Duchenne Muscular Dystrophy and Dystrophin

[@jonpaul6802]

This video taught me more about this disease than any doctor I've been to. Its hard to find answers when no one understands it.

[@megarayquaza6157]

agree

[@ragingshawn6944]

I have dmd and now i even understand it more cause of this video

[@nanishah3202]

rl

[@paull2937]

Anyone watch this at school

[@tenminutetokyo2643]

Most doctors are money-chasers. And none of them want to hear any info any patients has to give them. It's a blow to their inflated egos that you know more than they do.

[@jackspiecker704]

this vid covered my entire 4 week biology unit in eight minutes

[@Bigzthegreat]

School is slow and to teach as many as possible they slow it way down

[@LGRacing123]

No tears in my eyes to cry.... No any feeling when Im breathing ... No nothing to do anything except prying .... Im alone in this world .... My cute son with this problem DMD.....so sad.... If therei is any energy hidden somewhere ... Please help to find success treatment for this .... As soon as possible ... Still have a tiny hope till last breath ......😪😪😪😪

[@WeloveLego123]

Maybe you can try Black seed cumin oil

[@NeoEvanA.R.T]

I think you should look up Duchenne Muscular Dystrophy clinical trials at UC Davis

[@keshavbansal6565]

I do physiotherapy of 48 years old patient of Duchenne Muscular Dystrophy. Problem Of Chronic Forward Head Posture. Stay strong everyone with this Disease. No research can decide your life span..Stay Active and do regular exercise ..🙏🏻I also saw patient of Facioscapulohumeral Muscular Dystrophy(FSHD) and Becker Muscular Dystrophy (BMD)..

[@mmascarenhas4368]

Thank you for the simple visuals and clear explanation! Helps those of us struggling to read through heaps of information.

[@Medicurio]

Sorry about the hiatus! Last few weeks were final exams, so I was bogged down with studying for my classes.

[@peoplecanbestupid]

You should make a reddit account and post your video in different sub-reddits. So more people can watch the videos.

[@Medicurio]

I have my own subreddit here: reddit.com/r/medicurio

[@jackiedaniels]

Why would you want to study something that is naturally going to happen? haha JK! It is like can you just send a innocent person like this down the mental ward hill?

[@paull2937]

This video is lesson 3 in my biology class, and at the beginning of class, my biology teacher warned us it would knock our socks off. I agree. This video is like foreign language.

[@Undownn]

The more I watch it, the more I understand or learn something new.

[@WizKidNas]

I'm a nursing student and this was excellent work, thank you for helping me better understand this content

[@mazdaksheytunak6939]

What a great video! Thanks for taking the time and making the effort to explain this complex disease! Much appreciated

[@Speedymisha]

One of our family friends had 3 sons with this. They died at 27, 31, and 36.

[@ricardofr200]

Finally a proper explanation to something I lived with and ever (Becker's btw) and even i didn't understood in its totality. Thank you very much.

[@johnnydepp4469]

Contact doctor Akhigbe for your cure with his herbal medicine

[@johnnydepp4469]

Email him now

[@SiggiAriOlafsson]

My freind died because of this disease. It's hard to listen to this but its very educational and thanks for that.

[@ninjagaminglive6587]

So sorry to hear that At what age your friend died?

[@SiggiAriOlafsson]

@@ninjagaminglive6587 He was only 14 years old at the time

[@ninjagaminglive6587]

@@SiggiAriOlafsson my brother have this problem he is 21 but I don't know which type he is having

[@مسلسلواديب]

I have been suffering from this disease since I was 15 years old and I am currently 27 years old. Is there a treatment? Please reply😢😢😢

[@gullan51]

I know someone that is 24 with DMD.. i feels so bad for these people

[@bluedolphin4574]

Very insightful. Please keep making these awesome videos. Thank you.

[@espinoza_9072]

i have it and i'm beating the odds, work in heavy construction and lift weights at gym, 20 years old.. even though i struggle sometimes i push through

[@neoretrodude]

Incredible and so succinct. I have definitely subscribed to see what else you are hiding up your sleeve.

[@Avacado_the]

Nice explanation!!!!!

[@chelseahoffmann6285]

Great video. It would be nice to have a note somewhere in the video about the relationship to lack of dystrophin and the psychological effects it has on the brain. Most parents are not warned about that and can be blind sided.

[@cdeese2644]

Many believe the lack of dystrophin in the brain is linked to duchenne patients having adhd and/or ocd

[@torpegangofficial3736]

Hi . I am from nepal. I am suffering from Becker muscular distrophy

[@henrikl218]

Sorry to hear. Stay strong!

[@minminwu2106]

I hope you get well soon!

[@stephanmurugan3947]

Treatment please tell

[@writehandman2833]

Something no one has answered me about is: Can dystrophin be synthesized or harvested from healthy individuals and infused into patients?

[@raenah8882]

TZ sent me here, also as a part of the medical field.

[@engineeringlife9725]

Please tell me soluation of that diecies my saffering now he is only 4 year old

[@neurologybysaiduzzamanmunn3349]

many many thanks. I am a doctor, still it helped me a lot.

[@ingridysodre2521]

What an AMAZING video!!!! Thank you

[@pizzasloth82]

This is cool content! Keep up the good work!

[@RublixCom]

Hi! I have a question I hope you could answer. If calcium is doing the main damage to the muscle cells, would it make any good to greatly reduce or try to eliminate completely calcium from one's diet?

[@samirasalik6118]

you need calcium for your bones, heart and muscle. you also lose bone mass when you don't get enough calcium which really does more harm.

[@khoavu7674]

This is amazing! thank you for the elucidation

[@chloebreagan5193]

People complain about cancer being awful and I know it is, but loads of money is being spent on research and there is chemotherapy. For DMD there isn’t many options to help. My best friend has it and currently she is in hospital with something bad happening to her chest. It’s difficult

[@Medicurio]

Sad to hear that. There are still many researchers working on DMD (just not as much as cancer I guess, since cancer affects more people) so I hope your friend gets better and that new treatments are developed soon! For now, the only thing we can do as non-researchers is to raise awareness of this disease.

[@chloebreagan5193]

Medicurio Thanks for your reply, all we can do is stay hopeful!

[@selenasophie5245]

I don't know why stop making videos 💔but i hope u come back

[@carolineyoussef884]

Hi, I'm doing a research paper on this disease and I had a couple of questions. 1. What determines which muscles are affected or the ones that are weakening? it varies from a family history to another but is the gene mutation random or how does it work? The symptoms are different for each person. For instance, for some people their leg muscles are the ones weakening but for others it's their shoulders yet they have the same disease. What exactly determines this? 2. Why does it get worse with each generation? Does the excessive number of the nucleotides sequence multiply or is there another reason? 3. Also, for the weakening muscles can exercice reduce this process in order to prevent the disease in a way or is it just an internal issue in the muscles as it explains in the video such as getting rid of important proteins? Thank you!

[@Medicurio]

1. Likely dependent on the mutation (is dystrophin completely dysfunctional? Slightly functional?) and lifestyle (more or less exercise? What muscles are used more often?) 2. Don't think it gets worse over generations (let me know if you find something that says otherwise). 3. Proper types of exercise seem to delay some muscle wasting, but is very controversial as too much exercise can also exacerbate the condition. "Use it or lose it" is often said for people with DMD. Read more about it here: www.ncbi.nlm.nih.gov/pmc/articles/PMC2929216/

[@Manunitedfna]

Great video! I loved your emphasis on what destroys the muscles. Looking forward to checking out your other videos

[@dylincassidy1134]

I have a non server form of MD thats not as bad but the pain can still be awful

[@sulaimanwalugembe2567]

Thanks for the information

[@annaparievsky5060]

There is a mistake around 7:15. What you refer to as "exon skipping" is actually called "read through" therapy. Exon skipping involves skipping an entire exon to get the DNA back to the original reading frame. Read through involves skipping over an incorrect Stop codon which is what you're referring to and drawing here.

[@Medicurio]

What I have shown is in fact exon skipping - the "skipping over" of a segment of the exome with the early stop codon results in a truncated but functional protein (which is indicated by the "shorter" sentence analogy). Read-through therapy or nonsense mutation suppression would instead prevent the stop codon from actually stopping translation and result in a full-length functional protein. I admit it is slightly confusing because I did not animate the protein to become shorter, so apologies for that.

[@annaparievsky7417]

Medicurio Yes, that’s all correct and I agree 100%. The part I was saying is not necessarily correct is that the exon to be skipped in exon skipping does not necessarily contain a stop codon. The skipped exon is often not even the one containing the mutation. The skipping is meant to delete an exon with the intent to restore a reading frame, rather than skip a stop codon.

[@Medicurio]

Ah I see what you mean now. Yes I agree, it should be more correct if I labelled it as skipping over the exon with a mutation, not necessarily a stop codon as shown. It was just a bit easier to pictorially represent a restoration of the open reading frame in this manner, but yes the exon skipped may or may not contain the premature stop codon.

[@nethmawickramarachchi5056]

Thank you soo much. 🥰🥰 Nicely explained with all necessary facts.

[@BasicallySteve23]

Great job! Your explanation of gene mutation and why it leads to damaged proteins was well done, and it might make for a good video to explain the other types of mutations aside from frame shift and how they cause many different diseases and disorders. Otherwise, I will say this disease you covered today is especially horrible and debilitating and I truly hope advances in gene therapy can prevent the suffering it causes.

[@Medicurio]

Thanks! You're absolutely right, it is a devastating disease. I'm considering making a video just about just mutations and inheritance soon.

[@dobariyamiral2020]

Explains in very simple and easy way, like this vedieo

[@josephhicks9454]

Where are your sources?

[@bens10143]

incredible visuals

[@mohammedal-hammadi5085]

Thank you so much, it's so helpful and clear

[@beebob7136]

Amazing video , really helped me a lot! Thank you.

[@rikkigupta9546]

Thanks a lot 🙏 for ur guidance May god shower 😇all his blessings and love on u and u stay blessed always

[@dillydallydolly6847]

Question, can a patient have becker muscular dystrophy and Atherosclerosis? If so what is the chance of living a long life?

[@HASSAN_WISAL]

Keep up the good work

[@lorainearreglado4108]

Thank you! Nicely presented

[@zeinabalraea8888]

My son has muscle dystrophi cogenital megaconial, a very rare muscle dystrophi, I dont know much about this disease, there is alittle information on the web sinse it is rare, do you know about it, can you help me, I will as well set him into clinical trials, but I dont know how. He is 3.5, stable, talks and shows a difficulty in learning, but understands and make himself understood..please any tips if you have.

[@haninshaker8384]

Thanks 🙏

[@ashinaz4203]

My bro also suffering from this distrophy plz pray for him

[@CrazymarioO-cf9yf]

I pray for everyone like me with this disease to get better by the power of God!!!!!

[@ninjagaminglive6587]

Bro please reply me my brother also suffering from it

[@ahmedsana2560]

Thank you very very much

[@sarahrose3012]

Thanks for the amazying explanation

[@absurd7292]

tnx man . So much Informative💖💖💖💖

[@kayeannbacalso2738]

thank you for sharing this knowledgeable information especially to us as a student i love this video so much

[@Doumais_theelsa]

Interesting! Thank you so much for an awesome video!

[@radhikamarathe3427]

Awesome explanation.... made my work easy... thanks

[@vipashapmehta]

amazing video..v well explained & v good videography😊👍

[@jamescole8049]

Zootier sent me, not mad at it. Good job guys.

[@jewboi612]

This makes Ms. Bass class super easy

[@جوهرةالحياة-ز1ح]

I have Duchenne Muscular Dystrophy is there any treatment I want help please

[@burakdeveli2121]

Very helpful video thank you! I've subscribed

[@meeromeer8812]

Thanks, really nice video.

[@MaramHassan17]

You're amazing. Thank youuuu!!!!!

[@nausheensaboohi4949]

V. Good explanation.

[@ANDRESIBILIS]

I have a question, in minute 2:00 shows a protease, is that aldolase? since lab work shows increased CK and aldolase, great video by the way

[@Medicurio]

Not an aldolase, aldolases break down sugars while proteases break down proteins. Aldolase is found in muscle cells though. High CPK (Creatine phosphokinase) and aldolase means that there is muscle damage because it means that these enzymes have leaked out of the muscle cells and into the blood.

[@javiercordova2108]

I thought DMD completely didn't have the presence of dystrophin, while BMD DID, but not enough?

[@jackeline155]

Thank u so much!

[@dylanzhao8441]

Awesome narration, learned a lot. :)

[@misswonder9691]

Amazing one thanks for the explanation ❤️❤️❤️👍👍👍🙏🙏🙏

[@johnbeliveau]

Carrot water juice. Particular water to carrot. Grow this particular way and soak with a green hay. Net el Where did that come from?

[@mayhunt]

What can I say? Feeling how the blisters on my torso began to shrink within 3 days was very soothing, I applied what I talked about the other day and in two weeks the pain was gone. I just go’ogled Kaena Ramingler’s Shingles Solution and now I feel as smooth and relaxed as I've ever been.

[@vemanayogi]

can we take creatine supplement to make strengthen the muscles..

[@mussy4everm962]

I’m confused about the caluim bit because I have this

[@deemamattar517]

Man you are amazing☺️ thank you very much!!!💜💜💜💜

[@Sam-fp8zm]

A number of defective genes that can cause this class of symptoms are mannose related. Yeast is 9% mannose, and contains GDP mannose linked proteins so taking some brewers or bakers yeast each day might help.

[@huseyinarslan4051]

I'm from Turkey. İ watch this video and its great. Thank for video. My brother has dmd. Doctors says there is no cure. He is 30 years old. Last year he cant breath so doctors open trake way and give us breath machine. Now he can breath. İ and all of my family know that there is no cure for my brother. Now we are worry about have babys. What we have to do for know that will babys of us carry that dystrophy or not. Or when my wife or my sister pregnant doctors can learn that the babys have that illness or not?

[@ninjagaminglive6587]

Hlooo bro please reply me i want to discuss with u

[@ysabellawilliams7781]

This was really helpful thank you

[@あしたのかおり]

6:57 for personal study (gene therapy)

[@protistpoop]

Do you happen to have any links, I can't seem to find any relating to how calcium protease and muscular dystrophy actually relate...

[@Medicurio]

Here are two papers: www.ncbi.nlm.nih.gov/pubmed/6096040 jgp.rupress.org/content/136/1/29

[@Nejmaa_]

I failed on my bio test because I failed to explain how gene expression is related to DMD.

[@juandiegodistefano335]

Amazing video

[@nyawirawaithaka4993]

Great video!

[@jadathomas3684]

Beautiful tyy

[@LittleBigNinja]

My brother has it and he’s 26

[@malevolent1698]

I have it and I just turned 26 yesterday

[@rashmi53]

@@malevolent1698 are you taking any medical treatment for this ? One of my relative have this disease he is only 4yrs old. Plz help and guide me ?

[@amitkr495]

Please send your mob no ..or call on 7019370883 i need ur help

[@ninjagaminglive6587]

@@amitkr495 hiiii bro can i help u?

[@arunsakthi834]

Can use creatine Supplement for DMD ?

[@lauramazzocchitti8509]

thank you, i've subscribed!

[@breakfastberrito8990]

Any chance you could link to the sources for your information?

[@Medicurio]

These are some of the main ones. Please comment if you are looking for a specific reference to a particular piece of info in the video. 1. Rubin, M. Duchenne muscular dystrophy and Becker muscular dystrophy. Merck Manual, 2016. 2. Acsadi, G. Duchenne muscular dystrophy. National Organization for Rare Disorders, 2016. 3. Foster K, Foster H, Dickson JG. Gene therapy progress and prospects: Duchenne muscular dystrophy. Gene Ther. 2006;13:1677-85. 4. Nowak KJ, Davies KE. Duchenne muscular dystrophy and dystrophin: pathogenesis and opportunities for treatment. EMBO Rep. 2004;5(9):872‐876.

[@ivangarcialoza8079]

And if a female carrier inactivates the X chromosome in which she has the proper cope the gene ( I mean making the Barr body ) then she has a mosaic phenotype for the dystrophin gene?

[@Medicurio]

Yes, although it is much rarer for females to have DMD, in 2-8% of female carriers, incomplete X inactivation of the mutated dystrophin gene can make them "manifesting carriers" with muscle and heart symptoms (although much less severe than in males). Viggiano E, Picillo E, Cirillo A, Politano L. Comparison of X-chromosome inactivation in Duchenne muscle/myocardium-manifesting carriers, non-manifesting carriers and related daughters. Clin Genet. 2013;84(3):265‐270.

[@cariboowho]

Good video! I felt that the end of the video got a little off-track with the discussion of genes, but keep up the good work!

[@Medicurio]

Thanks for the feedback!

[@rachelg8097]

Very good video!

[@tejeswariujjina6798]

Can anyone please help me with the treatment details. My cousin 9 years old has the same problem. It started 3 years. At the beginning he is able to walk support now he is not able stand also. My family is struggling a lot. They are in depression. If anyone knows it please help me. It can change my little brother life. Please please please please 😭😭😭😭😭

[@Medicurio]

I am so sorry to hear your cousin and family going through this terrible crisis. Unfortunately there is no cure for DMD but there are treatments that can treat symptoms that you should discuss with your doctor. The Mayo Clinic has a good website on treatments: www.mayoclinic.org/diseases-conditions/muscular-dystrophy/diagnosis-treatment/drc-20375394

[@ninjagaminglive6587]

Hiiiii my brother also have this I would love to talk with people who have this disease

[@antoniodimaggio484]

6.50 The fat cat ate the big rat and the red ham ahahahha

[@vishakjayakumar248]

is it leads to non movable condition for patients?

[@Pathologyformedicalstudents]

MD can lead to mobility impairment or even paralysis

[@skjani1161]

Is there any cure for this

[@PyromagicExplosive]

I have ducchene muscular dystrophy I am 21 years old but I can walk. Sometimes falls

[@allakashivakumar]

Take care 😮

[@engineeringlife9725]

Please help me my son suffering now he is only 4 year old

[@Medicurio]

Unfortunately as I am only a medical student I am limited to what I can do. Please see a doctor as soon as possible.

[@engineeringlife9725]

Please pray for my son I cant sleep when i know about this

[@docantle3410]

Please research Dr Robert Morse on KZbin🍇💕

[@mar7956]

I like it thank you so much💗

[@sumamirji3956]

So awesome !!!!

[@RPGguids]

Could you do a video on Spinal Muscular Atrophy?

[@Medicurio]

I'll look into that

[@jayampriya3803]

Very useful pa .