Gastrointestinal | Liver Circulation & Portal Hypertension

Official Ninja Nerd Website: ninjanerd.org
Ninja Nerds!
In this lecture Professor Zach Murphy will be teaching you about liver circulation including the hepatic portal vein, common hepatic artery, hepatic artery proper, and many more important structures that are involved in the liver vasculature. We also talk about hepatic portal hypertension going into detail on pathologies such as Caput Medusae, and esophageal varices. We hope you enjoy this lecture and be sure to support us below!
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#ninjanerd #LiverCirculation #Gastrointestinal

[@tenzinpalzom]

When he said trust me for this, I'm like I trust you with whole of my both atrium and ventricles 🥺

[@dr.babitachopra679]

😃

[@johnnysins6940]

Conversion of Phytonadione into menaquinone-4: 1. Phytonadione into menadione 1(a). Phytonadione is converted into it's oxidized form called Phylloquinone thorough a process called hydroxylation by an enzyme called Phytoene-desaturase. 1(b). Phylloquinone is converted into menadione through a process called Prenylation by an enzyme called UbiA prenyltransferase domain-containing 1 (UBIAD1). Prenylation is the addition of a prenyl group to a substrate, the prenyl group is geranylgeranyl. Geranylgeranyl is a long, hydrophobic chain that is made up of two isoprene units. 2. Menadione into menaquinone-4 2(a). Menadione is converted into menadione-geranyl through a process called prenylation by an enzyme called UbiA prenyltransferase domain-containing 1 (UBIAD1). 2(b). MK-4 synthase is an enzyme that catalyzes the addition of four prenyl groups to menadione-geranyl. The prenyl groups are derived from the coenzyme Q10 molecule. The reaction catalyzed by MK-4 synthase results in the formation of a molecule called menaquinone-4. Is this process incorrect or not?

[@smithsabrinaa]

You deserve a large portion of my tuition, thank you for recognizing your gift and sharing it with others.

[@johnnysins6940]

Conversion of Phytonadione into menaquinone-4: 1. Phytonadione into menadione 1(a). Phytonadione is converted into it's oxidized form called Phylloquinone thorough a process called hydroxylation by an enzyme called Phytoene-desaturase. 1(b). Phylloquinone is converted into menadione through a process called Prenylation by an enzyme called UbiA prenyltransferase domain-containing 1 (UBIAD1). Prenylation is the addition of a prenyl group to a substrate, the prenyl group is geranylgeranyl. Geranylgeranyl is a long, hydrophobic chain that is made up of two isoprene units. 2. Menadione into menaquinone-4 2(a). Menadione is converted into menadione-geranyl through a process called prenylation by an enzyme called UbiA prenyltransferase domain-containing 1 (UBIAD1). 2(b). MK-4 synthase is an enzyme that catalyzes the addition of four prenyl groups to menadione-geranyl. The prenyl groups are derived from the coenzyme Q10 molecule. The reaction catalyzed by MK-4 synthase results in the formation of a molecule called menaquinone-4. Is this process incorrect or not?

[@austinbly8406]

It's incredible that you can talk for 45 minutes straight with few mistakes and little to no editing. Thanks for this video!

[@Supsup516]

best channel in the world

[@izzahflipsthetable7336]

Ninja nerd team out here saving med students' lives. God bless yall :"D

[@ChiomaMorah]

I wish this channel was available way back undergrad day☹️. Anyways, I am sitting for a professional exam and this video makes me cover a one week reading for instance, in just a few hours. I have never understood anatomy like I do now after watching your videos! I now enjoy studying anatomy. You were born with a rare gift, thank you so much for sharing with the world.

[@johnnysins6940]

Conversion of Phytonadione into menaquinone-4: 1. Phytonadione into menadione 1(a). Phytonadione is converted into it's oxidized form called Phylloquinone thorough a process called hydroxylation by an enzyme called Phytoene-desaturase. 1(b). Phylloquinone is converted into menadione through a process called Prenylation by an enzyme called UbiA prenyltransferase domain-containing 1 (UBIAD1). Prenylation is the addition of a prenyl group to a substrate, the prenyl group is geranylgeranyl. Geranylgeranyl is a long, hydrophobic chain that is made up of two isoprene units. 2. Menadione into menaquinone-4 2(a). Menadione is converted into menadione-geranyl through a process called prenylation by an enzyme called UbiA prenyltransferase domain-containing 1 (UBIAD1). 2(b). MK-4 synthase is an enzyme that catalyzes the addition of four prenyl groups to menadione-geranyl. The prenyl groups are derived from the coenzyme Q10 molecule. The reaction catalyzed by MK-4 synthase results in the formation of a molecule called menaquinone-4. Is this process incorrect or not?

[@drdeliz3748]

It would have made my life a lot easier if this videos had been available when I attended medical school. Always had doubts over certain subjects (I missed school time because of disease and for the death of my son). You explained everything better than anyone. So clearly... You are quite amazing.

[@obedbagona7402]

As a medical student, this was super helpful, especially as we're discussing Schistosomiasis in our current case study. God bless you bro.

[@josephsweat867]

Great demonstration this guy reminds me of my health teacher in high school, I learned more from him than any other teacher thanks so much.

[@mikegox2275]

You're the reason I passed my biochemistry exam. Thanks very much for sharing the informative videos💯💟

[@0Deirdre0140]

You are a truly gifted teacher. …even I can follow you without getting too lost….my nurse training was many moons ago and wasn’t so detailed or well taught! Bless you! Thank you!

[@kiwii1351]

Incredibly informative. The best tutoring video. I'm fortunate to have found his channel. Thank you so, so much.

[@herbaboa]

Same here, studying for a professional exam, enjoying all aspects of medicine combining these lectures with papers...he is brilliant and sends so much energy and empathy through his eyes. I will be definitely taking some of the courses he offers. The universe loves you ninja 🤓!

[@frfr77]

Wonderful Work as always ,thanks to all the team :)

[@manelomusa2805]

I need to give you my entire tuition 🥺🥺🥺you know your stuff so well and you give it your all when teaching. Thank you so much 🙏🏾

[@constancedemmas423]

This is fabulous 😊 I recently got a job as a Research Nurse in Hepatology.. new field for me . Although I may not “need “ this understanding to do my job , technically speaking , I am feeling lost without this basic understanding of how the liver works .I so appreciate your help. You are an awesome teacher. Thank-you

[@dianameynart3582]

I love your passion and how you simplify ! I am watching this because my BF has portal hypertension and kidney failure -Was total he has esophageal varices as well. Thank you!!!!!! I subscribed!

[@I_love_BTS_2025]

Thank you so much sir for your wonderful lecture, it is so useful and helpful to me.I couldn't understand this portion when I learnt from lecturers in our medical college, but once i listen to your lectures everything becomes crystal clear.You are really doing such a great service through these selfless efforts.I wish you good luck and all the courage to do more wonderful videos like this always in future. I am a fan of Ninja Nerds, from Sri Lanka

[@izzygee2216]

By far you are the best I’ve seen! Thank you so much for your exceptional and detailed video! 🙏🏽👏🏽👍🏽😌God bless you!

[@sarayounis9776]

Professor Zach thank you so much you are the best thing to ever happen to a med student. Magnificent explanation

[@luziqa4046]

perfect teacher, perfect video, perfect understanding & knowledge !!!

[@westfield90]

Superb as always. So impressed with your knowledge but also your ability to explain and articulate it all so well. This video was such a revelation to me. I had always assumed all returning blood from all organs was via the inferior vena cava but had no idea of this very clever portal to the liver. God or nature is so brilliant in its designs.

[@simionepowell6400]

Thank you for providing a comprehensive, in-depth analysis of the Liver. You have given me a new appreciation of the liver, I am even tempted to give up alcohol to protect this hard-working filtering system.

[@taniam.9026]

I wish you were my teacher!! You explain everything sooo well! Thank you!

[@mihikagupta6344]

Always makes learning so much easier ! Love this channel and thanks Zack for the great explanations !!

[@KateGlenn]

You really know how deliver! Search for info on Portal Hypertention and stumbled upon your video. I can now review the medical write-up with greater understanding. Thank you!👏👏

[@alluparantha]

I'm a nursing lecturer and your videos are my go to. Thank you sir 🙏

[@lovemagicandroad]

AWSOME VIDEO, Thank you so much. I'm a Board Certified Internist and didn't recall how the basic flow throught the liver went any more. So appreciate this fantastic video. I'm currently visiting Sweden (am a dual citizen) from Cal and parked myself here at a lovely Medical library. Finished watching your video here. Loved it!

[@men3m347]

Usually I get bored with long videos but yours I can't even think if I will get bored ,I wish you explain all medical lectures ,then I won't have any thing other to do rather than watching your videos,Dr Zach .

[@lyonsdavid]

I've been diagnosed with non-alcoholic fatty liver disease, high blood pressure, and high cholesterol I'm just here trying to learn as much as I can about my liver, I never gave it much thought before I always thought the heart, brain, or lungs where you're most important organ but now I know the liver is actually the most important organ thank you Doctor.

[@sittoris]

Great video. Really liked your gesticulations when describing sagital and coronal views - very easy to understand.

[@DrVarinderpalSingh]

Thanks Zack. Texting you straight from Punjab in India. Can’t explain the effect your teaching had on me. So satisfying. God bless you bro. ❤️

[@kellyeyo3950]

Hi! I just discovered your channel and found it's truly very useful with your clear explanation and drawing! very much appreciated!

[@alleeea8200]

Understand the hepatic portal Sys much better. Sir, thank you for the thorough explanation...salute!

[@joycedistler4332]

My 62 year old hubby has cirrhosis of the liver, a swollen spleen, a hernia, low blood platelets , low white blood cells and very high bilirubin and asceites (?). His hematologist doctor wants to put him on water pills or drain belly, do a bone marrow biopsy. She told him he needed a liver transplant. We asked her what role diet & nutrition plays in this. She said “NOTHING.” SO……We quit cold Turkey all alcohol, all processed foods, cut down drastically on sugar and salt. No pain meds, no prescriptions. He’s lost 33 lbs since diagnosed in August 22. I’ve only lost 9 ( Damnit). He says he feels so much better. We will - in the short term at least- continue to get blood tests and exam of belly ( CT Scan?) WE believe we can reverse this.

[@AkshatDave-qb1pe]

Incredible! What a bright shining lamp you are! Sir you are like the lamp which burns itself to illuminate the medical world. You explained so nicely in short time that was not possible for me to understand even after trying for many days. God bless you. Our good wishes are always with you.

[@KhushbooSingh-mw8wg]

The most amazing and clear vidoes I have come across yet. This is sth that i had not understood since med school and it all makes so much sense now. Thank you so much :) :) :) :)

[@RaviRavi-dh1sg]

Khushboo Singh you completed ..medical

[@DrNeerajArora]

Plz recommended some more channels for hepatology.

[@arlonbaas8800]

My daughter passed away at 31 from Cirrhosis of the Liver. Thanks for helping me understand more about what happened.

[@NinjaNerdOfficial]

We are sorry for your loss. We couldn't begin to understand your loss, but hopefully the understanding you've gained can bring you some closure.

[@karqoa3968]

best teacher Ive had so far

[@almash1417]

Thank you so much it's amazing how you make everything so much easier ❤️❤️❤️

[@aramhakobyan8549]

Best tutor ever. thank you so much for all this lectures!!!

[@christintesnar613]

Sooooo good…. Teaching is his calling/niché

[@ShubhalaxmiNaruni]

OMG IM SO GLAD I FOUND YOU... explained in a very well stepwise manner... Thank you so much...

[@harsha2165]

Loved this lecture. I have watched many many and this is one of the best one. TY

[@loveasmr5336]

This is a great video for a patient like me. I have PBC. Your diagrams are really easy to understand thank you. I am waiting for the result on my portal Doppler scan.

[@saqomahdi6413]

I actually came here came here not knowing the gross anatomy and now im leaving knowing the whole circulation thank you sooo much🙏🙏

[@mshparber]

Thank you, Professor!

[@PROPHYLAXISU]

Yesterday I can’t remember this topic when I studied with book suddenly I remember everything about liver after this miraculous video 📼 hats off bro u r hulk

[@sadafbashir5787]

Aww while teaching hus expressions were so cute.. gosh I am in love with him :(

[@abrahem9282]

😆😆😆😆😆😆😆

[@marinarosabarbosa]

I have a crush on him, too!!

[@dianar.6047]

This has helped me during my pathophysioly class! Thank you ! 😊

[@aslbekyuldoshev5264]

Thank you. Now I'm more interested in medicine than before because of your lessons

[@scooberdoo72]

Thank you for the knowledge shared. As it gives me more understanding about my diagnoses. And how things work❤

[@Mryounesfly]

Artistic presentation, really clear explanation thanks to you guys

[@MsAasifa]

how do u remember so many things.u r a gift of god to all of us. u r simply great.where were u since so many years.we missed u .

[@richtofen6584]

even tho this is a year ago. you sound sick. hope you feel better xD thanks for powering thru and teaching us under the weather

[@lisacervantes9792]

Perfect explanation of liver circulation!

[@RenaudRichet-CoachNaturopathe]

Amazing ! Thanks a lot. Best explanation ever.

[@djgoon13]

Love this, stellar presentation!

[@ramandkirandonthi9374]

Excellent information & very well spoken. In Gastric bypass surgery most common to see Vitamin -A deficiency ( fat soluble Vitamin absorbed from stomach ) from Ophthalmology standpoint & patients have to take Vitamin -A regularly as a medicine. Thanks

[@chittadas858]

such a great teacher you are...your efforts should be really appreciated...

[@kabweleviticus9149]

This is the best explanation I've ever gotten about this stuff, Im a RADIOGRAPHER by profession, this explanation makes sense I feel Bad for the I reported on sonograms before knowing this

[@shahzaibkhan-jo9fn]

Thank you very Mach sir ..... stay happy and God bless you .....

[@HafizahHoshni]

Brilliant explanation! Thank you so much! 18/11/2018 😃😃

[@Strykerman88]

Thanks for helping me understand how this works. My mom’s doctor is suggesting that speaking with a specialist about getting her TIPS procedure. This is scary stuff! 😔

[@chilufyachewe3843]

This guy is so good, he requires to teach at my university 🙌

[@Biomeducated]

You Sir, are bringing the swag into anatomy/physiology. This is what happens when passion and competence are nicely blended. If this is your way of studying/reviewing for yourself you are going to know your stuff! Exams are a walk in the park for you, me thinks. Also , way better source for me to recap GI-Liver basics before starting a PhD in this field. Screw dull paper courses, this is the future!

[@bhawnasuryawanshi2350]

I have no words 😭😭😭😭, thank you so much. 🙏

[@rjyoti4375]

This channel is a blessing!

[@jimlogan9883]

Excellent! Thank you so much for an informative presentation. I have liver disease and appreciated this video.

[@rafaeldis]

Me ajuda demais nas aulas! Você é fera!

[@littlepeky]

I have a major test tomorrow glad you uploaded this video. 😋

[@mirriambesa]

Iam a nurse student, l really enjoy this advanced knowledge on portal circulation and hypertension. Thank you so much

[@alaatalal3283]

you are a PHENOMENON bro!

[@AS-xg1nr]

Omg that was SO good!!! Thank you very much!!

[@men3m347]

I like it when you say alright and take a deep breath,I feel lovely❤️

[@priscilamiguel8438]

best teacher ever!!! thank you so much!

[@woodrowmeeks5009]

Finally, someone who can explain this subject.

[@starrysky4216]

Thank you so much you literally answered 5 questions of my homework ❤

[@pratikchavan7876]

What an amazing and conceptual video 😊 thanks sir for making this so easy 🥰

[@naveengautam9662]

Wonderful GI ninja technique!!

[@ScottDamery]

its like watching my memory working in live action ....awesome job. I always used colored pens/pencils to draw similar thoughts

[@mollybissell9277]

This video just changed my life THANK YOU SO MUCH

[@sayansarkar2030]

Thank you so much sir for such a well explained video!

[@investorclinton9356]

Great Job my Man. Keep up the good work

[@Nehasharma0a]

Sensei you are amezing love from india 🇮🇳, just the way you teaching us is great...

[@quickdesign7653]

You are amazing zack , all love and respect ❤️

[@himalaya396]

you are the best that cleared most of my doubt i love this

[@samanthax2848]

Thank you for this!

[@piyushsumera1433]

I have Lecture on Liver this saturday..Thanks for this..Now I can Say good bye to that lecture..

[@kartikeyasrivastava3719]

Amazing explanation, you’re the best online teacher out there :). Thankyou for the effort!! Had to mention this, shouldn’t the word be haematemesis at 43:52?

[@vccuong1]

I find this video so valuable as I am a patient currently with GI tract bleeding. I have this bleeding from about 3 months after the whipple surgery till now, a total of 4 times getting in the hospital but the doctors still not be able to find the source or the root cause of the GI tract bleeding. I have some blood clot in the portal vein which I am now thinking it is the main cause of my bleeding. Thank you so much.

[@MMarieinspace]

This is amazing, you are a wonderful teacher!!

[@tripti1339]

If I have to choose one channel on KZbin for life time, it is gonna be this one. ❤️❤️

[@sarahsahibqran2198]

Thank you to the greatest medical teaching King of all time 👑 👌

[@ngocdu6639]

One of the best tutor!! Thank you very much

[@EduMutasimAli]

i don't how anatomy could be without you

[@arindam9446]

Awesome You make everything simple

[@parimansuri3587]

wow! great explanation ! God bless you Ninja👍

[@deeppurple3489]

I was diagnosed with portal hypertension of the liver. I've several nodules also but nothing more. This was very imformative and made me feel better about the outcome about the stunt placement. My only worry now are the nodules.

[@saqomahdi6413]

Hope you get better soon

[@ARMINK6969]

Mere papa ko cld h stage 4 portal hypertension h medicines chal rhi h...unki life ko danger to nhi h?

[@SkallaNRafiq]

Thank you mr.knowing everything 💎🤩

[@frankkayemba2633]

Incredible, am really grate. You increased my efficiency amidst the work load of medical school.