Gabriel Malonic Ester Synthesis of alpha Amino Acids

[@kal7708]

this actually makes so much sense! thanks leah!

[@Leah4sciMCAT]

You're very welcome!

[@ravenarellano8415]

this was so helpful oh my word thank you God bless

[@Leah4sciMCAT]

You're very much welcome! :)

[@taylorcalibo4883]

Your voice is much easier to listen to than AK LECTURES. But I also love that guy. Keep it up! Subscribed and liked

[@Leah4sciMCAT]

Welcome aboard!

[@mohsinraza-dr2bj]

wow.... all the lectures on amino acids r amazing........ thanx ....keep up the good work mam

[@Leah4sciMCAT]

thank you

[@petergobina362]

Solid and solution phase synthesis of peptides

[@Leah4sciMCAT]

I don't understand whether you have a question. If you do, feel free to contact me through my website at Leah4sci.com/contact

[@m-linko]

Hi there, could you point me to the malonic ester video you mentioned? I couldn't find the link anywhere. Thanks for the video btw!

[@Leah4sciMCAT]

Hi! This is the Malonic Ester synthesis video. I'm unsure of which other video you're asking for, but the entire series can be found on my site at Leah4sci.com/AminoAcids

[@annieregan4940]

How can the R group attack from either top or bottom? Because the step before it is an SN2 reaction (i.e. backside attack) of a bulky group, and so surely the back of the molecule (away from the screen) is sterically shielded, forcing the R group to attach from the front?

[@Leah4sciMCAT]

At which specific point in the video?

[@cristinaalexandra3432]

hello, Leah! thank you for your work, organic chem seems more approachable now; what app is the one you are writing on?

[@Leah4sciMCAT]

You're very welcome!

[@ThorirLenvik]

I'd use it to make thalidomide analogues!

[@Leah4sciMCAT]

Cool!

[@ricarmmtz]

Thank you, Leah! I wanted to ask, does this rxn only synthesize methionine or can it be used for all amino acids?

[@Leah4sciMCAT]

Great question! This synthesis can be used to produce any of the alpha amino acids, even though this video works through the one example of synthesizing methionine.

[@fauxpassant]

Hmmm... you didn't really explain why EtO- was used other than the fact that there was COOEt for the malonic ester. It's to prevent transesterification?

[@Leah4sciMCAT]

My enolate Orgo series leah4sci.com/enolate covers this. See the claisen condensation video

[@Leah4sciMCAT]

But yes, it's to prevent a side reaction which... guess doesn't really matter here because you're turning the ester into a carboxylic acid

[@fauxpassant]

Ok thanks!

[@raphaelmpangala9399]

+Leah4sciMCAT l its same to my research [phone]

[@raphaelmpangala9399]

+Leah4sciMCAT l its same to my research [phone]

[@rachid12117]

you are the best , thank you

[@Leah4sciMCAT]

Thanks and you're welcome! :)

[@radhapatel1170]

Thank you

[@Leah4sciMCAT]

You're very welcome!