How does Zetia (Ezetimibe) Work? (+ Pharmacology)

[@nazzib3657]

Pls don’t stop making videos!!! They are super helpful

[@DrugChug]

More videos are planned to come!

[@rhondagregory5253]

These video are a great resource for studying for pathopharm exams!

[@SongbirdRanch2005]

My trouble is that my body produces cholesterol a LOT , blocking the dietary cholesterol absorption doesn’t really help.

[@MilanMazic-p9l]

It will

[@jupiterthesun3217]

I'm the same . Best wishes

[@MilanMazic-p9l]

increase soluble fiber and add Amla and Niacin a day and it will go down@@jupiterthesun3217

[@tesos2866]

The first thing you must do is find out if you are a hyper absorber, or a hyper producer If you are a hyper producer you use statins, pcsk9 inhibitors, bempedoic acid.

[@MilanMazic-p9l]

@@tesos2866 are pcsk9 safe?

[@maxine.celeste]

I literally cannot thank you enough! You break it down and make it so easy to understand! :)

[@DrugChug]

Thank you for the support!!😁

[@christellekankalian7824]

I really liked how detailed you were in this video otherwise I wouldn’t have understood it as well as I did. The way you thought it will always stick in my head from the examples you gave us. Also, It’s really cool how zetia’s dosage is only 10mg’s. Now I know that Zetia helps lower the LDL cholesterol.

[@HughSommer]

I took Crestor and Zetia for six months. I’m 82 and a diabetic. My total cholest is 105, ldl is 48, hdl is 40, tri is 88. No problems. Good look

[@Qliphirot]

Enjoy, Hugh

[@Candleflower42-zp3sh]

This is the combo I going to ask my doc for. What were your numbers before taking? Mine are quite high, should have gone on medication years ago.

[@alburybeverly]

Clear and easy to understand

[@ايهاببيانو]

To tell the truth you have the best channel ♥️♥️♥️

[@fatimaezzeddine1918]

your videos are life savers! thank you for being very detailed

[@Happy-Trails-To-You]

Nice, simple and clear. Thank you.

[@rubaabazid6737]

Your method in explain is very simple and useful . Thank you very much

[@DrugChug]

Glad you enjoyed it! Thanks for watching!

[@tinatam6205]

Very clear explanation.

[@mary-elizabethcoetzee685]

Ezetimbe made me ill. Stopped it. Got all side effects. Thought i was dying.

[@atiqrehman8562]

Very good explanation thank you

[@DrugChug]

Thank you for watching Atiq!

[@cg-pj8mj]

Please make more you make the best pharmacology videos on KZbin!

[@DrugChug]

Thank you! @Colton More videos will come in the future, thanks for your support!😁

[@ayobabalola8657]

Absolutely, I agree

[@maedorasmith33]

Thank you for your knowledge I found it very informative and easy to understand

[@abc_cba]

This channel is the best one on drugs of the hundreds there are on YT. I have three things to talk about or express : 1) You mentioned Ezitimibe blocking the *dietary cholesterol* what about the one created by the liver automatically, does that mean that ezetimibe can't block the cholesterol that our livers produce ? 2) It's funny how easily we at India can grab any drug without any prescription at 1/50th the price in US. I self change and try drugs on myself being a testing space. I got a combination of Rosuvastatin and Ezetimibe (10 mg each) for $1.50 for a strip of ten tablets. So, Simvastatin is the only drug that is used in combination with Zetia alone. Lastly, 3) You have an amazingly sexy voice and I am not actually hiting on you ( I think i am !) , And Thank you very much for this elaborate explanation. God bless you.

[@DrugChug]

Great Questions! 1.) That is correct. Ezetimibe only affects dietary cholesterol. That is why we typically use it with a statin. That way the ezetimibe blocks the dietary absorbtion, while the statin blocks the production of cholesterol (we target both pathways). 2.) Yeah that is crazy about the price of drugs around the world. And the only combo product is Vytorin in America (Ezetimibe + Simvastatin). You can take Ezetimibe with any other statin, but the drug companies have only done trials with simvastatin to be able to make this combo product specifically. 3.) And thank you! I'll keep making more of these videos then!

[@tenniskinsella7768]

Why if its so good do i still have to take statin morecside effects taking both why cant i just take the one tablet

[@zsuzsannavarga9370]

love this video very informative thx

[@DrugChug]

Thank you for watching!😁

[@mrcharlesjohnson]

Cool video, very helpful.

[@DrugChug]

Thank You! Glad you enjoyed it!

[@fumikosteiger]

Wow, I like this video!

[@lth1912]

God bless you man

[@hanialabed9100]

Very nice job really 👍👍👍

[@DrugChug]

Thank you for the support! 😁

[@hanialabed9100]

@@DrugChug you welcome I am going to watch all your videos 😊

[@Zahraa.Fadhil]

You are amazing !

[@DrugChug]

Thank you for the support! 😁

[@tnleung1]

love it. thanks!!

[@AM-qw9cv]

Does Zetia reduce the chances of getting a stroke or heart attack? Is Lipitor better than Zetia? Please advise.

[@tenniskinsella7768]

Ipitir has lots of side effects invading lip and face swelli g. I had to come off

[@juandelgado8820]

There’s guidelines that state you start on a statin and then you combine zetia if ldl remains high

[@ItsGivingRichAuntie]

Wow this is awesome! I passed the quiz btw 😂 My doctor is putting on this medication as of today and I needed to know what was up with it. I’m already taking Cholestyramine and I guess it not working because my LDL’s are elevated . I’m allergic to the Statins. We tried that first my body was so sore, thought I aged in 3 days to about 99 years old 😢 I was like absolutely not. Trash this medication immediately 😥 But this was a great video. Praying I don’t get that fatigue side effect 🤞🏾🤞🏾

[@jamesbirch6522]

how you finding it so far? ive just been prescribed this + 180mg bempedoic acid

[@DrugChug]

Hope you guys Enjoyed! Did you get the Quiz questions right at the end? Let me know!

[@CarolineBeautyInc]

Drug Chug yes!! Thank you for another great video

[@karlvillaluz7933]

Are you still making videos? You should make a education website, I’ll totally subscribe!! Your videos are straight forward and very helpful!!!

[@gregstuart5903]

@@karlvillaluz7933 - I agree. Informative yet concise. Just subscribed, will follow from now on. A website will be great, then we can search when needs arise.

[@andyc9982]

Can you use this as a preventive measure? and would it block Omega oils or Vitamin E supplements?

[@canadacalling6892]

If the drug is blocking intestine uptake of LDL, why is it taken at bedtime? Breakfast, lunch and dinner are long gone by then. A sincere question.

[@DrugChug]

Great Question! @ Canada Calling Yes you can take this medication at anytime because the half life of Zetia is about 22 hours, which means it only requires once a day dosing. However, if a patient is also taking a statin (which is a high probability) it is best to take this medication with the statin and this is where we can see a preference on when to take the medication: If a patient takes a night time statin, such as simvastatin, then they should take Zetia + Simvistatin at bedtime (Again only because the Simvastatin has a short half-life and cholesterol synthesis happens at night. We even see the combo product Vytorin which has Zetia + Simvastatin. But if a patient takes Zetia with a long acting statin (Like Atorvastatin) then they may take it at any time of the day! Hope this clears things up! :)

[@canadacalling6892]

@@DrugChug thx for the reply. I am refusing to take the statin because previously it was wrecking my brain and a few other unmentionable things. I am about to take Ezetimibe today. I am hoping all the side effects listed will not occur. Thanks again for the reply.

[@DrugChug]

@@canadacalling6892 No problem! Zetia usually has a better side effect profile! Hopefully it works well for you!

[@gregstuart5903]

@@DrugChug - Indeed this answer is important but no other source mentions it that I've noticed - Simvastation and Atorvastation have different acting half-lifes. Thank you for the clarification.

[@nenadcubric2663]

I take Crestor and Zetia 20/10

[@messelnoinoi6971]

Nice bro

[@DrugChug]

Thank You!

[@kharesiddharth2526]

Very useful .. thank you

[@joyceelmer131]

Just subscribed

[@darlenecaton4032]

Also raises Alt and Ast at least for me and some others. Had to get get off this drug immediately.

[@datmeme8967]

OK, pay big pharma for the rest of your life instead of improving your diet.

[@markthurlow6223]

It’s not a dietary issue for everyone. I have a family history and have always had hi ldl and low hdl. I have always been a healthy eater and exercised. Not happy about getting out on this medication but going to try it and see what happens.

[@datmeme8967]

@@markthurlow6223 Sorry to hear that, but we all know that the medical industrial complex does very little in the way prevention. My cardiologist told me to start taking statins. I told him I wanted to try lifestyle changes first or else I'll never know if they did anything or if it was the statins. I'm muscular, 6' 195, so not obese or out of shape and always ate a "clean" diet. I changed my diet and lowered my LDLs over 25% in 3 months. There are foods that raise cholesterol and others that help lower it. Red meat, whole eggs, whole dairy, etc. are all "healthy" foods, but I reduced my intake of them by 90% added ground flax seed to my daily oatmeal, started using plant stanol spread instead of butter and increased the amount of cardio over a day that I was doing. Everyone is different, but I wanted to see if the changes would work for me before committing to a life of drug use. Glad I did.

[@cdinaz]

So a phytosterol hyperabsorber would not benefit from zetia then - someone with variations in the SNPs for ABCG5 and G8 receptors? Fatigue, loose stool and nausea may be common but those are NOT small side effects. If you had those without the meds you would be trying to figure out WTH is wrong. HMG CoA reductase (mevalonate pathway) being disrupted also reduces production of MK4, geranylgeraniol and CoQ10. So perhaps doubling down on living better should prevail over meds.

[@jc10907Sealy]

For those of us with FH, no amount of clean living gets our numbers down.

[@951NewNow]

I thought the diatary cholesteral myth was debunked.

[@tenniskinsella7768]

Why have i read this tablet increases risk of deme tia. Is tbis true or notv

[@lucilledabney2340]

He makes a lot of sense this is the best video I have watch but I do have pains in my knee in my nick while taking this medicine I don’t like that part I can’t tell if it working or not I’m not for sure🤦🏽‍♀️💁🏽‍♀️

[@nastarannazari5062]

Excuse me, I am confused cause my instructor said that Zetia can increase the risk of gallstone. while these meds decrease the absorption of cholesterol in the gut, how does it increase the risk of gallstone?

[@vigienaidoo7413]

Wow I have just started this tab today came across this video today beautiful was a pleasure to watch have peace of mind taking it thank you ❤

[@subhash7408]

What about a combination of retrovastatin + fenofibrate. Sir.

[@erieviewer148]

Good video actually eating cholesterol can only raise cholesterol in a small way it is eating saturated fat that raises it.

[@Ke-qv3md]

Can you take Ezetimbe (Zetia) if you donate blood platlets?

[@tom-dr1ym]

so what are the side effects

[@NeetaAgarwal-mn3dk]

When to take ezitimibe tab Best time Night Before dinner/After dinner Or in breakfast/lunch Suggest best time in whole day for 10 mg ezitimibe to minimise any meal cholesterol absorbtion ??

[@nenadcubric2663]

It doesnt matter

[@tesos2866]

Zadia dropped my APO b 41% I am a hyperabsorber not a hyper producer. And ZERO side effects. I also take a very low dose statin to avoid a bounce back. Less than 5mg.

[@yolandasalone7949]

What if the patient is on a healthy diet and have been on a healthy diet for years for instant they don't eat any animal products What about that Sometimes I think they just wanna put you on drugs you don't need

[@gregstuart5903]

There are those doctors around unfortunately.

[@tenniskinsella7768]

A completely vegetarian diet not necessary a good all my life have eaten good diet so dhy ha e I got diabetes and high colestral is it because I'm old

[@lth1912]

I wish I could do more than like and subscribe

[@ameliahelmerfalcao5559]

Cometa o remédio que chama zete em português

[@jupiterthesun3217]

I've been a vegan for many years and I don't used cooking oils at all and then only cooking oil is use is avocado oil and as my lover can't process oils I am used to no fat diet but my cholesterol is off the charts ! I think it's mainly bad genes.

[@littleartist9043]

Then if this drug help us by make foods not digested whe we don't use it to prevent obesity 🤔

[@dougwood1658]

I was on Zetia several years ago...I was noticing a weight reduction, so I kept a daily log...lost 17 pounds in one month !!.. Doctor took me off Zetia and the weight came back on within 2 weeks ! .. Apparently it absorbed all the fat (cholesterol) so my body then took it elsewhere to maintain metabolism....just things I noticed...

[@بيسان-ظ1ج]

❤️❤️

[@Smartgran]

Ezetimibe undoutedly gave me explosive diarrhoea fortunately in the doctors surgery!

[@doctorshakoor4963]

Statin must take with food....well absorption with food ...any day time ...there is no specific time for taking this Medicine

[@tenniskinsella7768]

I take at night that whst my dr said

[@DK-pr9ny]

Can it be mixed with Crestor?

[@nenadcubric2663]

Yes 20 mg / 10 mg

[@johnsullivan8129]

Does it help prevent strokes or heart attacks

[@thelastidea20]

Ezetimibe should only be taken in association with statins.That’s why vytorin also has simvastatin.

[@jaymehatfield9540]

Hahaha "simis-sta-uhn" another millennial that cannot pronounce consonant "t" in final syllables

[@jonathanvasquez-mv9ic]

Sexuiol