Drugs of Abuse (Mechanism, Intoxication, Withdrawal, & Associations)

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My goal is to reduce educational disparities by making education FREE.
These videos help you score extra points on medical school exams (USMLE, COMLEX, etc.)
For educational purposes only; NOT medical or other advice.
Some videos contain mild profanity and hyperbole solely used to assist with memorization. Viewer discretion advised.
Opinions are entirely my own.

[@DirtyMedicine]

Didn't have a lot to talk about with LSD, so I dropped that one from the video so that you can focus on high yields only. EDIT: since people are asking for completeness sake: -Know that LSD is a 5HT2a agonist (increased 5HT activity) -Know that LSD produces both synesthesia (i.e. somebody touching your arm makes you hear sound) and depersonalization -For inhalants, know that the onset is generally rapid and it causes nystagmus, diplopia, tremor, and respiratory depression. The buzzword is a rash between the upper lip and nose. -For Bath Salts, think typical PCP presentation but prolonged.

[@tarun278roxx]

Thank your Dirty ! Could you make a video on Highest Yield Topics in USMLE Step1 which one must never leave before taking the Exam. 😊✌

[@VIVI1337]

Love how you said "dropped" in reference to the acid, pretty sure that one flew over everyone's head lol!

[@DrZip]

Don't forget Ketamine (Dissociation & formerly used as a cat tranquilizer).

[@cahyasatixoxo7207]

IMO a better way to think of the synthetic cathinones like bath salts, flakka or mephedrone is to compare them to high dose methamphetamine or cocaine but with even more agitation and psychotic presentation.

[@Moosemoose1]

If you could add Management for intoxication/withdrawal for the psych shelf that would be great!

[@cailinoconnell6981]

Ben wants it to happen more frequently and Barb wants it to last longer is the best mnemonic ever made. You’re a rock star, Dirty!!

[@ibraheemalma]

Where does it come from? Because I see that this mnemonic further needs another mnemonic to memorize it 🤦‍♂️ I memorized it just by associating the z sound in benzo with the c in frequency, whereas barbiturates and duration both don't have such sharp sounds

[@ibraheemalma]

@@KKK-rc6rk idk what that means

[@ibraheemalma]

@@KKK-rc6rk I get it Barbi durate Creative 👏 But I thought you were trying to explain dirtymedicine's mnemonic for me, (barb wants it to last longer or sth like that) I have my mnemonic too you know, benZo= frequenCy= they are similar in the sounds, these sharp letters ( c z s...) Where as barb and duration are free from that. Your mnemonic is easier though Oh all these details, what am I talking about 🥲😂🤦‍♂️

[@ashlitty]

@@ibraheemalma lol its a sexual, gender stereotypical reference. ben = guy and barb = girl

[@shaunascholl6692]

@@KKK-rc6rk zw wa-×-0

[@jannmikoingelrabagogamingc6012]

Timestamps for each drugs of abuse: @2:16 Alcohol @15:04 Opioids @18:54 Benzodiazepines @21:17 Cocaine @24:02 Methamphetamine @27:49 Phencyclidine (PCP) @32:05 MDMA (Ecstasy) @35:14 Marijuana

[@KatieMinckler]

I'm not even a med student nor do I intend to be, but I still find your videos incredibly informative and reasonably easy to follow. I have become frustrated trying to find videos on these topics that are concise, unbiased, and stand up to scrutiny. There's something comforting about learning from the same source as other med students, even if I do need to skip over the minutiae or mnemonics here and there. Thanks for doing what you do.

[@carolineb133]

A really good mnemonic for pupil size in opiates vs cocaine: make a fist for the O and then a letter C with your hand --> Opiates with closed fist (pupil constriction) and Cocaine with open fist (pupil dilation). I don't remember where I heard but it's saved my life on multiple occasions 😭

[@carolineb133]

I always forget that heroine is an opiate --> think of Zendaya's A1 performance in Euphoria S2 for opiate withdrawal (abdominal pain and SO MUCH yawning)

[@xaaboopinkly]

Huge thanks sir! Your videos are really one essential part of my studies, and I’m sure of thousands of other medical students too..

[@raeasher590]

you're the best online tutor ever!! please never stop with these vids!!

[@hasanbattla2805]

This is amazing! I've gotten a lot of questions on LSD and some on inhalants but the process of elimination def helps!

[@francidouglass8338]

I LOVED the rapid review at the end thank you so much!!!

[@hammadali7594]

I love you man. I hope and sincerely wish you succeed in every walk of life. Whatever you dream of, may you get it all. Blessed be.

[@TheRabidbunnies]

Love this video! I think if you re-ded this for whatever reason in the future, including common names for some of these drugs would be helpful - mostly thinking about heroin/opioids because I've seen NBME use that name a lot instead of opioid and I didn't know they were the same drug class at first!

[@Waseem.210]

I loved the slides talking about the “associations” in alcohol Genius!!! God bless

[@saurabhpatel3576]

Thankyou dirty! I watched this video yesterday and got 6 questions from this video on my exam today🔥

[@amaranathl9864]

You are amazing in explaining complex subject in simple way great and thanks

[@adeelsajid995]

This was much needed! Thank you!!

[@mariajahan6137]

Hats off to you!!!

[@kushangeeweerawardhane9645]

Thank you so much Dirty Medicine 😊 I passed my exam (Australian Medical council Examination)Your videos were of immense help 🥰🥰🥰🥰🥰

[@jagankandadai7007]

Congratulations!

[@falakjamil3565]

Really? Can we pass that as well? I’m preparing for AMC as well.

[@saroaltinoglu3123]

this was an amazing presentation for the EPPP

[@susanalsaeede3277]

Thank you so much, a good recap.

[@BeMihret5909]

Thank you and God bless you!

[@haminater100]

Hey Dirty i just want to firstly say thank you for everything you do and I hope God keeps blessing you man. Can you make a video on micturation because its another HY topic that seems to confuse me. Thanks again

[@haseebali2164]

Man you are a true life saver

[@rshnpkalam5879]

“What’s up man? you want some?” -will help me remember Ecstasy well! Thank you for doing this video and also for the laugh.

[@ramyasmruthismruthi1623]

this video is so so helpful .......i cant thank u enough , hope atleast i earn 1 to 2 points from this topic .....thank u so much , please continue doing this great work

[@nicolebonet6119]

This is SO helpful. Thank you!!!

[@yolandalimcangco3164]

Great presentation!

[@shreyajoshi1647]

Amazingly explained

[@tonichihab8394]

That hippy imitation was gold😂😂😂😂

[@umarahisrar2480]

Soooooo much respect!

[@vanessanwaiwu3163]

Thank you soooo much Dirty!!!!

[@deepalipimpale309]

Hello , thank you so much for every single video you have made so far . Please make videos on case history taking and all the disorders mentioned in DSM 5 TR

[@AbubakarUmarMusa]

Thank you you’re a life saver🙏

[@TheFarmerSJ]

Thank you so much for this video!!!

[@mimisworld732]

Thank you so much for sharing your knowledge. This video is so far the best and love the way you explained.

[@assourali1255]

Thanks again for your help

[@tobymichaels8171]

Undoubtedly valuable info here for improving test scores. Just don't mistake these high-yield test answers for the actual presentations you'll see in clinic.

[@drhasancb4]

Thank you very much. ❤

[@BOXHEADBLADEFACE]

Thank you so much. Dirty is there advice you can give, on How to approach a question, when you have zero Clue what it could be ? I know "they are telling you the answer" in the question, but many times even when I highlight the right info, for some reason I still cant figure it out. Your test bank videos have been a huge help, and I have finished uwrold, but the idea of coming across a tricky question on the real exam (in 7 days) is really freaking me out.

[@ashlengovender8888]

Just started my pharmacology block 👍🏾

[@zzkzkzzkzkzk8945]

Not even a med student but this was a good video

[@drsandipchaudhari8636]

Hey dirty ..Sir I got my 2ck score..It’s 245.Thank you very much

[@nooral4315]

good job! which dirty medicine videos are best for step2?

[@drsandipchaudhari8636]

@@nooral4315 frankly speaking I got 2 questions from Neurocutaneous disorders video too..drugs of abuse…ethics videos too useful

[@godlistenmsuya5828]

Thank you so much!

[@rasolove3]

Thank you so much ☺️

[@aceyshari]

Amazing videos.. useful to prep for my PMHNP exam

[@eydanniks8733]

Thank you!! ❤

[@michaelgoldstein8516]

Love it. Loved the Austin Powers cameo lol.

[@nehadharap700]

Man, I like your videos even before I watch it

[@pacifiquebusiness]

Thank You 🥰

[@draanchal1]

Loved it .thanks

[@sindhiashyras8800]

thank you soooooooooooooooooooooo much, very clear with lot of insight

[@studyturtle7159]

Never forgetting bzd n barb mechanism!!😂😂 🔥

[@wwhuang8178]

such a great video

[@LittleAyishie]

the love u at the end 😭💕

[@oraena5526]

your videos are awesome!

[@mohannedjamal9471]

thank you

[@nurulsyhrh82]

thank you so much for this!! ❤

[@phytx01]

Thank you for this amazing explanation, Can you please make a video for Renal Tubular Secretions and Diuretics. because they're really very confusing.

[@heenagujral244]

So sweet that you say love u at the end, we love u too

[@gavinbutler6243]

Thanks for the facts

[@Mohammad-xe2qw]

Thanks thanks thanks❤️🥰I am crazy about pharmacology🥰🥰🥰

[@yourremarkablyaveragepal781]

I died at the OpioYAWWWWning hahaha. Thanks, doc!

[@bobkennedy6382]

THE BEST!

[@nooblysm5556]

Thanks for the vid!

[@faezehabbasi1740]

Great thanks a lot

[@shushri2894]

🙏🙏Indirectly he taught for one Indian exit Exm. (ths r main topics) . Must needed Thank you so much dirty medicine

[@MS-ns4ki]

I’m about to redo the entire curriculum and CC my boss as well as my colleague so everybody can see all the hard work so I’m going to do - 💋

[@SuperHahahaha123]

I had a Uworld that said cocaine withdrawal can also cause vivid dreams btw. Dirty you're the best btw.

[@ibraheemalma]

I memorized it just by associating the z sound in benzo with the c in frequency, whereas barbiturates and duration both don't have such sharp sounds

[@nabeela6467]

Can you include part 2 which is next step in management (eg, tx)?

[@majdmuhannad7254]

you're the best

[@pinnacleatom]

Any concerns about multiple drug abuse and the inconsistencies in presentation ?

[@nikygreen9473]

THANK YOU

[@faba7786]

YOU'RE THE FREAKING GOAT

[@christopherlauw1570]

You're a legend

[@jahlanijackson9807]

Cool!

[@migs6869]

Clutch vid dirty thanks man !

[@p.kallas6692]

I have a decompartment left arm. I am having big doses oxicodon. My son died then i got ssri, bensodiazapam and iktovril sleeping pills. But i never been this tired of living.

[@mohsinabid9420]

whatsup man you want some was the best part 😅 it reminded me skinny from breaking bad

[@yeyo101]

BenZodiaZepines associate the Z of benzos with Frequency which is measured in Hertz (Hz)

[@cob7839]

Love you too 🥺

[@tasneembashir2733]

Can the stored Ecstasy be detected by lab test? Talking about the hallocinigen persistence symptoms

[@notpinhead3514]

"Ahh thank you" What a goddamn legend.

[@ronefana4015]

Thx❤

[@Mo-ez3hs]

ur amazing

[@priscilla9872]

love you too! ty

[@preethi7751]

GOLD!

[@hazelswords8573]

Hey do you have any idea why the yawning happens with heroin withdrawal. I can never find the answer even Google ???

[@DrZip]

@DirtyMedicine, Marijuana Hyperemesis relief with heat sounds to me like Uhthoffs Phenomena in MS; perhaps the heat is impairing saltatory conduction / neuronal stimulation in a similar fashion, thereby providing relief with MHS, where it would provide pathology in MS?

[@DirtyMedicine]

www.ncbi.nlm.nih.gov/pmc/articles/PMC3576702/pdf/nihms353647.pdf

[@benfilla2954]

Are you using the term 'withdrawal' the same the whole way through? For example with alcohol you are meaning the effects that a chronic drinker experiences when they stop, however I feel like some of the symptoms you are explaining for later drugs seem like they might be more like the 'come down' after using the drug.

[@DirtyMedicine]

correct - i am using the term to describe those concepts interchangeably for the sake of simplicity; there is a difference between coming off of a drug vs. neurochemical withdrawal

[@GREGhere15]

I love you Dirty med! :)

[@junaidbhat468]

How can right sided endocarditis cause janeway roth spots etc they are part of left side endocarditis

[@joewilliam1183]

M8 i laugh si hard on that "Whats up man, you want some??"

[@supernova5107]

You left out LSD my favorite one of all

[@guns-n-tuberculosis3467]

PCP is one of the only drugs of abuse to feature nystagmus! Like horizontal and vertical in addition to rotary. Don't let that trip you up like it did me :O

[@samalam98]

MDMA also

[@peterjuhl-yh3ne]

How about verbal abuse of people? Are there any examinations.

[@bernadettearellano5698]

What could come back as a pos Methamphetamine, false positive, even on a retest? Is it possible?

[@DirtyMedicine]

Please JOIN my KZbin membership, where you pay $4.99 a month to support the channel and in exchange you get the cool Dirty Medicine logo which will appear next to your username whenever you comment! Click the "JOIN" button under the video, or click the first link in the description of the video (the one that says "SUPPORT/MEMBERSHIP"). Thanks

[@sm4887]

❤️❤️❤️❤️

[@mac-ju5ot]

It's no joke.....a best friend of my ex just died of brain cancer nicotine and alchohol. She😭suffered for three long years .

[@gracewaithaka9382]

Thank you!