3.5 Keys to Improving Mitochondrial Health

[@Physionic]

Here is the first video in this series: kzbin.info/www/bejne/h4mcoGZ9lKxsibs

[@PPP-on3vl]

FASTING

[@ellie698]

Excellent! Looking forward to that. I found this video really useful. I have MS and notice that when life is working well so that I feel more positive, I do feel much better. It's nice to see that there's information and data that shows reasons why. It gives me ideas of how to incorporate more good things into my life, little and often and the motivation to do so.

[@SkyRiver1]

No interest in E5? Amazing. . .

[@melvillejayathissa7415]

What about supplements to boost mitochondrial health?

[@littlevoice_11]

And this is exactly why I haven't owed a TV in years! (And don't even miss it). Thank you 🙏 Educating entertainment the Physionics way 😊

[@dfung4351]

1. Exercise. Both strength training and cardio will help. 2. Fasting (Depends on your diet. All about maintaining 'healthy weight') 3. Be Disciplined about Staying Positive and Express Gratitude. Especially at Night.

[@immers2410]

Strength training doesn’t really move the needle on this, steady state cardio however is very effective. Read Inigo San-Millan

[@johnlakey4983]

Well written

[@aaaaaa-aaaaaaaaaaaaaaa]

which brand and how much does it cost?

[@henrymakumbi7753]

767

[@EVanDoren]

Red light

[@roqclimber]

In the evening, my Kitty sits in my lap and purrs, in order to sooth my Mitochondria. Very intuitive animal.

[@helenahandkart1857]

Cats are tremendously helpful in this way, bless'em!😸

[@nevinkuser9892]

Give that cat a treat

[@Peekaboo-Kitty]

Mitochondrions love Kitties!

[@emgregory528]

Nice

[@salleone6387]

I just want to share a book from 2010 by Dr. Terry Wahls who reversed her MS to a great degree by concentrating on the health of her mitochondria as the primary focus: 'Minding My Mitochondria'. Its great that researchers are finally catching up after 14 years.

[@SK-jf7dq]

Thanks for the referral!

[@mjinba07]

One of the best and easiest ways to improve mood before bedtime is making a gratitude list - things you're grateful for, whether from that day or further in the past - doesn't matter when. Also doesn't matter whether the list is written or just in your head. The key is lingering in a moment of gratitude. Surprising how many people find it difficult to do at first. It gets way easier with practice, until it's possible to get that warm feeling even when you've had a crap day.

[@babyboltbark]

FO.

[@yfa6244]

@@babyboltbark What is that short for?

[@TaraMae212]

The mood-feeling-mitochondrial relationship makes so much sense! Bruce Lipton talks about this is his studies of cell-environment relationships.

[@KenshinPhoenix]

Bruce Lipton is incredible, I first found him many years ago on a Food Matters or Gerson documentary, not sure now. Resonance is a fundamental force of our reality, intangible but undeniably powerful.

[@eastcoastkickz4891]

Sleep good, eat better , fast for 12H every day. Lift some weights and move.

[@User0resU-1]

Stay calm and carry on.

[@Bully-mu1su]

Eat plants also or carnivore?

[@eastcoastkickz4891]

@@Bully-mu1su plants too. Get carbs from plants. Like potatoes , sweet potatoes , etc.

[@nevinkuser9892]

Only ever eat fermented vegetables not starch.​@@Bully-mu1su

[@billa.2940]

Meat and vegetables are all you need to improve your health. If you don't like veggies, try saurkraut.

[@heyyou9839]

The issue with PhD scientists is that they take their laboratory subject “mitochondria” and study and make recommendations outside of the rest of the body. If you eat in a way that is a calorie deficit, with many anti-inflammatory compounds, and increase fasting window PLUS move more PLUS sleep enough - that will help a raft of different processes such as hormonal responses to food, your body composition, and your stress pathways, which will sure probably have flow on effects to intercellular organelles including mitochondria. The constructs that focus on one particular aspect of the body are spurious

[@sallyweiner4180]

My long covid has given me post exercise flat out exhaustion that can last weeks to months. Infrared light therapy, eating right, water, gratitude, community, anti depressants, doing things I love to do that I can physically do and for me this is painting and getting outside is what is slowly helping me. I am trying to get my mitochondria to heal and increase. AND I’ve detached from the news.

[@Bait1official]

Ray peat baby! Forget low carb. The mitochondria LOVE glucose. The issue never was sugar, if it was our ancestors wouldn’t have sought out honey and fruit. The issue is a mitochondrial one! fix them, fix your disease. ;) Go high carb low low fat. Not forever, for now. We wanna get the body metabolising sugar instead of fat and turn your body in to an energy producing machine so it can heal itself. Kick out PUFAS too.

[@jmc8076]

@18:15 This admission alone sets you apart from others on YT and why you’re growing. Humility and curiosity make the best researchers and scientists. Thx Nic!

[@Physionic]

That I'm a murderer? ;-P Thanks, JMC. Trust me, I never forget I have much to learn.

[@jmc8076]

Oops, well compliment still applies but not that you don’t already have a lot to teach and share. ✌️

[@gabriellew6467]

Most subscribers will probably agree with abc - but let me add that apart from informing intelligently and discussing knowledgably, you do it with the most delightful touch of humour. You are to serious information what yeast is to bread - making it lighter and more palatable 😊

[@karenf9137]

Great analogy.

[@Physionic]

That's really kind of you, Garbielle. Thank you.

[@HazardousHumorHQ]

Good work sir. A key takeaway from a latter part of the video, re: sleep, stress, mitochondria...for ⬆️ A.M. ENERGY, optimize stress PRIOR to sleep! Work towards consistently better mental mood prior to sleep time! Makes sense...emotionally better state during sleep onset --> more PNS-activated state during sleep onset --> positive neuro-emotive inertia starting out--> momentum carries through subsequent sleep cycles to some extent, perhaps facilitating (for example) better dreams and so on. Anyway, I'm sure findings in the field of psychoneuroimmunology would agree! Keep it up Physionic, and let's all take care of our emotional, cognitive and overall mental health and resilience, folks!

[@abc_cba]

I use your content these days to make my health tips notebook. Thanks for the immense amount of research you compile.

[@Physionic]

That's awesome, abc. I'm really glad.

[@abc_cba]

@@Physionic best wishes from now rainy India heading towards autumn soon 🇮🇳 And my name is Sam.

[@Physionic]

Autumn here, too, Sam. :)

[@vawiley4]

I’ve had a shift in focus: Instead of focusing exclusively on how to lose weight, I’m learning how to improve my mitochondrial function I think that focusing on these practices will improve my overall health and the result will likely be multifactorial

[@donwinston]

Your mitochondria will take care of themselves with regular exercise and a healthy calorie restricted diet.

[@r-type4945]

Same here. According to Robert Lustig mitochondrial disfunction is the main factor behind insulin resistance. Although there's a strong overlap and interplay, managing weight or blood glucose feels more like treating symptoms than causes.

[@MM-qp4pd]

👍

[@casta9172]

Thanks for this information ❤ I'm battling cancer and I need to know more about mitochondria

[@rahvastepaabel]

Study cancer metabolic treatment options, youre mind will be blown

[@bunsw2070]

Look into the Joe Tippin's Protocol. I don't know if it works but it sounds like it has real promise.

[@kristinerendulic5501]

Check out TED Talks. Eat 3 cups of vegetables a day

[@LK-pc4sq]

What has been your diet for the last 20 years? AVOID bread, carbohydrates and go vegan!

[@tobiasgarrard9271]

It's amazing people like you that make a difference with us humans. Thanks for being a great one. Keep studying and sharing⭐

[@07.buddhi]

Nicolas, please make a video about supplements that really help with mitochondrial health! Such as Q10 as an electron transporter and other interesting things 🙌🏻 Maybe about cellular respiration and overall more basic bioenergetics stuff 🤓 BTW like your work a lot! Keep it going! 🙏🏻

[@teddybearroosevelt1847]

Here are a few more: pqq, d-ribose, creatine, alpha lipoic acid, cumin seeds (you need to grind them or chew on them to have a chemical released that I would have to look up but that supports the mitochondria)

[@melvillejayathissa7415]

Also the UBIQUINOL supplemental form of CoQ10 as well, for adults over 30 years of age! Melville from sunny Malaysia

[@zahram4473]

Can you please share supplement names and brands?

[@martinlang9615]

@@bejul2yes, please mention brands as I too suffer chronic fatigue

[@HRVHackers]

Bejul mentioned peptides that help cfs

[@abdelilahbenahmed4350]

Thx Physionic for this another great video. May I ask you what are your thoughts on the impact of metformin on the mitochodria. Some people say it's a mitochondrial poison, but a pretty large number of studies indicate that it increases mitochondrial biogenesis. Other researchers say that even if metformin impacts the mitochondria negatively (but slightly) it's actually a good thing because it triggers the mechanism of hormesis in the body. Excited to see how you could clarify even a litte bit this complex topic.

[@billtrudell1636]

Martin is a great guy I've learned so much from him.

[@ThomasAT86]

Dealing with severe ME/CFS, these things sadly didn't do anything and that's true for almost everybody with this illness. I hope there's WAY more research coming out in this regard. Desperate to not lose another decade.

[@Mrskess]

Have you tried methylene blue? It’s helps to generate energy in mitochondria cells. Also just now I’m looking into Q10, Ive seems people say they’ve been taking it and it helped them.

[@paulmarijnus5136]

​@@Mrskess I have long covid and Methyleen bleu first gives me energy but makes me crash later

[@reggie5]

10:51 very interesting, particularly what you said about mitochondria downsizing in response to a nutrient overload. I've heard people say to continue your supplement regime during fasting - but maybe it would be more beneficial to discontinue the supplements during a 24/48 hour fast to freak the mitochondria out a bit more? rather than keeping them relatively comfortable despite the lack of food intake.

[@flcps]

That's what I do in my weekly 48 fast. Nothing besides water, black coffee and a bit of water kefir

[@rookhoatzin]

A positive attitude improves your biological function. We know that intuitively but I love to hear it from a scientist in the know....

[@salvadoroliveira6632]

Conventional agriculture usually uses fertilizers that contain N, P and K; the continuous maintenance of crops deplete soils and the fact that nobody. " makes number 2 " out of a toilet, prevents the recycling of minerals on soils. Is magnesium added to commercial fertilizers? Many enzymes cannot work without enough magnesium intake.

[@nieczerwony]

Well this is the charm of industrial farming which is more and more spread and supported by politicians worldwide.

[@DesertDog8989]

and many who take magnesium don't check their copper; this balance is critical ❤

[@nieczerwony]

@@DesertDog8989 I know people who take 30 mg or more zinc a day (as they heard that zinc= better immune system), and they don't even care about taking copper and selenium. So yeah I don't expect them to do the same for magnesium

[@salvadoroliveira6632]

@@DesertDog8989 Does the ingestion of magnesium affect the level of copper in the body? Or do you mean that people should also check for the level of cooper? Thanks.

[@littlevoice_11]

I wonder how issues such as chronic digestive issues such as IBS, SIBO, leaky gut etc impact mitochondrial health. I am aware these can impact mental health through the gut brain axis.

[@MarcoBrianza]

Hi, great content as usual. I just watched it during my 20 min morning bike (fasting) exercise to start the day and apparently to multiply my mitochondria. I constantly stumble upon the effect of red/infrared light on the cell even on energy production. Is it something you plan to cover in the future?

[@Chaotic313]

The interweaving of science and humor in your content is sublime. More? Yes please. ❤

[@Physionic]

Deal!

[@dchildr360diurnalnutrition]

I greatly appreciate what you’re doing. You provide a valuable resource to those of us wishing to learn more.

[@gaiacielo5090]

Yes this should go out to more people! Been following people talking about mitochondria health! Thank you good sure 👌🏾 😊

[@rosaflorpuig3971]

Looking forward to your “senolytics” video. Please include “Qualia Senolytics” contentions that their 2-day regimen actually cleans out zombie cells. Thank you.

[@sheradenart7907]

Oxytocin is connected to mitochondria, it helps balance the need for iron in electron transport and OXPHOS. So it makes alot of sense that happiness would be connected to mitochondrial health.

[@Appleblade]

Fred Hatfield's book, Bodybuilding: A Scientific Approach, had a section claiming (and citing studies, if I remember right) that mitochondria increase mainly when you stress muscles with 20+ slow reps... 90+ seconds of continuous tension... IOW, anaerobically (sarcoplasmic reticulum increases with 10-12 reps, actin & myocin increase with 4-6 reps). Has this information been lost among researchers? Was it speculative? IDK

[@Johnnysday]

You offer tremendous service to that greater body of knowledge.

[@pip5461]

Could you put your analytical expertise into the study of Tinnitus...?

[@sncnutrition7118]

Yes!!

[@pip5461]

Thank you...@@sncnutrition7118

[@drunvert]

👍

[@markchamberlain2865]

As soon as you say tinnitus, I hear mine... again 🎉

[@Cat-ht7ki]

Relates to insulin resistance if you dig into it

[@Resist.Tyranny]

Avoiding poisons and toxic substances may not be revolutionary, but someone understanding how prevalent these harmful substances are, and actually avoiding them is very rare. When umbilical blood was tested for toxins from many mothers births, OVER 200 chemical toxins were found.

[@littlevoice_11]

Id love to hear more about mitochondria in relation to MS and post viral fatigue or fibromyalgia

[@teddybearroosevelt1847]

Mitochondria play a role in almost every disease, as they do much more than just provide the body with energy

[@mike7920]

Alex Howard in his book Decode Your Fatigue goes into depth on this

[@MadisonPaige]

I take cardiovascular research brand magnesium taurate. I take 4 tabs a day which is 125mgx4 of magnesium. I also supplement separate taurine at 1g. Definitely beneficial.

[@Bepartofthepanacea]

Amazing work and explanation 👏 thanks ❤️

[@H4KnSL4K]

Thanks for highlighting details of our incredible design!

[@joyolsen2456]

Great presentation, love your enthusiasm and sense of humor.

[@a_bar8579]

We wish to translate this teacher's channel so that all languages can benefit from it.

[@michaelstreeter3125]

15:37 There's a book, Kahneman, D. (2011) *Thinking, fast and slow.* 2nd edn. New York: Farrar, Straus and Giroux. where he says question order is super important; if you ask (1) how happy do you feel? then (2) do you have a girlfriend/boyfriend at the moment? you get _completely_ different scores compared to asking the same questions the other way around. Because "do you have a girlfriend/boyfriend?" gets the subject thinking and sets them up for the next question.

[@SquatFull]

Thanks for the information on the mitochondria and the references to the studies.

[@AnneAlready]

Thanks for featuring Martin Picard and breaking down and expanding on some of his insights. Great video.

[@TsuchiuraBob]

Just a peripheral comment on the importance of neuromuscular junction (NMJ) maintenance in enabling exercise. An NMJ is the synapse between motor neuron and muscle fiber. There are genetic diseases as well as inevitable aging that cause the motor neuron to die back, causing fewer muscle fibres to fire, in turn weakening the muscle. Much remains unknown about this process that leads to sarcopenia (muscle weakness in the aged), but it would come as no surprise to me if mitochondrial health turns out to be one of the players in this process, possibly setting off a vicious cycle of weakness discouraging exercise, in turn leading to more die-back of motor neurons.

[@PaulHigginbothamSr]

Just let me say when younger my night vision was not as good as it is now. For 3 months I have been taking a supplement of taurine. I am taking 1,000 mg and have experimented with 2,000 mg on an occasion where I wished to check my night vision and it was reduced by doubling the dose. Before taking taurine at all I could see down the path 1/2 mile clearly. After taking taurine it was like everything was shut off beyond my bikes headlight beam. I could see all the way to the end of the walk clearly before taking taurine. What makes me wonder is my natural level of taurine being higher when younger reduced my night vision. I am seriously considering stopping my use of this supplement. I wish I knew the chemical reason for this reduction. I walk my dog early before light in the morning and have heard curious things in the dark. I am now 75 and many blood components have reduced significantly as I age further but night vision increase was not expected.

[@helenahandkart1857]

Very interesting.. i've always had poor night vision, & it unexpectedly improved after about 18 months of drinking 300mls of cold vaccum pressed raw full cream Jersey milk, daily. I think it may possibly've been the extra bioavailable retinol.🤔

[@MichielMortier]

And what about the additional use of CoQ10? As often used extra with statins? Do you notice results right away?

[@mitchellgould2053]

Great video, as usual. Have you by chance looked into any of the work Cohbar is doing with mitochondrial peptides?

[@lostinversailles]

Aha! Suspense - more to come in part 2! What a science opera 😁

[@EduardQualls]

We understand that you're excited to share your info, but, In your videos consider waiting a second or so before you start talking. Some Bluetooth speakers have a "lag" before they produce sound, so the first moments of your presentation are lost. For example, in this video, the words "I've been" are lost, and the first word we hear is "working." (There's an "alert" signal sent first by the source device, to "wake up" the speakers before sound-production commences, the response to which some senders don't wait for, but start sending audio data immediately. So, data sent during the speakers' handling of the "wake up" command can be lost.)

[@krzychukula]

Your mood is causing mitochondria to be healthy or not. This seems like a big exaggeration to me. 1. We know there is small correlation. 2. But it’s much easier for me to imagine that whatever impact my mood can have impact on my body. Things like stress, getting sick (feeling unwell), vitamin deficiencies, bad sleep etc. I’m writing this because people often jump to „just feel happier” advice which helps no one.

[@thehealthofthematter1034]

Moving...then, why do people with ME/CFS experience severe aggravation of their symptoms when they try to do so? HMMM! Fascinating question.

[@sleeplessforawhile]

No magic for now... but as always... great job to giving us a real landscape about mit. Just one question, talking about how phisical activity could increat mit. account... is there any study about how "mental activity" could induce similar process about increaing mit. account but in neurons?. Thank you so much for sharing you work. PD. I´m quite interested on PQQ , do you have in mind to do any video about it?.

[@h0ph1p13]

Please make a video about salt (yes, NaCl). It's a very controversial topic. I read "The Salt Fix" and "Salt Your Way to Health" both present a very interesting picture. I wonder what's your take on salt in our diet and also salt as a supplement for endurance exercise and muscle strength.

[@ambrsanford3703]

I am actually retaining this stuff. Thanks, again!

[@claudiomicheli3863]

Is mitochondrial fission inherently bad for energy metabolism? Its function is to only dissipate the excess energy? Can the newly separated mitochondria grow in size to match the previous mitochondria after the fission?

[@TheEngadine]

I feel proud of promoting you, Nicolas and this, your channel in each and every antiaging forum I follow. Hope it helps you and your team to reach your goals in YT. Big Thank You. 🎉

[@Physionic]

Really kind of you. Thank you. :)

[@vajaindransramasamy4107]

Fascinating information. Thank you.

[@artjaazz1]

Hey, great content. Please make an analysis of molecular hydrogen!

[@surajitgoswami1871]

Independent of glucose is my conclusion too using a sample size of one. To redress then fasting may improve mitochondrial health in addition to reducing food overload. Thanks.

[@darin7369]

People often like to major in the things that have the most minor benefit. People would be doing very well to simply cut out most high glycemic carbs, avoid a sustained calorie surplus and get plenty of exercise (especially zone 2). As far as fasting...finish whatever project you're working on and take a late lunch or dinner on occasion. The point is just to get into a state of hunger once in awhile and let the body adapt to it.

[@andreac5152]

What you mean when you say that the mitochondria burns fuel in an inefficient way? Why does this produce oxidative stress? Aren't free radicals a normal byproduct of mitochondrial function? Why they go awry? Another thing that can cause mitochondrial damage is fluoroquinolone. Plenty of people like me who have very high oxidative stress and high blood lactate. What should we do to improve? Can you take a look at this and give us an hand please? If the mitochondria is already stressed we cannot exercise, not considering that many people cannot even walk.

[@sq5]

I have a question regarding ME/CFS and the negative effects of exercise on patients with the condition, in relation to mitachondria health, which is known to be affected in these patients. If exercise promotes good mitachondria health in a person without ME/CFS, what effect does it have on the mitachondria of ME/CFS patients, where exercise usually causes a worsening of the condition and can cause relapses that last for days, months, and years? Is diet/fasting alone enough of a way to promote good mitachondrial health in a patient who cannot exercise? I would appreciate any insight into this matter.

[@Bllackdog]

Im neither a MD nor a researcher in such a field. But maybe the capability of mitochondrial transcription or translation is in a manner affected that makes it hardly possible for the body to adapt, to the by exercise forced stress, in form of increasing the amount of mitochondria. Meanwhile existing mitochondria might lack under needed substrates to ensure proper balance in the equation of energy needed vs. energy used. Thus the overall burden of stressed mitochondria increases, since the lack of needed substrates, which already is responsible for the lack of needed energy, also leads to the incapability of a proper maintenance of the existing mitochondria. Maybe this will result in apoptosis? What actually also leads to a lower energy-production? But maybe that's completely wrong. Just like a said, im not a specialized person, just a curious & interested guy.

[@SkyRiver1]

I have CFS and have for decades. It forced me to optimize everything about my life so that I could do more than get out of bed to take a pee. After such optimization exercise became a positive element, and I suffer some relapse if I become too sedentary.

[@reggie5]

I am also thinking this is a good video for people grappling with ME/CFS. I guess as ever it is a very very gentle increase in movement over many months alongside diet optimisation that will ultimately help.

[@sq5]

​@@BllackdogFood for thought indeed. I appreciate the time and effort you put into your reply. Thank you.

[@sq5]

​@@SkyRiver1Really great to hear that exercise has become a positive thing for you, and how you went about making it so. Thank you for your reply. I hope today is a good day.

[@laurieanderson9290]

My health is outstanding with an alternate days fasting routine (eating 8 hours/ fasting 40 hours) .

[@salvadoroliveira6632]

Can tetracyclin affect human mitochondria?

[@jeno427]

Very informational video. Would you consider making a video about exercise adaptation and antioxidants? Ubiquinol is an antioxidant yet it increases mitochondrial biogenesis, which is seemingly contradictory. There is not much info on it other than the bro science avoid antioxidants a couple hours before and after exercise.

[@arthurdolle5257]

Very informative discussion with information I haven't seen anywhere else. Do you think keeping a stiff upper lip through adversity helps mitochondrial function?

[@Korvxx]

20:20 what fat source? I feel great with coffe and cocoa butter early in the day, pure fat and the stearic acid is good for mitochondrial fusion as well?

[@ron-m7s]

being able to measure mitochonrial health and population is amazing, everyone knows extrinsics like emotion have everything to do with how we feel, now backed by this most fascinating area of research,, thank you for sharing this! you're a good man!!, despite having admittedly commiting murder in your lab

[@jenn1663]

Is this one way that taurine supplementation/exercise that increases taurine levels might be helpful in mitochondrial health/longevity? "Taurine deficiency and rotenone actions are similar, as both lead to reductions in complex I activity, inhibition of NADH dehydrogenase activity, reductions in respiratory activity and elevations in NADH. Because a primary physiological function of taurine is the maintenance of complex I activity, there is reason to believe that taurine therapy should reduce the severity of Parkinson’s disease (Alkholifi et al., 2015). "

[@clintatk]

I would also point out that the quality of movement is very important. Movement is a brain-nerve activity. The more skilled the movement the greater the brain-nerve network is developed. Just look at musicians. Their nervous system grew as they practiced playing, building a greater, more refined nervous system in their arms and fingers. The greater the skill set in exercising the greater the nervous system development.

[@Lulu-kt6gr]

Edit: okay I did hear a mention of it. Does “physically active” always imply aerobic exercise? Or does an average walk help? What about weight-bearing exercise? I rarely hear specifics on this.

[@leepeterson2079]

The video was very informative and your humor is so dry, love it.

[@DocSiders]

If you're metabolically healthy (Healthy/Plentiful Mitochondria).... you're more likely to feel more "energetic"...or "positive". REVERSE CAUSALITY LIKELY HERE.

[@mikeo2693]

This channel has been a great discovery. Thank you for providing this service.

[@danetteperez3863]

Why do scientists insist on presenting a theory as fact? Evolution is a theory. I wish the same diligence and impartial facts based research would be applied .instead of the taught preconceived conclusions of others opinions . But I am able to recognize the true science that YOU always present. Thank you for that. I appreciate that you clarified the process of nutrient overload as an adaptation .

[@lynnwilliams5432]

Normal weight but osteoporosis 81 yrs on cane fracture femur stem . Anterior hip replaced 10,000 steps 4 miles today going out once more to get up hill cardio. Was sprinting bf fractured occurred picking up trash. Do weight arms shoulders grip.

[@antoniakotsiros2836]

Thank you so much for your amazing video. Loved every minute and can’t wait for part 2. Have an amazing day 🎁🎁🌟🥁

[@peterazlac1739]

On the optimum diet my view and experience tells me that titrating glucose load against use and the ability to store it as glycogen is a key factor and this declines with age due to the inevitable loss of muscle mass. As a nutritional physiologist I find it a limitation to many of these videos and nutritional papers where they link their results to fat or protein when the cells do not recognize either but rather amino acids and fatty acids and the responses are different depending on which are involved and their ratios. This is especially true for excess omega 6 fatty acids and lack of essential amino acids, especially leucine but also other factors that determine their activity.

[@AnP865]

It's cool that you're keeping things complicated. Some of the mitochondria people are alluding to or even explicitly stating a level of simple certainty which doesn't seem valid, more like ideology.

[@FORTRAN4ever]

I have read articles that connect the dots about ME/CFS symptoms being brought about from some mitochondrial dysfunction . It is hard to imagine increased aerobics improving a ME/CFS patient's symptoms when doing so results Post Exertion Malaise (PEM).

[@id9139]

Yes, correct... What is the solution?

[@Burnrate]

It's like having a ton of engines running at low rpms is better than having a few engines running at high rpms and overheating to do the same work. If you have too much fuel being dumped in all the time your body will remove a bunch of engines leaving you with few engines.

[@areyouusingthatsquatrack8256]

why is it that cardio exercise is better for mitochondria than strength exercise is?

[@peaceonearth8693]

If you get enough Mitochondrians, can you train to develop The Force? And, is your Captain Picard really an expert on The Force? I noticed that he didn't bring it up. Which is understandable.

[@yay-cat]

With the feelings study. I wonder if they took menstrual cycle into account. Like I feel a bit more depro in my luteal phase (2 weeks after ovulation). But like I would think the cocktail of hormone interactions over this cycle has a larger effect than the mood. Like it might be correlation not causation

[@ccsimonds9590]

I grew up in a neighborhood that had large fields behind all of our houses. They grew cotton, soy beans, and corn and rotated each year. As kids we played outside all day and I can still remember the smell of the pesticides and herbicides they sprayed on those fields. Then in 1997 I had a flu shot. It was all downhill after that.

[@immortalityIMT]

What about drugs? Bezafibrate, SR9009, MitoQ, AICAR....?

[@northerncoloradotransparen1454]

I wonder how animal consumption (full of hormones' and antibiotics) affects mitochondrial health?

[@veniqe]

Definitely better than the pesticides and antinutrients from plants.

[@northerncoloradotransparen1454]

No meat is much better for all@@rfbead321

[@stefanisilva2493]

@@veniqe Pesticides more concentraded in meat, due to bioacumulation. Antinutrients that are antioxidant, anticancer etc that are the very reason plants are healthy.

[@HazardousHumorHQ]

Thanks for your work!

[@eltarahim5859]

You are delightful! Learned so much..thank you sunshine!! Sending love from LivelyLasVegas!!

[@Nivloc317]

Nicolas, I have read research that states that training in the adolescent period of mice greatly influences the number of nuclei and mitochondria in skeletal muscle, and that change is more or less permanent. Detrained mice were able to regain up to 90% of their losses. But mice never trained in their adolescence COULD NOT in the adult lives develop either the multi-nucleation of their trained peers or their mitochondrial density. So my question for you is this. Assuming that the mice study translates to human beings, what is a reasonable percent increase in mitochondrial density possible in adults who start training when they never trained as adolescents?

[@ijimstopit]

Again, another information filled science lesson entertainingly delivered.

[@iamleilaniquevedo4658]

Thank you for sharing

[@mikeward9870]

Nice! One key concept that is often missing in metabolic vids (keto, ...) is that fasting/hunger (to generate mitochondria) is more than endogenous use of MCT oil (with abundant nutrients).

[@markmetternich7629]

Have you studied Inigo San Millan’s work? “Maximum mitochondria expression” zone 2 training.

[@liveyourbestlifeguide]

This is so helpful!

[@homomorphic]

I know exactly what fasting regime is optimal *for me*. I derived that by taking labs frequently and adjusting for sustainability vs the results. For me it is 18 hrs/day. That is sustainable and produces excellent results in my labs (i have a BMI of 17.8, bp of 100/70, a1c of 5.1 and hsCRP of 0.9). I have no idea what the optimal level is for someone else, but I *know* for sure, it isn't 3 meals/day.

[@stargazerbird]

So vigorous exercise and a healthy weight. Everything always boils down to that. I hardly need to consume health info any more.

[@jamescalifornia2964]

😉 May all your mitochondria be healthy 🙏 ✨️

[@bhut1571]

Thanks. I enjoyed your previous spiel on choline. Myself being a 14 egg/ week afib person I was conserned and read this baby which you may find interesting. It doesn't seem to matter much on how much you eat, the choline metabolites seem to be independent and TMOA doesn't seem to matter. Here it is: Choline Metabolism and Risk of Atrial Fibrillation and Heart Failure in the PREDIMED Study Clin Chem. 2021

[@ericmaclaurin8525]

I'd argue the primary difference between damaged or mutated is that one is best fixed by helping the body fix itself. Mutated means your body would literally break it again if it had its way so you have to fix the mitochondria and then block the bodies mutated mitochondrial maintenance network.