How do Statins Work? (+ Pharmacology)

[@excelator]

Thanks

[@jadem.7227]

this is probably the easiest and clearest explanation of the pathophysiology of statins you'll find on youtube

[@JoshuaSafari-q2n]

I worked in Pharamcy for years yall. If you are able bodied and Are NOT being hindered by a disease or aliment. Please exercise often and eat more fatty fish and more avocados and avoid saturated fats. I personally increased my HDL from 50 to 62 and dropped my LDL by 30 points in about 6 months

[@LurkerPatrol]

I’m taking omega 3 supplements to raise my HDL which has always been under 30 and a recent lipid profile showed it to be over 40! However my cholesterol has always been high. Even when I lost max weight and was doing exercise daily my LDL over 250. Hypercholesterolemia runs in the family. I’m wondering if I need to get on statins. I’m 37 years old

[@deborahmcnaughton4394]

​@@LurkerPatrollol 😂 hilarious no no no, read the side affects silly. You will regret it. Muscles ache like the flu, a lot of side affects.

[@mulugrajbaiswmuthiary9648]

⁠@@LurkerPatrolget your thyroid profile done n visit an endocrinologist. Hypothyroidism may be the cause of stagnation of cholesterol levels.

[@noy6184]

Did you get OMega from Fish. Or what omega supplements did you take?

[@noy6184]

@@LurkerPatrol Did you get OMega from Fish. Or what omega supplements did you take?

[@geoffreybarry6769]

I went to school today, your teaching was exemplary

[@smartchoices2000]

Despite it being an old video, this is by far one of the best explanations! Well organized and informative! Bravo!

[@amandafranks544]

Great video! Like the quiz at the end, only suggestion is put the answers on the end slide 😄

[@jaithakore2421]

absolute brilliance great job there!!!!

[@DrugChug]

Thank you for watching!😁

[@leonardsturm411]

Awesome! An excellent discussion for non- medical people.

[@falcon127]

DO STATINS REDUCE (CoQ10) IN THE HUMAN BODY? & SHOULD A PERSON TAKE A CoQ10 SUPPLEMENT WHEN TAKING A STATIN DRUG?

[@stevewhiteman2344]

They do reduce coq10. Don't take a supplement, ditch the statin.

[@najmabegum5789]

Amazing video. Thank you. Will save it on my playlist so I could visit when I need to. Very informative

[@floasa8484]

Extremely knowledgeable and enlightening. Thank you sir.

[@DrugChug]

Thanks for watching!

[@johnnyrowe6258]

I'm 54 and just started taking lipitor. This explanation was very informative. The cartoon like visuals were perfect. Thank you

[@jamesbrandt3764]

I've tried two different stations. The last one made my muscles ache. Then the bones in my hands started hurting. I would rather die of high cholesterol than the side effects of statins.

[@Leik2487]

True

[@MikeStellino-t9v]

what ones ?

[@jenny6253]

Please explain what mechanism the statins use to attack muscle fibres and can they attack cardiac muscle also? Can you also explain the high risk and mechanism of developing type 2 diabetes? Surly that would be counter productive

[@mobutu65]

They stop production of co-enzyme q10 and our mitochondria in muscles and braincells get out energy ehat they need.LDL has 8 different types and statines lower useful too but we need to lower only really harmful oxidysed ldl or small LDL who really is bad.

[@ronpflugrath2712]

At age you are losing muscle mass. Is it accelerated?? Stuck during covid waiting for surgery muscles got weak hard too bring back

[@nenadcubric2663]

I take atorvastatin (Lipitor) for 2 years, yes it lowers, but it lowers HDL too

[@rayeemon]

Thanks man, my Pcol teacher doesn’t use power point only taking notes from what he says. You are a life saver

[@DrugChug]

Thanks for the support! Glad it helped. And there are way too many horrible professors out there

[@fatimabintezahir3956]

Very good explanation sir

[@jesusistruth.sthazel-adaug3279]

000p⁰0000

[@Serenity-7.0]

Thanks for your useful video. One thing you didn’t cover is what happens if we stop using statins? Are we going to have a ordinary cholesterol level after few years or as soon as we stop using the cholesterol goes back to high level like before? Appreciate if you answer. Thanks again.

[@suziquestionable2845]

L

[@misumobo]

From my understanding, statin are a lifelong treatment. Stopping them would result in your levels going back to what they were pretreatment. Also, they're used in combination with lifestyle modification.

[@JohnWest4]

​@@misumobo gotta watch dopesick movie before we take pharma fav blockbuster. More for profit than health? why should we take a drug forever? Why not look at causes for dysregulation?

[@ehayes7849]

@@misumobo so diet and exercise count for something (reduce medication) if not hereditary problem.

[@John-gw7dh]

Hi, I've heard that simvastatin is bad and that makes me a little worried, Im taking simvastatin 10mg because of high scholesterol, in conclusion it is 100% safe to take it?

[@darylprice-wx7fz]

Thank you for this easy to understand explanation. I've been on rosuvastatin for a while following a subarachnoid haemorrhage and high LDL cholesterol. It's good to understand how it actually works. Well done.

[@dominik13579]

Lab results came Friday My LDL is 260 Was unexpected as im not fat and relatively fit Was nice meeting you guys 🥺

[@kristianardon7072]

🫡

[@AndyHTu]

You got it bro. Let's keep you alive!

[@JohnWest4]

​@@g_1673 that wasn't mentioned. Is calcium intended to stabilize plaques? Trading atherosclerosis for hardened arteries?? It seems like everyone should be taking one of these? What us the actual reduction in disease? If 3% have heart attacks without statins and 2% have heart attacks with statins, is that fair to claim a 50% reduction?

[@ehayes7849]

@@JohnWest4 good eye! everyone in this country needs a statistic class - simplified in jr high and then full on in high school. companies will lobby against it as well as our greedy politicians - especially the ones like DeSantis.

[@JohnWest4]

@@ehayes7849 We all exchange service for money, or product for money, but am on the fence if medical service should be a profit industry, like other things. Maximizing cost has not done us well. .. Something is worth what someone will pay for it? or should it be tempered by cost of manufacturing, certification and delivery? Pharma wants a blockbuster drug to fill its coffers, but its at the expense of the society. Insulin costs for example. should cost $35 a month? SHould Sugar industry help pay some of that?

[@susanlockard9625]

Best explanation of this

[@morrism2388]

Thank you soooo much for making these videos. They are excellent, i am learning so much from them. Please keep making more pharmacology videos.

[@DrugChug]

Thank you for the support! Dont worry, more videos are coming soon!

[@misaVR]

One deca-liter or 1 daL is pronounced ˈdekəˌlēdər and is equal to 10L or ten liters. One deci-litter or 1 dL is pronounced ˈdesəˌlēdər and is equal to 0.1L or one tenth of a liter. Btw, awesome video. Thumbs up!😊👍👍

[@thethinkingman-]

is it a decker liter or a decker litre ?

[@misaVR]

@@thethinkingman- Both, British or American.

[@adal8653]

Thank you for this video, it’s help me to remember all the drugs for NCLEX

[@abc_cba]

I had a question if you could help me solve. I've been on Crestor 10 mg since 4 months, My LDL cholesterol reduced from 165 mg/dL to 78 mg/dL in a month. My question : What I wondered is when a statin stops the cholesterol production, how does the LDL reduce so quickly ? Does the body use it up for energy and begin the depletion of cholesterol since it no longer produces as it once did? Or The statins begin pushing LDL out of the body and eliminate it ? Or That Vitamin D and testosterone begin consuming the remainder of whatever cholesterol that the body has now that statin has stopped it's production ? I'd appreciate a response. Thanks for the best video on statins on YT.

[@DrugChug]

Thats awesome to hear! Yes statins work very quick, and they do the job of lowering LDL the best (First line treatment). When statins stop the liver from making LDL, our liver naturally responds by making more LDL receptors to uptake the excess LDL in out bloodstream. Once it takes the LDL from the bloodstream, it will use it for other processes like you mentioned. So the cholesterol will now be used for Vitamin D and hormone synthases!. Hope this clears some things up!

[@jamalsinjab5137]

@@DrugChug not realy

[@Kjuken69]

Why do you lower your LDL COLESTEROL TO 74?, DO YOU HAVE A BAD TYPE OF LDL COLESTEROL? colesterol is extremely important for the body!

[@abc_cba]

@@Kjuken69 well, I have a gene Lp(a), and my family history (both sides) have cardiac illnesses ! I've changed immensely since then with all my lifestyle and diet and herbs, so much more than just that.

[@tomasvalent3876]

question related to 5:36 : do Statins somehow prevent Macrophages from breaking already builp up LDL in arteries ? Or really Statins main aim is to prevent new LDL buildup?

[@jamalsinjab5137]

The video tells you that statin drug mostly work on the liver by blocking the enzymes from going forward in the process and not in the arteries

[@tomasvalent3876]

thank you, make sense. I just wanted to be sure as one doctor told me that "Statins directly prevent artery blockage" => So pretty much that claim is not true. Now it may be that I've just misunderstood her, and she meant something else but I wanted to be 100% sure (that's why this question)

[@thomashilson4158]

@@tomasvalent3876 I think you misunderstood a second time. If the drug works IN the LIVER by preventing the liver from making MORE cholesterol, since too much is already in the blood & vessels walls, then your doctor's explanation is CORRECT.

[@aloevera301]

Thank you so SO much! 💛

[@jimsgardenproject3507]

So all statins do is create/ add more “receptors” in our liver to remove the cholesterol from our bloodstream. But what about the glycated cholesterol damaged by sugar which is not recognized by these receptors and so just continue to float around the bloodstream causing most of the problems. As for the buildup of LDL in your bloodstream. That’s because there’s already damage from other things. The LDL which is not cholesterol but Carry’s cholesterol is a unit of repair and so if there’s buildup it’s because there’s already some sort of stress in your arteries. Sugar is the culprit. Cholesterol is like an ambulance trying to fix damage. Is cholesterol the fireman or the arsonist??? Statins also promote diabetes Ascvd- eliminate sugar/ reduce carbs Get your hdl higher and triglycerides as low as possible much lower than 150. Love that we give diabetics statins. The underlying issue with any of this as any nurse or doctor will tell you, is getting people to comply. Compliance is an issue due to flat out laziness or massive confusion because there’s a pill for a pill for a pill and people don’t want that. They don’t understand why they have to keep taking another pill and another. Lastly, food is so addictive now that why do I want to stop eating all this good stuff? It’s so good! But it’s also slowly killing you. Why are you basing statins on ldl base of 70? Key words” based on clinical judgement” are there studies (double blind) to support that judgement. Most of this video is wasted on the average person because of the language.

[@frankgyetuah-boadi601]

Another nonsense post. It’s not. Read a research

[@jimsgardenproject3507]

@@frankgyetuah-boadi601 explain nonsense please

[@frankgyetuah-boadi601]

Read an actual RCT and all the studies on statins mate. You won’t spew such uneducated takes

[@markmoreno7295]

Whew! I am so relieved! I should do fine but now I know what to look for.

[@DrugChug]

Woohoo! Thanks for watching!

[@SirThomasR]

Can you do one on PCSK9 inhibitors?

[@IsabelRodriguez-nv2ue]

Amazing video!!!! Thank you so much!! They are super easy to follow and help to remember the concepts! Love the illustrations and organization of the information. Thanks!!!!

[@DrugChug]

Thank you so much! Your support truly means alot! 😁

[@Divya21Sri_200]

Sir how to calculate percentage of risk

[@baqirhemraj7639]

The body needs cholesterol. Some types of cholesterol are essential for good health. Our body needs cholesterol to perform important jobs, such as making hormones and building cells. Cholesterol travels through the blood on proteins called lipoproteins. The liver produces cholesterol.

[@ajazhussain4064]

Fantastic video. Where have you gone? More please.

[@MichaelAngelo525]

Thanks you very much 😊

[@babugr7394]

Excellently explained very well understood statins thanks

[@DrugChug]

Thank you for watching!

[@willy4b]

I love how simple and clear ur explanation is!! thank u u actually saved my life!♡♡

[@DrugChug]

Thank You! Glad these videos helped! 😁

[@vinodeditz149]

very useful video ...thanks

[@gints2766]

I noticed that the pharmacist still recommends atorvastatin and rosuvastatin be taken before bed. Is there actually a benefit to this, or would the blood level be about the same if it were taken anytime within 24 hours?

[@jamalsinjab5137]

When they before bed time . That means by the time the drug start to take effect on the lever you are sleeping

[@DenysHartley-np2ob]

Thank you for your video! There is some great information here and it helped me understand the cholesterol/statin process. I also liked the comment that said, please put the quiz answers at the end of the slide. It stimulates my brain's reward center when I get them all correct. ;)

[@stephenmartin9393]

Statins seem to cause my leg and calf muscles to cramp. Atorvostatin is a problem for me even at a liwer dose. I have recently switched to a different type of statin so I will know more how this new drug works within a few days.

[@Roachehh]

Excellent video and excellent channel. I'm just studying to be an A.C.T but I love the pharmacology and this channel will definitely be added to my study material

[@rash9425]

Thanks very much. Great video.

[@hasnaherling5173]

I like this explanation. I have been using the avortastatin for lowering my LDL. Very clear,informative and understandable.

[@jaymadu4306]

hence he explained the the muscle pain you have been having right...

[@chettriaone]

Amazing videos. I am loving your channel guys, keep it up 👍. Blessings from 🇳🇵 NZ.

[@myathan3016]

Thank you very much.

[@maxine.celeste]

I love your channel! Thanks so much.

[@DrugChug]

Youre very welcome! Thank you for watching!😁

[@toysfunny6944]

A great explanation thank you a lot

[@DrugChug]

Thanks for watching and supporting!😁

[@bjorn6956]

youre the best dude, thanks

[@tonimcdougal4261]

Wow I really wish I would have found your videos sooner. They are great!! They still may save me though!! Thanks for making these!!

[@DrugChug]

You can do it! Never too late!

[@kaymoon2267]

Your video so useful and i love it I hope you update more medicine

[@sbu116sbu2]

Thank you. What a great video

[@lunstee]

Thank you for this and your other videos! You've answered questions that I've had, but as is always the case, raise new ones in their place. I'm wondering about the inputs to the cholesterol synthesis process when HMG-CoA is blocked. I gather from your other videos there are processes that convert free fatty acids to triglycerides, triglycerides to vldl, vldl to ldl; do we know more specifically where in the whole chain Hmg-CoA is involved? I'm under the impression that statins reduce not just ldl, but also triglycerides, so my guess would be it's similar to fish oils blocking the conversion of free fatty acids into triglycerides. If that's the case, I wonder what happens to the free fatty acids that would have otherwise been converted? Does the body have a harmless outlet for them? Or do they or other resultant products (adipose?) accumulate? Inquiring minds want to know! PS your pronounciation of decilitre had me very confused for a moment; it sounded to me like you were saying daL (10L) instead of dL (100mL). As a Canadian growing up with metric units, I've always known deci to be pronounced as "dessi", so as not to be confused with deca (dekka).

[@b.kodzoofori1491]

You explaind the deposit of LDL in the artery, but forgot to explain HOW the deposit came in there!Knowing that might REVERSE the cause and thereby lowering the necessity of taking a Statin Drug at all.Thanks.

[@myathan3016]

very good.Thanks.

[@bliornd]

Thank you drug chug for doing this video

[@giridv9303]

According to many videos, TG are made by adipocytes from excess glucose converted to glycerol and fatty acids from liver which is again made from excess glucose in the insulin dominant state. .. secondly by liver from glycerol from excess glucose and fatty acids. It also seems that 80 percent of dietary fat is excreted and only 20% is used for making chylomicrons which ultimately end up as cholesterol. So is it direct to say 70% of TG comes from dietary sources?

[@lachyt5247]

Adipocytes don't manufacture fatty acids, they're a storage site for TG. FA synthesis occurs in the liver during post prandial states via TCA cycle intermediates (when citrate builds up it is shunted out of the mitochondria for FA synthesis, likewise DHAP from the glycolytic pathway is shunted into G3P production).

[@KishoreKumar-mb7in]

In that case what stops you from outsourcing HDL from healthy person and inject it into the person with heart disease

[@perrypelican9476]

Why do you not pronounce the second t in the word statin. You say sta-ins. I never heard an accent that only leaves out random letter t’s in the middle of words. Is it a thing?

[@ymaster8719]

Because it is UK accent, 't' and 'r' are silent letters in pronunciation.

[@magpie1492]

It is NOT a UK accent. It's American !!

[@alphabeta123100]

Those suffering from fatty liver, statins are helpful for them or not ? Taking statins for years, a problem for the liver ? Thank you for your time 🙏

[@DF.7]

Great video! Thank you for this breakdown. Please consider doing the top 200 😁😉 Question, due to the statins work in our livers and can cause a certain amount levels of toxins in the liver.. would this medication be considered an NTI? If no, why not? Thanks in advance.

[@edc2678]

Very lightweight video. No mention of impact of statins on type 2 diabetes and no mention of the ACTUAL risk reduction being only about 1.1% for both Lipitor and Crestor.

[@shyamalsom1379]

Excellent insights.

[@ScottLive1]

Can you please do a video on pcsk9 inhibitors like repatha?

[@Vivovivo-fi5pt]

Thank you very much, it is really great video.

[@Bill-ot6gg]

They may lower your LDL but for many the side effects are worse than the benefits that they derive. I have taken statins for coming on 40 years but had to stop due to sever side effects.

[@andyontourbrokendreams7120]

What side affects Bill

[@perovato02]

@@andyontourbrokendreams7120 musical pain . Spasm. Brain fog , can't sleep. Loss of musical . Joint pain .

[@j.h8597]

Actually, those having bad side effects are a minority. Statins are so effective and protective, especially over time, that some countries are talking about adding them to the water supply. A better approach would be to change dietary recommendations and consumption of alcohol, cigarettes and sugar, but statins save lives.

[@perovato02]

@@ax1066a-ghd2 I stop taking them for 3 months. I am taking vitamins B3 I also no longer have cold fever and no longer have spasm.

[@tski3458]

@@perovato02 got all that.

[@dhillonamarsingh5033]

Kindly advice which Statin causes minimal muscle pains Fatigue and Brain fog I'm taking Rosvastatin despite taking 10mg on night after Dinner Thanks

[@danzelimako]

You were very informative so I subscribed.

[@sharps8726]

Statins make it impossible to lower weight and been causing me nervousness . Once i stopped weight went down and nervousness went away.

[@Mohammed-dd8jm]

thank you

[@DrugChug]

You're welcome 😁

[@danzelimako]

What if you have both chronic kidney disease CKD and liver damage, (fatty liver) should you take Lipitor ?

[@rosymary1434]

Great video, thank you!!! Woooo makes soon much sense

[@elviranoblejas9477]

Thank u for information

[@quentinrobertward198]

Great Video. But What is the Music you play at the end called ?.

[@jadem.7227]

Hiiii I enjoyed your video a lot! Only suggestion I have is if you could put the answers to the quiz at the end of the video? Thanks

[@ss_jk6141]

Great lecture 👍

[@DrugChug]

Glad it was helpful!

[@engiragaey9730]

Great videos keep going we are enjoying them.

[@NBay_]

This is great. Thank you for sharing

[@idee7896]

KZbin recommended this channel and I am so glad.

[@jamesgordon8867]

Do you need if you are taking too much fish oil?

[@rcz2023]

Awesome! Thank you

[@denvy91]

Quick question: Is it DeCIliter or DeCAliter? Deci is usually abbreviated dL and Deca is dcL in Francophony or daL in anglosax countries. A little confused about that part since there is a factor difference of 100 between both (daL = 10 L whereas dL = 0.1 L or 100 mL)

[@DrugChug]

Great question! @Vensie , 1 DecaLiter is = to 100ml and is abreaviated as dL (In the USA). Other countries and locations have different abbreviations, but typically in pharmacology we stick with DecaLiters (100ml's)

[@jesperdyhringpetersen503]

@@DrugChug dL is deciliter = 1/10 liter = 100 mL, and daL = deka-/decaliter = 10 litres. Used in other words like "decimal" or "to decimate" (literally reduce by a tenth) and "decathlon" which is a contest in 10 different disciplines.

[@CessSim]

Why is the LDL sticking to the walls of the artery? What is the route cause as to why this "sticks" ?

[@CessSim]

@@lindaj5492 thanks and completely agree with your comment. Obviously thousands and thousand of years of genetic evolution has designed us in such a way that our cholesterol is meant to kill us. Pure nonsense IMO....

[@lilyrobles323]

Thank you for a valuable information

[@thomaschurch7686]

So does the reducing of production of LDL in the liver just stop all LDL , including the small LDL. I read it stops all LDL both the fluffy ones (good LDL) and smaller bullet type LDL.

[@brendanlawlor4031]

"""Very well explained , thank you ."""

[@DrugChug]

Thank You! Glad you enjoyed it!

[@moniqueponce5782]

Thank you so much!!!!!!

[@eduardobravo-leon3894]

Nice job!

[@marizjustol4745]

Been taking atorvastatin last week. And i have a muscle pain wc u mentioned myopathy.

[@dhillonamarsingh5033]

Superb explanation 👌

[@nazzib3657]

This is amazing

[@DrugChug]

I'm glad it helps!!

[@killj84]

Great vid. I do have an issue with people who can't pronounce the words they are teaching. It's not "sta,ins" it's statins. And it's not "de(k)olitre" it's "de(s)olitre". No really issue just a pet peeve of mine.

[@AnnaUSUIIndonesia]

edit video in where? anybody can inform to me about app?

[@Dancesbetweenstars]

So great: understandable and memorable.....many thanks from Germany...I also improve my english

[@markmoreno7295]

Pretty good but while these drugs may lower LDL cholesterol, you didn’t say what effect, if any, they have on HDL cholesterol. Also even if you have no muscle pain, how does the body feed itself when on a low carb diet and it burns ketone bodies when exercising?

[@monicaboulis9001]

I think question number 3, the answer is B. I also thought pravastatin cause the least muscle pain.??

[@DrugChug]

Yes! Number 3 is B! -Great catch! Atorvastatin 40 - 80mg is considered high Intensity. Now it is true that Pravastatin is lipophobic (penetrating into muscles less, causing less muscle pain), but Rosuvastatin is the MOST lipophobic because of the sulfonamide functional group (because there are 2 oxygens attached to a sulfer). Hope this clears some things up!

[@monicaboulis9001]

@@DrugChug great, thank you! I enjoy your videos and your learning strategies.

[@cmy5774]

Very informative and really interesting to listen 😊

[@mar1na1993]

I must be in category 3. I have LDL of 174, and recently went on Simvastatin. I was wondering why I had to take it at night! I wish doctors explained everything in detail like this.

[@stefanserroul3572]

more of a pharmacist job and I'm sure your local pharmacy would be glad to explain any of your needs

[@suziquestionable2845]

@@stefanserroul3572 .

[@jamalsinjab5137]

@@stefanserroul3572 not really doctors get commissioning pushing these-kind of drugs so they owe it you to take one extra minute and explain it . But they don’t

[@thomashilson4158]

@@stefanserroul3572 Astoundingly NAIVE statement. You see the SAME doctor; the person "handling" your filled prescription could be any 1 of 6 people. The doctor MUST explain; not 6 people giving you six interpretations.

[@Kjuken69]

Why do you use statins? Because of and LDL of 174? Why are afraid of Colesterol?

[@johncooke2903]

Can you do one on Jardiance (empagliflozin) how it works, your videos are really good.

[@brentstokes2]

Brilliant thank you.

[@zaffarabbas9601]

Very Nice and informative Presentation