Fatty Acid Synthesis

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My goal is to reduce educational disparities by making education FREE.
These videos help you score extra points on medical school exams (USMLE, COMLEX, etc.)
For educational purposes only; NOT medical or other advice.
Some videos contain mild profanity and hyperbole solely used to assist with memorization. Viewer discretion advised.
Opinions are entirely my own.

[@ezikeadaobi]

Biotin also serves as a coenzyme for the rate limiting enzyme; ACC(Acetyl-CoA Carboxylase). Great video👌.

[@cuttingedgetechsongsmovies9662]

Teach me

[@Dmhiz]

💯

[@michaelsrowland]

What is a rate limiting enzyme?

[@frameshift_mutation]

@@michaelsrowland The slowest enzyme in the pathway

[@clarissabethmore1711]

I think this video is by far THE most simplified version of fatty acid synthesis. Thank you sooooooooooo much!!!

[@jessydecastro4686]

!!!

[@nurulaliahrizal]

Thank you very much! I love the tip you shared about memorizing the rate-limiting enzyme. fatty ACC-id synthesis A-Acetyl C-CoA C-Carboxylase

[@lana89001]

This is gonna sound weird...but your voice makes me become so much more focused. Thank you for the video!

[@harishsha1346]

It's not weird I felt the same too..

[@khadijah3343]

Your videos are so amazing! Hours of lectures that I've barely understood makes sense completely :))

[@leobarca678]

You are one of the few people that are so great at explaining such heavy stuff. Thank you so much, your videos are very helpful.

[@argumentumadbaculum]

All your biochemistry videos are pure gold. Thanks a lot.

[@maxbilo6191]

14:50 Citrate to Palmitate 17:10 Summary Slide of the net equation 17:45. Final Slide

[@lisagonzalez2902]

Once more, an amazing video. It's even better because you have a lot of repetition so it helps for information to sink in.

[@WhiteCoatPending]

your videos are always clear, concise and so helpful You are very much appreciated!

[@priyam1550]

Thank you for making these painful topics easy to understand!

[@duai7090]

I can’t describe how much you made my life easier. My prof made things quite complicated to understand. Thank you 🙌🏼💛

[@CathyMiscala]

You just earned a subscriber. Great job explaining this. Thanks!

[@eturley7533]

THANK YOU! This helped so much. I was wasting hours trying to learn this, but you made it so easy.

[@alvinscharles498]

Linolenic acid = the first "n" is third counting backwards (Omega 3) Linoleic acid = the first "n" is sixth counting backwards (Omega 6)

[@anamariem8715]

Oh WOW that is by far the best explanation of this topic . I don’t think I will have fun any where else studying biochemistry . Thanks a lot for the help.

[@brandofett017]

Your voice and humor reminds me a lot of the channel Casually Explained. Love the videos!

[@catfish7257]

I'm really having trouble to understand fatty acid synthesis explained by my lecturer, surprisingly when you explain it, it wasnt that hard!

[@Jord40]

Greatest of all time

[@rhymez3606]

Your channel help me allot in Biochemistry,now things became smooth

[@thevegandragon4676]

Brilliant video and explanation! Thank you soo much!

[@user-po4cu7rb5z]

I LOVE DIRTY BIOCHEM LIKE NOTHING ELSE IN MEDICAL STUDIES! DIRTY MED IS THE ONE THING WHICH WAS BEST EVER SOURCE WHICH MUST HAVE GIVEN ME SO MANY POINTS IN MY STEP 1❤

[@anouded]

Your videos are GREAT :)) Many respect from Jordan

[@yarenparlak1210]

This is the first time I've watched this channel but it won't be the last. English is not my main language but i understand more clearly than my lesson.

[@ThatViolistKatie]

Even though this is for med students, this is awesome for MCAT studying too! It’s more than you need to know but I love to think about the big picture not just memorizing things.

[@felipesolares]

Is there any way to watch the videos in order? The KZbin playlist doesn't put them in order and it's a bit confusing. Thank you for such amazing content. You are a life saver.

[@yourwellbeing95]

Countless thankx for sharing your knowledge..

[@Salam_1965]

Excellent video and outstanding teacher

[@iabdullah4126]

man you are the real GOAT

[@medicousa141]

This is pure gold

[@sililly1379]

Thank you so much.

[@vimalfestus8398]

Today I binge watched all of ur videos🙌🙌

[@mercifulserventurdu1753]

Wowww man you are just amazing, i have watched so many videos, but i stopped at yours, you explained so well and in an easy way 🌺👏 hat off 🎩

[@naginakhan1ify]

This isn't Dirty Medicine but Shining Medicine.. love the explanation. Thanks

[@user-pk5mk9hi2m]

The citrate shuttle is like that of the malate shuttle where oxaloacetate should first be converted to malate, which can come out of mitochondria and then get reconverted to oxaloacetate for gluconeogenesis.

[@ananyasharma172]

you're effortless

[@sherykhan3722]

Really helpful ! develop understanding and concept you really explain it in simplest way

[@giraybozkaya1377]

Thank you for the informative video. I noticed a mistake in the example of polyansaturated fatty acid. I remember that the double bonds between carbon atoms should be spaced at three carbon intervals, but the double bonds in the example are not spaced. Maybe you may think to change the example.

[@kehalilmengistie3462]

Thank you.

[@kayallen7603]

The name of this process is gluconeogenesis . Your body does this to remove excess sugar/starch (they're the same thing) out of your bloodstream because the excess is TOXIC hyperglycemia. but too little is also deadly hypoglycemia.

[@DrKat45]

Excellent ❤,thank you.

[@ND-zj2xe]

I’m so proud of my body that it remembers how all these processes work so perfectly … I would have never done that well by myself 😅

[@hama297]

Great vidoe great explanation,you don’t know how much you helped me thanks alottt

[@udennaebii1585]

Glad I watched this one . Thanks Dirty.

[@lucindadewaal9511]

THANK YOU

[@derricknarhsormenah9383]

Great lecture! Thank you Bro

[@nimraaslam7715]

You are the best!

[@tamunotonyeedward2544]

Thank you so much sir. Your video said it all. ❤

[@juaquannadavis9168]

Well done.

[@monika246]

Huge respect🙏

[@Jumanajum_]

you saved my life thanks

[@emmanuelmwale5719]

You are the best

[@derogatory.]

A true legend.

[@jojoo98alth33]

thank you you save my grades

[@hassanalikhan5523]

Good explanation

[@fgnsdfnbnd]

EPA means 20 carbons and DHA means 22 carbons. A grass fed cow makes more omega 3 FA's than a grain fed cow (grain fed makes more omega 6 versus grass fed) BUT a pinky size slice of salmon has equal amounts of omega 3 as 8 pounds of grass fed beef.

[@muneebtakesmedicine]

accha

[@TheUnXplainer]

Thanks!

[@mohammedfuadalusifiy7734]

Thank you so much 💓

[@Mohamed.AbdelNasser.]

thanks

[@salwaalmargny4685]

Thank you so much

[@JoshDanielGuitar]

Don't forget that an important cofactor of Acetyl CoA Carboxylase is biotin (vitamin B7)

[@dinayounis6473]

great video❤❤❤thank you

[@DrPilot23]

"guys an galls" thank a million sir

[@rosemarka9639]

Amaaaazing,thank U so much ❤️❤️❤️❤️❤️

[@manalhu1262]

THANK U

[@aliiraq9655]

Awesome ..

[@user-ur9dk1mo3o]

Please turn on the Translation

[@azuratriesnewstuff]

You're a legend

[@loveleenp.7311]

This video was so helpful!! Thanks so much!

[@agh6452]

Omeg 3 I recommended everyday for my patients

[@samjardavid6160]

Penjelasannya keren banget...

[@medicallifewithjohn8343]

Awesome

[@kemigishamichelle5263]

Wonderful video....🍓🍒

[@shonyagura8508]

Most fats in the body come from fats in food and not from glucose which is mainly converted to glycogen by insulin and stored in the liver and muscles. After exhausting the synthesis of glycogen, then excess glucose is converted to protein or fats depending in the body's needs

[@strongDr]

Lol 😆

[@michaelsrowland]

The body converts excess carbohydrates into triaglycerols which are stored in the adipocytes

[@michaelsrowland]

Not in England where people eat 2000g of carbs a day and spend all day sitting at a computer or in their car or watching tv

[@regminamuna1711]

Highly appreciate from Nepal🇳🇵

[@strongDr]

Keti Ko Keti Ko....

[@Devil-kp2ek]

Please start recording vedios bcz it is very useful for us

[@santhitapornklinthong9253]

Your lecture is wonderful. I have some questions. How many ATP will happen from the fatty acid synthesis and how many cycle occur until the palmitic synthesis complete.

[@kayallen7603]

w6 is what you usually get from terrestrial meat w3 come from oceanic fishes like sardine/mackerel/salmon "hence fish on Friday"

[@Poiuytrew.Q]

Maybe acetyl coA cant freely leave the mitochondria because if it did it would not as readily enter TCA.

[@kimberjaneblake8736]

thanks boo

[@georgeklucsarjr1988]

Not a student, but like to learn. Is palmitate the only saturated fat made, or can there be other carbon length saturated fats made too? I know like butter and coconut oil, have several carbon length saturated fats ( I have no idea on how these are made though )

[@chiahsuantsauo8375]

Wouldn’t the oxaloacetate be outside of the mitochondria which means it can’t take place in TCA? It’s not like the NADH generated in glycolysis or pyruvate metabolism that can utilize aspartate malate shuttle or glycerol phosphate shuttle to renter mitochondria

[@santyguita]

Great video, thanks.. This is why orange juice increases your triglycerides..

[@siegmac3267]

Because of citrate?

[@sgill4833]

Why does vinegar lower glucose response? Something to do with Acetyl Coa?

[@princetandukar9290]

At 10:29, why cant the acetyl CoA straight go into Fatty acid synthesis in the cytoplasm after glycolysis? Why does it have to go through the citrate shuffle??

[@Clevemac]

"citrate is easy to remember, because in the presence of citrate, what the hell are you gonna do with it, other than convert it?" lmao

[@inspiringvideosmsm5763]

do we need to remember the equation of these pathways for step 1 ??

[@karandeepkaur5211]

You made this topic so so so easy ...thank you alot💛

[@redpilledbachelor7776]

What about Epinephrine? Woild it inhibit FA sythesis as well?

[@daniellesan6466]

This great, but is not detalied enough for my exam in romania :(

[@salam95159]

May you activate Subtitles in English. Thanks

[@giftchulu3523]

Palmitate is a 16 carbon molecule

[@mahakhan9762]

this video is amazing for mcat prep! thanks

[@chisomchimezie]

Is it 6 molecules of water in the final reaction or 7?

[@vinitdasilva]

Nice vid! 11:54 - the TCA cycle image out of the mitocondria confused me.. Isn't the TCA cycle an intramitocondrial cycle?

[@salmanabashir1613]

Vinitdasilva: from my little research oxaloacetate (impermeable to the mitochondrial membrane) can be converted into malate ( permeable) by the enzyme malate dehydrogenase. Then malate can either be moved into the mitochondria to take part in the TCA cycle or malate can be converted to pyruvate by a malic enzyme - this reaction can produce NADPH which we need in fatty acid chain synthesis. I hope that helped, I am just a first year med student soooo if I did make a mistake please let me know.

[@cherryberry3850]

Same question.

[@bhumikachauhan333_]

🙌🙌💯

[@Jumanajum_]

dose always fatty acid synthesis start with glucose?

[@alaaabdelsalamalamin5619]

In each cycle we use 2 NADPH , I need 6 cycle to form the palmitate . That mean i use 12 NADPH , from where come the other 2 NADPH ??

[@luna.kashyap1313]

I just love u