Folic acid and birth defects

From our free online course, “Causal Diagrams: Draw Your Assumptions Before Your Conclusions”:
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Observational studies indicate that folic acid reduces the risk of birth defects. But the estimate changes depending on what the analysis adjusts for. How do we know which variables to include in our analysis to get the correct estimate?
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[@manuellestpierre5600]

Isn't folic acid bad (cause autism) and folate from food is best

[@manuellestpierre5600]

@@faryalkhan5930 yes and it has something to do with the MTHFR gene bring turned off....

[@Zextranet]

Oh boy, we got a karen here

[@opheliantsiful6138]

Six months pregnant can l take folic acid yes or no

[@julianakaragulian3894]

There’s no need as the neural tube has been closed already.