The BEST & WORST supplements that SLOW aging. Why some supplements are pointless.

If you want to learn how to introduce longevity into your clinic but feel overwhelmed with conflicting information then I'm hosting a webinar with Dr Nichola on the 28th May especially for clinicians to help you get started. This webinar will help ANY medical injector get started in longevity whether you're a beginner or advanced. Sign up to be notified when webinar registration goes live here: shorturl.at/etEM3
Knowing which supplements to take can be confusing with so much conflicting information out there. That's why I sat down with longevity expert Dr. Nicola Conlon to cut through the noise. In this episode, Dr. Conlon evaluates and rates my supplement stack, discussing the benefits and potential drawbacks of popular choices like creatine, Omega-3 oils, Vitamin D with K2, probiotics, NAC, TMG, turmeric, NMN, collagen, nitric oxide lozenges, and multivitamins. She emphasizes the importance of addressing the root causes of aging and offers insights into optimizing supplement strategies for better health outcomes.
Follow Dr Nichola on Instagram: / drnicholaconlon
Learn more about Nuchido here: nuchido.com/
Use code : DRTIM20 for a discount off Nuchido.

[@BoStanfordify]

LOVE her! In a sea of confusion she is so clear and well informed.

[@BillFlavell]

Dr Nichola correctly warned that many supplements lack evidence from clinical trials but then I wonder why Tim did not ask what trials Nichola's own supplement has undergone.

[@pranaorganics893]

She was on Asprey & was tlkn bout trial .. but idk or really care I wouldn’t take what I already take for much less

[@fbomb7184]

Creatine Omega 3 Vit D3/K2 (taken in the morning) Probiotic NAC (taken with glycine for longevity) Trimethylglycine (TMG) only gave a 5, unlikely to be deficient unless you have a “methylation problem” Turmeric but reccomends Curcumin as opposed to turmeric. NMN and she poo-poo’d it 🫢 and here is where I had to go 19:49

[@nicedoppy2077]

Wonderful!!.....u express yourself as a doctor, maybe r u right?!! Thank U for your so relevant great Comment!

[@stephanygates6491]

I take TMG for liver health and digestion. Collagen is not only for skin but fascia, a much larger organ. Decline in fascia has huge implications for how you good feel as you move. My collagen is 7 grams/ scoop. Mixes into any drink.

[@stuomsen5094]

This lady knows her stuff!

[@user-dl7kp2fn4b]

The major mistake people make when choosing supplements is bias. We categorize what we consume into pharmaceuticals (greatest bad), food (much is bad), and supplements (vitamins, minerals, etc) as the least bad. Think of any substance as potentially good or bad. So supplements can be as harmful to you as some prescription drugs. But people will hear about a supplement, buy it over the counter, and take it without knowing of its potential harms. Don't take any supplement unless you know its potential side effects, long-term effects, and interactions. And if it isn't proven scientifically to provide the benefits you expect, or there are contradictory studies, don't take it. The only supplements I take after spending thirty years researching them: 1. Multiple Vitamin 2. Omega 3 3. Vitamin D3/K2 as MK-7 4. Magnesium 5. Fiber 6. Electrolyte powder to mix with water when excercising. Also, if you are either consuming processed food, or food with added sugar, why are you bothering to take supplements? How are they going to make you healthier when you are poisoning yourself with food?

[@AbundantlyNika]

Any particular brands that you like?

[@AshisLydia]

Please dear, could you name good brands please? That will be appreciated.

[@paularand8783]

I take collagen pep and if I stop for about a week my joint pains return then I have to start taking it again therefore I give it a 9 out of 10

[@gokarnasargod6366]

Llllllllllllll

[@11kwright]

Pray tell which one you take please. It’s good to have a legitimate reviewer inform whether it works.

[@vapeking466]

I read an article on a very reputable high quality supplement companies website claiming these collagen supplements don't do much of anything.

[@Sailor.Ecilipsia]

Same here. It really worked for my knees.

[@SuperAmazingAnt]

Well how much did you eat protein before that ?

[@Kathleenschweiker]

Knowing what genes including SNPS you have makes all the difference. If a clinician doesn’t know what genes are active, then they are guessing. Knowing the status of the gut microbiome, methylation, detoxification, toxic exposures, mineral, vitamin deficiencies, the ability to use food,-- are for starters, essential to individualized, precision health care.

[@ronaldbohan2720]

Turmeric has helped people I know .with pepper and without. Pepper to bring down swelling in the body I use it all the time it helps me . Our teaspoon with a sprinkle of pepper in 8 ounces of water. My pain is reduced greatly within 30 minutes.

[@chantalclaeys9624]

Piperine is toxic if you take it everyday! I don’t know if pepper has the same effect. Tumeric is great especially flexofytol forte. Lots of clinical studies are done with this product.

[@kimgayler1478]

Tumeric has transformed my life by alleviating knee pain.I was skeptical but am converted

[@susymay7831]

Timestamps would help your nice videos ❤

[@sgtaneja]

Btw, How do you measure longevity gains in short-term trials ?? My pick : 1. GlyNac 2. NMN 3. Rutin 4. Methyl B+ 5. K-Mag (potassium+magnesium)

[@saradoherty3875]

why pay £80 for a product that a cheap citrulline( pathway 1) or beetroot juice (route 2) does the job of increasing nitric oxide very well?

[@metemad]

Exactly and watermelon.

[@MsElaine122]

2mg Cialis daily is a useful protocol for nox.

[@vapeking466]

I take 5mg daily.

[@stephanygates6491]

Eating beets daily makes my bones strong! Nitric oxide not only benefits mitochondria, also osteogenesis. I'm 66.

[@larryc1616]

Viagra works too

[@Marge-]

Thank you very much for this detailed and informative analysis. What id also like to know is if you need to cycle these supplements. I don’t think you can be on them indefinitely.

[@traciholland975]

She's onto everything here and knows her stuff!!

[@milosfilipovic7583]

s. boulardii is not bacteria, it is probiotic fungus, it is very important to take with antibiotics

[@vanessac1965]

Yeah it's a beneficial yeast that crowds out other microbes

[@jennysiepka9900]

I think the fact that she did not know that shows her expertise is def not in the gut...

[@vegan4life532]

A very valuable yeast in the battle against Candida Albicans.

[@galyna40]

Fungi are part of microbiome

[@isaaccraig3666]

Prebiotics have been proven to be absolutely useless as a supplement Have a look at the research done into prebiotics

[@quatropontoum]

I liked the guidance to take Vitamin D in the morning, I started doing this and I am sleeping better than when I took this vitamin at night. Thank you very much

[@MrElmagnific0]

Sorry for my next intervention, but the story of Curcumin and it's bioavailability [15:48] is not complete yet. Yes, it's true that Curcumin's bioavailability is very poor but actually there are ways to solve this problem. The keyword here is micellar capsule packaging of Curcumin. This rises it's bioavailability up to 185 times - far more than piperines and other so called "boosters". I would not be surprised if a micellular capsule packaging would also be a more effective way to improve Nuchidos bioavailibility instead of using piperine.

[@blankblank4130]

Exactly.

[@chantalclaeys9624]

Piperine is toxic when you take it too long!

[@bq3538]

@@chantalclaeys9624 it is harmful to Live

[@onlyonezino]

Her argument against NMN as a precursor goes directly against taking a precursor of GlyNAC for Gluthathione production. She never mentioned finding out why the body runs low on Gluthathione, instead of supplementing with Precursors. The sub argument against TMG also works against her recommendation to combine K2 to Vitamin D. She was better off discarding the factory analogy completely since it contradicts the need to restore gluthathione levels

[@user-fe7lf8ei3u]

Prefer Dr. BERG

[@wendiconrad6128]

I just looked up this product by Dr. Nichola and it has sunflower oil. Isn't that a highly processed oil? Why isn't she using a different oil in her product?

[@mjgrant1515]

evoo would always be the logical choice, i would think.

[@bperez8656]

Meh. Is she a big pharma doc?

[@jennysiepka9900]

S Boulaardi.. great for those who struggle with candidiasis. Also, liposomal glutathione is an option for grreater bioavalability. Also, I use a very powerful red light bed. I use nitric oxide Strips and I test before and after. huge elevation in Is nitric ox after ten minutes in the red light.. Now I don't know how accurate these strips are.But I will tell you that the color changes dramatically... And then I will test half an hour later and it is back down to baseline...

[@MrElmagnific0]

I would politely like to add an very important point regarding Vit D and blood measurment [06:08]. Currently it is only possible to measure the transport precursor form of the biologically active Vit D directly. This precursor transport form is called 25 OH, or Calcidiol. That's usually what is measured in the blood. But the biologically active Vit D form inside the cells is called 1,25 OH, or Calcitriol and this is the relevant compound regarding epigenetic regulation inside the cells. Intracellular Vit D 1,25 OH aka Calcitriol is activated then by another agent known as Vit A or Retinol. Together they form an enzymatic complex which acts as epigenetic regulator. It turns thousands of genes on an off. Regarding this it can happen that the measured 25 OH concentration in the blood sample appears high while the bioactive 1,25 concentration inside the cells is low. This can e.g. be related to a lack of Vit D binding proteins (VDBPs) which are necessary to get 25 OH into the cells. Furthermore a high 1,25 OH concentration inside the cells is not really effective without Retinol as co-compound.

[@blankblank4130]

Exactly

[@Vn-ye3km]

Thank you again Magnifico.. have you given any interview .. you seem to know a good deal of the internal working and the fringe details that many guests miss.. I found Dr Nichola explain why she did what she rated, logical. Abt Vit D & A - you mentioned it's good to add Vit A with D3 -bt will it be better for the body , if it is going to start a cascade of genes on n off?

[@MrElmagnific0]

@@Vn-ye3km Exactly, 1,25 OH - or if you want to use it's other label = "Calcitriol" - is the active form of Vit D inside the cells. It binds with Vit A/Retinol creating an epigenetically active complex which is modulating the expression of thousands of genes. Therefore it is so crucial for cell health and homöostasis.

[@Vn-ye3km]

@@MrElmagnific0 Thanks a lot Mr. El 🙏 Do you have any blogs or pods or interviews.. pls put link here whenever you do, Do you have any info regarding what is the best way to reduce neuro inflammation and gut inflammation or both (may or may not be related to ASD)

[@MrElmagnific0]

@@Vn-ye3km , I honestly thank you in return because your questions gave me the opportunity to share my limited wisdom as epigenetic and functional medcine coach with you. No I have no podcast yet nor I am planning to start such format. I can recommand you a basic lecture around this topic. It' s a book called "Why We Age And How To Stop It", by Dr. Sandra Kaufmann. It's a must read. In general: if you want to reduce inflamation im cells you should activate your SIRTUINS, avoid stress, change your mindset (be thankful, greatful, forgetful, loving, compassionate and do not live in the past. Use good high quality oils (olive oil, omega-3 oils, no industrial processed oils from plants), reduce meat especially processed food, sugar and bad/empty carbohydrartes from sweets. Use good and pure water - no plastic bottles. Change your diet to organic plant based. Exercise, meditatitate, be spiritual, search for constructive friendships and relations and have fun in your unique and wonderful life journey. All this points are relevant to reduce inflammation. Beside that you can supplement e.g. with Resveratrol, Quercetin, Astaxanthin, Curcumin, EGCG (component of green tea) to reduce inflammation.

[@mariavanbeselaere5417]

I honestly think Siim Land would be a good choice for your podcast. Next. K2 to “add” to vitamin D3. That’s obvious. BUT TMG rather not in in order to compensate for a disadvantage for another supplement. I do not discuss that. However the arguments for one combination in order to support and then later oppose against another combination?

[@DrTimPearce]

Siim is great, I am a big fan.

[@catahuanco]

Thank you for making this video, it has helped me clarify many questions I have had concerning these supplement of which I happened to take some of them.

[@shuaibchaudhary5600]

What about taking L citrulline instead or L arginine :Do the same as nitric acid gummies but cheaper

[@loungeact7997]

Only watched half of this but let me guess…she gives her product a 10/10 even though it’s mainly just NR…??

[@daveoatway6126]

This seems to be a infomercial. Her take on NMN is not consistent with my 10 year experience. I am 80. I take 2 gm NMN daily with TMG in water with electrolytes. I walk 3-10 miles a day, do expert witness work for attorneys, race a Laser sailboat and workout 3x week. When I started with NMN alone, I found my hair returned to brown from white, and my energy was much improved. I hiked the Inca Trail to Manchu Pichico 5 years ago with no problems. I also take some of the high rated supplements you do. I recently started Taurine and have found it useful and gave me better sleep. I don't see any references to peer reviewed work supporting her claims. I can't reset my age - and am happy as I am. I am disappointed with this video.

[@vroomgc]

Of course she will talk about her own product but what she had to say in general was good information and probably pretty sound advice, you ignore all that because you have had success as an individual with NMN. Products and supplements all work differently in each person, some things can work for a few and not most just like MNM can.

[@mrhenkdirecteur]

She's a scientist that uses rigorous methods to study chemicals, you're just one sample without base line, double blind, controlled substance variants, body weight dosage measurements and many more things. Very funny though. What you are claiminig about hair color, is without scientific research much more of an informercial to be honest.

[@daveoatway6126]

@@mrhenkdirecteur Where are her peer reviewed papers? Who has validated her claims?

[@IPMan-me6lo]

@@mrhenkdirecteur His 10 years experience don't need any double-blind studies, just for himself.

[@krystynaboyt1082]

❤

[@funksoulbrother2934]

Really interested in this and thanks for a great video. Please can you tell me the brands of the products you buy and where from. Thanks

[@onesource9527]

I would suggest having Dr. Cate Shanahan to talk about her book "Dark Calories" on your program. She has a different take on health and longevity. By improving metabolism and learning how to fine tune and optimize it, internal senescence can be delayed.

[@MyHomeExperiments]

What happened to the idea of preventing NAD decline by inhibiting CD38 enzyme by taking apigenin?

[@debddc]

S-Boullardii is for IBS-D (diahorrea) seems she wasn’t aware of that one

[@luismiguel69able]

For those (like me) who need clarification, when she says Amiga, she means Omega.

[@MoSec9]

Thanks for the clarification. Let me correct my notes, because I just wrote down “Eat your girlfriend regularly”.

[@galyna40]

Because she is not american

[@paulsmart5051]

She is a geordie, I understand her perfectly

[@green9832]

@@paulsmart5051 she sounds Welsh to me.

[@pramuanchutham7355]

​@@MoSec9isn't she sweet with this delicate accent? 😊

[@arcielbaez3219]

Really interesting her low rating for collagen. I would say collagen is 8 because of the benefits of glycine. I don't think that looking only at the skin effects is fair for collagen. Would love to know if I'm missing something.

[@junejuly9219]

It thought this was helpful, but overall left a poor impression. All went well until the NMN - there she goes straight for the jugular. No wonder, as it turns out she sells the product which is in direct competition with it.

[@johnnyb1368]

100% agree with you, it was going so well until she started to deminish NMN and had me puzzled, then her product came out.

[@BlackjackCZ]

I have noticed zero benefits from taking NMN. Each to their own.

[@johnnyb1368]

@@BlackjackCZ the NMN that you took was probably fake or had very little actual NMN in it.

[@mindtheprivacy]

She didn't say alternatives to generate collagen, it was t asked either. She didn't say alternatives tomfox the 'machine' instead of using nmn, she didn't say 'what she knows better ' about nmn after 5 or 6 years of clinical studies. And also nothing is being asked to further knowledge and opinions.

[@buffc.7515]

Unfortunately, this video has some promotional purposes for a product that is rated quite low for the ingredients. Everything was going very well till she dismissed the green multi vitamins cause in competition with her suppplement 👎👎👎👎

[@DrTimPearce]

AG1 has many buzz word ingredients without hitting the effective doses. What I like about Nichola is how often she talks about bioavailability and effective dosages. It's easy to sell something that seems like it would work without it actually working.

[@pramuanchutham7355]

​@@DrTimPearceso this lovely lady is named Nichola! 😅 You're right, effective dose and bioavailability should be considered. Cheap Zinc Gluconate doses at 50mg while better-absorbed Zinc Glycinate 30mg. More is not always better, meaning less is absorbed. Then there's this NZ doctor with minimal vitamins and micronutrients multivitamin at very high price, claiming to avoid 'mega-dosing'. Then he tries to meet the magnesium supplementing-requirement of 126 mg by having to take 4 capsules of this expensive brand he created. I'd rather take Magnesium supplementing-requirement separately from the multivitamins. Same with the 4700mg Potassium daily. 😅

[@Chris_Faraday]

I love her angle on NAD and precursors and the reason for NAD decline - but minerals and oils are key for recycling

[@jeffs.8970]

Interesting …. I’ve been taking vitamin D and K2 with olive oil and MCT oil before bed for years and I sleep like a baby

[@deannkennedy1795]

I would really like to know the science besides what she said the circadian rhythms which can work for one at night I was in instructed that since it is a hormone, it’s a good idea to take it in the evening. I just want to take it the best time of the day, I would like to know

[@matkapuhelin2011]

What a shame that an useful video is just used for marketing her very expensive nad+ booster which in clinical trials boosted nad+ only by a tiny fraction.

[@vroomgc]

Instead of looking at it that way just take it as good information on everything else it provided

[@11kwright]

@@vroomgcExactly, with that stupid mentality he’s missing out on good relevant and informative information. Can use this video for one’s own health benefit. Most of these doctors promote their own products even Dr Brad Stanfield, Dr Eckberg etc do the same but whilst also giving beneficial information.

[@EduardoMartinez-ys6fb]

Currently I take 10g of collagen with Orange juice (vit C) primarily for tendon health. Biotin together with 10:1 ratio Zinc,Copper for skin health, Saw Palmetto for prostrate health and reduced hair loss. I'm 62 and have exercised most days, all my life.

[@pohaa]

Investigate boron for prostate health.

[@pramuanchutham7355]

​@@pohaaBoron supresses the effect of IGF-1,thereby suppressing prostate cancer...i read.

[@pramuanchutham7355]

Try takng 30mg Zinc Glycinate daily, to prevent enlarged prostate (BPH) and Prostate cancer . I've taking zinc since age 41 and now at 67 without prostate issue (My PSA is right in the middle of the range).

[@kroyal4296]

Any genetic testing you’d recommend over others?

[@leohanrahan1776]

Better to get your omega-3s from food and not (potentially rancid) fish oils. I've recently started eating sardines, (in water- not seed oil) a few times a week. In my local grocery store, you can get 10 cans for $10. There's about 1500 mg of EPA and DHA in a 3.5oz can. That's more than an equal weight of salmon and less likely to be contaminated by heavy metals (like the larger predator oily fish). Yes, it's more expensive ($1/ dose) than a pill, but it's better for you.

[@singularity6761]

Better avoid cans because of BPA

[@larryc1616]

No one wants to eat canned fish everyday

[@snort5203]

Excellent. This brought to light a much deeper way of pondering vitamin intake.

[@Vn-ye3km]

Thank you for all the clarity around Nad .. i found the ratings and reasoning logical. Thank you Drs. Tim n Nicola

[@RobbyFindlay-uq2dy]

There are abbreviations used here with no translation or meaning. I am not an apothecary (someone who prepares and sells medicines and drugs, a chemist) and so you could do just as well if you were speaking swahili. At about 35 min's in it felt as though I was sitting in the middle of a Bantu village. I couldn't make out the abbreviations, which were many. What I did understand was interesting and informative. Translations please.

[@emileimilheitor3456]

Oh boy, 1:30 hour only to realize this was all a giant commercial for the ladie's pill. I'll stick with Sinclair thanks.

[@polybius666]

An even bigger charlatan and snake oil sales man.

[@pohaa]

So many excellent "low fruit" supplements not mentioned here. Look up: Boron Taurine Pycagonal Methylene Blue And MAGNESIUM! Mg is absolutely essential. Why isn't it being discussed here?

[@aldifortuner278]

Taurine, B3 and Methylene blue should be on the list

[@nikollezeinikolle6519]

🎯

[@ThriveCollective1188]

She doesn’t impart much knowledge beyond what many of us would know from our own cursory examination of recent research papers but a few interesting things I didn’t know were discussed. She contradicted herself regarding Turmeric supplementation. Yes, she’s correct, you have to consume high amounts of Turmeric to reach the levels associated with health benefits but that’s exactly why high quality, high concentration curcumin supplements that include the activating black pepper concentrate are so beneficial. Eating turmeric every day will not achieve statistically significant, independently verifiable benefits that supplemented curcumin deliver

[@bperez8656]

Typical big pharma doc

[@sandrasmith5943]

Can Dr Nicholas supplement be taken while on thyroxine? Thanks for such a brilliant video.

[@pohaa]

Taking magnesium glycinate with NAC has an added benefit of giving you the combination GlyNAC.

[@bperez8656]

And what do those do together and separately?

[@baldwad]

When she suggested Curcumin in favour of Turmeric, she’s wrong according to Dr. Greger’s interpretation of nutritional studies. The whole food is better than an isolate. Is she selling Curcumin?

[@kathisottosanti1240]

Loaded with great information! Thank you!

[@nazisubha8837]

I watched the whole video I thought I m going to get benefits what supplements should I take and which supplements not to , but in the end I realised he is actually promoting her supplements by giving her 10/10 and giving others 5/10 and plus discount too, very disappointed waisted my time . 👎

[@richarddobson4382]

I have listened to the first 3 or 4 and they all have scores of 8 to 10. I disagree with what you say.

[@vroomgc]

@@richarddobson4382 Ya I agree , some people are just narrow minded, you cant please everyone it seems

[@astonuk9403]

Thanks. Great video! Subbed. Thoughts on MSM for joints and detox?

[@raibalama]

Commercial answer especially the NAD alternative

[@randomperson8771]

I do take creatine. However, the fish oils I hear from many others who know a lot more about the supplement form than I ever will suggest taking it in this form well it's already rancid!!!! is the word they often use and tell ya to eat fish instead!

[@jonathonpotts5666]

that's good to hear. I already eat so many sardines. It seems pointless to take oils

[@DrTimPearce]

Omega three oils specifically is what you should take. They should be third party tested.

[@daimos6686]

I got Acne because of this fish oil supplement

[@andanssas]

14:13 "I don't think you should *take a supplement to deal with another supplement* negative effect"... So is vit. K2 an exception? As mentioned at 3:53, K2 avoids vit. D3 calcification issues and thus "should be paired together" to avoid this negative effect... 😕

[@samdefore2692]

It would be helpful if you had a list of your supplements in the description or the first comment. Both of your accents are so thick I can’t understand what you’re saying half the time.

[@evarkf5303]

I wish they would talk more about all these supplements on gut health. I strongly believe that collagen peptides caused me collagenous colitis. And that glycine, tmg, oil supplements and more, are causing diarrhea too.

[@DrTimPearce]

I can imagine this is a side effect of many supplements. Gut bacteria may be the key and may be one of the fundamental variables in many drug side effects and diseases.

[@marilynnsmith2636]

Monotone voices are difficult to listen too.

[@juancassanello5219]

excellent inputs and tips. thanks

[@lauracarmenaanei9411]

Hello, invited lady could read the medical guidelines to learn what Saccharomyches boulardii is important important for.

[@pramuanchutham7355]

Well, she may not have enough time in front of the camera, and to learn of atleast 5 other Lactobacilli and 3 Bifidobacterium.

[@MyHomeExperiments]

You should add timestamps.

[@jakobw135]

When it comes to taking omega-3s - which algae oil supplement for a vegan diet would you recommend, in view of the fact that many of them come together with a substantial amount of omega-6s?

[@ThriveCollective1188]

Sea buckthorn oil gives a balanced ratio of omega 3,6,7 and 9. Herbs of Gold is what I use.

[@nancydayo8392]

Hi, kindly write the names next time. Missing out on a few

[@crimzdad]

Who said NAD is declining? Who said the fsctory doesn't work? Why is she assuming everyone shouldn't take it? Strange

[@DrTimPearce]

It's proven across species that it declines with age .www.ncbi.nlm.nih.gov/pmc/articles/PMC7442590/

[@siobhanmitchell1650]

What about mitochondrial supplements like MitoQ? Mitochondrial function is a huge mediator of aging and there's not a lot on supplements that keep mitochondria healthy

[@bokigitara1]

SOD or D Ribosa?

[@viktorandre8545]

Vitamin D3 has a half life about 15-25 days in your system...I do not understand how taking it in a morning or evening would impact your sleep.The important thing would be your 25Hydroxy level. Regarding K2 and calcium , vitamin D3 supplementation will NOT raise your calcium level unless taken pharmacological level. 50.000-100.000IU daily for long run!! In that case having vitamin K2 will not be of help either.

[@user-js8op2xy8d]

The comments didn't seem logical, in first instance she cautioned D3 should be taken with K2, and high D3 could be dangerous without K2. Yet she demonised NMN for needing to be taken with TMG?

[@praveenreddy4427]

😂

[@Vn-ye3km]

From what i understand those are totally different supplement pairs and different impacts

[@user-js8op2xy8d]

I watched with an open mind, genuinely interested in views as a new user of NMN, the illogical reasoning and lack of detail didn't expand my knowledge base. The interviewer was polite and well mannered, but not probing or inquisitive

[@bperez8656]

When I hear that level of ignorance I begin to think Big pharma doc

[@nicedoppy2077]

noo...D3 is ok without K2 buuut could be better with K2 to absorb better and give to the bones more benefits...

[@shamster7182]

I knew when she dissed NMN, she was in competition with it

[@DrTimPearce]

Did you hear the reasoning though?

[@shamster7182]

​@@DrTimPearce, you didn't challenge her when she said you shouldn't take a supplement if you have to take another one to offset a potential problem (TMG and NMN) as to why that is, it didn't seem a genuine concern, rather a part of the take down of NMN.

[@hannahmulligan1103]

She is saying that we should be increasing NAD through fixing the root of the problem essentially. There is a balance to be maintained as well, we do not want to much NAD and we do not want to little NAD. We should be able to optimize our NAD levels without NMN and TMG. I think a good option would be for those in the midst of working on their methylation issues to use NMN and TMG. Once you have, then try discontinuing them. It takes a very long time to address methylation issues. I've used quite a few different supplements until I was able to optimize my health and be well without them.

[@davepayneflip652]

@@DrTimPearce of course she'd come up with a reasoning honey bun she's not gonna say oh it's because we're in a race against each other innit...? lol

[@davidflorez1196]

​@@hannahmulligan1103and how you increase NAD levels without taking any supp

[@wmp3346]

I give her a 10 ❤

[@awolf913]

Simp

[@user-kw9dg8gi5o]

May we have the name of sipliments writed on screen?

[@robertgale2084]

Huge conflict of interest here. I suggest you do your own research on NAD, NMN, etc. This is in essence a very thinly veiled infomercial.

[@timskolnik3819]

For her to say TMG isn't beneficial unless you need it is so unbelievably ignorant and negligent. Wow. The benefits of TMG for EVERYONE are a mile long.

[@bperez8656]

Big pharma doc

[@paradisekohchangstyle2150]

TMG to reduce homocysteine levels, right? Why doesn't she bring this up?

[@althe]

omega 3 fish oils oxidize an hour after produced - unless direct from the fish with its antioxidants.

[@eleanorweiss4217]

What about omega 3 from flax oil?

[@bperez8656]

My doc makes pills that use no fish

[@lingchinn2389]

Dr Nichola knows what she's talking about!

[@MrElmagnific0]

Allow me another (hopefully helpful) remark regarding TMG and methylation [10:42]. I would rather not supply additional methyl-groups via e.g. TMG as long as the intrinsic methylation process inside the cells is working. Sure, the intrinsic concentration of methyl-groups seems to decline with age but in this case it is mostlikely more efficient to supplement with methylated folic-acid (Vit B9, --》bioactive Quadrofolic) and methylated cobalamin (Vit B12) which are crucial compounds of our bodies intrinsic methylation-cycle inside the cells. High homocystein blood levels can be a strong indicator for a distortion of above mentioned methylation-cycle and it's pathways.

[@Vn-ye3km]

Wow.. i was just wondering abt it.. thanks for explaining

[@Vn-ye3km]

I m ok with l-methylfolate n b12 though

[@MrElmagnific0]

@@Vn-ye3km, yes but B12 should also be methylated in order to donate the attached methyl- group to Homocystein which then is converted to Methionin. Without this step the levels of (unmethylated) Homocystein can rise to an unhealthy and pathologic level. Therefore it is crucial to check the Homocystein status via blood testing. Is it's level outside of the "normal" range I would strongly recommand to supplement with Quadrofolic (B9) and methyl-cobalamin (B12). Take it forca period of at least 6 months and retest your Homocystein status again to check whether this intervention was succesfull -》your Homocystein blood concentration should be significantly reduced.

[@lyricgirl45]

I keep trying to take a high quality and strength D3 but every time I do I get terrible bloating what could be causing this please ?

[@rogerbruce2896]

so what is the best way to boost NAD? We need the details. Really disappointing response from Nichola to knock down something without giving any alternatives.

[@DrTimPearce]

Here are five effective ways to boost NAD levels, supported by scientific research: Nichola has concerns that from my understanding come from the consequences of over supplementation caused by not dealing with over consumption of NAD by CD38. However there are many ways to raise NAD, it's the context of that change in the system we are topping up that Needs to be understood. Here is a summary of papers. Nicotinamide Riboside (NR) Supplementation: Nicotinamide riboside (NR) is a precursor of NAD+ that can significantly increase NAD+ levels. A study showed that NR supplementation in humans led to a substantial rise in NAD+ levels, with a 40% increase observed in individuals taking a recommended dose and up to 90% increase with a double dose over eight weeks (Dellinger et al., 2017). Nicotinamide Mononucleotide (NMN) Supplementation: NMN is another NAD+ precursor that has been shown to boost NAD+ levels effectively. Studies indicate that NMN can improve various physiological functions related to aging and disease by increasing NAD+ availability (Freeberg et al., 2023). Dietary Supplementation with Niacin (Vitamin B3): Niacin (nicotinic acid) can elevate NAD+ levels in the body. Research has demonstrated that niacin supplementation can cure systemic NAD+ deficiency and improve muscle performance in patients with adult-onset mitochondrial myopathy by increasing blood and muscle NAD+ levels significantly (Pirinen et al., 2020). Combination Supplements (e.g., NR and Pterostilbene): Combining NAD+ precursors like NR with other compounds such as pterostilbene (a polyphenol) can enhance the effects. This combination has been shown to be safe and effective in increasing NAD+ levels sustainably in humans (Dellinger et al., 2017). Exercise: Physical activity can naturally boost NAD+ levels. Exercise stimulates NAD+ synthesis by enhancing the activity of enzymes involved in NAD+ metabolism, which helps maintain cellular energy balance and supports overall metabolic health (Li et al., 2021). These methods are supported by research demonstrating their efficacy in increasing NAD+ levels and providing various health benefits.

[@tapuit1]

The Okinawans, and Sardinians who live very long lives do not take any supplements.!! Do we really need all those supplements?

[@kroyal4296]

Thank you! It would be great if you could tell us the brands ioe at least the amounts to take. For the omega fish oil’s. It is not specified how much Dha versus EPA. Higher DHA is very important This is very important

[@MostAlpha]

Very interesting wrt Methyl depletion.

[@Zen_gineer]

CD38 and inflammation is activated for a reason... inhibiting it via a molecule doesn't resolve the reason and I wonder what effects it has? That sounds like taking steroids to solve a cold. It will get rid of the symptoms, but actually makes the pathogen it was fighting worse right?

[@rogerbruce2896]

this is a great review. ty

[@cathycoppin5682]

Nmn does work it’s change davied Sinclair body age so it does work and seen blood texts for people who took the nmn and there levels have gone way up

[@LoveLife-wy8gt]

iM A 70 YEAR OLD MAN WITH 4 STENTS HOW MANY MG OF CALCIUM SHOULD I BE TAKING .

[@barbarafairbanks4578]

'However, other studies have found mixed results. For example, a study published in the Journal of Clinical Psychiatry in 2019 found no added benefit when researchers combined omega-3s EPA and DHA with the antidepressant sertraline (Zoloft). A 2016 analysis of 40 clinical trials also found mixed results " Depends on which study(s) one wants to believe

[@pohaa]

Omega 3s are easily oxidised. There's research coming out now that raise some concerns about mega-dosing.

[@pohaa]

Krill oil is arguably better as it has Astaxanthin in it (giving it the red colour) which is a powerful antioxidant.

[@thearivera2569]

Hello i am 35 and starting to research on longevity supplements. Do u think j should start now? When is the best age to start all of this? Thanks

[@DrTimPearce]

We should all be living life from the start in ways that our system needs- so lower sugars, Mediterranean diet, fasting periods, regular good quality sleep, regular exercise, and supplements play a role for sure.

[@EaganChris]

Shes very pretty and well-informed!

[@fidrewe99]

TMG because it can replace some choline more effectively, safely and cheaply than choline supplements and because it helps to lower homocysteine and make sure to get enough methylation and methionine even in a diet favourably low in methionine. It's also good to maintain or improve cognition, mental health, muscle mass and physical performance.

[@enriquerodriguez3215]

What about the most important vit C

[@larryc1616]

🍊

[@Sedefsweetpie]

Long before lines and wrinkles happen , there occurs an expression loss. This is the stage we need to intervene to work on levels of muscle, adipose, nerve and capillaries. Long before any lines happen expression is already distorted. When you want to understand a system. Look at the most energetic parts. Such as nerve such as capillaries and muscle They do create the most distortion. All rest otherwise is tale to do the best in a worst. Worst bc modern medicine has never explained facial changes properly. Mean no disrespect🙏

[@89mmyo]

What are the brand please let me know

[@TSLApilot]

23:10 are there links providing more details on ways to stop the decline of NAD outside of using precursors?

[@TSLApilot]

39:20 I see it’s covered later in the video

[@TSLApilot]

The irony of dismissing the use of TMG to complement the use of an NAD booster while promoting a supplement with complementing ingredients has not gone unnoticed.

[@Ms17796]

For sure some promotional purposes. For her no supplement worth it .. um I have taken a lot of these supplements and they have worked wonders and helped me so much . Contrary what pharma says . I’m for all those supplements.

[@michaelboller5314]

But fish oil and Omega 3 capsules failed in most studies. I guess fish is much better.

[@AC-pl5kx]

Alpha ketoglutarate AKG seems to have some evidence - so NAD+ or AKG or both?

[@Chris_Faraday]

AG-1 is to low in beneficial compounds and has calcium carbonite. If new to health it's OK to transition

[@samdefore2692]

Not that I want to critique but she said you shouldn’t take a supplement and then take another supplement to negate the harm of the first supplement well then she said that for vitamin D that one should take Vit K,