Epigenetic Aging: How old is your DNA?

Dr. Steve Horvath, a professor of genetics and biostatistics at UCLA, has found a way to measure biological aging - a type of "clock" - based on the methylation pattern of an organism's genome. Methylations are biochemical processes that modify the activity of a DNA segment without changing its sequence - a type of epigenetic change. This video primer explains the basics of epigenetic clocks, the topic of our interview with Dr. Steve Horvath, coming soon!
Get the show notes here:
www.foundmyfitness.com/episod...
Episode chapters:
00:00 - Biological vs chronological age
00:40 - Estimating biological age with epigenetics
01:17 - The Horvath clock
01:54 - The GrimAge clock
02:19 - Altering biological age
About FoundMyFitness: Rhonda Patrick has a Ph.D. in biomedical science from the University of Tennessee Health Science Center, and St. Jude Children’s Research Hospital. She also has a Bachelor’s of Science degree in biochemistry/chemistry from the University of California, San Diego. She has done extensive research on aging, cancer, and nutrition.
It is Dr. Patrick’s goal to challenge the status quo and encourage the wider public to think about health and longevity using a proactive, preventative approach.
Learn more about Dr. Rhonda Patrick and her mission for FoundMyFitness at www.foundmyfitness.com
This episode was fiscally sponsored through The Film Collaborative and a grant from a generous anonymous donor. www.thefilmcollaborative.org
#Epigenetics #Longevity #DNAMethylation

[@FoundMyFitness]

Interview with Dr. Steve Horvath coming out next week. Let's get 2021 kicked off with a bang with a whole bunch of great new videos. Don't forget to *like and subscribe* and maybe even switch the bell notification to the on position. Show notes for this primer here → www.foundmyfitness.com/episodes/epigenetic-clock

[@thepamo2812]

Rhonda would you be happy to share your results of your test! It would be fascinating to see how your supplementation and lifestyle choices have played a role in this :) thanks for all you do! 👍 😀

[@gururajbsavakar7154]

Interesting, ANTI- AGING EPIGENETICS awaiting your interview with Dr Steve Horvath THANKS DR R. P.

[@FoundMyFitness]

@@thepamo2812 The test was a derivative of the actual chronological one (rather than the biological age grimage one), so it's not too surprising that it nailed my actual chronological age almost perfectly. Glad you asked!

[@archiehickox6518]

Fluoroquinolone Toxicity

[@SamStormbornOrmandy]

Are you kidding, I've been subscribed since the very first video I saw and I always watch until the end. 😃 Thank you and a very Merry Christmas to you Dr Rhonda 🎁🎄⭐

[@TheSheekeyScienceShow]

Epigenetics is the reason I decided to specialise in Biochemistry .

[@MrRobertFarr]

Hi there, I am interested in genetics. It's really difficult. Where, Scientific work is surely going to drastically age people. Even in finding out about D.N.A. it kind of wastes, so much time. It's very difficult, to communicate about these issues with the general public. I can see people learning about this type of information but by observing their actions. I am really not seeing them understanding this issue.

[@John-hj6ed]

I taught courses in biological, marine and environmental sciences at the college level ... before I retired (20 years ago) I developed a course: The Biology of Obesity, Ageing and Disease and have followed the research in these areas ever since. In my estimation Drs. Rhonda Patrick and Valter Longo are absolute leaders in the field in presenting emerging scientific research in terms understandable by anyone.

[@thomasfresolone4441]

Dr. Rohnda rocks!!!!

[@robertkopp873]

She does...

[@mickz4601]

Yes she does 🤙🏻

[@joesmith-ju7hh]

The perfect lady. All talent and looks with a traditional attitude.

[@KenOtwell]

I'm 64... the faster you get this info out, the better! lol.

[@sleepsmartsmashstress740]

Dear Ken over 96% human lifestyle decisions are based on emotions or what makes them feel good or avoid feeling lousy. Information is the LAST thing that impacts human lifestyle choice. So, presenting information to humans is largely wasted effort. Hounds of brilliant scholars like Dr. Patrick and Dr. James Hansen of NASA have gone hoarse trying to make public listen to science but all human chase after is short term dopamine highs not long-term outcomes. People refuse to tolerate the discomfort of a face mask while risking long term disability from COVID19. In short humans are scientifically stupid or decision ally dumb. Despite all the research and lecturing on longevity and turning back the clock the lifespan has shrunk in the US for the past 3 years in a row and that is about to speed up with COVID19. The best use humans would derive out of the research on epigenetics is to speed up the aging clock by drinking more etc. The sales of alcohol have gone up about 20% in the pandemic as there has been a drop in the physical activity by a similar volume. My anti-aging research work tells me that aging would remain incurable because humans are effectively a stupid species an stupidity is incurable. I have offered thousands to comply with my sleep and stress combatting strategies thus far zero takers. Humans dont really want to live longer unless they can get it in a pill like MNM.

[@cameradudeNYC]

@@sleepsmartsmashstress740 Very well put! Thankfully, stupidity is not evenly distributed, I am happy that things that I have learned have led to changes in diet, exercise, etc. Some of us will benefit greatly from this research!

[@KenOtwell]

@@sleepsmartsmashstress740 I'm not speaking for anyone but myself.

[@micahwilson4244]

@@sleepsmartsmashstress740 the more educated people are (with information), the more rational and reasonable they are. But I doubt you’ll take this to heart, it’s information, and you’re a stupid human.

[@lpg12338]

@@onlyhis5870 Well said. 👍

[@aemind]

I love these infographic style videos. They're so engaging.

[@phoenixgazette5947]

I think you mean simplistic.

[@jonny1943]

LOL

[@inzo313]

I can't wait to see the upcoming interview you mentioned.

[@FoundMyFitness]

That's great! Make sure to subscribe with bell notification! It's coming out next week.

[@antoniomele436]

Rhonda, this video is fantastic! You have made massive improvements since your original videos on magnesium and athletic performance. Congratulations! You are on your way to becoming one of the most influential science communicators of the 21st century.

[@TMPCarbs]

Great video. Excellent lighting and composition. I like the background music.

[@anisheshdas362]

Thank You, Dr.Patrick. I recently stumbled across your channel and I have been on a spree since then. Thank you for putting such amazing content out here for free.

[@anasputra2140]

dr rondha never skipped her video as other ppl do.... just amazing...

[@timmothyburke]

I love your videos, your enthusiasm for helping people is so admirable.

[@daxd8358]

Great , clear , at moving pace to absorb information, thank our Dr. Patrick. Layout of information w/ graphics to me with a form of dyslexia makes for attention getting Video . Please keep it coming and enjoy your interviews .

[@catalyticcentaur5835]

Thanks, Dr. Patrick, for this/your presentation.

[@tjames22123]

Definitely changing it for the better, Dr Rhonda!! Basing that off your enthusiasm levels!

[@mcgeebag1]

Great content as usual and very nicely produced!

[@kepdani]

Can't wait to see the interview, I'm really excited to learn more about this topic

[@alexnickolaev]

Awesome visuals. And awesome news. Thanks for your work Rhonda!

[@bloodsport326]

Your the best Rhonda. You make it look easy, keeping it clear and easy to follow ❤

[@vishnukrishnaprasad424]

Love the short videos, please make more of these from the longer interviews with specific topics

[@casey8974]

Hello, on youtube search for “fmf clips”

[@timothymiz9275]

Dr. Rhonda is always on point! She breaks it done better than anyone on the subject of aging.

[@diego_sarkaglobal1793]

I'm excited to learn more! Dr. Rohnda, looking forward to the interview!

[@markrice3019]

Excellent Review!!

[@masa26762]

Thanks! The video and the graphic really helped me understand this. It's hard to come by youtube video that's this complete.

[@arnavdeshpande3764]

Amazing. Short. Crisp. Loved it

[@sednolb]

I am so into your work Dr. Rhonda Patrick!

[@FoundMyFitness]

Thank you!

[@stevediben7900]

Love the production quality of the video!

[@ComedyJesus]

Another outstanding video, thanks DRP!

[@Anthony1337]

Outstanding video Dr. Rhonda Patrick! I’m sitting in the sauna right now! Great work, and thank you for Inspiring so many lives for the better.

[@sxsxpl]

Love those shorts, great animations as well.

[@davidstrong7854]

Can’t wait for the interview , thanks you ,,

[@FoundMyFitness]

Subscribe with bell or get on my newsletter to make sure you know when it comes out! :)

[@antokindness]

Fantastic, as usual of you!

[@tyrone1son]

Excellent video all the way around

[@Diamond4Jesus]

You are the most phenomenal doctor I've ever met! And you are one beautiful angel 😘💗

[@enriquecastellanos8214]

I love you Dearest Dr. Rohnda, thank you so much for shared, thanks a lot!!

[@susymay7831]

Well done lead in to your personal introduction and content.

[@stevesimmons6849]

Wow ! Very much looking forward to that interview 🙂

[@sleepsmartsmashstress740]

How do you plan to benefit personally from that interview?

[@cherylnegus2441]

Absolutely brilliant, thank you so much DrRhondaPatrick for sharing your genius with us.

[@erkutgurun]

Subscribed dear Rhonda. Just started my Reversing-Aging journey. I have about 20 youtube videos of yours lined up next. :)

[@keepmoving1185]

Well done!

[@altargull]

This is really good.

[@johntibaldi9496]

I love this style of video!

[@neobellator]

😮 Really interesting! Great work with the infographic. Makes things easy to understand. 👍

[@gracelebleu7216]

Love the graphics/animations!

[@TheJugga21]

Wild!! Thanks again Dr. Patrick

[@AndreObradovicAus]

love your work Rhonda I am proud to be a paid up member and love the T'shirts also, thank you I love my Sauna also

[@user-lc8zk7pj3n]

Great content!!

[@RobertWadlow292]

Thanks for all your work breaking down the science on topics for some of us lay people. I enjoyed watching your tryptophan metabolism and fish roe videos. I have now added that to my diet. Any new insights on the potential advantages of that over regular fish DHA? Also, could you do a video on the benefits or Red Light devices?

[@tryptaminenurse9851]

Dr. Rhonda Patrick is 42 and looks like she’s 32. Thank you for all of this life saving information Dr. You are helping thousands around the world.

[@fabianwahle5119]

Love the animation upgrade :-) (and the content as always)

[@steelrain52]

new video! yay! keep'em coming!!

[@FoundMyFitness]

New interview next week! Make sure to subscribe with the bell notification so that you know when it hits.

[@steelrain52]

@@FoundMyFitness I will! thank you for your amazing videos!!

[@philosophicalmonkachu7711]

Nice information,video editing is quite a lot improved....makes it easier to understand.. Thank you for sharing ma'am

[@FoundMyFitness]

Thank you! This new video format is just the tip of the iceberg. We're gearing up for a lot of amazing new content. Join our member program to get extra science emails, a t-shirt, and other great stuff. FMF premium membership is the mechanism we're going to use to bring more *free* and *open* content to the public, all-the-while giving members a really great and cool members only extra content stream that wouldn't exist otherwise. Learn more at foundmyfitness.com/crowdsponsor

[@kenycharles8600]

Thank you.

[@DoctorHemi]

Very cool research! Thanks for the video.

[@sleepsmartsmashstress740]

Should we not call sauna research hot ?

[@alexandrucolta6765]

You are the best !

[@sleepsmartsmashstress740]

Are you sure or just a bit infatuated with her ?

[@namek3163]

Great animations and edits!

[@laurajackson6860]

Thanks, Rhonda! Epigenetics - fascinating!

[@sleepsmartsmashstress740]

Did you know that Epigenetics is also largely pre-determined. Your epigenetic fate is decided by what your grandmother ate or did not do etc.? You are much better off working on the microbiome or microbogenome which does interplay with epigenome.

[@jeffreyleung5603]

I love Dr. Rhonda Patrict!

[@sherievaughn6475]

Looking forward to that interview to see if dr. Horvath talks about fasting and how it triggers change through epigenetics...

[@miguelbertonatti]

Wow. Amazing!

[@xavierghazi4939]

Exciting to say the least and looking forward to watching the interview. A note in passing though. I wish there was no background music added to this introduction video or any other similar videos. I struggled to listen to what you were saying with the interfering music on. I suffer from Misophonia (literally hatred of noise) and this condition is more common than many suspect and noise/sound make us immensely uncomfortable. Thank you either way.

[@xavierghazi4939]

What is Misophonia: www.webmd.com/mental-health/what-is-misophonia#1

[@majluke]

you are one hell of a lady, I enjoy watching your vivid and expressional videos

[@alpha.0]

Fabulous, looks amazing, where can we find this wondrous interview Rhonda?

[@FoundMyFitness]

It's coming next week! Make sure you're on my newsletter so that you get a notification. foundmyfitness.com/newsletter-2

[@moonoom764]

Awesome video, Rhonda! Have you heard about Cipro toxicity? Do you know what to do about it?

[@higherresolution4490]

Excellent presentation. Much appreciated. Fascinating subject. Apart from methylation of histone proteins, 8 of which form the basis of chromosone packaging when the double helix of DNA wraps around themj, histone modification also takes place at different locations on different amino acids in the form of phosphorylation, acetylation, ubiquitylation and sumoylation. By no means is methylation the only game in town.

[@JakeRichardsong]

Thanks.

[@bapcorp8303]

This research is Amazing, look forward to more. We are told that heat stress is extremely positive for the body.

[@snorgonofborkkad]

Wow, someone got a motion graphics animator to help them out. Very ambitious. Looking forward to all the new video styles you'll be experimenting with.

[@FoundMyFitness]

Expect more like this. Not only that, my members platform is getting better at the exact same time. Short, science-focused curated segments from interviews with helpful explainers are now coming out approximately weekly. www.foundmyfitness.com/aliquot (This paid content is a great value add mechanism FoundMyFitness has that helps us put out better and better *free content* on places like KZbin).

[@Dmadiroe]

Awesome video! The music is a bit too loud and distracting in my ooinion. Appreciating the production value tho! 😊 All the best. Dan

[@larrykraft2743]

Loved the playful P.S. at the end of this video. Given that you, “turned up [your] heat shock proteins”, yes, I imagine you must have changed your epigenome. Thanks as always for your evenhanded explanation of the science that is being done in this area. Thanks also for the reminder that I intended to get a sauna after seeing the evidence you shared about that before!

[@t5o7m]

Credit where credit is due ... here because of comments below a Dr Eric Berg video ... so, I SUBSCRIBED and rang the BELL "All" ... looking forward to learning more about you and from you :)

[@MMcGui]

Dear Dr Rhonda, It seems that you geared up the stuff; the content format! I am looking forward to see you enlightening us with your humanistic work with also other practices and molecules such as Honokiol, berberine, hydroxycitrate and so forth! Best,

[@FoundMyFitness]

We're going to do so many great videos in this upcoming year! Make sure that if you've subscribed on our channel, that you've clicked the bell on... because it's going to be nothing but great videos for the next year. You won't want to miss out!

[@bneymanov]

Words cannot express how excited I am about this! I notice that this video doesn't mention NAD boosters, hope you cover this topic in the interview though!

[@FoundMyFitness]

We did do a really in-depth video on NAD+ a while back... www.foundmyfitness.com/episodes/nad-nr-nmn

[@bneymanov]

@@FoundMyFitness And that video without any exaggerations is to day my most favorite video on all of KZbin. :) It's incredible content explained really well at perfect pace, so thank you for that! Why I hope that you touched this topic with Dr. Horvath, is trying to get a diverse set of opinions and to see how it contrasts with his own research. :)

[@sleepsmartsmashstress740]

NAD would be only remotedly linked to epigenome if at all so that would have been deemed outside the scope of the talk. One cannot be totaly inclusive. What role the NAD boosters play in the rate of aging ?

[@marian.trandafir]

NOW THIS IS TRULY EXCITING! Capital letters exciting level 😂😂

[@patricfarah2858]

That's amazing.

[@ericschneider7294]

Half of what you say I don't understand, but taking out the big words I get the just of it. That's what matters. Thank you for sharing your knowledge! : )

[@sleepsmartsmashstress740]

Would you mind sharing the summary of what you learnt. She does talk some foreign language I think

[@didinx8417]

The Horvath Clock....still sounds like an Umberto Eco novel.....😊

[@ste-fi1qy]

Sounds awesome

[@Pyriphlegeton]

Goddamn, the quality of the graphics is fantastic!

[@FoundMyFitness]

Like, subscribe, and become a frickin' member for more like it! The FoundMyFitness premium membership comes with some really cool perks where we're shipping something cool every single week. Totally worth it and it helps us "next level" our content like this video did today! www.foundmyfitness.com/crowdsponsor

[@kral3046]

Rhonda, i don't if you upped your skin-care game or actually reduced your biological age but you look soo healthy and fresh in this video which makes me produce lots of serotonin alongside the trajectory that aging research and awareness is gaining! Maybe 2020 isn't so bad! 😁

[@rezavaziri6900]

What are your thoughts on David Sinclairs work on OSK-induced epigenetic reprogramming? It sounds like a pretty unique way to achieve the desired methylation patterns, and strengthens the the case for a correlation between epigenetic age and biological age. Thanks for posting more epigenetic content!

[@keepme5225]

You hit it out of the park Rhonda. I was wondering on a loosely related note: do you think I could get away with a mustard seed capsule taken right after my broccoli sprouts or does it need to be blended into the smoothie? I want to take my sulforaphane optimally, but I’m having a lot of trouble getting down that spicy taste.

[@ChannelAA]

Great presentation as always. However, background music a bit irritating though. Thanks.

[@Beyond_Partisan]

She is getting much better at relaying this information in layman's terms ❤ Can I ask my Family doctor to order me some of these tests? 😊😊

[@sleepsmartsmashstress740]

Even if the doctor does order them and you get the tests taken, the key is in the interpretation. An why not just assume that there is some minor flaw with the testing and that there is some aging and take preventive steps anyway e.g. assume that you are going to develop diabetes and modify your lifestyle to prevent that from hitting you. Good idea?

[@sleepsmartsmashstress740]

@@onlyhis5870 Satanism is STUPIDITY not Science Leave Dr. Patrick out of this insanity Post elsewhere Get lost !

[@sveingustavhovland1913]

The study is so exciting, everybody talking down the IGF-1 pathway these days. Seems they don't see the effect Metformin has on the mTor and Ros, they don't even see the effect of HIt/HIIT, IF, sleep and such on mTOR and ROS (to inhabit them). We should not be so negative on the IGF-1 pathway, as long as you see the overall picture.

[@larrypedringer6352]

That bit in the sauna at the end made me lol. Great stuff! I hope the sauna is working to positively change your epigenome.

[@braedonfirebrand6342]

The sauna MAY be changing your epigenome on its own, but if I'm not mistaken, if you were to jump in a cold shower directly afterwards, it triggers the same dna refreshingmechanisms as pure wasabi, calorie restriction, and to a lesser extent, the 5-day fasting mimicking diet, correct? I come from the world of nutrition science, but I looove geeking out on this stuff with you. Thanks for presenting it so... digestibly.

[@sleepsmartsmashstress740]

Cold conditioning is a great alterative to sauna and triggers the same heat shock proteins. Bathe for 3-5 minutes twice daily in ice cold water at 5-6°C. Start with 30 secs and may use 9°C water and gradually build it up from there. I can now go for 5 minutes at 5°C water twice daily on most days. Sure, wakes you up. Sauna can be mixed with the cold therapy. Some people can do 10 minutes of cold exposure but benefits beyond 4 minutes are not great. Dr. Sinclair calls it cryotherapy that is used to burn warts no for cold conditioning. I grew up in a very cold part of India and my system can take extreme cold well. Older adults exposed to cold while shovelling snow have had heart attacks so it is a risky thing.

[@qmm6054]

Yes, I do think the sauna is changing your epigenome! Thanks for the awesome video. I look forward to the interview with Dr. Horvath!

[@teemlee51]

Don't know about you Dr. Patrick but my sauna is making my telomeres grow like a weed under a rain gutter, ha. Always excited to hear your information! Cheers...

[@brandonessick775]

Interesting.

[@toddvolpe6396]

Yes, I do 🔥

[@Earwaxfire909]

Can you review the paper: Aberrant DNA methylation profiles in the premature aging disorders Hutchinson-Gilford Progeria and Werner syndrome, by Holger Hueyn, Sebastian Moran and Manel Esteller?

[@melissacostin4464]

Great info, clearly explained..sharing ..I'm wondering if you've looked at ox DNA ie hydroxylation as also accelerating aging ...hence value of antioxidant rich whole foods ..I reccomend you look at cannabinoids as fat soluble membrane components which prevent oxidation and thus DNA damage ..might pitch the clock to cannabis industry looking at research ..thinking topicals on sundamged skin cropping SCC would be great patch to test prevention and treatment of senescence / advancing oncogenesis ...I'm glad my myotherapist Reccomended your channel ..

[@christopherellis2663]

Hibernating between meals, like from Friday to Monday, is a great epigenetic hack, the sauna is, too.

[@misbahjassem6971]

Cool!

[@MichaelWilson-cx1hh]

I did my genetic makeup test with ancestry. Would I be able to use this data with the grim clock to find out my epigenetic age?

[@williamtomkiel8215]

Thank you how to access these resources- who can provide these tests?

[@FoundMyFitness]

The work Dr. Horvath is talking about is still ultimately an investigational tool in his lab. But, there's been some attempts at commercialization for the *chronological* part. Check out myDnaAge.com (no affiliation).

[@ac27934]

Whoops, only one A. Link should be www.mydnage.com

[@isaacmay7522]

where is the interview with Dr Horvath?

[@ksuhuh]

Lol @ Rhonda in the sauna at the end

[@borissman]

Hey, Rhonda! Can you PLEASE have a friendly debate with Paul Saladino about the dangers of sulforaphane? He is a really nice and respectful guy. Please consider!

[@synsynsy]

no he is not. he is not nice and not respectful.

[@borissman]

@@synsynsy i watched many-many hours of his debates. I must conclude that he is. Why do you say that he is not?