Pharmacology - Glucocorticoids

[@armandohasudungan]

📌MAKE THIS LECTURE STICK: FREE PRACTICE QUESTIONS HERE! 🎓 youmakr.ai/test-playground/questionnaire/673d4b3e859b9c170836f12d

[@drsheikh]

Dear Armando, I can barely comprehend the hard work that may have gone in making a video like this -the graphics, accuracy of information, and the delivery of the presentation is immaculate. Your free videos have massively contributed to my knowledge base of basic sciences. Thank you. If I get somewhere in life, I will make a contribution to this channel.

[@armandohasudungan]

Thanks mate. I appreciate it!

[@Luli-vz6qq]

please dont stop doing videos like this!!! My univeristy doesnt explain anything. You are the reason why im passing. THANK YOU !!

[@wajihafatimasyeda7901]

YOU ARE SERIOUSLY SOOOO GOOD. You've helped me throughout high school and now I'm in dental school in my second year and you still continue to help me! Amazing videos and great work! So much appreciation. Thanks a ton!

[@TausugDC]

But.. how.. how... HOW CAN YOU DRAW THAT WELL!?!?! You are AWESOME! THank you!

[@melissahahn8552]

the first 10 seconds are like "jsdifjhsdifhkdsjfikdsjfkdsjfödj" and then it gets - as usual - awesome! you're so magical man. thanks

[@foreveryoung4667]

Can i get your number

[@niteshchoudhary665]

10 secs it's like bbc hardcore

[@nathananyimahmensah1104]

😂

[@alfakeerchik]

you are the best human being in the world, my hero

[@LRotter42]

Wow! 8 years old and still quite relevant. After watching enough of your videos, I'm happy to support you via Patreon. Keep up the good work!

[@davicaldasdossantos9484]

I'm from Brazil, more specifically from the state of Pará, your work is very productive. Congratulations.

[@stevensparks6192]

Great video Armondo! One small error though. You are correct in saying that Prostaglandins and Thromboxanes are produced via the COX enzyme; however, Leukotrienes are produced via the Lipoxygenase enzyme not COX.

[@bhumiyadavbhu4889]

Right. However, LT (Leukotrienes) will decrease because of inhibition of arachidonic acid

[@clarkkent1253]

@@bhumiyadavbhu4889 Hmm, but won't that contrast with the load bearing gas powered defibrillator research done in Norse japan?

[@KITAMEBUKI]

Dear Future prof, Armando Hasudungan Thank you for your kindness to show us your treasure. your "YOU TUBE" is beautiful. Your aesthetic feeling is huge like a ocean. I am so moved. Your attitude is scrub yourself,which is like "scrub a bathtub" thank you for your brightness. I always enjoy sun bath from U. from JAPAN

[@acehussain11]

best tutorial , best explanation and best drawing . thanks

[@andymg1321]

Good job! Im a French pharma student, you made my life a lot easier! Thanks for that

[@victor_ylap]

Thank you! You’re making grad school a lot easier for a lot students!

[@marklawrencedelarosa9451]

Thank you so much for your pharmacy videos! Greatly helped me a lot in surviving pharmacy school.

[@saranazar5025]

U helped me understand this in few minutes while I couldn't understand what the professor explained in 1h U da best

[@Jaylynnm1]

PLEASE MAKE MORE PHARM VIDEOS!!

[@favourirobe5698]

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[@michiko968]

This was great, thanks, I have been researching "thyroid cure ayurvedic" for a while now, and I think this has helped. Have you heard people talk about - Yannabarn Vanish Thyroid - (Have a quick look on google cant remember the place now ) ? Ive heard some great things about it and my m8 got amazing results with it.

[@snekjuce]

@@favourirobe5698 lmao you could have just said hey guys im trynna sell some bullshit. if you may be interested in wasting your money look up this bullshit. you could also have just said wtf that remedy is rather than refer to google and then to a source. lmao and the dude michiko mendola is either another account by you or another moron you asked to help you. He, as well, recommended googling it lmaooo. yall funny thumbing up ur own comments too bahahaha

[@ajitanshusingh]

@@snekjuce so true man xD

[@Philosopheee]

Actually at 8:46, gluccorticoids don't actually directly promote osteoclast production. They do however inhibit osteoblasts like he mentioned, but in contrast to the increase in osteoblast apoptosis, the lifespan of osteoclasts is prolonged. Therefore, with longterm therapy, osteoclast numbers are usually maintained in the normal range while osteoblast and bone formation plummets. (Weinstein, Robert S. "Glucocorticoid-Induced Osteoporosis and Osteonecrosis.")

[@Philosopheee]

Absolutely phenomenal video regardless!

[@guanqunli4341]

One minor mistake: leukotrienes is not made by COX, rather by 5-lipoxygenase.

[@heydudesfromthebronycringe8422]

Gotta confuse the med school students right babe?

[@ramontxtx]

Hey Dudes from the Brony Cringe Video lol Rich Panini is everywhere now

[@ujoijas5254]

Another minor mistake: "glucocorticoids" is NOT spelled "glucocoticoids" (without the "r")!

[@pffa9675]

@@heydudesfromthebronycringe8422 so to avoid confusing them, let's teach them factually wrong science?

[@chalavadiguruswamy7662]

Yes

[@DaleMooreCRNA]

I love your videos. You make things sooo simple! We all appreciate you sharing your knowledge with us. You are helpful to many people and we all sincerely appreciate it!

[@silviopina_111]

Awesome work! Learning about Glucocorticoids in Robert Sopolsky’s book “Why Zebras Don’t Get Ulcers” led me to you🤩

[@jaykay3590]

your videos are so helpful. a really good overview of glucocorticoids & the roles they play. keep the vids coming!

[@EminentlyEms]

Oh, jeez. Fantastic drawings and great explanation! I've never seen anything like this.

[@medgurl358]

Can we all appreciate the hardwork and the DIAGRAM ❤️❤️!!! Loved the video.. ITS UMMMAZING!! ❤️

[@nyloxyloto4871]

I have appreciated and enjoyed all your videos up till now. Please keep up the hard work !

[@peterjensen7533]

Thank you for this clear overview. PS: I have always found the term "nonsteroidal anti-inflammatory drug" (NSAID) hard to come around, because it partly refer to a negative. It appear to me now - and please, anybody, correct me if I am wrong - that this reference in NSAID is the glucocorticoids, they are the ones that are both steroidal and anti-inflammatory.

[@mourilshah2054]

No NSAIDS and Glucocorticoids are different Nsaids are non steroidal as the name suggests unlike Glucocorticoids Nsaids inhibits cox enzymes whereas Glucocorticoids inhibit Phospholipase A2 via lipocortin so both COX and LOX Enzymes are inhibited

[@romeolhk1008]

Best video I watched about the topic, thank you!

[@786abcfull]

Very lucid. Many of these recent pharm findings were not around when I attended health school 30 years ago. Keep making educational videos and may be ask for voluntary contributions in the future. Could even put on DVD for sale. A support remedial tutoring.

[@samiahaseeb]

Thank you for these videos! Some of my teachers did not know what they were doing! Thanks for clearing things up!

[@SaraAhmed-uh8qm]

Your drawing and teaching skills are mind blowing please make more videos regarding pharma and patho , Thankyou

[@alfakeerchik]

هون ما بفهمو فارما و باثو لازم تكملي الكلمة كلها عشان يفهمو فارماكولوجي و باثولوجي

[@milenadanielyan3944]

Thank you soo much!much love from Armenia

[@dranantgupta]

Excellent way of explaining! Great video Correction: Glucocorticoids cause immunosuppression, but they do not reduce WBC count!

[@Madiha50]

These efforts of yours are really appreciable. Please make more videos of pharma

[@zukagavasheli9262]

Armando thank you for making this amazing videos, much appreciated.

[@misfit943]

You saved my life dude cheers !!

[@Mayayapayapa]

Thanks for the in depth explanation, i use them from time to time to control my extreme eczema, it's an amazing creation, i couldn't be alive now without it, but it has a lot of cons!

[@kristelmaguysio8109]

Words aren't enough to thank you, Armando. However, I must say: Thank you! So much....

[@sararevelosaltos3296]

Stunning drawings and brilliant representation of information. Thank you!

[@verasofia5470]

Best explanation ever

[@sulemandhanchora5322]

Why haven’t you mentioned that glucocorticoids such as prednisone are contraindicated in Diabetic patients. That’s so important especially in clinical practice. If possible please explain the mechanism of action with regards to how it increases sugar levels. Great content!!

[@ejirosuzzyakpomedaye6005]

Glucocorticoids increase gluconeogenesis, suppress glucose uptake and utilisation leading to hyperglycemia

[@FBWUniverseMode]

@@ejirosuzzyakpomedaye6005 thank you!

[@marychapin6456]

Excellent video! I was surprised when you indicated that glucocorticoids are used to treat pain. I take prednisone when my asthma flairs out-of-control. This is unrelated to pain.

[@mrsdeh2]

Glucocoritcoids help with inflammation, which can cause pain. I take prednisone occasionally for costochondritis - a huge, mind numbing, life changing pain when it flares up. But a good friend of mine took prednisone regularly for a breathing issue she was having. And if you research other breathing treatments, you will find that some of them are glucocorticoids.

[@tha5289]

Timeless video. Thanks!

[@Mariah-ge5be]

I wonder what we would do without your videos...!👌🙏

[@hossainmazra2103]

Very clear explanations and perfect drawings. I found it very useful so thank you.

[@kathryniii]

Thank you so much for making this video!!!

[@janicesmith1156]

This is a great video. I love the explanation. Thank you!

[@VastusShire]

Thank you so so much! I’m was struggling so much in my first year in med school. Alhamdulilah you made it bearable and you’re really helpful.

[@hakaromer]

thanks but there is one small mistake around 5:28 cox enzyme converts arachidonic acid to PG but not leukotriens actually leukotries are made from arachidnoic acid by 5-lipooxygenase enzyme! anyway thanks for the video!

[@nursemyk]

Great stuff! I like the paper and real marker look better than the whiteboard marker look

[@TheBathroomGirl]

just thought of an INGENIUS money making idea for you ! you should make these drawings into posters and sell them !! they're beautiful and can be even used an a visual revision booklet!

[@miraalsalem5494]

just so amazing ..may God protects you !

[@KellyTowe]

Thanks armando❤

[@annajost5973]

Awesome video! Great drawing and explaining!

[@iChrisArt]

Hi Grate Video, I did not understand it all but gone enough to know why i am having so many problems with prednisolone( taking prednisolone for 7 years)

[@miknelltech221]

At first I didn't even know wether you were speaking English or not 😂 Nice video mate 🔥✨🇳🇬

[@BrandtSharkey-Maxwell]

Thank you, I came to this video trying to figure out why glucocorticoid cause fluid retention and now I have an explanation and much more, now I know that glucocorticoids can acts as a mineraloglucocorticoid such as aldosterone and lead to fluid retention, I wonder why they can act like aldosterone but I suppose I will answer that question another day. I also now know that glucocorticoid could lead to osteoporosis, I forgot about that and it was a good review; thank you!

[@GRey-rk9ww]

Thank you for this short but really detailed information. It helped me a lot. thanks!

[@ParabolicDavid]

Thank you! Great visuals!

[@michtren]

Great artist. Great teaching video

[@anandsalve8982]

Fluid retention is caused by na retention in the renal tubule.....

[@CheensCreationsUK]

#AWESOME! You should put these notes up for sale afterwards.

[@biancaz4074]

You draw nicely

[@katelagesse8585]

This was fantastic! Thank you!

[@Bernie-k5k]

wow your videos are really good!!! look the way you draw things, is perfect, and you explain very well, keep going with the good job, you actually made a better video than khan academy

[@tahira3758]

That was really helpful!

[@wfox6985]

Fantastic. Extrememly helpful.

[@lauruzia666]

So fantastic ! Thank you !

[@shwetashajil3983]

Thank you so much... You made it so easy❤️

[@hruthvikbojja9459]

wow!!! That was amazing. i tried to read it by myself but didnt understand anything. thanks for the video

[@kalaichelvan2111]

Simply super ..ease of understanding

[@ماهرصبري-ك2خ]

Thank very much to your work 😍😍💚

[@Leges1000]

Amazing! unique and gifted person. Keep it up!

[@mousaalbalwi227]

Thanks a lot. Keep up the good work.

[@mohsinfareed1797]

Great as usual. Thanks . very clear and informative.

[@LS-gh8sz]

thank you very much, the video you have made is really detailed and also very interesting to watch, all thanks to your wonderful artistic skills;)

[@mizalabiba7528]

great explanation

[@zehramirzeli9214]

Thank you!

[@parigerami2005]

Thank you so much xx

[@ishmael4489]

Wow. Very detailed and clear for my non-scientific brain to understand. Now I know how they work! :)

[@claudineetienne915]

Hello, I am writing you because I'm attempting to publish a research paper and used this video to help me understand the mechanism. I cited you in the paper, however, I would like your consent to do that. Thank you.

[@softtonyj]

amazing...good one Armando. .

[@sage9710]

thank you!!

[@Mielina1390]

If we were to try to support the immune system at the same time as taking corticosteroids what should we do ? For fluid accumulation I think potassium is critical to balance sodium retention. Thank you and nice video !

[@BMHEALTHCARE4U]

Great work

[@drannemathews1]

Love it love it love it keep up the awesome work!!!!!

[@VijayKamble]

one more minor mistake Glucocorticoid at central part but anyway your teaching skills is amazing Thank for video :)

[@munaalogaili4685]

Thank you very much that was very useful as usual ♥️

[@pseuzieq]

Helpful for this Nurse Practitioner student! Thank you :-)

[@drshruthimanjunath5750]

thank you sir...... its very helpful

[@ahmedalmarshedi9801]

Amazing video,,, thank you.

[@hbsk2900]

thank you so so so so so so much

[@Mr.RDN.]

Your video is very helpful.

[@rixxz5456]

EXCELLENT VIDEO!!!

[@FriendofJesusChrist1]

Very clearly explained

[@sitiaisyahahmad9130]

Thank you

[@chandeepajayakody1018]

Really well explained.thank you so much!!!

[@giuliaciancarella1874]

Very helpful, thanks a Lot! Please make more pharm videos (exam in June! )

[@how5870]

pls make pharmacology of asthma drugs...thanks

[@meghabhatt2195]

Amazing video

[@Peachendk]

That was fantastic 👏👏