ESKAPE Pathogens

ANTIBIOTIC RESISTANCE is increasing day by day. Worldwide it is considered a serious threat. This video talks about mechanisms that bacteria use for escaping antibiotics effect., and ESKAPE actually stands for some Gram-positive and Gram-negative microbes which have these strong mechanisms to fight back.
CHAPTERSCAVAILABLE:
0:00 ESKAPE Pathogens Microbial concepts
0:43 Pathogen is one that has the potential to cause disease. * ESKAPE is an acronym for pathogens that are resistant to antibiotics. ESKAPE stands for their names and their ability to escape the effect of commonly used antibiotics. Including both gram-negative and gram-positive bacteria.
1:52 Enterococcus faecium Staphylococcus aureus Klebsiella pneumoniae Acinetobacter baumannii Pseudomonas aeruginosa Enterobacter species.
2:41 Antimicrobial Resistance Mechanisms of ESKAPE Pathogens 1. Drug Inactivation or Alteration: Bacteria produce enzymes that irreversibly modify and inactivate the antibiotics, such as 8-lactamases, aminoglycoside-modifying enzymes, or chloramphenicol acetyltransferases. One of the well-characterized enzymes is 8-lactamases.
4:26 Porin Loss: The outer membranes of Gram-negative bacteria contain proteins called porins that form channels that allow the passage of many hydrophilic substances, including antibiotics. A reduction in the number of porin proteins results in decreased drug influx into the cell, allowing the bacterium to develop resistance.
11:42 Enterobacter spp. Enterobacter species are non fastidious Gram-negative rods that are sometimes encapsulated. • Many Enterobacter strains contain ESBLs and carbapenemases, including VIM, OXA, Metallo-6- lactamase-1, and KPC.
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[@nooraldeenalsolihi6778]

Thank you so much

[@sadiqaisha4057]

Great lecture, thanks

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Tnku ma’am 😇