Elizabeth Blackburn (UCSF) Part 3: Stress, Telomeres and Telomerase in Humans

www.ibiology.org/genetics-and...
Telomerase, a specialized ribonucleprotein reverse transcriptase, is important for long-term eukaryotic cell proliferation and genomic stability, because it replenishes the DNA at telomeres. Thus depending on cell type telomerase partially or completely (depending on cell type) counteracts the progressive shortening of telomeres that otherwise occurs. Telomerase is highly active in many human malignancies, and a potential target for anti-cancer approaches. Furthermore, recent collaborative studies have shown the relationship between accelerated telomere shortening and life stress and that low telomerase levels are associated with six prominent risk factors for cardiovascular disease.

[@grigoriinos7048]

This genius lady got Nobel prize for discovery of telomarase, by the way

[@theinterfaithshepherd9075]

excellent video - thank you for taking the time to make it!

[@sagarak999]

What an amazing presentation! I also thought of an anology for telomeres as a pair of running shoes! The more you use them, the more they wear down. Also, you must have a pair of matching shoes, otherwise you'll still have problems!

[@tonyrabone4668]

Thank you for a great series of presentations.

[@kazbekdzhanibekov9154]

Thanks a lot, Elizabeth, great!

[@unknownchannel3141]

Thank you for posting this.

[@AnabellaVidaSana]

I'm impress , its so important to know that we can change our telomeres doing good changes in our style life.

[@rk19902005]

i suggest that when the cell turns to a cancer cell, telomerase activity increases massively... but while beeing a "normal" cell that gets in contact with a lot tabacco, its matabolism is very low so it will not replicate very often and telomerase activity is down like in most of somatic cells ..

[@giuseppespagnolo370]

Telomerase, a specialized ribonucleprotein reverse transcriptase, is important for long-term eukaryotic cell proliferation and genomic stability, because it replenishes the DNA at telomeres. Thus depending on cell type telomerase partially or completely (depending on cell type) counteracts the progressive shortening of telomeres that otherwise occurs. Telomerase is highly active in many human malignancies, and a potential target for anti-cancer approaches. Furthermore, recent collaborative studies have shown the relationship between accelerated telomere shortening and life stress and that low telomerase levels are associated with six prominent risk factors for cardiovascular disease.

[@jamiameliadior9129]

Wonderful woman . She's Australian like me . I use TA 65 , works wonders for me

[@ki1188ki]

早くこのことを世界に伝えて欲しいですね。

[@joemartinez7771]

Thanks

[@Lex3n]

How does Telomerase get produced or what activates telomerase? It's a question for my paper, but I don't find anything about the production of Telomerase or the steps of activastion of it. Somebody can help me?

[@RandomNooby]

Thankyou

[@TheLoserKingdom]

Well, it is an enzyme; a protein. So I might imagine that is is produces by genes during protein synthesis. Don't take my word on it, I'm still a student.

[@kipling1957]

There must be a selective force that selects against high levels of telomerase expression in adult somatic cells (given its protective role in genomic stability and against disease), perhaps because the telomerase genes are pleiotropic in nature. This conundrum is never addressed. Also, why is telomerase expression correlated with higher chronic stress levels when the opposite might be expected given potential injurious impacts (ROS, inflammatory cytokines, increased maintenance, and renewal) of stress at the cellular level?

[@greatreset667]

Some ppl say covid VA damage permanently your telomerases. Induicing premature death. let's see.

[@2008pmx]

Hmm! if smokers have very low telomerase activity then how do they end up with lung cancer?!? Interesting!

[@delyanasyarova4016]

So basically one can be cancer prone if the telomeres are too short or way too long?? Im noticing a lot of this has to do with the bone marrow

[@robynhope219]

Yes, prone to all diseases of aging...

[@annettewilkinson5224]

So, my mum was 82 and my dad was 76, would that mean I would be 79 when I pass away?.

[@TheEnsakz]

nope

[@sidmichael1158]

How do we increase telomere lengths?

[@jararacavoadora5868]

Read her book

[@jararacavoadora5868]

she shows various strategies for that

[@robynhope219]

Healthy living...read The Telomere Effect.

[@powerlocri]

Alla luce di queste considerazioni, il governo deve riconsiderare l'età pensionabile dei caregiver familiari, riconoscere tale attività come lavoro usurante.

[@georgeconstantinescu688]

near future treatment of cancerous cells

[@rogerscottcathey]

120 year old Brazilian said cigars, ciggs, coffee, booze and being happily married (wife doesnt nag, haha!) all contributed to his easy going, enjoyable long life . . .

[@robynhope219]

I have the book, which I am reading for the third time...very depressing! Made me realize how unfortunate the human race really is. Our telomere health hinges on genes and environment...both out of our control. God forbid you're born with hypersensitivity bc your telomeres are short or shorter. And if you think your thoughts are inconsequential, forget about it...negative thinking results in shorter telomeres. am old now with severe fatigue due to chronic stress and childhood adversity. Not much wiggle room for improvement. Wish me luck!

[@imanhamad7707]

123

[@AndresFriday]

No Annette Is not a kind of formula; your specting of life depends, yes in teh genetics, but in your environment/life factors too

[@JamiesonJKTV]

Check the anatomy of a lobster.

[@johnreidy9960]

Amen Just made a reservation at my local Red Lobster...I feel better (older) already!