Eating Protein Does THIS to Autophagy | New Study Findings

[@PuppetMasterdaath144]

The transcript discusses the relationship between autophagy (cellular repair and recycling) and building muscle. Traditionally, it's believed that consuming protein, which activates mTOR (associated with muscle growth), inhibits autophagy. However, the transcript refers to a study published in Cell Reports suggesting that protein ingestion may not negatively impact autophagy. The discussion delves into the molecular mechanisms, explaining how the ULK1 complex triggers autophagy, and how mTOR, activated by protein intake, inhibits this process. The mentioned study indicates that a high protein intake, even up to 100 grams, did not disrupt autophagy markers in healthy lean individuals. This challenges the conventional belief that protein hinders autophagy. The speaker emphasizes that the study focused on lean individuals, and autophagy might be somewhat dysfunctional in overweight or obese individuals. Despite potential discouragement, it's suggested that losing weight could enhance autophagy in such cases. The conclusion advises incorporating lean protein, even in higher amounts, at the end of a fast or during a deficit. For healthy, lean individuals, this might not impede autophagy, and for those trying to lose weight, it can aid satiety without disrupting autophagy, providing overall positive outcomes.

[@lisapet160]

Fasting upregulates autophagy. Breaking the fast to balanced eating downregulates autophagy to baseline levels. Excess of protein does not downregulate autophagy further. The choice is clear, to each their own. It's a very old saying.

[@JohnnyBrooks22]

WAIT another 2-3 Months , there will be Another "New Study" for Clicks !

[@kkulhavy1960]

Thanks for the info. Maybe this explains why I am at goal weight but inches keep disappearing (lost over 80 lbs in 12 months ketovore, 63-yo female)... entire body has "normalized."

[@willcook403]

Congrats !!! Every day must feel like a Win ❤

[@DrAJ_LatinAmerica]

Autophagy is always On. How much or how little - depends. Similar to the use of fat and glucose. Always On. Similar to an athlete or couch potato - both using oxygen. All these items are on a spectrum. When autophagy is off in one area (cell), it's on in other cells in other areas of the body.

[@marble25]

That's like saying fat burning is always on. DUH. What is important is when it is ramped up.

[@whlewis9164]

@@marble25how wude

[@NateDohDoubleGee]

Researchers: If you're reading this, please also check for HGH levels after taking various amounts of protein during or maybe ending (depending on results) the fast. If autophagy is still intact per this study, and we still get the benefits of boosting HGH during a fast then MAYBE protein-only is safe to take while continuing/extending fasts!

[@blackbeltnutrition7946]

I do believe the capacity to do autophagy isn’t directly driven by how lean you are but how fit. It correlates perfectly with VO2 max for example. Autophagy means the cell beak down proteins, organelles and stuff. When it do so it needs to rebuild them and this requires protein. Therefore protein doesn’t inhibit it. In fit people that’s as pointed out.

[@minutemartialarts3152]

VO2 max exactly fits what I posted.the greatest driver of autophagy is endurance /aerobic exercise

[@coffeetalk924]

Fascinating study. What a game changer! Actually slow the rate of catabolism in the muscle without stopping atophagy? Sign me up! 👍

[@jjmcg9688]

What about gluconeogenesis? Many of your recent videos discuss eating much more protein in one setting but how does that work with gluconeogenesis?

[@RLeeErmy]

Loved seeing you on Dr. Gabby's podcast today! I'm still harping on that darned Mr Jeff Cavalier about how awesome it would be to have a sit down video with Thomas Delauer!

[@radezzientertainment501]

athlean delaur collab would be sweet!

[@monnoo8221]

yeah I am waiting since a long time for it, will definitely be fun :))

[@CheeseStickzZ]

Jeff Fake weightsalier

[@Chris__Scott]

We love getting into the weeds. Go deep brother.

[@megm.c4026]

Could this have something to do with why so many on a carivore diet get relief from symptoms? So interesting. Thanks.

[@erikakurti3585]

I would say absolutely. Been thinking a lot why carnivore is so healing. This could be the answer.

[@rainbowtravelingyogi]

Details are important. Thank you for his one, Thomas. You're awesome.😊❤

[@ohbbyilikeitrawr]

I stll want that fat loss skin eaten by my body wanting protein.

[@roustabout4fun]

Maintaining muscle seems to be a priority of the human machine~ kinda cool!

[@neuromax3766]

The one statement which counts here is "you cant' do autophagy if you're obese". Diet and exercise, baby.

[@R27035]

It's getting to the point where whatever we know today will probably not be true in the near future. Everything we were so sure of and also worked for fat loss and muscle gain yesterday will most likely change soon enough.

[@jodiefoster6900]

Amen! I’m in the verge of not listening anymore. Eat whole food, lift heavy things, at least two cardio sessions and yoga.

[@monnoo8221]

interesting. It shows that there is a long way for our understanding from molecular and biochemical pathways up to the functionally integrated body. And from these many miles we got just a few steps done.

[@alan_yong]

🎯 Key Takeaways for quick navigation: 02:56 🔄 *Autophagy is triggered by stressors like exercise and fasting, while the presence of nutrients and active mTOR inhibits autophagy.* 04:43 💡 *Consumption of up to 100 grams of protein does not hinder muscle protein synthesis or autophagy markers in lean individuals.* 07:33 🏋️ *Autophagy may be less effective in overweight or obese individuals due to dysfunctional mechanisms, but weight loss can improve its functionality.* 08:56 🥩 *Lean body mass and high protein intake in healthy individuals may override potential autophagy inhibition by protein, suggesting that protein consumption may not impact autophagy in lean individuals.* Made with HARPA AI

[@wallacebonner7939]

According to this video, autophagy is not a light switch, it's a dimmer switch, so it doesn't stop no matter what you're eating. kzbin.info/www/bejne/m6jQcml6bKd1aNU

[@margomoore4527]

Wait-I’m not having autophagy as a result of exercise BECAUSE I need to lose 30 lb? I was so happy when you said exercise works better than fasting for this! ‘Cause I’m not keen to fast, but I can always work out a little more (I’m 73 and don’t overdo-I work with a trainer doing weights 2x/wk, plus I’ve just added 25 min cardio)-so I can stand to add more. This is hard to follow or make sense of.

[@Andy-df5fj]

If you need to lose weight, the cardio is what will do it as that is what will burn serious calories. Also, if you have visceral fat to get rid of, cardio and/or caloric deficit will be the only way to rid yourself of it.

[@freigeist777]

no, cardio without caloric deficit will not work@@Andy-df5fj

[@stephenr85]

Don't get hung up on autophagy. If you're losing weight, it's happening, and if you feel good, you don't need to get derailed chasing something else that you can't feel or measure. He also had a video recently about how not all autophagy is good. You'll develop schizophrenia trying to parse the nuance. Just stay the course ✊🏼

[@cenauge]

Autophagy being disfunctional in fat cells isn't necessarily the same thing as autophagy being disfunctional in the muscle cells of overweight individuals. I wouldn't worry about it because exercising for autophagy is like doing a port polish on your engine to squeeze out a little extra power--it's the sort of thing you worry about when your body is already a supercar.

[@willcook403]

Remember as you’re older we have a more blunted protein response so we need to have More protein not less. You can easy do 2grams per kilo of body weight. Or roughly 1g per pound .. You’ll get at least 70g alone just out of a 10oz steak though - so it shouldn’t be that tricky..

[@brazenclips]

This is misinformation as-presented and a distortion of the paper’s findings. *Consumption of methionine activates mTOR which definitely affects autophagy. Unless you’re eating a source of protein which has a dearth of methionine, you’ll likely be inhibiting autophagy. In addition the study you’re referring to utilized only casein protein. You’re presenting this as if it’s protein across the board. Not only that you got something fundamentally wrong. Autophagy is more effective in overweight and obese individuals. There’s already research papers on this subject showing that much of the process of mitophagy relies on available fatty acids from subcutaneous fat, specifically. Do you even know which type of autophagy you’re commenting on? There’s standard Macroautophagy, enhanced Macroautophagy, Microautophagy, Chaperone-Mediated Autophagy, Mitophagy, Pexophagy, Ribophagy, Lipophagy, Glycophagy, Nucleophagy, reticulophagy, Zymophagy, and Ferritinophagy. This is a poorly researched and presented video and should be taken down or heavily edited. Your continued sweeping generalization for autophagy are doing your viewers no favors. You should really have Physionic on your show so you can learn some legit things about all-things autophagy. Your continued blunders are frustrating misinformation going out to millions of people. [*] The effect of methionine on inhibiting LC3-associated autophagy is more about how methionine’s presence or absence influences the cellular nutrient-sensing pathways that regulate autophagy. While methionine can influence autophagy indirectly through these pathways, it does not directly inhibit LC3. Instead, changes in methionine levels can modulate the autophagic flux by affecting the broader regulatory networks that control autophagy initiation and progression.

[@Dr_Boult]

But the protein here was mostly casein, which is very slow. Nothing in the study says it applies to meats.

[@blahizake]

As long a your insulin:glucagon ratio is good to go, you can easily balance growth and cellular maintenance factors. After-all, you don’t need insulin for growth - just leucine.

[@earth9531]

So can an obese, otherwise healthy, man gain muscle mass in caloric deficit eating a carnivore diet by moderate weight lifting?

[@blahizake]

@@earth9531 You don’t need to worry about caloric anything. Make sure you’re eating adequate protein to accommodate exercise, putting on lean mass, and recovery - address energy levels in such a way that maintains a suitable insulin to glucagon ratio, and the rest will take care of itself. Whether that lower insulin is carb or fat dominant - whatever. If I were you, I’d hop off of the calorie paradigm immediately. Often, there are situations where people find themselves more easily losing weight after eating more calories. This is because there’s a lot more at stake hormonally than just counting calories (which is a measurement of heat).

[@jamiehonie4164]

carnivore diet

[@d8vidtruthseeker]

I bet you a protein supplement company funded that study lol

[@ellenhartley4998]

I have a low calorie protein shake at lunch when I do my 60 hr fasts. I was told to do this a year ago when I started my far loss plan

[@MrQuadcity]

The key takeaways from Thomas DeLauer's discussion on the relationship between eating protein, autophagy, and muscle growth are: 1. **Traditional View Challenged**: Contrary to the traditional belief that autophagy (cellular repair) and muscle growth (via mTOR activation) are mutually exclusive processes, recent studies suggest that protein consumption does not necessarily inhibit autophagy. 2. **Study Insights**: A study highlighted in the video found that muscle protein autophagy was not affected by protein ingestion, even in large amounts (up to 100 grams). This suggests that it is possible to consume protein and still maintain autophagy, potentially allowing for cellular repair and muscle growth simultaneously. 3. **Mechanisms Explained**: Autophagy is initiated through a complex involving ULK1 and other compounds, activated by stressors like exercise and fasting. Traditionally, nutrient presence, particularly protein, was thought to activate mTOR and inhibit this complex formation, thus stopping autophagy. The new findings challenge this understanding. 4. **Implications for Lean Individuals**: The study's findings are particularly relevant for healthy, lean individuals, indicating that high protein intake does not disrupt autophagy for them. This opens up the possibility of optimizing nutrition for muscle growth without sacrificing cellular repair processes. 5. **Autophagy in Overweight/Obese Individuals**: Autophagy may be dysfunctional in overweight or obese individuals, indicating a need for weight loss to improve autophagy efficiency. This suggests that achieving a healthier weight could enhance the body's ability to engage in cellular repair. 6. **Dietary Recommendations**: DeLauer recommends high protein intake, especially from lean sources, post-fast or during caloric deficits. This approach supports muscle synthesis without compromising autophagy, beneficial for both muscle growth and cellular health. 7. **No Clear Upper Limit to Protein Benefits**: The video suggests that, based on current research, there might not be a clear upper limit to the benefits of protein intake for muscle synthesis and autophagy, although more research is needed to fully understand this relationship.

[@jodiefoster6900]

Thanks! Sometimes I find all the cutaways in his videos annoying and I’ve forgotten what he was saying

[@et2792]

People need to stop looking at only one small thing at a time.

[@CrazedCorgi]

There was a term I heard before, fed fasting. It's protein only but I don't remember where it was from.

[@skorpers]

Hamza talked about it.

[@cenauge]

Correct me if I'm misunderstanding, but autophagy being disfunctional in a fat cell is not the same as autophagy being disfunctional in overweight individuals. I haven't read anything suggesting autophagy is disfunctional in the muscle tissues of overweight individuals post-exercise. And what does the autophagy look like in specifically the fat cells of lean and normal individuals? It feels like different things are being conflated. From a certain point of view, it makes sense for fat cells to respond differently since, to put it in machinery terms, they aren't the same kind of moving parts that lean tissues are. Fat cells are fuel storage; what is the evolutionary benefit to fuel eating itself?

[@OttoBoy]

Protein in study: does anyone know the protein source/type?

[@Burt_Sampson]

Hi Thomas. I know you probably won’t see this and are really busy so if you can’t respond now worries but I’d really like some quick advice. I’m so close to giving up and idk what to do. Jan 1st I was 262 pounds, and I started doing 18-22 hour fasting daily in addition to only 1500 calorie keto as well as an hour-2 hours of exercise 5/6 days a week. now I am at 242 and I am super happy I lost so much so quickly, but this last week I have been doing the same and have gained a pound over the week instead of going down. I consulted my doctor and here is what he said, I would love your input: You may have been in a deficit for too long and your metabolism has not decrease too much. For the next 10 days increase your caloric intake to 2500 per day with 3 meals daily. Includes carbs in this. Continue to exercise normally. The two days after that go back to intermittent fasting and 1000 calories, the next day go back to 1500 calories for the next 1-2 months. If your metabolism has slowed, then you should actually not gain any weight when eating 2500 calories and you should also notice a boost in energy. Thank you or any other commenters in advance! Cheers 😃

[@christineanderson7371]

Many experts remind us to @changing it up” with fasting protocols. Our bodies will adjust to anything over time. So, that is the critical part of your doctor’s message, I think? Good luck and DONT give up, you are doing wonderfully well 👍

[@Luanara101]

I think that is pretty solid advice. Our bodies always try to adapt, so when you are in a deficit for too long, your body will compromise energy demands by downregulating important processes in your body. This might go unnoticed for a while, but can have consequences in the long term. Even if you gain a a little in that 2500 calorie window, it will most likely be water weight since the plan is to increase carbs as well. I would not worry too much about it. The energy kick will sort it out, since when you are energized you naturally move more etc. As long as the trajectory is the right one over the course of a few weeks, then everything is fine. And also if you are a woman, consider that a few days before your period you will naturally be more heavy since the body clings to water. Never weigh yourself before your period :) If you are a man, 1500 calorie baseline is too low. It does not even cover your bmr. Be careful. good luck and much success. 😊

[@Burt_Sampson]

Thank you both!! 🫡🫡

[@jodiefoster6900]

I just wanted to say you’re doing a great job and to not be discouraged ❤ Thomas has a lot of videos around the ideal length of fasts for fat loss, but you must eat a good number of calories when you do eat. Maybe also look at your training - are you overtraining? Beyond that there are too many variables for me to give you advice, so I will just stick to encouragement 🎉

[@Burt_Sampson]

@@jodiefoster6900 thank you so much 😊 I appreciate it! I feel better than ever and actually ended up going down to 239.5 as of this morning! Definitely posssibly overtraining. Was supposed to take Saturdays and Sundays off but still did a 5 mile hike this morning. I’m addcited now and can’t stop 💪. Thank you so much for your support!

[@danielleal1037]

The take-home message is that no autophagy will occur in the presence of Twinkies, Little Debbies and Ding Dongs.

[@Pamela.B]

😂

[@davidneal6920]

This channel is awesome

[@sr9253]

It would help if you had diagrams with the proteins and chemicals you are talking about.

[@PickleRick72596]

I wish I had the intelligence to fully follow the science behind this video, I'm just not following how autophagy isn't the same thing as muscle growth. My understanding is that when you work out, specifically when you train with weights, the muscle fibers get these little tears in them, and the protein you eat repairs those tears, which is how you gain size in your muscles. Well, how is the repair work on the muscle fibers any different than cell repair with autophagy? I in no way intend this comment to be disrespectful or challenging in any way, I'm just trying to understand. Love the content!

[@faithevrlasting]

Havent watched yet, but why in the world would ANYONE ever think more protein would decrease autophagy? As long as you pay attention to your mitochonrial function status and correct it? Hers my situation after listening. I dont get all the chemistry as a lowly RN MSN, but had GLP1 induced gastroparesis post years after gastric bypass resulting in dehydration and malnutrition induced low sodium and SIADH, then brain demylinization after SSI use near fatal. Upon dc from hospital continued to lose weight. Corrected w some supps (amino acids) and started PT because normal activites were not even possible. Continued to lose 45 lbs, obvious sarcophagy, age 71. Could just a grad increase in activity actually allow muscle building as I had no clue not to bombard my body w extra protein shakes while trying to stop losing? Finally stopped losing after some gut work and a bit more exercise.

[@dubinmarks1]

What about gluconeogenesis? With this new study you can eat 100g of protein without gluconeogenesis occurring?

[@grombec]

I wonder if collagen protein wouldn’t interrupt autophagy in the same way.

[@Robert-Leons]

So many great videos on the Chanel. Great info, on so many things. BUT … I’m a bit confused. How would you categorise your own diet? Personally I’ve had great initial results from Carnivore, reduced back pain, skin much clearer from psoriasis and energy levels up. But I’m struggling with it now. It feels heavy and off putting. Like I say I’m confused

[@tonydillinger2553]

He is now doing a more carnivore(protein)/Mediterranean diet. When it comes to health and diet , we have to remember that everyone is different because of blood type /different salt levels, karma, life style, what you are trying to do, etc..

[@Robert-Leons]

@@tonydillinger2553 I was actually thinking of going carnivore/med but without grains/legumes that are on the Mediterranean side. It’s amazing to have so much info out there, yet confusing at times.

[@Robert-Leons]

@@tonydillinger2553 and thank you btw 🙏

[@dennisward43]

@@Robert-Leons I think grains(including whole grains) are vastly over-rated in general for good health.

[@kinggrimm4338]

🥩

[@jpdoc5722]

thanks 🙏 for the constant updates 👍

[@lisapet160]

Fasting upregulates autophagy. Breaking the fast to balanced eating downregulates autophagy to baseline levels. Excess of protein does not downregulate autophagy further. Make your choice accordingly.

[@michellecook-hill]

Thrive! Keep Thriving!

[@sharrison55]

Oh no what happened? You're not characteristically exhibiting your biceps in the covering shot???

[@johnhoward3525]

This one doesn't make complete sense to me. Previous videos, and other articles indicate Leucine (and others) spikes insulin, which will take you out of autophagy. What proteins are low enough in Leucine, other EAA/BCAA, that will not affect insulin? I think I need more protein, so I'm definitely interested in any suggestions.

[@Viceroy_tv]

so does this mean i can take a scoop of protien powder before bed that has 20g p 2.5g carbs and .5g of fat and it wont break my fast?

[@Antigone10]

This is dumb, autophagy and anabolism always happen at the same time. For example, you skin doesnt stop replacing itself while you are in a calorie deficit. Your body also eats up dead cells all over your body when im a calorie surplus. Imagine if you couldnt freaking talk and walk at the same time, derp.

[@TheoryMaK15-255]

What about Gene Mutation of the GLUT1 Transportation Disorder or Syndrome

[@L.A.6482]

Please don’t show video to normalize women in headscarves. It’s so demoralizing to the rest of us trying to fight for our rights to be free of suppression by men. Thank you!

[@spartallica9128]

Had to look up the definition of autophagy.

[@ST-online]

Everything on KZbin is so contradictory these days, one expert says this and another says that literally so confusing

[@haydeesimmons9655]

You look awesome with a beard. This is coming from a 75 year old lady who has benefited from fallowing you for years.

[@hlarledge]

So did I hear you right? Autophagy gets stuck in folks who are overweight?

[@angelaivyleong]

I don’t know why he seems to skip over the fact that this study refers to muscle protein autophagy and not autophagy in general.

[@minutemartialarts3152]

I saw some research that the activity that is the king of autophagy is aerobic exercise for sufficient duration.

[@markgransbury8377]

hi what percentage body fat would you expect this to kick in at?

[@macaronafterparty]

These cell reports are way better than the ones I read back in the clink. ;)

[@matthewrundell9685]

I’m curious as to what is the basis for determining obesity? According to BMI I’m considered obese, but I don’t feel like I am. I workout regularly, train BJJ and try to eat fairly good, 5’9” 225#, obviously I’m trying to lose weight in fat, but a cut physique is not necessarily my end goal.

[@ianzee1112]

I'm 6"2, at 207 lbs and I come up obese on BMI (only just) but the truth is I'm 15.8% body fat measured correctly with callipers. The reality is that I'm muscular, well built and lean. BMI is bullshit, never use BMI 😊

[@MarkRodriguez-l4m]

I think insulin effects it so if you're always in a low insulin state you're good

[@hoffmancapote]

Well we have to realise it is only one piece of research and if I am right it was financed by a food company

[@emergentform1188]

Love it, you da man TD!

[@TheHolydruid]

I need you to dumb this down with pictures and crayons :)

[@SuperPerfectEnglish]

The study it s completely biased as focuses on a niche of superfit individuals. Cannot be applied to general population. In fat people it doesnt matter as losing fat is more important than any possible effect on autophagy. Anyway losing fat increases itself autophagy

[@phines93]

Wtf are u talking about?lol protein literally helps you lose weight wtf are you saying

[@johnnykeller5186]

In most instances obesity is relative to insulin resistance, due to a carbohydrate saturated diet and heavily processed foods. Glycogen is a form intermediary glucose storage in which the body stores excess glucose in musculature as opposed to increasing adipose tissues (white fat) for long-term glucose storage. If you increase muscle density by resistance training (not bulking or for aesthetics) you increase intermediary glucose storage to both prevent and reduce adipose tissues; fat storage (again being relative to excess unused glucose) then becomes less of an issue reducing strain on the circulatory system, reducing stress on the respiratory system and reducing adrenal fatigue from endocrin responses. Building muscle does not inherently infer that someone wants to get jacked or look like a model there are people like myself that have been forced due to the amount of damage we've unwittingly and ignorantly done to our bodies through poor dietary practices and a sedentary lifestyle, to build muscle to off-set the damage done and wright our metabolic health. Science builds...just because you find research unagreeable...that's fine, it doesn't have to fit your narrative, however if you want to learn and grow, perhaps be more amiable....just food for thought

[@phines93]

@@johnnykeller5186 👍

[@leonardopatrizio]

So what? Get super fit and become one of the super fit individuals then. Like me!

[@ioschris]

@@leonardopatriziobingo👏🏽

[@neuromax3766]

Just because there are still "markers of autophagy" present after consuming protein, doesn't imply that you cells are still in autophagy. It just means that the markers hang around for awhile.

[@anonperson3972]

5:00 I love how they are just confirming something that loads of us that lift and fast already knew. I kept hearing all this information about how you need to spread out your protein intake and anything mroe than x amount of grams would be wasted etc. I knew that is wrong because I am 225lbs 14% bodyfat and only eat 2 meals a day. So if that was true, I (and many other people) would not be able to exist!

[@2BWiley2]

So, lets say we fast for 24 hours, get ready to break the fast by hitting the gym or taking a walk, then only break the fast by consuming lean protein (say 100 grams) and nothing else (assume no carbs), and then go right back into another 24 hour fast (and repeat that every 24 hours as desired), does this mean that from an autophagy maximization standpoint so long as we only break the fast with lean protein we can effectively extend a "fast" (i.e., no cessation of autophagy) days, an entire week, or more?

[@popanator7759]

Good question!

[@anamosity_soso]

No, proteines won’t break autophagy I saw a video on KZbin from a doctor and biochemist about that.

[@WadmanP]

What happens if you’re lean but but have metabolic issues like Type 2 diabetes? Example, I’m 5’6”, 58 y/o, and 148lbs.

[@DanBrandow]

If I remember correctly, the study used whole milk proteins, which means casein as well as whey. It is postulated (by Dr Attia among others) that the relatively slow-digesting casein is what causes the increased mTOR over time.

[@fallenpastabean804]

I miss when this channel provided coherent information about improving your life on the daily. Now it just became an overly-obsessive convoluted channel about gene expressions and how to live like a robotic biohacker who has no regard for living life simply and healthily..

[@alphacause]

Thank you, Thomas, for this interesting information, which upends so many of our presuppositions on this topic. If exercise induces greater autophagy than fasting (3:46 - 3:54), what type of exercise and what duration is best? Is simple cardio required or weight training better? If cardio is the optimal route, at what intensity and what duration is required, and at what point does the law of diminishing returns kick in. If resistance training induces the best autophagy, is there a marked difference between light vs heavy weight training in triggering autophagy?

[@dp27thelight9]

So pound that tofu and peanut butter powder

[@tomjones2348]

Excellent information! Topic request: Thomas, please do a presentation for people like me that are very fit, over 65, and aspire to maintain muscle mass. Thank you.

[@5tonMongo]

Thomas DeLauer, You say that autophagy is not compromised in "lean, healthy" individuals. What about the chubbatones like me? Can I still fast, experience autophagy and maintain it while ingesting pure protein OR does this only work in people that don't have significant fat stores? Curious to know more.....

[@ultimateghost]

Thanks Thomas

[@urikot9708]

Thank you for very valuable information. Would love to hear about Large protein consumption and it's benefits right after a workout.

[@mlbf4700]

So I can be fasting not just with fat fasting, but with protein fasting, so basically the carnivore diet a couple of days a week.

[@joshuagenes]

It seems to me that with exercise you are damaging cells by tearing muscle fibers so it would make sense that the body triggers autophagy however with fasting it is seeking out the bad cells in the body that are ever present and recycling and replacing them. I think fasting is superior in some ways because you aren't causing the problem in the first place just repairing. That being said exercise is still important.

[@Suree.Lifestyle]

LOLZ...you could've used the remarks at 7:50 in your bro science video!

[@vancemowat7544]

I know you said a lean protein source. Does a fattier protein source disrupt autophagy more? Is a chicken breast superior to a ribeye or some eggs to keep autophagy going post workout?

[@Coindom65]

Excellent news! I've been slowly increasing my protein intake anyway lately now I'll be a carnivore 2 days a week for sure

[@RLeeErmy]

On a side note, I think it would be pretty awesome to see a superchat or some sort of live stream conversation of you and your viewers. Only problem there is, I have a million questions LOL

[@skyleawood2649]

Hey Thomas! You're looking much healthier this year. Good for you, brother! ❤

[@user-jz1ht8ry2w]

Does taking protein powder, vitamins and boiled eggs, stop the fasting process?

[@harveysand9587]

Calories in and calories out. Same stuff going on for a few decades. Stop re inventing old wisdom.

[@glennsampayan2322]

Thomas, you sounded like a very smart and medical expert.

[@kyokoyumi]

Carnivore for life :)

[@novanomi3362]

So does this mean we have no control over autophagy other then weight or that only calories and weight matter for autophagy?

[@Coby_Got]

lol/. Today up is down! Tomorrow down is up!! lol. This never ends….

[@PickleRick72596]

Do you ever reach out to followers and ask them to contact you on Telegram?

[@nelsonvelazquez7723]

Those that also mean for protein powder intake or just lean meat protein.?

[@gbwhitewarrior]

It means that proteins do not spike your insulin as you believe

[@ocho33]

I can’t wait for Layne Norton to talk about this in 5 years.

[@dawnnwilliams2946]

Thomas, full disclosure I’m not your biggest fan. However, I do watch some of your content. I have a suggestion. When your explaining something it might be useful if you first say it in lay terms and then say the scientific name for what your describing instead of the other way around. I hope I’m not coming across as trolling, because that is not my intent. May the force be with you.

[@sigeptim1982]

What a terrible way to leave a comment

[@tomaszs1243]

What a passive aggressive way to comment.

[@DJSTOEK]

❤

[@kylecarter8098]

Been carnivore eating 90% beef grass feed and finished. Can’t get my GKI lower than 2 without fasting and apparently a GKI around 1 is were autophagy kicks in. On a side note if I workout fasted on a OMAD scheduled it happens much faster, which I do twice a week.

[@pauldomnich1334]

Autophagy is always on to some degree. Can you send link regarding gki less than 1 to activate robust autophagy? Online info says less than 1 difficult to do and should be done under medical supervision. Takes me 72 hours fasted to get there

[@evecruz0167]

❤

[@neuromax3766]

What works for me is - 3 day fast with nothing but water and a little green tea. On the second day I do resistance training and on the 3rd day HIIT. NO PROTEIN. Your muscles will be screaming for amino acids for repair and growth so this puts your whole body, including your brain, into full-on autophagy and it will chew up your misfolded, junk proteins and enzymes to get the amino acids it needs to do the muscle repair. It will clean out your age-related cellular garbage. I don't eat anything until noon of the fourth day. It works.

[@phines93]

For me its only really noticable on the 5th day ...I probably got more damage that needs repair that's why...I donate plasma too an get to see my protein levels on the regular and on day 4 or fasting my protein was still at like a 8 so I'm bout to start doing these 5 day fasts on the regular

[@phines93]

I took so many supplements for so long too that I'm in no way shape or form worried about any deficiencies

[@SuperPerfectEnglish]

Nice to pick a study that supports your sale of proteins when most of the other studies suggest not have more than 25 g of proteins a day to keep autophagy going :-)

[@SuperPerfectEnglish]

@-Mr_Thomas_DeLauer- you can talk publicly as I am a PhD in nutrition I can answer

[@blahizake]

You might want to try listening again to what was said and jumping back into the studies. Critical thinking and attention to detail will be huge with this topic.

[@harrisonschwartz565]

@@blahizakeI mean the study just says “without compromising markers of autophagy” but says nothing about the degree to which autophagy occurred nor in which organs. His conclusions are not clearly supported by the science, and also contradict the more well known science that shows a consistent negative correlation between high protein diets and autophagy, as well as high protein diets and cancer and aging. I like Thomas’s videos, but he is increasingly biased by those who fund him. I recognize most of his viewers are those who may benefit from weight loss of high protein diets, but the science is pretty clear on the negative impacts of keto-type diets on young and healthy people.

[@blahizake]

@@harrisonschwartz565 Thank you for clarifying. Are the high protein and autophagy concerns based on mouse studies? If he were to focus mainly on promoting his sponsors, he could easily skirt around the topic of autophagy and focus on other factors that seem to healthy aging and acquiring lean muscle and/or strength.

[@NickMeinzer]

Aaahh anyone translate this?!