Fatty Acid Synthesis Pathway: Overview, Enzymes and Regulation

[@michallyson8922]

Just some to clarify some small inaccuracies for some people that may be confused: -Before butyryl-CoA is formed it must undergo the reduction, dehydration and then reduction again whereas here it is shown that as soon as joining of Acetyl moiety to Melonyl-ACP takes place, the butyryl-Coa is formed. -It also stays attached to ACP therefore it should actually be butyryl-ACP. -The 6 carbon fatty acid is also produced on the second cycle not the first. This is a great video tho and it helped me to fathom this process. To those, like me that are learning for undergrad study I recommend using a variety of sources and deeper research in general to help solidify this knowledge and to be able to apply it when answering questions.

[@pthuong.0110]

As I'm cramming for biochemistry final, I'll always start any pathway with your video before reading our book. This condensed content is exactly what I need when my attention span is... limited at best and non-existent at worst. Thank you!

[@owaniedmond8914]

Finally understood the difference between hard work and smart work. You are just too smart 🤝

[@anahitarezaei3057]

Thank u so much I was almost crying I have an exam in 2 hours!!!

[@khoshalsaidy526]

Finnaly i found, that from where our teacher is learning and teaching fatty acid synthesis😐

[@anielkavaleska9123]

😂

[@samikshapathania3786]

😂😂

[@advikdutta]

😂😂😂😂

[@pctnowin1251]

You should appreciate if your teacher is putting in effort to make the topic easier for you

[@epiccutie105]

😂😂😂😂😂

[@KainCorvin]

Really good explanation. It really helps to connect the dots! I new, for instance, that both malonyl CoA and NADPH were important but not exactly for what. This overview gives you the answer. Perfect for repetition for exams.

[@maxwellsimon4538]

In highschool biology, we were only ever taught where sugars come from and how they're formed. I always wondered how fatty acids, as well as the other groups of organic molecules were formed, and now I know

[@omurukakingsley]

thanks JJ Medicine. I've been really finding it difficult to understand the cycling reactions but after watching your video, I just understood. Thanks so much.

[@interestingandinformationcombo]

hats off to u sir g apka lec leny k baad mujhy ye topic sbsy easy lg raha hy

[@AtaAta-dk8vg]

Thank you so much!I study in Turkey and I didn’t understand in the class but I get it now 👍🏻

[@mariediederichs2604]

this was the best video I saw on this topic, very precise and comprehensible explanation!

[@snlvl]

Thank you so much! A really really good explanation. I see it more clear now!

[@a2300_]

Thank you for the explanation! Also would like to add, that as you have mentioned (in the summary) the utilization of 7ATPs in the acetyl-CoA carboxylase reaction, you should have also mentioned that in that exact reaction 7 CO2 are used, so the total production of CO2 should be 0, not 7

[@zapataboy9377]

Very usefull thanks

[@ElizabethMadisonnutrition]

This was great, simple to understand overview of fatty acid synthesis. Thanks so much!!

[@hirarafiq4970]

Very clear explanation of end product

[@logy3481]

God bless you and your efforts

[@Tehve1]

Thank you so much, God bless!

[@alevelsdemystified3410]

a couple of things to add for the sake of elaboration. This palmitate can be elongated. by the addition of 2C units in the SER. Malonyl coA is still the 2C donor and NADPH provides reduction. The brain is special in that it can produce very long chain fatty acids. The resulting fatty acid can be desaturated in the SER by acyl coA desaturases (addition of cis double bonds). This is how unsaturated fatty acids are produced denovo! This process requires, oxygen, NADH, cytochrome b5 and FAD linked reductase. First double bond normally added between the 9th and 10th C atom. The fatty acid synthase has 6 enzymic domains. 1.Condensing enzyme (3-ketoacyl ACP synthase) domain onto which the initial acetyl coA is shifted from its original attachment to ACo domain (a non-enzymic domain) 2.malonyl/acetyl coA-ACP transacylase 3. 3 ketoacyl ACP reductase 4.3 hydroxy acyl ACP dehydratase 5.enoyl ACP reductase

[@SalsabeelAraby]

Extremely helpful and simple. Thank you so much🥰🥰🥰🥰🥰

[@mziwabantuyaya9600]

Saved a life, you made it straightforward and simple. Thanks

[@map7378]

Best explanation of faty acid biosynthesis

[@seldo7825]

Perfect explanation ❤

[@ht5381]

Very good video, really appreciate the clear explanation. Thank you !

[@katarinala]

Best Biochem teacher! 😙😙😙

[@abdelrahmanrady7995]

Keep going!! U're definitely awesome with fantastic diagrams thank you!!

[@NehaSingh-tb4vm]

great video....will share it with my students...thanks !

[@iamarpanghosh]

This video is very helpful! Thank you!

[@Chels-yk2ox]

is there a video on fatty acid breakdown?

[@alevelsdemystified3410]

Such an excellent video!

[@paphiopedilum1202]

Hey man, it might be irrelevant in this channel but please come back to your piano channel to continue Claire De Lune. You really helped me to start off :)

[@hesamb9135]

What a wonderful video!

[@user-nu7ut8mq7v]

this is awesome !!!

[@soemoe5087]

This video is awesome..Thank you!

[@aidatesfe4247]

very good video. nice explanation and not boring at all.thanks so much

[@srikantpanda7993]

best video thank you

[@afrifagyasiwaah]

Thanks

[@goodguy3075]

Amazing 😘😘Love it and really helpful

[@bnengin]

amazing! thanks for a million

[@nebukednazar]

more than perfect

[@MisterVB]

+ CO2 for acetyl coa carboxylase

[@jasurbektursunov6918]

Very understandable 👍.

[@devilterminator7406]

Keep the good work 🖤🖤

[@costancekhoza1815]

Badly need synthesis of membrane lipids

[@030bhumikadas5]

Thanks..its awesome

[@caladbolge]

dude you rock

[@maniinani7675]

Why it is necessary for fatty acid synthesis to complete 7 cycles?

[@georgeklucsarjr1988]

Not a student. Does the process always stop with a 16 carbon chain?, or can other smaller and/or larger chains also be made? If so, are certain enzymes regulators for determining the length?

[@sikemiitunu]

Yes the carbon atom can be longer than 16 and that is the usefulness of the last acetyl coA formed, it's used for elongation of the chain.... And yes, fatty acid denovo synthesis is being regulated by some hormones and enzymes...e.g to activate the synthesis, insulin, citrate are used while to inhibit it, glucagon, epinephrine etc...are used

[@augustortiz]

amazing video

[@Sarapareche]

THANK YOU THANK YOU THANK YOU

[@beautysparkles07]

Amazing

[@PatelAkshay]

thank you so much

[@ionictotalwar6389]

thank you

[@nikhitakumar]

Wow nice

[@victoirelacaille3009]

how does the -s goes away before having palmitate ?

[@alifasatyanis7742]

Thanks a lot!

[@btudrus]

Saying that ChREBP is activated by "calories" is very misleading. ChREBP is a pure carbohydrate (glucose, fructose) sensing molecule. So, for example, in the state of ketosis the cell have abundand "calories" available BUT it will not lead to FA synthesis. In other words, it is primarily carbohydrates which makes one "fat"...

[@gayathrithakshila3235]

Thank youuuuuu🤗

[@balukajovia2487]

im still not understanding fatty acid synthesis especially after the formation of malonyl

[@GoodsonSampa]

Acetyl coa + bicarbonate forms malonyl coa

[@r1c3d75]

In the formation of butyryl coA you haven't shown the formation of its keto acyl and skipped directly to the result i.e. reduction, dehydration and again reduction were not shown in the step for the preparation of butyryl coA

[@ugonnaogwuegbu3000]

How is it 14 NADPH when NADPH molecules were only used after the formation of butryl coA, shouldn't it be 12 NADPH molecules?

[@zapataboy9377]

After you obtain Butryl-CoA you have 2 reduction by the KR and ER enzymes. you have 7 total cycles so 2*7=14

[@vangalavenkatachalapathi8730]

Awesome

[@dradaezejoymadubuike7741]

Plenty kisses for you. You just simplified the whole stuff.

[@dr_shyma]

goooooood

[@sanjanalaksh]

Isnt it 12 NADPH ? cause NADPH is added only in the reduction unit and in reduction unit there is only 6 cycles , cause butyrl coA has 4 C atoms already so just needs 12 more . Im a lil confused

[@hiroshiro7443]

I think he included the first one in the cycle

[@marwa5834]

how are 14 NADPH formed with 2 per reduction reaction? arent there 2 reduction reactions in each cycle with 7 cycles total ?

[@femidaelettil1002]

At the end of 7 cycle 2 fatty acid is synthesised simultaneously (fas complex is a dimer).. 14 NADPH is needed for 1 fattyacid synthesis(2 reduction reaction×7)

[@harshitakaushik9058]

Great video, but please increase the volume. Even with earphones at max volume i had to strain my ears.

[@elizabetheckenrod2203]

Where is the CO2 in your net equation?

[@elizabetheckenrod2203]

Aha - you didn't net any CO2 because they were used in the formation of malonyl-CoA. Got it.

[@calmrhythm6403]

I LOVE YOU

[@preronaagogoi6247]

How 8 acetyl co A ?

[@user-lkkljhi]

coz malonyl CoA is coverted from acetyl CoA by acetylCoA Carboxylase (add 1 carbon group to it).Thus by balance the equation, end up its using Acetyl CoA while malonylCoA is just a intermediate

[@vloerish3982]

It's so great to not have an indian guy explain this stuf for a change. Thank you, very cool!

[@mohammadasifpatel748]

Wow

[@campbeja001]

Not correct pathway Arrow pushing wrong direction as well.

[@sharifishahidan4850]

Actually...actually...actually...actually

[@Real_Life_Motivation1]

كفو

[@zmitch88]

Fatty acids. Yep

[@mariemmohy9496]

Thank you