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Hi. With this video, we will discuss the use of Fluconazole in Dermatology and be better prepared for treating our patients. This video is directed towards dermatologists and is not at all advisory for non-medical personnel.
Introduction - 02:33
Pharmacology - 05:55
Pharmacology: Skin - 09:45
Pharmacology: Nails - 12:20
Pharmacology: Hair - 13:28
Mechanism of Action - 14:18
Uses: FDA Approved - 16:38
Uses: Candidiasis - 17:56
Uses: Dermatophytes: Onychomycosis - 20:05
Uses: Dermatophytes - 22:43
Uses: Non-Dermatophytes - 24:39
Adverse Events - 25:42
Drug Interactions - 31:43
Pregnancy and Lactation - 34:00
Monitoring - 36:26
Resistance - 40:07
Further Reading - 44:42
End - 46:29
Good articles on Fluconazole:
1. DIFLUCANTM: Product drug insert.
2. Martin MV. The use of fluconazole and itraconazole in the treatment of candida albicans infections: a review. J Antimicrob Chemother. 2000;45(4):555. doi:10.1093/oxfordjournals.jac.a020880
3. Rosa MI, Silva BR, Pires PS, et al. Weekly fluconazole therapy for recurrent vulvovaginal candidiasis: a systematic review and meta-analysis. Eur J Obstet Gynecol Reprod Biol. 2013;167(2):132-136. doi:10.1016/j.ejogrb.2012.12.001
4. Alsaad AM, Kaplan YC, Koren G. Exposure to fluconazole and risk of congenital malformations in the offspring: A systematic review and meta-analysis. Reprod Toxicol. 2015;52:78-82. doi:10.1016/j.reprotox.2015.02.009
5. Zhang Z, Zhang X, Zhou YY, Jiang CM, Jiang HY. The safety of oral fluconazole during the first trimester of pregnancy: a systematic review and meta-analysis. BJOG. 2019;126(13):1546-1552. doi:10.1111/1471-0528.15913