Fischer to Haworth shortcut for Glucose and Fructose

[@fatts96]

amazing explanation, u saved me once again!

[@Leah4sciMCAT]

I'm so happy to hear that!

[@GaverMote]

iam from iraq this is in ❤University of Kufa. I searched very hard to find someone talking about this topic. Thank you very much. I feel that I understand the topic a little

[@Leah4sciMCAT]

I'm glad I was able to fill that gap for you!

[@maximilliansaar5512]

Perfekt erklärt! Vielen Dank

[@Leah4sciMCAT]

You're very welcome!

[@SucpwBcosbsv]

In min 0:52 It isn’t enough to put the last chiral carbon’s alcohol on the left for L-glucose (and other sugars), you have to change all the alcohols to their respective opposite side. If not then you will get a different sugar (an epimer in 2,3,4 of L-glucose, not L-glucose) Same problem for fructose

[@Leah4sciMCAT]

Oh my goodness you are right. I don't know how I didn't know this for over a decade teaching this. Thank you so much for pointing it out. Mind blown 🤯

[@aysanrasti1058]

thank you soooo much😍

[@Leah4sciMCAT]

You're welcome 😊

[@ursamajor5744]

Is it because D-glucose’s hydroxyl groups are in equatorial position, so it is more stable in that conformation?

[@Leah4sciMCAT]

Exactly 💯

[@miladabdolahzadeh8473]

I have a question, I'm studying veterinary biochemistry and my professor drew the haworth projection with the first carbon on on the left part of the pyran and the c6 down , is he wrong or this is another way of showing it?

[@Leah4sciMCAT]

Molecules can rotate in space. This means that while convention has us drawing it one way, the molecule can also be drawn flipped or upside down. So long as the stereochemistry and connectivity doesn't change, the structure is still correct

[@ShikahAlmuharif]

This really helps me thank u sm ❤

[@Leah4sciMCAT]

You're so welcome!

[@timecode37]

Could it be that the first skeletal formula for D-Glucose isn't quite right? My Fischer projection ends up with all the hydroxyl groups on the right side. If you compare it with the picture on wikipedia, the skeletal structures for D-Glucose don't match. When doing the projection starting from the skeletal structure from wikipedia, the fischer projection matches the one in the video. Can someone tell me what i'm doing wrong?

[@Leah4sciMCAT]

Yup, I've been teaching this for well over a decade and only JUST learned that I've know and taught this wrong all along!! I will be redoing this video 🤦🤦🤦

[@mistyor3754]

Hiii teacher , I’m a bit curious about where does the blue OH comes from ?

[@Leah4sciMCAT]

Great question! The blue oxygen is the aldehyde oxygen in the Fischer projection of glucose. It has been converted into an alcohol group in the Haworth.

[@kroliia3116]

What happens to the purple “H” that’s attached to the red “O” that attacks?

[@Leah4sciMCAT]

Good question! The red "O" becomes deprotonated in solution and loses that purple "H". It is no longer a part of the structure when glucose is drawn as a Haworth projection.

[@NforAbanda-b4w]

Why is glucose called D or L glucose

[@Leah4sciMCAT]

The D and L have to do with stereochemistry of the molecule

[@ppnugget346]

I dont understand it at all imma fail so hard

[@Leah4sciMCAT]

Oh no, I'm so sorry! When do you plan to take the MCAT?

[@mimi1506.]

Same dude, same...

[@ppnugget346]

@@Leah4sciMCAT MCAT??? im in the 11th grade I got 58% on the bio test btw (im in belgium so its a pass)

[@sn-bo3un]

That’s crazy I’m learning this as a 24 year old in university organic chem 2

[@BenjaminMakurAnyaar]

Look how fast you're!!!😢

[@Leah4sciMCAT]

I hope you found the video helpful!