Fallout 4 Chems Tier List

[@ErosXCaos]

The game code treats all varieties of *Nuka Cola* as _chems,_ as well as *pre-war food,* *raw meat,* *veggies* and *wild veggies,* too. Therefore, taking the *_CHEMIST_* perk _increases_ the amount they heal. The game classifies “irradiated” as chems. Enjoy. With the 50% heal buff magazine, an Ice Cold Nuke Cola Quantum heals 2,400 hp or so, with max Ranks of Chemist.

[@civilez7060]

Nuka Cola Quantum (not Iced) with full Chemist and BioCommMesh, it heals for 2700.

[@nothitler941]

Tato build goes hard

[@alexskocy9948]

@@ErosXCaos this is extremely useful for my survival game

[@MrCheese4cake]

On behalf of Australia, I apologise for ruining peoples immersion during their playthrough as a drug user.

[@TheTrueFool]

It's actually fun having unique names for chems in Fallout.

[@jasonpiedra9633]

Not to go full nerd, there's jet and buffout in the older games so I think those were the names given, but med- x I believe was a fallout 3 thing and that's when the foreign market influenced the names,or i could be wrong and that's why they were named that in 1-2

[@siri7005]

Don't, it's way better like this. It would look and feel dumb if they used the names of real drugs.

[@mitchellbarton7915]

Honestly, it's not that much of a loss. Probably would have made it easier for the devs, sure. But as a result we have iconic names and terms for them. We've got you aussies to thank for actually bringing originality to the fallout universe. This is a rare case of censorship done right, I'd say.

[@TheGaara802]

It's far better with the unique names actually then the real world members

[@Trian.]

18:32 Overdrive also lets you crit OUTSIDE of Vats. Very fun and overpowered with guns like a freezing flamer.

[@floor_tile]

How does that work?

[@civilez7060]

​@@floor_tileit just says you critical hit on a pop up notification.

[@floor_tile]

@@civilez7060 ok!

[@GasGrassOrAssetto]

Yeah I combine it with jet and psycho and just turn into a war machine

[@44WarmocK77]

@@floor_tile it adds 25 percent your critical hit chance (which is baseline 0 percent) for 5 minutes. The crit effect in VATS basically just gives you a one-time 100 percent boost when you activate it. Gets quite funny when you add mods to the mix which add new ways to increase your critical hit chance through other means and have them stack on top of each other. Frenzy and Freezing legendary effect will become your best buddies forever. ^^

[@Biomancy]

X-Cell also has one of the highest addiction chances out of all the chems.

[@cat-meowhood]

Fallout 4 added some chems for certain builds which is something I didn't expect from bethesda, but the basic chems seems to be good enough for me since they offer a lot already.

[@ZacharyH20]

You forgot the biggest selling point of psychojet: It makes you sound like the Kool aid man. OH YEAH!

[@ErosXCaos]

Charisma boosters are top shelf, because you will never fail a speech check with 11 CHR. Jet Fuel gets bumped up due to it being the only long lasting Jet chem, for when you get addicted. Med-X is excellent, since there’s no other in-game poison resist. Mirelurk Queen spit is as deadly to Power Armor as it is to Naked Guy. Psychotats is excellent because you get DR, unlike Psychobuff. A primer on how to stack chems would’ve been nice. Decisions on what to take might be based on what can stack. (Edit: Poisoner’s Armor Legendary effect.)

[@basicallybacon2593]

Mysterious serum is infinite if you side against jack cabot. You come back every day after using it and he gives you more.

[@xpoaze]

fun fact it also cures the molerat disease

[@GasGrassOrAssetto]

​@xpoaze lmao really? I'm going to try that

[@xpoaze]

@@GasGrassOrAssetto im pretty sure it does but im not 100% certain

[@-TakingSomeLs]

Putting Day Tripper in the worst tier is some fucking wild shit

[@ReapeeRon]

Really I never end up using it and just sell it.

[@danielmyers-cowan3416]

​​@@ReapeeRon it's the best charisma Chem in the game, +3 makes a huge difference on most Speech checks. For survival daytipper is essential, that and a suit are always in my back pocket 🤣

[@snekkobean]

@@danielmyers-cowan3416 grape mentats are +5?

[@deathclawsv101]

@@snekkobean Use both

[@Llamaguru]

At least put in the outlawed in Oz tier. Taking that before buying or selling is very nice

[@KiraBakudan]

As a raging alcoholic and Psycho addict, I've been waiting for this one!

[@ReapeeRon]

Hope that you enjoy it!

[@leviyoder296]

grape mentats as mid? literally lets you pass every charisma check with low charisma and cha gear, L take

[@KerioFive]

I use it all the time for that 👍

[@jhonea6535]

Plus the drawback us a cha penalty...that doesn't apply when you dose up...

[@GasGrassOrAssetto]

Use it anytime I buy anything

[@swissarmyknight4306]

Its also very worth it for major sales and purchases.

[@fangthedergon1863]

Addictol IRL would be a groundbreaking discovery

[@DustinDonald-cz9ot]

Daytripper might not be that great as a drug but it is awesome when trying to build up your settlements due to the charisma increase since the amount of settlers you can have at each location is based on your charisma score and is one of the only 3 drugs that increase charisma and they stack the others being x-cell(extremely hard to get worse than daytrippers) and grape mentats which are easy to make.

[@lesser8531]

Antibiotics and Herbal Remedies don't appear outside of Survival Mode and there are no illnesses on other difficulties. Berry Mentats highlights every enemy and NPC, robots included. Buffjet is pretty crap as the secondary effects only last for as long as the slow time does. Grape Mentats are very easy to craft and let you buy OP items early. The whole point of Overdrive is to have crits outside of VATS, it has no effect on regular crits.

[@curtharakaly4620]

Was gonna say...didn't think antibiotics were even non survival lol

[@leviyoder296]

Resilient sludge cocktail reduces rad resistance, not increases it. X-111 and mysterious serum are not limited

[@screamingcactus1753]

I believe the mysterious serum is limited if you kill Lorenzo. If you free him, he'll occasionally give you one when you talk to him, but if you kill him, you get a unique variant of the Gamma gun.

[@screamingcactus1753]

I always try to keep at least a couple grape mentats and a suit or dress on me if I'm playing a low charisma character. That instant plus seven charisma is enough to reliably pass almost any speech check in the game no matter how low your base charisma is. Throw on a formal hat and black rimmed glasses and you can get one charisma character all the way up to ten for the purpose of speech checks.

[@kayn9651]

One thing to consider about chems that give you big negatives, or if their addicted status does. Idk if they fixed it or not, but you were able to use them to boost your stats above 10. So you'd stack debuffs from chems and chem addictions for like -7 strength, put perk points into it up to 10 then heal at a doc and boom, permanent 17 strength, that can be further boosted by items and other chems.

[@bowaster57]

About Calmex Silk, the stealth attack multiplier is additive not multiplicative. Also using the chem on survival mode will advance your dehydration by around 3 stages so if you want to use it you're going to have to drink up to 6 purified waters. Still a very strong chem but be warned.

[@ReapeeRon]

Thanks for the heads up I thought it was multiplicative.

[@darianrodriguez3544]

Reapeecon i wanna say thank you your coverage of the fallout games is truly something special

[@sting3242]

Recently discovered your channel because I'm on another Fallout bender and I've been watching your videos like every night before bed. Haha keep it up man, your hard work is much appreciated.

[@joepesci2269]

Grape mentats are very good for charisma checks, because you can open pipboy and eat them in the middle of dialogues

[@Dustyholes]

Mentats and Buffout are my personal favorites. No reason just vibes.

[@NightfallFIN]

Hey Ron and greetings from Finland! A brand new member here, I found your channel about a week ago while I was searching for FONV content. Great videos, keep up the good work! 👍

[@ReapeeRon]

Hello Nightfall! Welcome to the channel, that is very kind of you! I have not yet been to Finland but if it is anything like Denmark then it is a very lovely place to visit!

[@billw.overbeck8913]

Suomi mainittu tortilla avataan! Perkele

[@Flood520]

Very timely. I'm around mid game on a druggie character right now. She eats the various buff out, jet, psycho blends like it's an open buffet. And thanks to Party Girl she's drunk 24/7. There are 2 X-cel in the Concord Speakeasy and I always make sure to grab them to help with early skill checks that I might not otherwise pass.

[@rumbawakka7166]

i wish real life drugs were this cool

[@ReapeeRon]

Me too dude!

[@Dilllonm]

But you end up like a fiend from nv irl 😂

[@stevenbragg85]

How you done a steroid cycle with meth as a preworkout?

[@LeleiTheTigress]

I remember the mysterious serum glitching in my first playthrough, and the effect would just keep resetting itself for some reason. I don't know what caused this, neither could I replicate the glitch on any other playthrough. But hey, permanent strength, damage resistance, and the ability to negate radiation was nice

[@neripheral]

What's the name of the song/music that starts playing around 16:00?

[@kingmayonnaise4913]

Only chem I ever find myself using much is grape mentats because I usually go straight to nuka world at level 1 and need them to pass the speech check to get the problem solver to have any hope of clearing the dlc

[@JMD_Ikonix]

Bloodied builds are starting to find their way into fallout 4. If you're focusing on a low hp/high rads build then the sludgepaks are just a damn good cherry on top of a already high damaging sundae.

[@mortenbecksrensen7409]

I always live on a combo of Bufftats, Psychobuff and Ultra Jet for the best of all worlds. Easy to have infinite uptime on bufftats and psychobuff too with how long they last. I also use Jet Fuel with the others, but it is more a quality of life than anything. And unlike the other chems it is basically free to craft and it lasts just as long as bufftats and psychobuff too.

[@Jaime0007]

I think the grape mentats are actually underrated, the better prices are not that good I can agree with that, but they almost guarantee that you will pass any speech check. That's whatbI use them for exclusively lol

[@Zygwired]

It can definitely help early game getting a good weapon, if you need to buy overseers or an equivalent forking out 10k caps is hard and you can raise the price of everything you’re selling to counteract that.

[@caseykirsch2448]

Especially for how easy the supplies are to find

[@johnflier4873]

My first thought after looking at this is that there should have been a Psycho Jet tier. No need to beat around the bush, it's the best chem for combat in general and it's not close.

[@bowaster57]

It's actually better to take psychobuff and jet sepererately, you will get bigger buffs and you will get them for longer. Psychojet is the noob bait chem.

[@mortenbecksrensen7409]

@@bowaster57 Never understood why people insist on doing psychojet. Like look at how much you ruin the long duration of a good psycho drug lol.

[@alex111683]

There's doctors ALL over the place. You can even have them in your settlements

[@Capta1nAsh]

This guy gonna be doing misc item tier lists for fallout 3 soon. Pounding these videos out until Fallout 5 doesn’t come out

[@nerdywayfinder1827]

So dumb newbie question here. But you mentioned skill checks several times such as for computer hacking. But isnt fallout 4's system of those based on how many skill points you've put into that skill and not special stat bonus? For example if I have only novice in lock picking but have an advanced lock in front of me. I thought it wasn't possible to pass the check no matter how high I boost any relevant special stat to the check. I'm still at level NOVICE so therefore taking any drug wont help. Am I wrong?

[@ReapeeRon]

You are right about that. I meant this when talking to characters. I might have said that thinking of the hacking and lock picking thinking of fallout 3 and NV.

[@MrJarrydLee]

excuse me good sir, how can you say Intelligence is good for XP gain but you think Night Person is a D tier perk when it gives you that same XP boost for half the game 🤨🤔

[@ReapeeRon]

Because that requires perk points that are better spent else where. I'm never going to go for night person when idiot savant is so much better.

[@MrJarrydLee]

@@ReapeeRonthat’s fair, Idiot Savant is my favorite perk in the game but you gotta respect Night Person 😂 at least give it a C

[@Dilllonm]

Of course, Australia is being a crybaby about drug names in a game or you can blow people up and about 30 different animations be a slaver and a bunch of other stuff but it turned out to be a rare win because the names are iconic

[@davidcollinsjr4288]

Antibiotics don't appear in game unless you're on survival, and the only illness that drains health over time is infection

[@TheWatchmanOfTheEnd]

Mentats are essential to having a 99 Charisma with the debuff stacking glitch. Top tier chem. Paired with the You're Special book dupe glitch is pretty broken.

[@Fengxain]

I can understand the durable sludge pack if you are trying to pop nerd rage all the time. 10:56

[@exoticbutters4212]

Real life drug tier list next

[@davidjacobs7465]

Lots of these are great for melee builds. I mostly just focused on the strength stat itself to increase from chems, but fury is just too damn fun. It gets really cracked when you factor in sneak attack multipliers. But if you do let me advise you to first get Deacon's companion perk, then get the ninja perk. Oh and maybe use the blitz and rooted perks too.

[@swissarmyknight4306]

Daytripper is solid if you're bartering, and it isn't that bad being overencumbered temporarily if you're bartering with a stationary merchant, even in survival modes.

[@jadezade5330]

Doesn’t the Resilient Sludge Cocktail actually decrease radiation resistance instead of increasing it?

[@monumentalsin3552]

Stem packs and rad way are all i ever use. Dont see use for anything else

[@bowaster57]

Fury is a really bad chem because it's bugged. If you have Big Leagues 2 (or 3 I'm not sure), you won't actually gain the extra melee damage. So while it sounds like an excellent chem for a melee build, it won't work if you have THE most essential melee perk.

[@ReapeeRon]

Is it? I don't really use melee in Fallout 4 so that's kind of funny.

[@bowaster57]

@@ReapeeRon The unarmed buff works fine as far as I'm aware

[@ReapeeRon]

@@bowaster57 lol that's even stranger. But it does make sense for Fallout.

[@StriderFitzsimmons]

Nuka cola tier list when?

[@ReapeeRon]

I might do that for all of the named drinks through out fallout.

[@StriderFitzsimmons]

@@ReapeeRon awesome thanks 👍

[@SulfurFurious]

Psycho-Jet. Nothing else.

[@silverjohn6037]

2:18 If you haven't tried it a VATS build with a stealthy pistol user is pretty overpowered.

[@tones9_6]

Addictol might be the best and worst because you'll still have the active benefits of the drug you were just addicted to. Realistically a chem fiend can abuse any drug with out ever experiencing side effects.

[@markgustafson7039]

How did you decide on the Thaddeus costume?

[@jakewarman7277]

You can get more of the better then radaway compound by bringing the person you got it from more viable blood samples.

[@Biomancy]

Mentats were really good in Fallout 3 and New Vegas because by boosting Perception and Intelligence (and Charisma in New Vegas) they also boosted the Lockpicking and Science skills, so you could get into a locked container or door or terminal that you weren't skilled enough to get into otherwise. But Fallout 4 doesn't have skills so I guess it just increases vats accuracy or something.

[@MissSimone02]

Doesn't the refreshing beverage in FO4 remove addictions? You craft it in the chem workbench. You shouldn't be struggling with addiction in that game.

[@Psychonautical89]

It depends on how you're playing, because I find Chem Resistant one of the MOST useful perks on Survival Mode because I am always using Jet and Jet Fuel to survive tougher battles and skate around quicker. I literally carry dozens of each around and use them and every other chem quite liberally, to the point that keeping on top of the couple of rarer components of Refreshing Beverages is a chore. I still don't even bother with Party Boy/Girl, so occasionally I'll get addicted to booze and find them useful for an occasional cleanse of rads and the creature. But not having to worry about it while I've got Jet, Jet Fuel, and Psycho on my Chems hotkeys is super convenient.

[@MissSimone02]

@@Psychonautical89 I mean that's a strategy, but refreshing beverages are quite easy to craft without having the need to pick Chem Resistant as a perk.

[@BigSleepyJoeCooking]

Sneak + fire belly + psycho + calmex = ridiculousness

[@mixedtrails2435]

Loving the videos man! keep up the awesome content :)

[@ninjasheep7492]

I personally love mentats. You are essentially just trading caps for level ups. Given there is a very high level cap and leveling up is rarely bad I would take that deal. If it was “pick one drug to use and never use any others” then it isn’t too useful, but the way I see it is if you have caps, and you want XP, it’s always useful, no matter the build. Also you can get an infinite amount of mysterious serum for free, but only 1 at a time. Its stats are so ridiculous that I use it as a “get out of death free” thing. With melee builds it’s insane and with all other builds it can help very much to survive that random raiser with a fat man.

[@Capta1nAsh]

I think I’ve seen Calmex once in the 700hrs I’ve played Fallout 4. I forget it exists tbh. I love Overdrive. Makes the game feel like Fallout 3/NV and makes automatic weapons really good. Minigun is somewhat useful with this chem

[@GasGrassOrAssetto]

I just got it for the first time in the institute

[@MrWhite3777]

So after watching two dozen of videos from this guy, I’ve come to realize that he only knows about half of what’s going on inside of the games.

[@ReapeeRon]

Thanks I think, half is a lot for these kind of games.

[@GunnerR3X]

​@@ReapeeRon antibiotics aren't even in fallout 4 outside of survival mode 😂 you don't even get sick in vanilla

[@blakethatcher4399]

The herbal anodyne and stimulant also cure thirst

[@chrisschade5578]

Where you getting antibiotics not in survival?

[@ReapeeRon]

In my brain i think...

[@meeklynobody3230]

Grape mentats are S tier in my survival playthrough. Paired with dress/shades/pomp wig/ +2 chr on arm slots through legendary. Im getting 10 chr least +better vendor prices. I always need ammo.

[@brantnuttall]

2:39 oh no. the most fun I've had in any Fallout game was as Home Run Boy with blitz. You know what my weapon was!

[@MultiKingmon]

Why don't you like melee in fallout 4? Is it blocking.

[@simonyu8838]

Pretty sure M rated games were outlawed entirely in Australia back when the first two games were released so I don't think that played a role in the names of the original chems. It definitely affected Med-X's name in Fallout 3 though.

[@inductivegrunt94]

Buffout is my favorite chem that isn't Stimpacks, Rad-X, or Rad-Away because of how often I get overencumbered with how much of a loot gremlin I am.

[@screamingcactus1753]

If you really wanna push your carry weight to the max, stack it on a Dirty Wastelander for a total +5 strength

[@sting9849]

My boy Ron out here ranking drugs, I mean uhhh chems!

[@ReapeeRon]

Just a little bit.

[@bacd-nn2lg]

I almost never use chems for my overall Fallout 4 walkthrough, since were competent enough to deal with every enemy. But my top shelf chems that I always use are Rad-X, Stimpak, and RadAway. Ps. I also never finished up Fallout 4 on Survival mode, since the game wasn't that stable on PS4, but maybe things changed after the next gen update.

[@baldrian22]

i dont usualy use inteligent at all. the idiot savant perk (Specialy at T2) is far stronger than even maxed out inteligent even if you get it off the roof with all the boosts you can possibly get. i would not however use the T3 because that drasticly changes the amount of times it procs on building, completing quests etc.

[@Tucher97]

This may sound weird, I prefer the name changes, it makes them sound more "fantastical" in a way. Also if Buffout is not top tier, lets say the Pyscho and Jet will look mighty friendly with fist to face therapy. Ok jokes/threats aside, since after playing Skyrim, which I kept a strength potion on when I felt like really hoarding stuff, in 4, I kept a bottle of buffout in my inventory at all times. However as a fare warning, this habit needs to be dropped completely if your playing Fallout 76. Mentats eh, that is a chem I keep around in Fallout 3 and New Vegas, not so much in 4, I do not know, it might be because In 3 and NV, I would use the mentats to give me some extra points when hacking which 4, hacking and lock picking are dependent very specific 'perks'.

[@Lord_necromancer]

Berry mentats should be at the absolute top peak tear. It gives you extra XP game, so it's great to use pretty much anytime if you are killing enemies or turning in quests, and also the highlights living enemies is great to make sure that you clear out enemies. I absolutely hate whenever I'm looking around and my heads up display says caution, but I cannot find where the hell that last enemy is hiding. Just follow the purple glow! Also, it does absolutely nothing for hacking computers because whether you can hack computers based entirely on the perk and nothing else so that tells me that I don't think you know all that much about fallout 4 lol you are thinking of fallout New Vegas mechanics

[@crimsonknight7011]

One of the more evil things to do with chems is to cure Cait of her addiction and then force her to carry all your chems just to tempt her

[@jastermereel4946]

i'm a vats freak, so i love me some orange mentat, calmex silk, and jet fuel

[@zanesnyder9611]

Finally downloaded fallout 4, I'm so glad i k ow which drugs to take!

[@thomasshirley318]

Pretty sure psycho was steroids

[@ReapeeRon]

Was it? I would think that would be buffout but I don't think that was in the first game.

[@Astolfo_Courier]

Psycho is a mix of cocaine and PCP and buffout is steroids

[@brantnuttall]

over 2000 hours played and I didn't know some of these. Also, do super stimpaks exist in this game? You didn't cover them.

[@Rj-pw7zs]

Man I haven't even heard of half of these.

[@ReapeeRon]

I don't use most of these either.

[@Foreign501st]

Tier list idea: Magazines from F3, NV, and F4. Maybe separate them into 3 different videos, though.

[@JohnAymar-k4o]

Rarely play fallout 4 but ummm grape mentats are my favorite because the boost to selling is good

[@TasTheWatcher]

4's Jet is just New Vegas's Turbo

[@wildercerrate7295]

Honestly the in universe names are better. Makes the world feel deeper and all the backstory to the drugs add onto that

[@ItzLoona]

Most Psycho perks are an easy S Tier, popping a Psycho + Jet is practically a free win in every single fight as long as you aren't genuinely braindead.

[@meldamo]

Mixing anything with jet is a waste, you lose mins on the stats. Jet fuel and ultra jet are the ones that make good use of jet without wasting other ingredients.

[@ItzLoona]

@@meldamo ok but Psycho + Jet + Never Ending Double Barrel Shotgun = you win absolutely everything and you physically cannot lose this fight.

[@KodasGarden]

damn they missed the opportunity to rename "Psycho Buff" to "Psych-out"

[@ngepeakfic5716]

feel like im watching a Goblin 420 video

[@ripdimebag42]

Putting the points in charisma so you can put doctors in your settlements makes addictions a non issue

[@andyking7621]

Now I want to play Fallout 4

[@MARTINRIGGSS]

I take everything. I only use stims lol

[@johnoglesby-vw7ck]

Glad to see someone appreciating the distinction😀😆

[@mycoal3016]

Med-x placed higher tier than "Mid tier med-x".

[@weistber9582]

Chems are for winners.

[@ReapeeRon]

In Fallout they are!

[@johnoglesby-vw7ck]

Day Tripper...Beatles approved😀

[@Wildcat_93]

I hate how slow and telegraphed unarmed is in Fallout 4.

[@ReapeeRon]

Yeah me too.

[@Housefreaky12]

Drugs tier list fr

[@ReapeeRon]

fr fr

[@bonweech3346]

The antibiotics, herbal stuff and anything to do with illness DOESNT EXIST in base Fallout4. The illnesses don’t exist in base game. If you’re making videos on the game, that seems like a large detail to miss bro

[@pouemo9658]

Now do an irl one plz

[@drakesingh9845]

I highly disagree where berry mentats is placed. Its great for dungeons especially when solo. Long term i think its the best variant of the mentat or tied with grape mentat. Just my opinion. Great video

[@Chamuko99]

I love cheeems mmm

[@ReapeeRon]

Me too!

[@anthonygrassi4690]

....So much in the air cause it seems you have 1 build and that's it...Okay enough video but hearing "I don't do this build just sell it" just lost all interest in seeing anything of your further...

[@KerioFive]

Stimpak F

[@EdgarStyles1234]

>fallout 4 So not fallout eh

[@lordweeb8928]

What does this even mean are you trying to say fallout 4 is bad?

[@lucashogberg9336]

Bro said vats is bad in fo4 don’t take anything seriously lmao

[@stateyourbuisness1928]

Depends on your build very heavily