Elucidation of oxygen sensing pathways in human and animal cells // Peter Ratcliffe

Peter Ratcliffe is a physician scientist who trained in medicine at Gonville and Caius College, Cambridge and St. Bartholomew's Hospital, London, before moving to Oxford to specialise in renal medicine.
After studying the physiology of renal circulation, he became interested in the regulation of the haematopoietic growth factor erythropoietin, which is produced by the kidneys in response to reduced blood oxygen availability, and in 1989, he set up the Hypoxia Biology Laboratory at Oxford.
His work on oxygen sensing has won a number of awards including the Louis-Jeantet Prize in Medicine, the Canada Gairdner International Award, and the Lasker Award for Basic Biomedical Research.
Peter was elected to the Fellowship of the Royal Society and to the Academy of Medical Sciences in 2002. He is a member of EMBO and a foreign honorary member of the American Academy of Arts and Sciences.
He was knighted for services to medicine in the New Year's Honours, 2014.
In 2004, he was appointed Nuffield Professor of Clinical Medicine at the University of Oxford and served as Head of the Nuffield Department of Clinical Medicine from 2004-2016.
In May 2016 he was appointed Director of Clinical Research at the Francis Crick Institute, retaining a position at Oxford as member of the Ludwig Institute of Cancer Research and Director of Oxford's Target Discovery Institute.

[@jasonmcgee4502]

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[@janethrees9907]

Oxygen is toxic and not present in nature. It is a man made product derived from air. To make ‘oxygen’ air is compressed and dried repeatedly before being contained as ‘oxygen’ the product. Oxygen is super dry and once released it will remove water from its surroundings. In industry it is introduced to kilns to become incorporated into alloy matrices to prevent corrosion by moisture because water acts to undo manufacturing. Oxygen sensors like the finger infra red light clips are measuring blood hydration and reflect the cell’s 4th phase of water absorption of light. You know the RBCs change shape depending on how much water they are carrying. Venous RBC’s will be darker because they are denser. Red blood cells carry water to the tissues not oxygen. Lungs require air to be at 100% humidity. The alveoli remove water from the air and transfer it to the RBCs and plasma. The alveoli use bubble tech to harvest water from air and expel water vapour carrying metabolic waste (The acoustic bubble by Tim Leighton) lung sounds are from bubbles facilitated by the alveoli and their surfactant. This is why at altitude where the air is cold and dry and at a lower pressure it is harder for the lungs to extract moisture. Hyperbaric pressure increases water extraction from air. The Wim Hof method of breathing utilises hyperbaric stacking and novices can hold their breath with ease for 2-3 mins. Alveoli exposure to oxygen results in their collapse. This is because it dehydrates them. Look at the effects of oxygen toxicity. 90% of people anaesthetised and exposed to oxygen will have alveoli collapse. The kidneys regulate water pressure, circulatory pressure and body pressure in sync with the lungs. The diaphragm and lungs create the vacuum for venous return and provide the pressure behind the heart’s release to the arteries. The heart chambers acting more like regulatory valves. Gerald Pollack, the 4th phase of water has shown cells use water to create potential currents and do work with this energy. Water requires infrared light to become energised. Water is an element and not H2O. 100 reasons water is not H2O free eBook www.smashwords.com/books/view/930017 This misdirect has retarded science and medicine. Orchestrated at the time of Lavoisier, Cavendish and Watt. Discovering water by David Philip Miller Water doesn’t react with anything. It carries and accommodates like a colloid. Water could never cycle otherwise, it would have been bound up long ago. Water and air are the same element in different states. Water energised with heat or under a vacuum (decreases pressure) gives rise to bubbles. Bubbles transit water to air. Air is responsive to pressure and temperature - it can release water or pick it up. Nitrogen gas is also a man made product. Produced the same as oxygen but at the end nitrogen is added in required concentrations. Plants do not produce oxygen or extract nitrogen from the air via root nodules. Instead they utilise water and air and minerals from the ground.

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