Enzyme Examples, Cofactors/Coenzymes, Inhibitors, and Feedback Inhibition

[@AmoebaSisters]

We like to pin important comments to address issues or clarifications in our videos. We promise the read is worth expanding! :) We greatly appreciate a commenter who revealed to us that there is an inconsistency in introductory biology sources for non-competitive inhibition. The peer-reviewed source we like to use as our main factual reference is Openstax where they have "In noncompetitive inhibition, an inhibitor molecule binds to the enzyme in a location other than the active site, called an allosteric site, but still manages to *prevent substrate binding* to the active site." Direct Link: openstax.org/books/biology-ap-courses/pages/6-5-enzymes However, in the popular Biology "Campbell" book used by introductory biology courses, the 11th edition states that the substrate can *still bind* but the "active site functions much less effectively." So which is it? After looking at more sources and conversing with some science communicators online and in a biology group Pinky is in, what we are hearing is that while the non-competitive inhibitor alters the enzyme's conformation, sometimes the substrate *can* still bind - and sometimes the substrate *cannot* bind - it depends on the non-competitive inhibitor type and enzyme. Thus, focusing on the binding can be problematic since substrates may still bind so we have now included this sentence *"if the substrate still binds, the enzyme's active site might not function well. Or at all."*

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I was really confused about what feedback inhibitors are until I watched this video. Now it makes sense. Thank you!!

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A GREAT video for helping to explain regulation of cell processes. This is Advanced Placement Biology content all the way, but it is also still very useful for general bio. Outstanding explanations! This helps my students a lot! Sincere Thanks!

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I have an exam tomorrow and now I finally understand allosteric reactions and feedback inhibitors

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This video was sooo helpful for understanding inhibitors.

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i´m a med student and these videos help me A LOT finally a funny way of learning... i´ve get an F from the feedback inhibition, cause I had no idea what it was, I thought it´s complicated as hell, but thanks to you I discoverd it´s not that bad.. I owe you my future degree :DD

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Can you give more of feedback inhibitions and Immobilization of enzymes it would help a lot. Thank you

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