Robert Tjian (Berkeley/HHMI) Part 1: Gene regulation: An introduction

www.ibiology.org/genetics-and...
Transcription, the conversion of DNA to RNA, is one of the most fundamental processes in cell biology. However, only about 3% of our total DNA encodes genes to be transcribed. RNA polymerase II, the enzyme that transcribes DNA to RNA, relies on a large set of proteins known as transcription factors to recognize the coding sequences and to transcribe the correct genes, in the correct cell type, at the correct time. In Part 1 of his lecture, Tjian gives an overview of the complex and critical role that transcription factors play in regulating gene expression.
How do different cells from the same organism, such as muscle cells, neurons and red blood cells, all of which have identical DNA, have such different phenotypes? Tjian addresses this question in his second lecture, where he expands on the mechanisms of gene regulation.

[@hamidkiangaikani]

This is one of the best iBiology lectures ever. Sometimes, it is so hard to imagine how accumulating a bunch of proteins "on the promoter" can help RNA polymerase start transcription at the gene coding sequence. But he shows all the steps using models, reminding us that all the steps are happening in 3D space and not linear DNA. Thanks for this. Amazing stuff!

[@thorfriis6284]

I read stacks of Robert Tjian's papers from the early 1980s when researching the promoter region my favorite gene for my PhD. He's not exaggerating when he says that gene transcription is complex and that we still don't fully understand...well I certainly don't. What a pleasant surprise to find these informative videos with a man whose work I greatly admire.

[@IScreenshotNFTs]

Is your PhD thesis done?

[@MonquiJulia]

Excellent lecture! You are a very good teacher. Thank you!

[@StewartChaimson]

Excellent lecture, thank you very much for producing it for us!

[@madhabimadhusmita9377]

Best lecture series

[@TrungDuongCMU]

Thanks a lot for a very informative but easy-to-understand lecture!

[@martinbakht2214]

Than you Professor Tjian. Particularly, I enjoyed watching the carton about transcription.

[@oliverdave8532]

Very clear and informative! Thanks for helping me with my molecular biology course lol.

[@brentweissert6524]

an excellent presentation. thank you so much.

[@partypao]

This is so......Awesome. I want to know more about this!!

[@NarutoUzumaki-qf3lw]

Thanks IBiology You are my HERO

[@1Shoda]

Very informative, thank you going to tell my friends so they so can pass and be informed about genes! :)

[@dizcorral6430]

Thank you

[@Krisangel23GodlessTv]

This video is related in part to the theoretical work of Richard Dawkins? Genes are the fundamental unit of evolution. It would be good to make a conference where to explain the work of William Donald Hamilton and Richard Dawkins and the impact of the gene centred view of evolution.

[@mahmudulhasan2922]

Love ibiology.

[@austinunterbrink9805]

Awesome!!!

[@user-nl7uq2hc8s]

thanks for subs!

[@lulusanchezcabral2382]

and motifs?

[@lanaadileh6559]

domain

[@karensofiasisa3019]

wow

[@engdanielle]

Go bears!

[@Maxarex]

who wants to play some among us?

[@jshssh8930]

Lol and they say there is no god wow