of This Interview With Dr. Peter Attia Here: kzbin.info/www/bejne/q6WyeIqugrCbd5o

[@laurarichardson4165]

As a pharmacist, it's exhausting dealing with our instant gratification culture. No one wants to try looking at the "why" with food addiction and obesity. I myself stuggle with these issues, but I continually work on being aware of why I want to eat, I fast, I exercise, etc. .. I wish more practitioners would encourage more lifestyle therapies instead of prescriptions

[@RabbiGlick]

Lifestyle changes don’t make anyone any profit….

[@velocitygirl8551]

What does that have to do with you being a PHARMACIST!? And your blanket statement- NO ONE EVER LOOKS AT … isn’t cool. You don’t know what people go thru BECAUSE you are a pharmacist lolol. That’s laughable.

[@nanasloves]

The thing with Ozempic is that it changes disregulated hormones, unfortunately not permanently. I believe many fat people have ‘food addictions’ from disregulated hormones and maybe different things we don’t understand yet. Maybe it’s NOT a moral issue….

[@thebutterfly6975]

@@RabbiGlickexactly all the answers have been coming from the medicine cabinet and the doctors and big pharma will push it till the mega suits come. That will be fine cause they’ve made billions so the payouts won’t really hurt them financially and of course there’s the new meds to treat all the metabolic, muscular and cancer issues to come. It’s a win win for them all and people are just to lazy to do anything else to help themselves. Pretty sad

[@1972spurs]

Agreed.. lifestyle changes are an important key to help with these issues, speaking as a fellow pharmacist, UK

[@davidgrana1268]

This is the first time i watch this podcast due to Peter Attia and omg, never seen a podcast with so many ads interruptions, awful

[@daphneweldnichols3846]

That’s why I love premium KZbin!

[@davidgrana1268]

@@daphneweldnichols3846 i dont mean youtube ads, i’m talking about the hosts ads

[@vintagebodymindsoulradley9151]

Yes for very little $$$$$$$. You can buy premium KZbin and no ads.

[@_JustClipped]

I love the irony of the replies... They are literally just ads😂

[@GSmith215]

These people deserve to make a living

[@SpiritualDivine]

I completely disagree. I've lost fat (35 lbs) and have never been healthier. My muscles are more defined, my knees dont ache when I work out, my autoimmune disease side effects have almost completely gone away....Mounjaro saved my life. I have 15 more lbs to go & will be stopping the medicine soon. My hormones were all out of whack which made it extremely difficult to lose weight. Additionally, my family history has a broad range of obese women/men. I dont agree someone should take these drugs for a quick 10lb weightloss...however those struggling to lose 50lbs+...its a tool. My body has re-learned to not crave sweets and junk food like it did once before.

[@dinomiles7999]

Peter is lost in the Rockefeller medical matrix conditioned mind. Sad 😢❤

[@Christinelsa]

Dr. Attia is so intelligent and informative and it’s very impressive how he communicates with balance. He knows what’s unrealistic for people and what would turn them off- in the fitness and health industry it really bothers me when experts pretend like everyone is like them and can mechanically put measures in place, eliminating anything remotely unhealthy. We could technically all do that to a degree, but if a newcomer to health and fitness got that impression, they wouldn’t even try. Also he really shows class here- wouldn’t take the bait when she tried to get him to examine her husbands dad bod on the phone… he appeared a bit uncomfortable but composed like he’s thinking “nahh, here to talk as an expert, not to bash your husbands dad bod, let’s move on” I do enjoy hearing such a high caliber guest talk to more immature hosts. It looks challenging, and i hope this couple matures in their business and relationship

[@workstationmark4103]

That is because he is Canadian

[@rckptt0076]

This girl acts like she's in high school. You have Peter Attia somehow on your show. Act like an adult.

[@annaweeks4662]

I've been on TRT for years and it has made such a huge difference in sexual health. Want it, crave it, love it. This has been the greatest thing for my marriage. And has also made a huge difference in my period symptoms. So much more manageable.

[@NotMyRealName1]

“Don’t drink crappy alcohol” what a great thing to live by.

[@thebutterfly6975]

Top shelf - never order just i.e. a rum and coke has to be always my name to get quality liquor

[@chrisrecord5625]

"Medical science is making such remarkable progress that soon none of us will be well.” - Aldous Huxley-1932 Huxley was more than prescient when he wrote his book "Brave New World" in 1931. The quote was from an interview concerning the book.

[@dinomiles7999]

Bryan Johnson Blueprint, Ai will soon take the guess work out of it and all gurus and snake oil salesmen will soon be gone. See you in 2500.

[@nae4830]

Yeah. I don’t drink anymore. 13 months now.

[@heathergasol569]

Peter was an extremely, informative, educational guest. He was a wealth of information. I just wrote a long paragraph about the show. However, when I went to edit it, it wouldn’t let me do it so I started over. I’m a Clinical Nurse Practitioner. We administer small amounts of Ozempic & their sister drugs so to speak to only obese patients. So far, we’ve only had 8% favorable outcomes with 92% unfavorable outcomes. Very sad. I work in a major well-known teaching metropolitan Hospital. I agree with him on the supplements. I was happy he didn’t advocate NMN in oral form. I stopped taking about 6 months ago after reviewing the peer-reviewed studies. I eat salmon 4 times a week. I take glycine & Magnesium-Threanate b/c it crosses the blood brain barrier. I have my Vit. D level checked every 6 months. Peter explained Insulin Resistance like you were in school which I thought was FANTASTIC!!!!! I can’t say enough great things about him & this episode in particular. I listen to his podcasts. I listen to podcasts he’s a guest on. I just purchased his book. I can’t wait to read it. Thank you guys. I think he’s been your best guest thus fa & that says a lot b/c you’ve had great guests. I’ve been with you since episode one! 👏👏👏👏👏👏👏

[@TheSkinnyConfidential]

Thank you for listening and being around since the first episode!

[@nicolebeavers2684]

i’m so 😊😊😊😊😊😊😊😊😊😊😊😊😊😊😊😊😊😊😊😊😊😊😊😊😊😊😊😊😊😊😊😊😊😊😊😊😊😊😊😊😊😊😊😊😊😊😊😊😊😊😊😊😊😊😊😊😊😊😊😊😊😊😊😊😊😊😊😊😊😊😊😊😊😊😊😊😊😊😊😊😊😊😊😊😊😊😊😊😊😊😊😊😊😊😊😊😊😊😊😊😊😊😊😊😊😊😊😊😊😊😊😊😊😊😊😊😊😊

[@nicolebeavers2684]

i’m so 😊😊😊😊

[@HH-gv8mx]

What are your thoughts on Berberine? I work full time and trying to finish nursing school. Was an avid runner but with my busy schedule I can’t get the workouts or long runs in like I used to. Also I don’t eat during the day as it makes me tired and I find that intermittent fasting (fasting all day) keeps me sharper and my energy up for the things I need to get done. I eat late at night but take Berberine before my meal.

[@natashawiscombe]

@@HH-gv8mxlove it! I utilize it at Peptide Courses before/after/instead of GLP-1’s 💡🔓

[@Olovoll]

Peter is the best! What a great great guest and show. Kudos to you guys!

[@donnakarr7561]

So informative ! I love Dr Attia, Thank you !!!

[@jaymeaills1261]

Wow these episodes were some of the best I’ve heard of any podcast - thank you so much !!!!

[@TheSkinnyConfidential]

thanks for tuning in!

[@foodfoundation2448]

From beginning to end your content,guests,vibe flows organically!

[@gkatchuk]

Great discussion loaded with great information!!! Loved it!

[@TheSkinnyConfidential]

thank you for watching!

[@laurabolieu-realtor4052]

Just found your channel and im binge listening. 🎉

[@samantha-kemp-therapy]

Such a good conversation

[@santoinetteberger]

Great interview. Book is so informative, I purchased copies for both my adult sons.

[@ann5028]

Forgot about pt 2! What a nice surprise 🤩

[@jeyre5996]

So much respect for Peter Attia, and the questions were good. When you have this high level of guest on, you might consider reducing the swearing and vulgarity. It's a mismatch.

[@chuckleezodiac24]

the Dildo of Enlightenment rarely comes lubed.

[@nancym4049]

Agree.

[@ZeldaZorch205]

It is only the woman who is trying to be cool with the F-bombs. It's not working. I agree that it does not match Peter's extreme precision and deep courtesy with all of his language choices, scientific and vernacular. I also did not enjoy the snarky, repetitive "sabre-toothed tiger" "jokes". Not funny and made the husband uncomfortable and unsupported.

[@jonathangensel4884]

She has disordered eating, you can tell how she lit up when Peter said a stronger version was being tested.

[@patde1264]

Peter is Awesome and a genius

[@sofiaalves8124]

So good!!

[@TheSkinnyConfidential]

thank you!

[@spatty2589]

I couldn't tolerate Mounjaro or any of the other GLP1 medications. I was terribly sick not just nauseous. It affected my entire lymphatic system. I had a severe inflammatory reaction in my lymphatic system as I continued from week to week. It never went away over the course of 2 months. So I just stopped and continued with working out and going to the gym. Many others I know were successful though.

[@lezliesecunda843]

My current patients have finally become interested in learning about food and a small group stopped using alcohol and or drugs. Just my group on tirzepatide. I did see a girl with BMI 18 go on semaglutide and no weight loss happened. She gained some muscle when she came off. Tirzepatide made many sick usually due to starting at 2.5 recommended dose. Start at 1 or 1.5 someway somehow.

[@rhonarandom]

I will definitely read the book, great podcast, thank you guys ❤️❤️❤️ Although I hated the part about alcohol, I love my wine 😭😭😭

[@soniaapodaca9324]

Great part he isn't preaching don't drink it! Enjoy it in moderation and responsibly 😊

[@emh8861]

I always hate that part. 🤣 I did hear someone say on another podcast that you can drink a couple of drinks a day and there is no evidence that it is bad for you. 🤷🏽‍♀️

[@bennguyen1313]

Speaking of Austin eats.. Tim Ferris recommends Home Slice Pizza which is walking distance from Comedor. I like the talk on the appetite suppressant drug, Ozempic (48m)!

[@marwar819]

That couple needs to watch this together. They discount each constantly and have no respect for each other. They seemed seriously irritated with each other throughout the podcast. I didn't like listening to them.

[@cleopatra9102]

I agree, though I liked listening because of the educational factors but their communcation is very unprofessional …

[@pattypat8413]

I agree as well. First time listener, I found the podcast bc of Dr. Peter Attia, Her impulsive interruptions are really irritating. Her comments regarding his body and his behavior waking her up was extremely inappropriate. Not understanding her use of "F" bomb with a guest like Dr Attia, ....not cool.

[@ZeldaZorch205]

Yes, she is not reading the room and is extremely self-absorbed and fake. Not really listening, just waiting to show off and jump in, subtracting from the quality of this brilliant doctor's discussion.

[@lisatowe778]

Love listening to Attia. He and Huberman are amazing and don’t seem to overdo the science since some of us have a limit in what we can grasp in an hour of listening. Interesting to me the guys these days can talk an hour with real words. The chicks these days use the F word a lot which is odd. This one is a little vulgar in how she uses it which is the actual act of sex. Most of us use it in frustration. Ah well humans are devolving in many ways I’m curious about testosterone in women but Attia seems to indicate he doesn’t give that to women

[@MarlenaPosa]

loved both parts! so informative, great ?s you guys. my only problem tho was taylor NOT telling lauren to fix her hair the whhhhhhoole time!! taylor cmon!!!! 😩 our poor laurrrrrr 💔 she’s still gorGGGG

[@nicknoonan7593]

At 58:14 is he referring to Retatrutide?

[@Dedicated_.1]

I’m surprised there’s podcasters still doing episodes with No timestamps.

[@TheSkinnyConfidential]

We updated the video to include timestamps for you!

[@Dedicated_.1]

@@TheSkinnyConfidential thank you

[@johnjeoffreym]

I love non alcoholic beer...is there any ill effects?

[@jonjennings1045]

As always, Peter was really informative. Interesting podcast. I know this sounds old and prudish, but the hosts are way too vulgar for me to "subscribe."

[@soniaapodaca9324]

I agree. This was my favorite video as far as easily understanding the advise Peter Attia gives, and I think a lot of it was thanks to the husband. He was asking uncomplicated questions and getting uncomplicated answers (which I appreciated) but the wife...just not for me. Appreciate these two episodes from them, though!

[@ZeldaZorch205]

Husband deserves a wife with more class and more intelligence. She comes across as bogus and should find her authentic self for this work.

[@M3W3]

Read how royal jelly is harvested… then you will think twice abt consumption. I used to take royal jelly but after finding out the harvest process i stop taking royal jelly no matter how nutritious it is… it is simply too inhumane.

[@aweinblatt6]

It’s kinda shocking to me that since we know the ROOT cause of Insulin Resistance, another MAJOR ‘fix’, besides exercise wasn’t mentioned, which is LOWERING YOUR DIETARY FAT INTAKE. Lowering your daily fat intake to about 10-15% of your calories for day will GREATLY improve your insulin sensitivity & it doesn’t take long for it to significantly lower your fasting blood sugars. I’m a T2 diabetic, 52yo, high insulin resistance, after following a WFPB-low fat diet (

[@evec2022]

100% agree. Sounds simple to me, but it's an unpopular "fix"... For the life of me I can't understand why people don't just try it.

[@yerrterrb8435]

That sounds like caloric restriction, and you just lost weight leading to increased insulin sensitivity.

[@aweinblatt6]

@@yerrterrb8435 I used Cronometer to track what I ate so that it could tell me how much fat I was eating in a day & by default it calculated my calories as well. To MY surprise, I was routinely consuming 1900 - 2400 calories per day, so even though I know it’s tempting to go down that road, it’s just not what was happening.

[@HH-gv8mx]

What are your thoughts on Berberine? I work full time and trying to finish nursing school. Was an avid runner but with my busy schedule I can’t get the workouts or long runs in like I used to. Also I don’t eat during the day as it makes me tired and I find that intermittent fasting (fasting all day) keeps me sharper and my energy up for the things I need to get done. I eat late at night but take Berberine before my meal.

[@dinomiles7999]

Choose another career. Nursing now a days will kill you .

[@HH-gv8mx]

Like what? Going back to working in the hospitality industry running a hotel that works me from morning until past midnight and won’t offer me more than $13 an hour with very little dental coverage and terrible health care plans?@@dinomiles7999

[@jellybeanvinkler4878]

Go into Research!

[@ILthegreat]

I just spoke to a nurse practitioner yesterday about berberine. I told her I was taking it and she told me good job. That's a great supplement.

[@lezliesecunda843]

I tried it and my blood sugar still spiked sometimes. Ultimately it didn’t work.

[@ironmaidenfitness654]

58:35 the drug is called Retatrutide

[@patisserie1524]

If a guy was body shaming a girl like she did about the baby, it would have been cratzy. He tried to keep avoiding it and Peter also tried not to be rude but she kept going.. girl please! Lead by example.

[@kanis999]

Should debate Dr Mike Israetel. Nothing wrong with using drugs to help with weight loss.

[@Blahblahblahblahhhhh]

Lauren how are you going to hold back on showing us the dad bod photo!!

[@laza6141]

35:00

[@TeaRose9]

Latest studies say there is zero benefits to consuming alcohol. 💯🎯

[@nicolemillward287]

Yes! I’m still amazed that Peter doesn’t just come out and say that. 1 drink of poison a day is fine as long as it’s an expensive one? Our bodies can’t tell the difference between a 200 dollar bottle of wine and Boones farm. It’s all carcinogenic. Seems like he’s justifying his desire to continue to drink.

[@jennysiepka9900]

agreed. i think it should be obvious

[@urszulasierpinska4288]

The number and length of ads on this video is extremely annoying

[@reneeraw6927]

TOO MANY ADS HENCE LOW SUBS

[@laurentgaildraud9164]

Why Peter is there?

[@TheSkinnyConfidential]

For our Podcast!

[@chuckleezodiac24]

once upon a time, Peter's mommy & daddy fell in love and reproduced...

[@Kathleenpoors]

After listening to it all, Dr. Attica is informed, but admits medicine and pharmacology knows so little.

[@patriciamacfarland7573]

I’m trying to like this podcast but the long breaks of promoting products is hard to sit through.

[@tamekiashumpert373]

True. I thought it was me feeling like that.

[@ZeldaZorch205]

Me too, but I just click ahead and skip them. Doesn't work from across the room!

[@barbaramackenzie7918]

Too many commercials

[@kathya1956]

she's ditzy

[@kimbe910]

One drink per day😢

[@Bobopidoo]

I’m shocked by your advertising of alcohol and your comparison to Aderall… really, there is no shame in selling here.

[@mishkathlay]

Is there some trend of a group of trolls that purposely come to this channel to bash on the wife or the couple? Wtf? It’s the same theme of critical commentary with every podcast they post.

[@chuckleezodiac24]

nah, it's just new viewers reacting to the couple. i've never heard of them. came here for Attia.

[@Christinelsa]

I’m brand new here and I’m a bit taken aback by it. I can’t tell if she’s actually that immature or if it’s kindof part of the brand to attract viewers

[@TeaRose9]

Really not a good thing that you donated your toxic products, I mean seriously. 😡

[@alisonanderson4732]

Isn’t Magnesium and coloured lights etc all pseudo science?

[@nothanksmegan]

A drink a day is far too much, 5 per week for a man and 3 per week for a woman.

[@Maliksamuels33]

“Liquid clarity” ah, the good ole snake oil. Bunch of clowns (the hosts, not Peter)

[@nerminemedhat9542]

Great episode and great questions. I learned so much, but the woman is so vulgar

[@sunnygirl9691]

Esther Perel very overrated- don’t bother.

[@dinomiles7999]

Bryan Johnson, Blueprint AI will soon take the guess work out of it and all gurus and snake oil salesmen will soon be gone. See you 2500. Peter is so yesterday. Lost in his own ego .

[@pinkshelly]

Lmfao no it won't! Who can afford to take 100 supplements per day???? Delusional

[@jag721000]

Blah Blah so Boring!!

[@cleopatra9102]

Loved all the information in this podcast but the couple should seriously consider going to couples therapy and working on their communication. For (some of) us and maybe even for your guest in the studio, this is very cringe to watch 🫠 Idk what the name of the girl is and I don‘t want to be rude but please show a little more respect 🫶🏼

[@mishkathlay]

When she broke out that pic of his dad bod, that was comedic gold. Nonstop impulsive antics with her. Priceless.

[@cleopatra9102]

@@mishkathlay idk if I‘d like my partner to comment on my body like that in front all of the viewers 🫠 imagine him pointing out how her face looked before all the fillers etc, imo that‘s a no go

[@chuckleezodiac24]

@@cleopatra9102 meowwwwrrrr.

[@mishkathlay]

@@cleopatra9102 I don’t consider this the same. .. and he wouldn’t. All in good fun.