Effexor (Venlafaxine) VS Pristiq (Desvenlafaxine) What you NEED to Know!

In this video, we compare two serotonin norepinephrine reuptake inhibitors, Effexor (venlafaxine) and Pristiq (desvenlafaxine).
Intro: 0:00
How do Effexor and Pristiq work 0:33
What are Effexor and Pristiq used for 2:23
Common Side Effects of Effexor and Pristiq 2:53
Considerations of Effexor and Pristiq 4:53
Final thoughts 7:44
Resources:
Deprescribing Guide: amzn.to/4dZEUMk
Stahl's Prescribing Guide: amzn.to/3UXj8QL
🎥 This video was edited by:
Rahul Kanchi / rahulkanchi24
🚑 If you are in a mental health crisis, please dial 9-8-8 from the U.S. Or text HOME to 741741 and connect to a crisis counselor.
You can find a list of international crisis lines here: blog.opencounseling.com/suici...
References:
Effexor ER (venlafaxine ER) FDA Label (2017). Retrieved from www.accessdata.fda.gov/drugsa...
Pristiq (2018) FDA Drug Label. Retrieved from www.accessdata.fda.gov/drugsa...
Rege, S. (2022). Venlafaxine (Effexor) and Desvenlafaxine (Pristiq)- Mechanism of action, differences, psychopharmacology and clinical application. Psyc Scene Hub, psychscenehub.com/psychinsigh...
Stahl, S. M., Grady, M. M., & Muntner, N. (2021). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications. Cambridge University Press.
Stahl,S. (2017). Stahl’s Essential Psychopharmacology: Prescriber’s Guide, 6th Ed. Cambridge University Press.
UpToDate (2023). Desvenlafaxine: Drug Information. Retrieved from www-uptodate-com.libproxy.eku...
UpToDate (2023). Venlafaxine: Drug Information. Retrieved from www-uptodate-com.libproxy.eku...
Disclaimer: All of the information on this channel is for educational purposes only and not intended to be specific/personal medical advice or substitute for diagnosis and treatment of any conditions discussed herein. Furthermore, watching these videos or getting answers to comments/questions, does not establish a provider-patient relationship. Please consult with your own healthcare provider for proper diagnosis and treatment.

[@LevelheadedMind]

www.levelheadedmind.com/contact Need help with your mental health treatment plan? Contact me so we can discuss treatment options best suited for your unique needs.

[@KiatheGymRat]

I use Desvenlafaxine 150 MG daily . No other depression medication ever worked for me.

[@Iliketurtlezz]

Great job explaining this!

[@yimkwonglun62]

I deeply appreciate your sharing of information especially your thought and comment on those type of medications.

[@LevelheadedMind]

Thank you!

[@user-yl9ni4dr3n]

بمضادات الاكتئاب. هذا الطب غيرني للأفضل.

[@garysimone4977]

Don't ya. Just love Dr who write this posion. Thank God for providers like Ms Rosa...

[@robertivers4200]

I have been on just about every antidepressant available over the last 30 years and gone thru horrendous withdrawals switching including hospitalization and suicide attempts.I started Pristiq desvenlafaxcine 5 yrs ago after many years on effexor. The Pristiq helps more with anxiety for me. Deathly fear withdrawal in case of major disasters. Wish doctors informed us lab rats about withdrawals.Guess they and pharma likes the money

[@irishgirl1753]

Hi Robert was given so many over the years too todays app ointment was pushing Prozac even tho I said no 😢I finally agreed on trying Zoloft again god help us

[@LevelheadedMind]

I'm sorry you've had such a bad experience.

[@santa5240]

better don`t even start any antidepresant. It makes more problems than benefits.

[@ThanksWyatt]

How can you not see that the drugs are the problem. 30 years? And you're still not doing well? Come on.

[@danishofficial9529]

I support you and pray for you recovery soon 🙏

[@indradevpandey8257]

Excellent video

[@LevelheadedMind]

Thank you for watching.

[@catherineers]

Had depression and GAD for most of my life and I finally started antidepressants this year. I've been on desvenlafaxine 50mg for a little over a month now and I instantly felt better. Only side effects I got was extreme sleepiness the first 1-2 weeks and a constant need to yawn which has lessened by now. I love this medication and I'm so glad I finally started. Don't be afraid to start antidepressants. This med changed me for the better.

[@LevelheadedMind]

Thanks for sharing your story. Glad you found something that works for you.

[@GerardGordon-bu9gf]

​@@LevelheadedMind I really know the information is well intended, but it's delivered in a way that causes more anxiety for people on those medications. Seems to be a common theme in the videos.

[@edie4321]

No, be afraid. They only work for a short while, but are close to impossible to come off of. Cymbalta was my nightmare. It's been seven years since I quit and I'm still not back. I was never depressed like this before Cymbalta. It was prescribed to me for pain. I'd get off now, and look for something like nature.

[@jaypalnitkar4400]

​@@edie4321how long have u been on cymbalta

[@tulinbeyduz920]

@@GerardGordon-bu9gfsaved my twin sisters life ..

[@amintazi5904]

Effexor XR is the best tolerated antidepressant in my experience, I can say it saved my life very effective against anxiety and negative thinking and neuroticism

[@kristymeyers8415]

It almost killed me I went into physchosis and ended ten times worse then ever

[@amintazi5904]

@@kristymeyers8415 sorry to hear that, but remember psychosis is a genetic predisposition so a lot of things could trigger that (mostly cannabis), as for myself no side effects in nearly 3 months of treatment, other AD gave me big side effects so I'll stick with it for a while

[@struck.kobe1999]

@@kristymeyers8415it has a very short half life, just don’t take it for 12 hours and side effects should subside.

[@mpat100]

yes me too I never realised how effective it was until I took it; saved me too; it works for nerve pain also which I have

[@mpat100]

@@kristymeyers8415 what dose were you on?

[@MakAnndCheeese]

Thank you for doing these videos! Always so informative

[@LevelheadedMind]

Thanks for watching. Glad you like them!

[@donwanderley7156]

Use caution when dismissing Effexor as "poison." No other drug has worked as long or as well for me. Being a KZbin doctor has its limitations!

[@LevelheadedMind]

I'm glad it has worked well for you!

[@Jakey4000]

Same with me, but for pristiq. I started it in Australia after having nothing work well enough for me, moved back to NZ when covid came around to find out that my country doesn't have pristiq and I was switched to effexor, everything spiralled pretty quickly from there... I was diagnosed with adhd a bit after this and was finally getting my life on track, I studied to be a pharmacy technician and recently I searched for desvenlafaxine from our suppliers, nothing popped up but I still kept looking from time to time until I thought to try searching via brand name, and boom there it was! ff to talking with my doctor and showing him he was happy to write a script and I finally have it in my hands. I'm incredibly privileged to be in the job I have, it has made finding this drug possible through means I never would've expected. I am a little worried i could be getting ahead of myself as it was quite literally the only box in the country, I have contacted our suppliers to confirm if I can keep getting this supply for the forseeable future

[@eimearmcmanus372]

How I wish I had found Effexor earlier. I spent years unable to sleep, I was too nervous to talk to people, I couldn't focus and I was unable to study or work.

[@Carol-mq6fe]

About 20 years ago I started on Effexor. I felt great, no anxiety or depression, unfortunately I blew up like a balloon…I gained a lot of weight quickly. I had to change medication. I did not have any withdrawal issues.

[@HeyYall398]

My first dose of effexor last week killed my anxiety instantly. It numbed me from the anxious feeling and that part was great. It also killed my ability to orgasm. It had an all-out numbing effect on me. After 72 hours of abstinence, I was back to normal. Anxiety returned however. Pretty scary stuff in my experience. Thank you so much for your content.

[@LevelheadedMind]

Thanks for sharing your experience. Unfortunately, that is a common occurrence in men. I hope you find a treatment that works well for you.

[@HeyYall398]

@@LevelheadedMind Thank you kindly. I came across a lancet paper named "Comparative efficacy and acceptability of 21 antidepressant drugs for the acute treatment of adults with major depressive disorder: a systematic review and network meta-analysis". Would love your thoughts on it based on your real world clinical experience! The ranking there based on efficacy and the discontinuation rate was also fascinating.

[@ABigNUT69]

Sooo are you going to continue taking it??

[@HeyYall398]

@@ABigNUT69 I stopped it as it's just not for me. Everyone's experience is different. I also met people who consider this as their life saver.

[@mohunrosida4078]

How many day this medicine work

[@KiwikimNZ]

This drug was out of this world as far as side effects go when I was on it. I understand some people respond to this drug well and that’s great, we are all different and what works for some doesn’t work for another. I was on max dose and it was like i had defibrillator paddles on my legs the shocks were so bad, they would fly up into the air lol. Withdrawal symptoms if reducing and coming off was brutal a lot of GI upset, dizziness and I felt like I had been given drugs I just wasn’t with it. Never again. But happy for those who do find it works for them. But yes be careful if you ever want to stop taking, never stop abruptly, and another thing I had to ensure when I was taking it, was to have spare medication on me at all times. If you do mistakenly skip a dose due to an unexpected delay or something comes up and you can go home to take your meds at your regular time, I would feel terrible within only 4-5 hours of missing it. So I would always carry a dose in my handbag and a spare dose in my car just in case and it really did save me from having problems if I couldn’t get home to take them.

[@bovedli]

Whether it is poison or not, effexor helped my bipolar depression a great deal while other meds proved to be inefficient. Depression is way worse than the side effects you mention. I don’t like the drug but it is giving me relief from debilitating, disabling symptoms. Honestly I couldn’t care less about the side effects as there is currently no effective substitute for me that actually pulls me out of the most severe form of depression. And no it does not make me manic as I take lithium too. It’s by no means perfect, but it works. U gotta give it two months to work though and withdrawals are difficult but I usually withdraw in 2 months when I’m starting to feel a bit hypomanic.

[@LalondeFilms]

What dose are you on?

[@mirm0n]

The thumbnail is crazy 😂

[@ats-3693]

I was on 150mg per day pristiq for anxiety and depression for about 6 years, it actually did a good job of stabilising my mood/emotions and i didnt have any noticeable side effects for the entire time I was on it except it severely reduced my libido. About 18 months ago I decided to get off pristiq, I tapered off over a 3 month period with no withdrawal symptoms except bad brain and body zaps that continued for several months even after I had finished tapering off.

[@robfigga4473]

It started off good lol

[@foushize]

Your libido back to normal?

[@Elijah8890]

Your libido back to normal or do you see a permanent damage?

[@ats-3693]

@@Elijah8890 Back the same as it was before i was on the meds.

[@deanjenkinson593]

Hi. I'm on 50mg pristiq and have been for 4 years or so. I tried to taper but the eletric shocks/zaps in my head made it hard. Did you find anything to help with the zaps?

[@littlelotta7975]

I'm looking for the ingredients does anyone know or are they even available.

[@illegalsmirf]

You’re quite right to refer to them both as poison. But they do the job for very disturbed people

[@jayantilalsoni3945]

Madam please video rtms tms tdcs therapy. Please reacvest

[@godoforder1828]

I have high functioning autism and started using venlafaxine a year ago, my family reported i was on a higher mood and would be more active and have more initiative. When i stopped taking it slowly, i noticed no withdrawal symptoms whatsoever, thankfully. I just started taking it again because of major anxiety and depression episodes i started experiencing due to life events, and its helping a lot, but i dont know if i will have to keep taking this medication in order to function

[@tahirayub5452]

Madam what is the best ssri for heart pt. In your opinion?

[@truehuman9449]

Finally u said u will not priscribe. What would you suggest for a patient like me with chronic GAD none of SSRI works?

[@anais6319]

I'm on the same boat. Would be great to get an answer to our question 🙌🏼 I was prescribed with Effexor, but I'm concerned about the side effects

[@fraudexposed5486]

@@anais6319 I’m having good luck with Pristiq

[@teniaspence8821]

When fluoxetine no longer worked for me, they switched me to Wellbutrin which unfortunately didn't work either. Next was Venlafaxine. It worked well but I was never told about the side effects or that I can taper off after a year. They just keep prescribing and I just kept taking it. Five years into it now, it doesn't work as good anymore. Now I'm scared af at the prospect of Venlafaxine withdrawal and the side effects of my remaining medication choices. It seems like I'll have to choose between massive weight gains or uncontrollable restlessness just to keep myself off suicidal tendencies.

[@LevelheadedMind]

Discuss your concerns with your provider. And taper off Effexor very slowly, over 2 years.

[@KeishaKiger]

@@LevelheadedMind if you’ve taken it for about two years, does that mean it’s time to get off of it and how long would that take to taper off?

[@fraudexposed5486]

What is your most common prescription then for major depression?

[@edie4321]

If you take drugs for your disorder, you can expect a worse rebound from them in time. It's been seven years for me coming off many deadly prescription drugs. They have damaged me greatly. I was never depressed like this before the nasty drugs.

[@TheBmonster1]

I have only been on Pristiq I started going through a alcohol rehab 10 days in I started getting headaches while in rehab no alcohol involved. I was in there from March 6th to April 6th so a 30 days. I would workout I would get a headache. I used to workout all the time and not have this issue. And the headaches got so bad my eye sight would go. I would be blind for at least a few minutes 5 at the max. This has happened at 5 times since I got home. Which was April 6th. I recently got off of it and have a had the blinding headache happen again on Wednesday July 5th. Irritating that doctors are saying it's migraines. I don't have these

[@onediversity6317]

You say you avoid these substances. Is there a good alternative?

[@reiskywalker0964]

I'm only hitting one week on venlafaxine and have to take it with mytra. Side effects are a tad rough adapting to

[@PeanutButter-19]

Has there ever been any lawsuits over Effexor?

[@elberalghbiwy6236]

Does desvenlafaxine increase norepinephrine in areas of the brain that differ from the areas where venlafaxine increases norepinephrine and correct vice versa? So that they are all complementary to each other in treating depression? Thank you for the beautiful video

[@letslearnphysicstogether3555]

hi...i have not been on antidepressants ever..i fear that i will totally lose my libido...anyway doea social anxiety specially public speaking anxiety completely go away with the medications..??

[@yurijablanzki7638]

Can you respond please been taking pristiq at 125 mg for a year up however 2 months ago ago I started to get these huge headaches followed by anxiety , pulsing in my head and feelings of impending doom however it isn’t daily as it comes and goes My thoughts are either high blood pressure or low sodium levels

[@fabulousandplump]

I took venaflaxine for ,four years and recently came off it because it was no longer working i stated paxil it didn't work and has some bad side effects i am starting prostiq i hope it works

[@babynaysc]

I started Venlafaxine 1 and a half weeks ago, I feel terrible sleep, I keep yawning all the time, feeling tired, headache, hand tremors

[@Deba7777]

Would you comment on this: if someone has been on 100 mg Pristque for more than a year with poor effects, so they're already at high risk for withdrawal, do you see any potential improvement likely to transfer to Effexor XR? (I know you're not giving medical advice!) Thank you!

[@LevelheadedMind]

No, this type of cross over may make things worse.

[@BeigeRecluse]

Effexor XR at 300mg is the only thing that has made any difference. I have OCD, so my dosages tend to be high.

[@ilatribal]

Hi, could you please make videos about bpd

[@thisgirl5933]

I had NO IDEA how low the N ratio of Effexor is. I weaned off 112.5mg 2months ago and debating trying 25mg again because my anxiety is back and just got laid off too so not doing well mentally. Not sure if going back to Effexor will be less harmful than a whole new antidepressant. I feel very little satisfaction after accomplishments and have poor motivation so thought about Wellbutrin, but that one sounds both great or possibly disastrous. Really don't want to feel suicidal...

[@LevelheadedMind]

Please discuss your concerns with your doctor to help guide your decision.

[@Phantomsx-]

I been prescribed venlafaxine for my anxiety it’s so bad causing real bad chest pain but looking at the comments and hearing the stories I think the meds is worse still don’t know if I should take it or not

[@crassillweed]

To anyone coming off these meds feeling these symptoms, I have one question? Was it worth it? If you had it to do again, would you have started the meds in the first place?

[@heidimayo8455]

Nope

[@heinz-georgschneider3567]

No, never ever, these drugs are neurotoxins and shorten life span.

[@andrear3325]

I’m taking pristique and it’s improved my life a lot.

[@jo3592]

Definitely not.

[@zengwenyoga2894]

NO!

[@danielrv1325]

I’ve been almost a year on Pristiq as I was diagnosed with persistent depressive disorder, this was my first medication and I haven’t switch but I’m afraid of withdrawals effects, is there a suggestion alternative? I would like to address it with my doctor

[@LevelheadedMind]

You can discuss cross tapering over to fluoxetine or Bupropion as these have the least withdrawal effects reported.

[@Iliketurtlezz]

@@LevelheadedMindwrong. Never cross-taper a SNRI to a SSRI. It wont stop the withdrawals at all.

[@glahaye]

@@Iliketurtlezz Actually, it is common practice, especially to fluoxetine because of its long half life. Google Prozac bridge for me info.

[@abhijithashok3537]

​@@LevelheadedMinddesvenlafaxine is better and we'll tolerated upto 50 mg if sleeping issues then take mirtazepine 7.5 mg

[@jaypalnitkar4400]

Why cant people try prolonged fasting 48 hours or more before even thinking of popping pills?

[@quemidelquemide]

Tomo pristiq hace 10 años y ya no me ayuda. Mi depresión sigue aumentando. Sin embargo, no puedo dejar de tomarlo pues si lo hago, caigo en un estado de depresión terrible. No sé que hacer. Necesito ayuda

[@marcuscent1988]

Defo can make weigth gain sadly lot of peeps on group s and my self gaind

[@teriaguiar8244]

Since you don’t prescribe these two medications, what med do you prefer?

[@AdamGbl95]

Wow unbelieveable all the side effects. Dr prescibed me that as a first timer. Didnt even mention 1 thing about a side effects, withdrawls, etc. I had to bring it up but she just said "eh...dry mouth, thats it". Unbelievable that any doctor can prescribe something without any knowledge about it. The fact that you can't just stop and back out cold turkey if side effects are bad. The more i consider meds as a first timer, the more Im turned away.

[@LevelheadedMind]

Yes, that's why I emphasize skills before pills.

[@babynaysc]

Why are doctors not honest in saying that side effects can last longer? I only start to improve after 1 and a half months onwards

[@LevelheadedMind]

You may have a gene that makes you more prone to those side effects. Get a genesight or genomind test if it is available to you.

[@jillradovanovic3460]

My neurologist prescribed me pristiq fir persistent dizziness pppd....what do you think? My gp recommended sertraline I'm confused

[@LevelheadedMind]

Find the root cause of this dizziness first before going to psychotropic medication they can actually cause neurological damage in some people.

[@jillradovanovic3460]

​@@LevelheadedMind thank you

[@jillradovanovic3460]

I haven't started pristiq yet..but neurologist uses this one as he says it desensitise the sensations

[@IrinaBotezatu-ov9wb]

Venlafaxine is used fpr migraine prevention too

[@cespo77]

Effexor causes very high blood pressure and cholesterol.

[@beeathome1064]

Of these two, which one would you choose to prescribe over the other

[@LevelheadedMind]

I have more experience with Venlafaxine and getting patients off of it successfully, so that'd be my pick.

[@beeathome1064]

@@LevelheadedMind thank you for responding . I love your videos. One other question I had about pristiq.. do you see patients having weight gain with it

[@DrRinse]

It's not a great leap forward in terms of antidepressants, more of an evergreening drug - isolate the more active isomer and market it as if it's a totally new med. Having been on citalopram and escitalopram for the best part of 20 years, it's a swizz. The R-enantiomer has no antidepressant effect and doesn't interfere with the action of the S-enantiomer. You could take 10mg Escitalopram one day and 20mg Citalopram ad infinitum and not notice a jot of difference. Clomipramine, on the other hand, hits SERT and NET hard, via its metabolite desmethyl-clomipramine. That's a more balanced SNRI drug than Venlafaxine, Desvenlafaxine and Duloxetine. Milnacipran and Levo-milnacipran are better balanced at SERT and NET too.

[@sadcatsclub8949]

Thank you for only prescribing this only sparingly. Venlafaxine is ruining my life and it maybe wouldn’t have happened if I wasn’t prescribed this so early in my medication journey to find an antidepressant that worked. They were right, it worked… now my body is extremely dependent on venlafaxine after being on it for 8 years and upping slowly to 300mg. My tapering process will take years from the strength of the withdrawals… I feel wronged by that doctor….

[@LevelheadedMind]

Sorry to hear that! I hope that you have a complete recovery. Remember that Venlafaxine comes in liquid if you find when you get down to the lower doses it becomes more difficult.

[@heidimayo8455]

Its taken me three years to to get off it from 300mg haven't had any in 4 months. Its tough picked a terrible time but I'm hanging in there

[@thisgirl5933]

​@@heidimayo8455Are you on anything else? I'm off 2 months and anxiety is back.

[@danishofficial9529]

One of the ignorant and selfish doctor prescribed me venlafaxine and mirtex 2 times a day and i refused to take it and to cope up my GAD and depression i am hving ayurveda medicines and its working great and if some of you want to know the name of that ayurveda medicine please reply.

[@maemaetru7731]

I would love to know what is working for you

[@danishofficial9529]

@@maemaetru7731 what problem you are facing ?

[@saurabhpruthi29]

please tell name

[@subbareddysanaga2528]

👍

[@LevelheadedMind]

Thanks for watching.

[@subbareddysanaga2528]

@@LevelheadedMind please make video about dapaxitine

[@chastityrenee4682]

Got to love how the insurance doesn't want to cover lower doses of Effexor.

[@bonnie3937]

Effexor XR works best for me. I have been on just about every antidepressant and found Effexor XR at 75mg to be the most helpful. I also take Lamictal XR 200mg daily. Everybody reacts differently. I have had horrible withdrawal symptoms from Cymbalta, Paxil as well as Effexor. But, I will most likely stay on Effexor since it has helped the best.

[@KiwikimNZ]

That’s fantastic I’m So pleased that you have something that is finally helping you. Good luck :)

[@dirasadirasa2499]

How did u fix the side effect of Effexor sexual effect was bad ?

[@isaacjacobs4397]

I am on the same dose, 75mg. I went from living on a benefit to working as a painter which is what I want to do, also moved cities... I take 75mg of quetiapine at night to help me sleep also. I have been diagnosed with major depression and anxiety, I have been trying to be diagnosed for add or adhd but it's hard to see a specialist. Apparently Enlafax xr is prescribed off-label for ADHD. Ive tried so many antidepressants that didn't work and I think that is because my depression and anxiety is caused by add or adhd

[@mohunrosida4078]

Good how many day this medecin work my docteur give me medecin

[@videogazer801]

Wait a minute, so, is there an actual difference between Effexor and Effexor XR?

[@jeffhucle6436]

Wrong. I took Effexor in 1997 for almost a year. It made me fat

[@lizmaurer3830]

Who is your audience? Not general users. Too much jargon. Not helpful.

[@Iliketurtlezz]

why dont you stfu. She does an excellent job at explaining. Go back to school.

[@shirleyvigus8938]

Please stop excessive hand movements so annoying and unnecessary

[@warnerbasement1628]

Effexor was nightmarish in its withdrawals. Just terrible.

[@_b_u_l_l_s_h_a_r_k_]

The only thing that was worse than the withdrawals was being on it for me. Literally the worst drug I’ve ever been on.

[@amenhotep7704]

How was it ? And are you still on it ?

[@warnerbasement1628]

Terrible. I'd eat the ass end of a mule before I'd ever take Effexor again.

[@dniceddv]

Can Effexor cause hair thinning/slow hair growth? My hair is really thick and grows very fast after a haircut. No long the case after being on Effexor/dextroamphetamine

[@Kalley_Kavia]

What do you think of the growing problem of PSSD?

[@LevelheadedMind]

Definitely an unfortunate circumstance. As I understand it can even be permanent for some.

[@ryanBAMF95]

Hello I’m 28 years old male looking for help with treatment resistant depression. Was on Zoloft for 12 years. Got to the highest dose. Eventually stopped working for me so I switched to Prozac and am now at the full dose. I don’t feel like it’s helping with the depression either. I was also prescribed Wellbutrin and it has helped a lot with motivation and energy levels. I also was recently prescribed seroquel to help as and adjunct with my other meds but haven’t noticed a difference. Was on abilify before seroquel for a couple weeks and it did stop my crying spells but gave me horrible akethesia so I switched to seroquel. My doctor is now recommending I switch from Prozac to Effexor and increase my Wellbutrin. What do you think about this? (Side note I’m also on trazodone for sleep and klonopin for anxiety but am tapering off klonopin for obvious reasons)

[@LevelheadedMind]

Sounds like too many medications! Please get a thorough work up done and look for root causes as I discuss in this video kzbin.info/www/bejne/joOlo2ymerChrpI

[@tyrel-fg7zf]

​@@LevelheadedMindI chosee weed

[@janazimmerman5917]

I was on Effexor first, I gained 40lb on it.. now I’m on Pristiq and I have lost all the weight o gained due to other stuff but Pristiq works for me much better than Effexor. But the withdrawal form Pristiq is much worse and happens if I miss 1 day!!!