(Fig 5-C.02) MRI Findings of Autologous Matrix-Induced Chondrogenesis

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📌 Autologous Matrix-Induced Chondrogenesis (AMIC)
Autologous matrix-induced chondrogenesis (AMIC) is a surgical technique designed to enhance the effectiveness of arthroscopic microfracture procedures.
✅ Procedure
Curettage: Cleaning the cartilage defect area.
Microfracture: Creating small fractures in the exposed subchondral bone to form channels for bone marrow stem cells to migrate to the damaged area.
Membrane Attachment: Attaching a collagen I/III membrane to the damaged area using sutures or allogenic fibrin glue.
✅ Indications and Efficacy
AMIC is typically used to treat articular cartilage defects greater than 2 cm².
Clinical studies have shown that AMIC can significantly improve symptoms in patients.
✅ Potential Complications
Clinicians should monitor for the following potential complications, which may lead to poor clinical outcomes:
New cyst formation
Partial detachment of the collagen membrane
Accompanying synovitis
✅ Bone Marrow Stimulation (Microfracture)
Bone marrow stimulation, also known as microfracture, is a key component of the AMIC procedure.
However, bone overgrowth has been observed in 25% to 49% of cases, though its clinical significance remains uncertain.
References
Knee Surg Relat Res. 2022 Jan 28;34(1):1
Semin Musculoskelet Radiol 2018;22:377-385
Semin Musculoskelet Radiol 2011;15:69-88
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#AMIC, #CartilageRepair, #Microfracture, #OrthopedicSurgery, #KneeSurgery, #StemCellTherapy, #CollagenMembrane, #ArticularCartilage, #BoneMarrowStimulation, #ClinicalOutcomes