Types of Enzyme Inhibition: Competitive vs Noncompetitive | Michaelis-Menten Kinetics

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Instructor: Dave Carlson
Enzymes Part 8 - Enzyme Inhibition

[@shadowarena]

I will never understand how a KZbin video can explain concepts easier and simpler than my textbooks. Thanks for this! It helped me understand enzyme kinematics

[@santimadrid8196]

It's hard to believe when I saw my test results turned negative of HSV2 after using the herbal medications I got from (Dr. Anii) a great doctor who I came across on KZbin who help people get rid of their sickness thank you so much Sir.

[@renuk8560]

Yeah, textbooks' explanation might be frustrating, but most of the time if you read carefully, processing every word, you can overcome that inconvenience and finally comprehend what it means. Though, videos like that are better, because they may sometimes underline important details, on which you wouldn't pay attention in usual circumstances.

[@MrPridizzle]

I felt, for a minute, that you were looking through the camera and into my soul... it was powerful :) great video, cheers from Arizona!!!

[@clip012]

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[@PremedHQ]

@@clip012 Dr. Dave Carlson is doing much better now! Thanks!

[@clip012]

@@PremedHQ Good to know. I wish him well. Hugs from Malaysia.

[@PremedHQ]

@@clip012 Thank you!

[@zuu4673]

@@PremedHQ i love your videos so much doctor.

[@LikeDaniel]

Finally Km and Vmax make sense! Thank you so much for laying it out so simply!

[@TheTosi98]

This is great. Our teaching systems don't understand how important is the repetition of concepts, and you really make it. Thanks very much sir! From Italy.

[@carolyncrawford9992]

You have a gift for making seemingly complex topics feel simple and easy to understand. Thank you so much for these videos, they have helped me immensely in my studies for the MCAT.

[@bitseatgetaneh5873]

Such a great explanation!! Can’t thank you enough for clearly explaining something I’ve been wanting to understand for over 3 years!!

[@jakobroze7017]

Such a great video. Really breaks down this information into logical steps!

[@rompiendoelcorojo]

This is the best explanation I’ve ever seen on this topic. Thank you so much.

[@angelalourine1199]

am having exam tomorrow. and you saved my life thanks..i love the teacher .he repeats to clear stuff, helps you grasp it.he doesn't get boring 😙

[@harshsane8325]

Dayum I liked how this video helped me during my entrance and now during my 1st year medicine. They way you taught > the way my professors taught ❤️

[@321123Nelly]

your voice is so smooth. thank you for these amazing explanations

[@DrPhysician]

I love the way you explain things! I'm frustrated that you did not explain these inhibitors with the Lineweaver-Burk Plots as well as the Michaelis-Menten plots.

[@priyankaprajapati8217]

Thank you so much for such a simple explanation, glad I found this video while preparing for a technical interview!

[@faisha1917]

Finally, I got a clear vision and explanation about enzymes fully, after all this years ^.^, thank you! I have subscribed by the way, hopefully will make me easier to study more

[@ne6761]

wow!!! are you God? because you explained it so well as if you were the one who discovered these things and made them come to reality!!! i've never understood a concept this good!!!

[@santimadrid8196]

It's hard to believe when I saw my test results turned negative of HSV2 after using the herbal medications I got from (Dr. Anii) a great doctor who I came across on KZbin who help people get rid of their sickness thank you so much Sir.

[@princesspat5239]

i'm in biomed and i really want to get into medical, i wish i had found these resources. Love your videos, they're great for my bio course!

[@motivational_Insights]

I think we should begin to advocate for a kind of Video textbook. Those textbooks are just bunch or words lumped together. This video explains what several pages of text cannot. It can't be clearer than this. At the end of the day, all you need is an understanding of the subject. Thank you so much professor.

[@Weifan]

how is Dr.Dave Carlson doing now? He is so helpful in teaching those concepts.

[@akosuafrimpong4465]

I have no idea about how I stumbled upon your channel, but I am so grateful. People like you motivate me to work harder everyday, thank you and God bless you!

[@user-po3ii1tl9z]

You should read up on his story. I believe he's in medical school now (or maybe about to graduate) but he was also going through some serious medical issues at the time which you can search up. He really is an inspirational individual.

[@pranavraheja]

Was trying to learn this from past 2 days... Thank got KZbin recommend me this 🙌 .... Love from india ♥️

[@Chelsea-gs7qj]

I love your videos, but there are 4 types of inhibition tested. Why didnt you mention uncompetitive or mixed?

[@nicholasachuz8329]

calm and straight to the point

[@nicolevillalon9737]

Brilliant explanation. Thank you!

[@noorel-tawil8775]

this was the most helpful video ! Thank you !

[@nethinduwarapitiya5497]

crystal clear teaching! great video

[@williamallotey270]

I liked before the lecture, this i know you are the best

[@siakapmerah5018]

thank you so much for the explanation! so grateful to see this video!!!

[@nathanrumpf5660]

Fantastic explanation. Thank you!

[@VeronicaJosef-ls2dx]

So wonderful, well explained and understandable...👍👍👍🌹

[@mounikab8735]

Excellent sir, and , thank you so much sir. Now I am clear with this concept.

[@myagagasy]

Thank you so much 😊 you're a life saver 🙏🏽

[@lowkeycam9151]

thank you! this is truly a lifesaver

[@koushikchatterjee7375]

I have seen many videoes from different sources but none explained it better like you did , love from India ❤❤

[@PremedHQ]

Thank you!

[@mohammedahmedjalloh531]

Hello Sir! I cannot thank you enough, this is really a groundbreaking video for me!!!!!!!!!!!! THANK YOU

[@PremedHQ]

You're welcome! Glad you made a break through!

[@PS-qc9gc]

It was so very helpful.thank you so much...you are a very good teacher.i liked the way you explain things.😊

[@starrani5264]

Thanks , all these lectures are very useful.

[@lakhdeepsingh9132]

Also apparently noncompetitive inhibitors can bind to either the allosteric site of enzyme itself or of the enzyme-substrate complex... something I did not know.

[@sabrinasin123]

Thanks for your sharing, sir. By the way, I have a question that wish you could clarify for me. Is it the Michaelis Menten Plot actually is a standard plot that can comparing with the certain enzyme that we want to study? And is it we could identify our inhibitor whether is competitive or non-competitive after plotting the graph? Thanks.

[@leishembilyting5086]

Just blessed to have seen this 🌸!

[@lancevercitti3904]

I just happened to find this today, thank you so much! My book is not too good at explaining this concept.😀😀

[@dianagreen4450]

this is brilliant!!! so well explained, thank you

[@rugvedkulkarni1593]

So Km is the concentration of substrate needed to get to 1/2 the maxiumun reaction rate?

[@ssomu1993]

At last the concept of enzyme kinetics is now clear....thanks !

[@PremedHQ]

You're welcome!

[@audioderyne]

thanks so much. you are an excellect teacher.

[@aditichokshii]

This helped so much!! thank you!!

[@maarinahope]

You are the best tutor

[@drsunilkumarsknowledgehub5288]

Nice for the students of different courses like MLT and Biochemistry subjects people

[@ranahaddad5446]

Wow! Well explained! Thank you!

[@tikizone2535]

Thank you so much Sir. Greetings from India

[@user-so2vd9wc8r]

you are my lovely professor😊😊😊😊

[@rolandmalone5431]

Awesome explanation

[@alvin1342]

You're a good Teacher Sir, I didn't like this course before, and because of your teaching, you've inspired a positive reaction in me

[@PremedHQ]

Wow, thanks!

[@Atrionix]

Hence, you could say that he was the enzyme that catalysed your positive reaction :D

[@rtdpoe620]

thank you for this clear explanation

[@zpii9317]

so helpful video. love from Georgia

[@User-s868]

That was definitely helpful, thanks 😊

[@stirfry3018]

wow how are these free?! thank you so much

[@stasiuschlaffke3444]

When will the competitive inhibitor molecule leave the active site?

[@bambangkiranadi2576]

Excellent lecture.

[@aamnakhan7856]

no concern with enzyme but I randomly click this video, why he is so smoothly teaching😍🤩

[@seelamlakshmi1002]

Very well explained sir!!

[@bhawnasuryawanshi2350]

Wow, so clear explanation

[@mikaelaprim4273]

but why does km change? doesnt the active site change when non competitive inhibitor binds, hence decreasing affinity

[@zuluflexxboswellow133]

I wish i had the power to give you a billion views,coz this is far from just a job well done...simple english everything is just understandable

[@zolani-kabane]

Well explained. Thank you

[@tiringozerihun6110]

It really helpful Thank you.

[@astaghfirullah10000]

Great video.

[@darondasavage4140]

Thorough explanation. Thank you

[@PremedHQ]

Glad it was helpful!

[@hajraafzal1570]

Well explained.

[@sandyzhao2706]

this video was soooo helpful. Thank you very much ^_^

[@muireey1475]

You are awesome thank you very much

[@urukhai666]

Thanks a lot! That was really helpful))

[@luwambrhane4570]

It was really good explanation thanks

[@sayliparab7851]

You are really good at teaching sir....I was always confused how km and vmax is affected in both the cases....thanks for the help

[@PremedHQ]

You're most welcome

[@sabrinasin123]

Ya. His video is really informative!

[@Ltrina_02]

So much better now!

[@santimadrid8196]

It's hard to believe when I saw my test results turned negative of HSV2 after using the herbal medications I got from (Dr. Anii) a great doctor who I came across on KZbin who help people get rid of their sickness thank you so much Sir.

[@SameeraKetavarapu]

Thank you so much.😀

[@rehanabokhari4482]

Nice explanation

[@sunshine-qw5md]

omg thank you, this video explains it so well. and I also just realised I've learned this stuff before lmaoo

[@user-po3ii1tl9z]

The reason why I really like this video is because you don't even have to memorize anything anymore, the way you explain it ACTUALLY teaches people in a way where we can logically come to conclusions about what happens with Vmax and Km (like at 2:40, you can already guess that Vmax doesn't change but Km will increase, not because of the graph but because of the way you explained it so elegantly). Thank you :)

[@ankitasanmukh8554]

If km=1/2 vmax then ... How is it possible that vmax is changing but km is not.. ?

[@nyikomhlarhimusic]

Thank you veeeery much🎉

[@Muzee123]

In competitive inhibition vmax is not affected why?

[@14Truthfulls]

Thank you very much

[@IHappyChicken]

Thanks!

[@aishahhearts8294]

Thank you sooooo much!!💕🌹🌹🌹🌹🌹🌹🌹🌹🌹🌹🌹🌹

[@naciburakcakr2793]

You are really awesome

[@RizwanAli-ry3nm]

Ty so much sir 🙏❤

[@shivamgarg2711]

Thank uh sir ❤️ you made it crystal clear... am from india preparing for neet ug....your teaching style 💕❤️

[@santimadrid8196]

It's hard to believe when I saw my test results turned negative of HSV2 after using the herbal medications I got from (Dr. Anii) a great doctor who I came across on KZbin who help people get rid of their sickness thank you so much Sir.

[@charlesukonna3502]

You're really really good 💯💯

[@santimadrid8196]

It's hard to believe when I saw my test results turned negative of HSV2 after using the herbal medications I got from (Dr. Anii) a great doctor who I came across on KZbin who help people get rid of their sickness thank you so much Sir.

[@sagarsatapathy4600]

I watched 10 videos to understand this concept but I was not feeling confident and then after watching this, I didn't need any other video to understand enzyme inhibition more

[@PremedHQ]

Thank you! Please share this channel with your peers!

[@deejabaage]

Thank you soo much!

[@bd1271]

Thanks a lot!!!

[@guruvunaik8818]

great explaination like from india

[@amnashaikh-sl1qi]

thank you!

[@AJ-gk9iu]

But what about uncompetitive and suicide inhibitors? Is that not on MCAT?

[@chicagostreetstyle822]

Thank you

[@syedmoomin2816]

Amazing 🔥

[@jacklyngarcia8887]

I love the video but there is no explanation of uncompetitive inhibitors :(

[@syedmoomin2816]

Thanks # from India

[@bubbyxd2012]

thank you thank you thank you! 😄😄😄

[@LilyGraceySa]

I nearly cried because a lot of people explained it to me and it didn’t make sense! You are such a treasure, you actually explain what it means! Would’ve loved if you taught me the whole biochemistry course, then the stiff material would’ve actually became imaginable. Thank you!! ❤❤