Autonomic Nervous System (Pharmacology, Receptors, and Physiology)

[@DirtyMedicine]

Errata: @4:27 I meant to write/say SALIVATION in the SUBMANDIBULAR GLAND for the Superior Salivary Nucleus. CN7 does also supply parasympathetic input to the Lacrimal gland as well.

[@Muhammadk6]

Dirty Medicine please cover LIPID LOWERING DRUGS next.

[@ayshasarmad1240]

@UC_BXx1XwqsEI1fHXFTGFOfw can you please explain the mistake to me

[@bobbygreene6924]

OK, it's a stretch for Mnemonic Muscarinic agonists, but METHacholine affects Bronc/Lungs, so smokin' METHacholine gets you in the right system. And this is even worse.......CARBachol ....Carbs and you have to butcher Glaucoma to GLUCOma like glucose. Truly horrible, but I'll remember 'em. Thanks for the vid.

[@pratibhajaggi7]

Plz cover opiods ans analgesic

[@alih6953]

Sorry you mentioned you had the sympathetic video of this see graft one. However, I could not find it

[@husnainahmed6716]

Pmeumonic for M3 locations “AEIOU” A: Airway E: Exocrine I : “Eye” and “I” sound the same when you say it O: the letter is circular so think of the GI tract as a hollow circular tube U: Urinary Tract

[@komaddog]

Can we really remember all the mnemonics we create? :(

[@user-kl7of2db6e]

I like that one!

[@husnainahmed6716]

@@komaddog lol worth a try

[@jerry-rsuprien4441]

that's a great one thank you @Husnain Ahmed

[@tanyasaxena1580]

Thnx

[@vanshajchandra307]

I wonder why do people dislike his videos. He is doing all this great work for free, you should be grateful people

[@Pikachuwhereareyou]

Just had the same thought. Makes me wanna fight them lmao.

[@tannerroberts1273]

I liked it so you have 69 likes :)

[@lynguy8824]

They jel much🤔

[@mostaanroya]

Because people are stupid, it’s in our genes 😂😂

[@wipegod9434]

One more spam

[@ligiafragoso9086]

This is the best summary explanation of parasympathetic function and pharmacology out there. I would have given so much for a lecture this clear during my preclinical years. Thank you.

[@DirtyMedicine]

Glad it was helpful!

[@pankajkalaiya4240]

He is doing a great job

[@christianbaker2582]

Watched this while driving to the testing center at 1.75x speed. Got two questions because of it. Great video

[@emmanuelogelle3965]

Wow. 2 correct question can be a difference maker

[@irame5701]

Absolutely love this teaching approach - quiet, structured and intelligent: no screaming, drinking or eating, repeating 100 times. Thank you so much for the classical approach to the lectures! 🙏❤️🌷

[@Dr.joshibanez]

GlycoDRYRATE Glyco: Represents glycopyrrolate. DRY: Represents its ability to reduce excessive salivation (sialorrhea). Rate: Emphasizes the therapeutic effect on heart rate control.

[@medicaldiaries]

Thank you

[@Samehxt5qg]

thank you

[@RACHMNV]

I say glycopyDROOLATE

[@bradm8454]

This is literal gold. This before the sketchy videos would be the ultimate way to learn these concepts.

[@89josegarcia]

I agree with you

[@dr.rehmatsafdar1578]

I have spent thousands of rupees on apps for studying medicine but none of them have helped me the way you do for free... I don’t know how you guess but your videos cover all topics I have a tough time learning... So thank you ... love from India ❤️

[@wideeyewanderer1785]

I really want to donate, I promise I will, but you it will have to wait until I’m done because medical school is expensive but I will never forget. Someday I will reward you handsomely.

[@curium4026]

Urs is the only channel where I watch ads. You kinda deserve them.. Thank u

[@chumadoshi6987]

ME TOO!!

[@arzoo2sehrawat]

ME THREE!!!

[@Sasukeloverxxx]

BLESS YOUR SOUL. THIS is what I've prayed for and needed, especially with STEP around the corner.

[@s.fraser5221]

How did it go?

[@adeelsajid995]

Carbachol for Glaucoma: "I have a glock (GLAUC-oma) in the back (BACH) of my (mi-osis) car." Methacholine for Bronchial asthma test: "i got asthma from smoking meth". Edrophonium for Diagnoses of Myasthenia Gravis: "The ED (emergency dept) PHONes me to tell me about my diagnosis of MG".

[@Dks2114]

love these!! you could prob add ""I have a glock (GLAUC-oma) in the back (BACH) of MI OL[d] SIS' (mi-osis) car." hehe

[@jwhender21]

DIG Those ABS Over DUMBBELSS - muscarinic antagonists (Dicyclomine, Ipratropium, Glycopyrrolate, Trihexyphenidyl, Atropine, Benztropine, Scopolamine) used for stoping: (diarrhea, urination, bronchospasm, bradycardia, emesis, lacrimation, sweating, salivation)

[@debigdogk9563]

This is the best . Wonderful and thank you 🙏

[@jaxonvictoria4345]

Intern pharmacist here, thanks for this quality lecture. Been refreshing on ANS pharmacology for the NAPLEX/CPJE and this has been very helpful.

[@michaelpolchert9367]

Trying to help with glycopyrrolate mnemoninc...for any greeek root fans out there - salia in greek means saliva; glyco is the root for sweet - so there is a connection there sweets make you salivate...

[@navintiwari9532]

one of the best videos i have ever come across. IN a shorter span of time almost all the important and vital aspectcs have been summarized in excellent method.Great........

[@sakinaNP]

I have been trying to understand this for the past 2 years. FINALLY I understand. Thank you Dirty!

[@hakankoca2917]

Oh, Dirty! I really appreciate that. This is exactly what I need! You are amazing. Keep it up the great work. Thanks A LOT!!!! Give him the thumbs up guys.

[@justinkacyon3444]

TrihEXPhenidyl- EXP- EXtraPyramidal

[@damodarwilson8329]

For trihexphenidyl , the hex makes me think of hexagonal pyramid. So trihexphenidyl . Use extra pyramidal side effects

[@beaudaciousbrownies]

I always said “TRI a HEX to cure your Parkinson’s” 😂

[@ojodeborah4620]

Wow! That's just on point. Thank you.

[@PS-pr5py]

Great Vid as usual! Thank you! I use "hit of meth, short of breath" for methacholine and "carbachol, don't hit a wall" (you can see) to keep them straight. Meh memory aids but works for me.

[@yes7855]

good ones imo, thanks!

[@nursenelly72]

I’m an LPN and this is quite helpful. Thank you so much!

[@austingrist7467]

CARbachol: "My glaucoma is better, I can drive my CAR now"

[@sukhjinderbhatyal6252]

❤

[@medicaldiaries]

Thank you

[@sh-ka3211]

Xoss

[@aishbala]

you're a godsed. this was SO good. i keep forgetting every time i understand the ans and i have a feeling this one will be the one that sticks. so wish i saw this in my preclinical years. THANK YOU!

[@penguinshoes7928]

The 3 slice pie logo of Mercedes Benz forms triangles, like the face of a pyramid, a triangle, as in TRIhexphenidyl. Triangles, like pyramidal cells. It's an easy association to view the 'Benz' or 'Tri' with pyramids and pyramidal cells, possibly more so with the well-known car logo.

[@arzoo2sehrawat]

Good job, this is awesome

[@veesridhar7601]

I don't even understand how else to thank you for this video. This helped me SO much! Appreciate it, thanks!! :D

[@TFrenchHughes]

TRI riding the BENZ into the CNS. (BBB looks like a dashed line) (driving makes me think of EPS jerking the wheel)

[@DirtyMedicine]

!!!!!!

[@childemperor7475]

Ur a mini dirty I love it. I had some crap like I TRI BENZos but they fucked up my head. But yours adds in the eps portion and that's fricken gold

[@lifestylemedicine2501]

The ABSOLUTE best video I have come across explaining this topic! Do you have one on Adrenergic receptors?

[@taiaburrahman9380]

Please make a video on PCR,CRISPR Cas, Microarray, FISH, Flow cytometry,,I m eagerly waiting for Your reply. Thanks for all your hard work.

[@chandanaabayasekara1976]

Thank you so much ...very productive lecture ...until today I have lot of confusion about autonomic nervous system....but my mind is very clear now Thank you So much From Sri Lanka

[@Iuzishah]

Man!! You're literally saving lives 😅

[@tayanemelo7915]

i'm from Brazil, student veterinary medicine, i'm lovelyyyy for your work. congratilationsss

[@nbme-answers]

you da man dirty dude! 2021 and still pumpin out the goods!

[@arth1234]

Perfect timing, was just about to review this! Thank you for your amazing videos as always!

[@pershielamabale4622]

Been looking for Pharmacology videos that uses charts and graphs. Because it helps a lot in my memorization. Thank you for this!

[@catiefrye2815]

"PHONe your doctor to test for MG" EdriPHONium

[@abheeksharma987]

Omg i just had the similar thought

[@nadapenny8592]

I have very little idea of what I'm seeing here but it makes enough sense for me to understand why certain medications are prescribed to me and why they do or don't

[@vijaykota4444]

thanks for your effort in helping us making a better doctor. this video is extremely helpful. all the love and support.

[@SaadNagi12]

this video changed my life

[@ladyfree3492]

I just discovered this channel OMG its so helpful thank you very much I will watch all the videos

[@hiraalptekin8762]

for benztropine and trihexphenidyl- benz is mercedes-benz so if a patient shows up with tremor it can be related to a bumpy road(tremor) while driving a mercedes and it is a strong car(stiffness) and trihexphenidyl has tri in it and this is for parkinson disease and it has 3 major symptoms- bradykinesia, rigidity and resting tremor so we cover 2 things at once

[@adamuchiyama]

For trihexphendyl and benzotropine Tri= 3 Benz= Mercedes Benz it has a logo with 3 pointy things Pyramid= imagine triangle with 3 points Hope it helps

[@annad6619]

Thank you 🙏🏻 we need more biochemistry videos please 😓

[@sweetcandygirlhe8966]

preparing to take licensure exam, and your lecture videos help me A LOT for free! thank you so muchhh!

[@okidokidoc]

Thank you so much for this pharmacology series!truly helped me survive med school ❤️❤️❤️❤️❤️❤️

[@ahmedalsadi0010]

This man deserve all the money that i was paying for my hall years in university

[@drkrunalpatelortho]

B for bladder retension Bethanacol C for like cornea So use in eye

[@AnImprovActor]

For pilocarpine I just remember it by knowing all cholinergic agonists have Chol except carpine. And Carps have ry eyes and mouths when they are out of the water. So this med treats that specifically.

[@susanetiendem8719]

Glycopyrrolate; gliding secretions (for Drooling)

[@zimuzoradaeze8336]

I wish I had come across these videos a few months earlier. You’re doing an amazing job. I’d definitely support your channel once in start earning. Keep it up.

[@hodabahmanoff7835]

For alzheimer's: DON't forget ( cause you have alzheimer's) the GALA dinner on the RIVer ( DONEPEZIL, GALANTAMINE & RIVASTIGMINE) And I think all the great stuff happens on the pillow and they all cholinergic: erection stimulation, sweating, salivation, and lacrimation (cause some people burst to tears after they COME. and watch your videos)

[@hodabahmanoff7835]

For MG, I use the Matrix movies. NEO, FIGHTS for people's lives and use PHONe RIDe. And that would be NEOSTIGMINE, PHISOSTIGMINE (fights for lives as antidote), EDROPHONIUM (they could identify each other), PYRIDOSTIGMINE ( use the phone as a ride and disappear)

[@tantricsphinx]

Thank you for the mnemonics. Also, the opinion piece is solid.👍

[@janenabasinga1958]

This is so perfect. Thanks. Greetings from Uganda

[@Rena0530]

could you please do a video on neuromuscular blockers (depolarizing vs nondepolarizing)? Your videos are amazing!!

[@oraena5526]

plz make more pharmacology videos... these are amazingggg thank you sm for everything

[@clariceallierodriguez8103]

Thank you so much! This video was very helpful🥹

[@medstudent777]

Best explanation ever!! Thank you so much. I can't find the video of the sympathomimetic drugs😅

[@nahla9678]

For Ipratropium and Tiotropium-- "I PRAY TIO will BREATH again"

[@DirtyMedicine]

love it

[@user-ep5pf4hb3q]

Spoilers for Trails from Zero/Trails into Azure Tio is one of the party members in the games and eventually you find out that the entire party already (including Tio) died once but time was re-winded to create a future where they'd all survive. Hence it's as though a prayer allowed Tio to breathe again.

[@mankwerabotho2001]

at 4 minutes, i already feel i am at the right place for the topic. thumbs up

[@SaffyKaffy]

Great Video! Thank you so much for making the system/drugs concept easy; I am currently in NP school and appreciate your presentation!

[@jordmanbatgod]

"Ipratropium = Inhaled" - both start with 'i'!

[@Avoug]

For Tiotropium > "Tie" goes around the neck > Makes it harder to breath (Asthma, COPD)

[@mashoodabbasi7288]

Ipratropium could be I-Pray, I-Breathe (since its a M3 antagonist and cause bronchodilation)

[@navnita8440]

Hi the dirty medicine, I have my step 1 in 2 months. I love love love all your videos. Thank you so much for this free point stuffs. Could anyone please help me I can’t find his video on sympathetic pharmacology.

[@22yellowstreet]

I do be crying on my pillow at night because of how good this video is !

[@DNP820]

Thank you for helping me learn more while in nurse practitioner school!

[@Sasukeloverxxx]

Will you be making another video for the sympathetics? I know there's the chart one but for the receptors and stuff like with this one. Thanks for a sweet and to the point vid!

[@masterimbecile]

He has a video where he shows the BP/ HR tracings for Epi, Norepi, and Isoproterenol. That's most likely what's gonna be tested on for strictly sympathetic stuff. The rest can be derived from this vid.

[@alih6953]

@@masterimbecile Sorry do you have the link? I cannot find it. Please help friend

[@yes7855]

@@alih6953 same

[@hendyrulz]

Better explantations than my postgraduate provider! Awesome

[@TravelTherapy022]

In order to Drive a "CAR" you must have a good vision. 'CAR'bachol treat glaucoma.

[@crazysingerr]

benzTRopine & TRihexphenidyl used in treatment of TRemors

[@ayesha2014]

AMAZING AMAZINGLY AMAZING WORK !!! ABSOLUTELY LOVED THIS !!! THANK YOU FOR SUCH AN AMAZING REVIEW ON SUCH A HIGH YIELD CHAPTER. Hoping to learn more from you soon :)

[@jalaluddinshaikh6860]

😊😊😊

[@MOHAMMEDALFILQI3145]

30:20 they have the suffix STIGMINE not only STI

[@nneehhaal]

YOU ARE AMAZING I WAS TRYING TO STUDY THIS FOR A WHOLE MONTH

[@Jason-o5s]

Cheer~~~the branch of medicine concerned with the uses, effects, and modes of action of drugs.😊

[@ChristianFerrel]

I wish your channel existed in 2016 when i had the pre-clinical module on this. THat lecturer was horrible and i didn't understand anything. Now i have to go through all of them again in final year and thank god i run into your channel.

[@DirtyMedicine]

Thanks for being a Dirty Medicine member :)

[@ironyynori824]

Hey man awesome video, really appreciate your high yield content!

[@rajeswarkumar6078]

BENZ has THREE pointed star logo (Trihexy) used for EPS (3) due to high Ach(3) in PSY(3)chiatric treatment

[@mattdrews3168]

no

[@enyinnahchidinma576]

Been trying to understand this for a while. Thank you.

[@aiyshaamjad6346]

This is literally exactly what I was looking for THANK YOU SO MUCH

[@mohammedalrubaiaan9138]

Benzthropine, trihexphenidyl: Mercedes BENZ to the PYRAMIDS (extra pyramidal) pyramids are HEXagonal (trihexphenidyl)

[@yogeshbhusal8945]

Life saving video thank you so much...pls do upload breast and thyroid pathology again

[@H.and.eeeeeee]

"Carbachol curtain call," closed curtains (eg after a theater performance) analagous to constricted pupils/ a lower pressure environment

[@mohammedelsayed3262]

Thank you very very very very very very very very very very very very much Excellent work

[@edahontheinternet]

This video just saved my degree 😭

[@SomaTVxo]

😂👍🏾

[@Ann-ne1fu]

My mnemonic: eDrOPHoniuM : Diagnosis OPH Myasthenia gravis

[@pinu4744]

Thanks a lot.... U just made it very easy

[@dr.1956]

This guy is so good, you should quit clinical practice and go into full time Academia

[@roshanvalentine2737]

IpraTROPium : TRachea OPener(Bronchodilator)

[@googefacts7389]

This is so awesome! It took me just one minute to realize how useful your video is and to hit the subscribe button. I expect more pharmacology videos. Thank you!!

[@samiaarif230]

Very informative video.. Thankyou so much 😊

[@arshiajahangir871]

Mnemonic for EdroPHONium (32:40): PHONe to tell the diagnosis (of Myasthenia Gravis)

[@Dayi1981]

Thank you for your amazing work ! it is so helpful and understandable.

[@elhuda868]

This was Amazing, Chukraaan!

[@user-kl7of2db6e]

I associate benztropine with Benadryl for treating EPS because they both start with “Ben.” It’s not great, but it helped me for psych.

[@mithadewi2591]

Hydrophonium to check it’s a real or phony condition

[@wiseyouth4615]

eDROPhyneum used to diagnose MG is cases DROP eyes in MG... I hope it ok...

[@wiseyouth4615]

DROP =ptosis

[@ellimacbyun1324]

Thank you so much for this! I finally understand it more. So happy I watched this vid!

[@CoffeeWithRafee]

mnemonic for Edrophonium @32:11 - Use the prefix Edro / it has Dr in it / Dr Diagnoses Myastenia Gravis.

[@ojodeborah4620]

Thanks for this video. It's so helpful and timely!

[@mattttyp6126]

I pray that my tio (spanish for uncle) can breathe. (ipratropium and tiotropium)

[@shelchicago8997]

Gracias