Cisplatin Part 3

[@Mtijn1988]

I think Cisplatin is able to produce interstrand crosslinks.

[@b.alyousef1362]

+Martijn van der Heijden he didn't say it's not possible but he said it's just very rare

[@Jude_Ifechukwu]

Thank you

[@bungeegum9286]

Thank you, you're a genius! I'm watching all your videos on cisplatin right now. I'm only in high school but you're so good at explaining + drawing, so I can understand it. One thing I don't understand, though: why does cisplatin form covalent bonds to two guanine instead of just one? I mean the N7-nitrogen in each guanine has two free electrons, so I'd assume that it could share it's last electron with cisplatin, as well, instead of letting another guanine 'steal it'. Is there not enough room for cisplatin to bind to only one guanine or is it something else?

[@noha1878]

Yes, you're right. In this video, he only explained bifunctional adducts where cisplatin bind to two purine bases. However, cisplatin can form a monofunctional adduct where it is conjugated to one base only.

[@bungeegum9286]

@@noha1878 Ahh okay thanks

[@aravindr4806]

what are other 13% intrastrand cross linkings?

[@samsonyonathan5246]

doesnt water displace the chloride atoms once the complex enters the cell

[@SuperRahul1122]

why doesnt the other N of imidazole ring bond with platinum.....it also has a lone pair

[@b.alyousef1362]

the formula of cis-platin is Pt(NH3)2Cl2 not Pt(NH2)Cl2 so I guess u made a mistake at the beginning

[@finno-px6of]

I love you