Enzyme Examples, Cofactors/Coenzymes, Inhibitors, and Feedback Inhibition

[@AmoebaSisters]

We like to pin important comments to address issues or clarifications in our videos. We promise the read is worth expanding! :) We greatly appreciate a commenter who revealed to us that there is an inconsistency in introductory biology sources for non-competitive inhibition. The peer-reviewed source we like to use as our main factual reference is Openstax where they have "In noncompetitive inhibition, an inhibitor molecule binds to the enzyme in a location other than the active site, called an allosteric site, but still manages to *prevent substrate binding* to the active site." Direct Link: openstax.org/books/biology-ap-courses/pages/6-5-enzymes However, in the popular Biology "Campbell" book used by introductory biology courses, the 11th edition states that the substrate can *still bind* but the "active site functions much less effectively." So which is it? After looking at more sources and conversing with some science communicators online and in a biology group Pinky is in, what we are hearing is that while the non-competitive inhibitor alters the enzyme's conformation, sometimes the substrate *can* still bind - and sometimes the substrate *cannot* bind - it depends on the non-competitive inhibitor type and enzyme. Thus, focusing on the binding can be problematic since substrates may still bind so we have now included this sentence *"if the substrate still binds, the enzyme's active site might not function well. Or at all."*

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