Elaine Ostrander (NIH) 1: Canine Genetics: Dog Genes Tell Surprising Tales

www.ibiology.org/genetics-and...
Elaine Ostrander provides an overview of canine genetics, and explains how scientists are using genetics to decipher the molecular basis of different traits such as height and cancer risk.
Talk Overview:
Although all domestic dogs belong to the same species, different breeds display unique morphological traits and different disease susceptibility. Dr. Elaine Ostrander provides an overview of canine genetics, and explains how scientists are using genetics to decipher the molecular basis of different traits such as height and cancer risk.
In her second lecture, Ostrander explains that canine genetics can be used to understand disease susceptibility and cancer risk. By analyzing the pedigree of dogs, her laboratory identified a series of genes involved in the elevated cancer risk of particular dog breeds. Specifically, her laboratory studied invasive transitional cell carcinoma of the bladder, a disease for which breeds like Scottish Terriers have a high susceptibility. In human cases of this disease, the cause is unknown in 50% of patients. Ostrander’s laboratory identified genetic mutations that explain the elevated cancer risk in these dogs. This information may improve diagnosis and targeted therapy in dogs and humans.
Speaker Biography:
Dr. Elaine Ostrander is the Chief and Distinguished Investigator at the National Human Genome Research Institute at the National Institutes of Health (NIH). She received her B.S. degree from the University of Washington (1981), and her Ph.D. from the Oregon Health & Science University (1987). Ostrander continued her postdoctoral training at Harvard University. A few years later, she joined the Lawrence Berkeley National Labs at University of California, Berkeley, where she began the canine genome project. In 2004, she joined the NIH and her laboratory studies the domestic dog as a model organism to understand the heritability of traits and disease susceptibility. For her scientific contributions, she was named NIH Distinguished Investigator (2011). Visit her lab website and learn more about Ostrander’s research:
www.genome.gov/12513335

[@uorya]

I love how you talk with your hands, it really helps me stay comfortable because I constantly want to move while studying 😅 god bless ❤😂

[@boredwarlock5216]

Really great speaker. I love how she says, "This is a busy slide," that really helps ease you into it. Fantastic work, and so interesting! Thank you.

[@rottenwings]

Thank you so much for putting these online! Interesting stuff

[@kimberlyr2289]

I did wisdom panel for two of my three dogs (third is without adult a Manchester terrier). I love that these lectures exist explaining the science behind it.

[@richardhawkins3636]

Good clear and rewarding presentation. History inaccuracy: the Irish wolfhound was recreated in the 1880s and 1890s!

[@cartelbullies8847]

My wife and I are dog breeders and this video was extremely informative. Thank you!

[@amandajs971]

Incredible research being done by this team!

[@therealtttjt]

Really helped me on my school project thanks!!!

[@dwilliams9801]

I wish you would do a video on Haplotype sharing to figure out what went into making the Rottweiler we know of today . That breed origin is still a mystery

[@alr293]

I’m so fascinated by how the body size genes express differently from dogs to humans.

[@detergodtatvide]

Great and very informative! Can you tell which breed has the biggest variation in alleles?

[@danbolser5913]

Where is part 2! Great talk!

[@walkswags8471]

Really great information, explains so much ! Do you have any data on the Bali Dog? The Bali dog is the one Im most interested in which I have read goes back 5000 years. I was wondering if you have any genetic studys that have been done on this Dog? Thank you so much !

[@1972laushu]

How do I get my dogs in on this study. I'm a trainer with 30yrs experience and I also compete in multiple sports with my dogs

[@janettemartin4604]

AWESOME! Is there a similar video explaining color genes? Standard Poodle to be exact?

[@moonoggin]

Where is the sheepdog?

[@jaredleicht1656]

Most bloodlines went to shit when people started breeding based off mathematical equations. Breeding is an art. And anyone who uses equations to pick a pair of animals to breed doesn't have the eye for breeding and shouldn't be a breeder.

[@beanerschnitzel794]

Why do dogs have the same genes from hyenas wild boars and wolves

[@CarterColeisInfamous]

tales lol

[@KellyIHolly]

This video is informative! I've been trying to research for KZbin vid similar to yours that really educates the stuff in this video! 🧑🏻‍⚕️ 🧑🏻‍⚕️Your tip for sure is like the videos of Dr Ethan. Dr's tips are educational and I really learned a lot for my diet! He is the helpful medical student in Nottingham and he teaches health symptoms and conditions. Go check out his KZbin out and give Dr Ethan a like! ➡️ #DoctorEthan

[@ajdaames]

I would to see a genetic profile of the Boerboel. The Boston terrier's history is now proven to be false. This takes all the fairy tale stories out of dog breeds. I've been waiting for this for decades.