Fatty Acid Chain Elongation (The Four Steps)

[@ehrenw721]

Thank you! My med school professors confused the crap out of me and now I am no longer confused.

[@kylaw6485]

Sir, yr video is underrated

[@szshz]

Precise and easy to understand, thanks!

[@osayameedwin6246]

It was a very helpful lecture. Thank you

[@choochootrain329]

These videos are great :) Please keep making them!

[@wondersofchemistry]

Thanks Chewyjoohee !! (Cool name) so glad to hear that you are benefiting from my videos :-)

[@nrnflowers]

Thank you so much for this video! I just didnt understand how it needs 8 acetyl-CoAs. The preparatory step required 1 acetyl-CoA & 1 malonyl-CoA - malonyl-CoA from carboxylation of acetyl-CoA. The 7 cycles require 1 acetyl-CoAs each. So shouldn't it require 9 instead of 8?

[@wondersofchemistry]

Hi Seihee, there are a total of 7 chain elongations in the production of the C16 Fatty Acid known as Palmitic Acid. The first chain elongation requires the input of one acetyl coA and one Malonyl CoA. Recall that the preparatory step uses an acetyl coA to produce this Malonyl CoA. So in short, 2 acetyl CoA's are required to get the first chain elongation started. This leaves us with a remaining 6 chain elongations out of a total of seven. Each of these 6 chain elongations requires one acetyl coA. If we now add up all the acetyl CoA's from each of the chain elongations we end up with 2 from the first chain elongation and 6 for the remaining 6 chain elongations. This gives us 2 + 6 = 8 acetyl coA's. Hope this helps? Regards, Wonders of Chemistry

[@nrnflowers]

@@wondersofchemistry Thank you, I understand now :)

[@wondersofchemistry]

@@nrnflowers Thats great! You probably helped so many people by asking that question :-)

[@riyanbabar8416]

Very amazing video, easily understandable 👌

[@工藤幸子-p2u]

Your videos are very helpful. Thank you !

[@wondersofchemistry]

Hi Sachito, thank you for your positive comment :-)

[@wondersofchemistry]

Thank you

[@anndsouza3620]

Great video! Really concise.

[@andreaenamorado1566]

Thankyou so much!! LOVED ALL YOUR VIDEOS

[@ruqiasaeed3887]

Thank you much 🤍🤍🤍🤍🤍🤍🤍

[@motive_media2103]

Nice 🎉🔥

[@wondersofchemistry]

thank you :-)

[@emelias7512]

so helpful thank you so much1!!!!

[@chandanargowrav5162]

Does the elongation of fatty acids and Biosynthesis of fatty acids mean the same??

[@wondersofchemistry]

Biosynthesis of fatty acids includes a number of preparatory steps (including the commitment step) before chain elongation can occur. Based on this i believe it might be an oversimplification to think of chain elongation and Biosynthesis of fatty acids to be the same. This however is only my opinion. I would suggest you talk to your lecturer to see what they think? This is especially important if it is something that might be deemed as examinable with the course you are enrolled in. Hope this helps?

[@chandanargowrav5162]

@@wondersofchemistry Thank you🤗

[@wondersofchemistry]

@@chandanargowrav5162 no worries :-)

[@Phosphoenoylpyruvate]

@@chandanargowrav5162elongation also involves the elongation of palmitic acid (16c) performed by elongases after the fatty acid synthase produces palmitic acid

[@Phosphoenoylpyruvate]

@@chandanargowrav5162desaturases also produces unsaturated fatty acids by adding double bonds (cis and trans)

[@gabrieladelgado1]

Thank you so much!

[@wondersofchemistry]

Hi Gabriela! Thanks for taking the time to send me your appreciation for my video :-)

[@gabrieladelgado1]

@@wondersofchemistry how could i not? This helped me alot. I have my block2 exam for med school in biochem and this is a life saver🙌🏻🤍

[@wondersofchemistry]

@@gabrieladelgado1 No worries. Just here to help if i can. These are troubled times we are facing, so if i can make a difference to even just one person in their understanding of a subject that they might be struggling on ... well ... i guess you know where i'm going with this... Good luck with your studies Gabriela :-)

[@kmkim37]

Neat

[@begumjunior2230]

❤❤

[@reemabosada6639]

perfect thank you so much

[@wondersofchemistry]

Glad it helped!

[@kylaw6485]

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